{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:40:57Z","timestamp":1777329657349,"version":"3.51.4"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LeibnizScienceCampus Phosphorus Research Rostock","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"name":"LeibnizScienceCampus Phosphorus Research Rostock","award":["n.a."],"award-info":[{"award-number":["n.a."]}]},{"name":"FP7 EU-project ECO-FCE","award":["311794"],"award-info":[{"award-number":["311794"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12864-018-4584-2","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T02:25:41Z","timestamp":1522808741000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lowered dietary phosphorus affects intestinal and renal gene expression to maintain mineral homeostasis with immunomodulatory implications in weaned piglets"],"prefix":"10.1186","volume":"19","author":[{"given":"Franziska","family":"Just","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Oster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"B\u00fcsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Borgelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Murani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-6790","authenticated-orcid":false,"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"4584_CR1","doi-asserted-by":"publisher","first-page":"620","DOI":"10.4103\/2230-8210.113752","volume":"17","author":"N Prasad","year":"2013","unstructured":"Prasad N, Bhadauria D. Renal phosphate handling: physiology. Indian J Endocrinol Metab. 2013;17:620\u20137.","journal-title":"Indian J Endocrinol Metab"},{"key":"4584_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.livsci.2010.06.113","volume":"134","author":"K Partanen","year":"2010","unstructured":"Partanen K, Siljander-Rasi H, Karhap\u00e4\u00e4 M, Ylivainio K, Tupasela T. Responses of growing pigs to different levels of dietary phosphorus - performance, bone characteristics, and solubility of faecal phosphorus. Livest Sci. 2010;134:109\u201312.","journal-title":"Livest Sci"},{"key":"4584_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3945\/jn.109.117390","volume":"140","author":"LS Alexander","year":"2010","unstructured":"Alexander LS, Mahajan A, Odle J, Flann KL, Rhoads RP, Stahl CH. Dietary phosphate restriction decreases stem cell proliferation and subsequent growth potential in neonatal pigs. J Nutr. 2010;140:477\u201382.","journal-title":"J Nutr"},{"key":"4584_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0301-6226(99)00013-5","volume":"58","author":"HD Poulsen","year":"1999","unstructured":"Poulsen HD, Jongbloed AW, Latimier P, Fern\u00e1ndez JA. Phosphorus consumption, utilisation and losses in pig production in France, the Netherlands and Denmark. Livest Prod Sci. 1999;58:251\u20139.","journal-title":"Livest Prod Sci"},{"key":"4584_CR5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0301-6226(99)00009-3","volume":"58","author":"JY Dourmad","year":"1999","unstructured":"Dourmad JY, Guingand N, Latimier P, S\u00e8ve B. Nitrogen and phosphorus consumption, utilisation and losses in pig production: France. Livest Prod Sci. 1999;58:199\u2013211.","journal-title":"Livest Prod Sci"},{"key":"4584_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1146\/annurev-environ-010213-113300","volume":"39","author":"D Cordell","year":"2014","unstructured":"Cordell D, White S. Life\u2019s bottleneck: sustaining the World\u2019s phosphorus for a food secure future. Annu Rev Environ Resour. 2014;39:161\u201388.","journal-title":"Annu Rev Environ Resour"},{"key":"4584_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/jpln.201400327","volume":"178","author":"J Kruse","year":"2015","unstructured":"Kruse J, Abraham M, Amelung W, Baum C, Bol R, K\u00fchn O, et al. Innovative methods in soil phosphorus research: a review. J Plant Nutr Soil Sci. 2015;178:43\u201388.","journal-title":"J Plant Nutr Soil Sci"},{"key":"4584_CR8","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.gloenvcha.2015.12.005","volume":"36","author":"M Chen","year":"2016","unstructured":"Chen M, Graedel TE. A half-century of global phosphorus flows, stocks, production, consumption, recycling, and environmental impacts. Glob Environ Chang Elsevier Ltd. 2016;36:139\u201352.","journal-title":"Glob Environ Chang Elsevier Ltd"},{"key":"4584_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.jnutbio.2005.08.008","volume":"17","author":"LJ Hittmeier","year":"2006","unstructured":"Hittmeier LJ, Grapes L, Lensing RL, Rothschild MF, Stahl CH. Genetic background influences metabolic response to dietary phosphorus restriction. J Nutr Biochem. 2006;17:385\u201395.","journal-title":"J Nutr Biochem"},{"key":"4584_CR10","first-page":"2585","volume":"86","author":"LS Alexander","year":"2008","unstructured":"Alexander LS, Qu A, Cutler SA, Mahajan A, Lonergan SM, Rothschild MF, et al. Response to dietary phosphorus deficiency is affected by genetic background in growing pigs. J Anim Sci American Society of Animal Science. 2008;86:2585\u201395.","journal-title":"J Anim Sci American Society of Animal Science"},{"key":"4584_CR11","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3945\/jn.109.110080","volume":"140","author":"KL Saddoris","year":"2010","unstructured":"Saddoris KL, Fleet JC, Radcliffe JS. Sodium-dependent phosphate uptake in the jejunum is post-transcriptionally regulated in pigs fed a low-phosphorus diet and is independent of dietary calcium concentration. J Nutr. 2010;140:731\u20136.","journal-title":"J Nutr"},{"key":"4584_CR12","doi-asserted-by":"publisher","first-page":"R917","DOI":"10.1152\/ajpregu.00215.2015","volume":"310","author":"M Oster","year":"2016","unstructured":"Oster M, Just F, B\u00fcsing K, Wolf P, Polley C, Vollmar B, et al. Towards improved phosphorus efficiency in monogastrics - interplay of serum, minerals, bone and immune system after divergent dietary phosphorus supply in swine. Am J Physiol Regul Integr Comp Physiol. 2016;310:R917\u201325.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"4584_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2527\/2001.792413x","volume":"79","author":"EB Kegley","year":"2001","unstructured":"Kegley EB, Spears JW, Auman SK. Dietary phosphorus and an inflammatory challenge affect performance and immune function of weanling pigs. J Anim Sci. 2001;79:413\u20139.","journal-title":"J Anim Sci"},{"key":"4584_CR14","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3382\/ps.2007-00517","volume":"87","author":"N Liu","year":"2008","unstructured":"Liu N, Ru YJ, Cowieson AJ, Li FD, Cheng XCH. Effects of Phytate and Phytase on the performance and immune function of broilers fed nutritionally marginal diets. Poult Sci. 2008;87:1105\u201311.","journal-title":"Poult Sci"},{"key":"4584_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1017\/S0954422415000049","volume":"28","author":"CME Heyer","year":"2015","unstructured":"Heyer CME, Weiss E, Schmucker S, Rodehutscord M, Hoelzle LE, Mosenthin R, et al. The impact of phosphorus on the immune system and the intestinal microbiota with special focus on the pig. Nutr Res Rev Cambridge University Press. 2015;28:67\u201382.","journal-title":"Nutr Res Rev Cambridge University Press"},{"key":"4584_CR16","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR. Intestinal mucosal barrier function in health and disease. Nat. Rev. Immunol. Nat Publ Group. 2009;9:799\u2013809.","journal-title":"Nat. Rev. Immunol. Nat Publ Group"},{"key":"4584_CR17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri2710","volume":"10","author":"LV Hooper","year":"2010","unstructured":"Hooper LV, Macpherson AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat. Rev. Immunol. 2010;10:159\u201369.","journal-title":"Nat. Rev. Immunol."},{"key":"4584_CR18","doi-asserted-by":"crossref","unstructured":"Mann E, Schmitz-Esser S, Zebeli Q, Wagner M, Ritzmann M, Metzler-Zebeli BU. Mucosa-associated bacterial microbiome of the gastrointestinal tract of weaned pigs and dynamics linked to dietary calcium-phosphorus. PLoS One. 2014;9(1):e86950.","DOI":"10.1371\/journal.pone.0086950"},{"key":"4584_CR19","doi-asserted-by":"publisher","first-page":"706","DOI":"10.4049\/jimmunol.180.2.706","volume":"180","author":"V Lukacs-Kornek","year":"2008","unstructured":"Lukacs-Kornek V, Burgdorf S, Diehl L, Specht S, Kornek M, Kurts C. The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol. 2008;180:706\u201315.","journal-title":"J Immunol"},{"key":"4584_CR20","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nri3523","volume":"13","author":"C Kurts","year":"2013","unstructured":"Kurts C, Panzer U, Anders H-J, Rees AJ. The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol. 2013;13:738\u201353.","journal-title":"Nat Rev Immunol"},{"key":"4584_CR21","volume-title":"Empfehlungen zur Energie- und N\u00e4hrstoffversorgung von Schweinen","author":"GfE [Ausschuss f\u00fcr Bedarfsnormen der Gesellschaft f\u00fcr Ern\u00e4hrungsphysiologie]","year":"2006","unstructured":"GfE [Ausschuss f\u00fcr Bedarfsnormen der Gesellschaft f\u00fcr Ern\u00e4hrungsphysiologie]. Empfehlungen zur Energie- und N\u00e4hrstoffversorgung von Schweinen. Frankfurt am Main: DLG-Verlag; 2006. ISBN 978-3769006834.(in German)"},{"key":"4584_CR22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1741-7007-10-90","volume":"10","author":"TC Freeman","year":"2012","unstructured":"Freeman TC, Ivens A, Baillie JK, Beraldi D, Barnett MW, Dorward D, et al. A gene expression atlas of the domestic pig. BMC Biol. 2012;10:90.","journal-title":"BMC Biol"},{"key":"4584_CR23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domrachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30:207\u201310.","journal-title":"Nucleic Acids Res"},{"key":"4584_CR24","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/bioinformatics\/btn647","volume":"25","author":"A Kauffmann","year":"2009","unstructured":"Kauffmann A, Gentleman R, Huber W. arrayQualityMetrics - a bioconductor package for quality assessment of microarray data. Bioinformatics. 2009;25:415\u20136.","journal-title":"Bioinformatics"},{"key":"4584_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","volume":"4","author":"RA Irizarry","year":"2003","unstructured":"Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249\u201364.","journal-title":"Biostatistics"},{"key":"4584_CR26","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing [Internet]. Vienna, Austria; 2015. Available from: http:\/\/www.r-project.org \/."},{"key":"4584_CR27","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1073\/pnas.1530509100","volume":"100","author":"JD Storey","year":"2003","unstructured":"Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A. 2003;100:9440\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4584_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1079\/NRR19910011","volume":"4","author":"G Breves","year":"1991","unstructured":"Breves G, Schr\u00f6der B. Comparative aspects of gastrointestinal phosphorus metabolism. Nutr Res Rev. 1991;4:125\u201340.","journal-title":"Nutr Res Rev"},{"key":"4584_CR29","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1079\/BJN19780069","volume":"39","author":"IG Partridge","year":"1978","unstructured":"Partridge IG. Studies on digestion and absorption in the intestines of growing pigs. Br J Nutr. 1978;39:539\u201345.","journal-title":"Br J Nutr"},{"key":"4584_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1152\/physiol.00034.2008","volume":"24","author":"T Berndt","year":"2008","unstructured":"Berndt T, Kumar R. Novel mechanisms in the regulation of phosphorus homeostasis. Physiology. 2008;24:17\u201325.","journal-title":"Physiology"},{"key":"4584_CR31","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1159\/000209740","volume":"27","author":"JG Taylor","year":"2009","unstructured":"Taylor JG, D a B. Calcium and phosphorus homeostasis. Blood Purif. 2009;27:387\u201394.","journal-title":"Blood Purif"},{"issue":"Suppl 1","key":"4584_CR32","first-page":"20","volume":"47","author":"M Oster","year":"2017","unstructured":"Oster M, Gerlinger C, Heide K, Just F, Borgelt L, Wolf P, et al. Lower dietary phosphorus supply in pigs match both animal welfare aspects and resource efficiency. Ambio. 2017;47(Suppl 1):20\u20139.","journal-title":"Ambio"},{"key":"4584_CR33","doi-asserted-by":"publisher","first-page":"E598","DOI":"10.1152\/ajpendo.00214.2003","volume":"286","author":"F Barletta","year":"2004","unstructured":"Barletta F, Dhawan P, Christakos S. Integration of hormone signaling in the regulation of human 25(OH)D3 24-hydroxylase transcription. Am J Physiol Endocrinol Metab. 2004;286:E598\u2013608.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4584_CR34","first-page":"267","volume":"59","author":"P Robak","year":"2016","unstructured":"Robak P, Ozgo M, Micha\u0142ek K, Kolasa-Wo\u0142osiuk A, Taciak M, Barszcz M, et al. Identification of TRPM6 and TRPM7 expression changes in response to a diet supplemented with inulin in porcine kidney. Arch Tierzucht. 2016;59:267\u201374.","journal-title":"Arch Tierzucht"},{"key":"4584_CR35","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1152\/ajplegacy.1968.214.2.348","volume":"214","author":"I Clark","year":"1968","unstructured":"Clark I. Effects of magnesium ions on calcium and phosphorus metabolism. Am J Phys. 1968;214:348\u201356.","journal-title":"Am J Phys"},{"key":"4584_CR36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/BF02008092","volume":"1","author":"I Clark","year":"1967","unstructured":"Clark I. The effects of alterations in dietary magnesium on calcium, phosphate and skeletal metabolism. Calcif Tissue Res. 1967;1:204\u201318.","journal-title":"Calcif Tissue Res"},{"key":"4584_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1053\/j.ackd.2010.11.004","volume":"18","author":"Y Sabbagh","year":"2011","unstructured":"Sabbagh Y, Giral H, Caldas Y, Levi M, Schiavi SC. Intestinal phosphate transport. Adv Chronic Kidney. 2011;18:85\u201390.","journal-title":"Adv Chronic Kidney"},{"key":"4584_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1194\/jlr.R031534","volume":"55","author":"G Jones","year":"2014","unstructured":"Jones G, Prosser DE, Kaufmann M. Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res. 2014;55:13\u201331.","journal-title":"J Lipid Res"},{"key":"4584_CR39","doi-asserted-by":"crossref","unstructured":"Weaver CM, Fleet JC. Vitamin D requirements: current and future 1 \u2013 3. Am J Clin Nutr. 2004;80(6 Suppl.):1735S-9S.","DOI":"10.1093\/ajcn\/80.6.1735S"},{"key":"4584_CR40","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1152\/physrev.2000.80.4.1291","volume":"80","author":"MJ Rebecchi","year":"2000","unstructured":"Rebecchi MJ, Pentyala SN. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev. 2000;80:1291\u2013335.","journal-title":"Physiol Rev"},{"key":"4584_CR41","doi-asserted-by":"publisher","first-page":"F485","DOI":"10.1152\/ajprenal.00608.2009","volume":"298","author":"D Riccardi","year":"2010","unstructured":"Riccardi D, Brown EM. Physiology and Pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Ren Physiol. 2010;298:F485\u201399.","journal-title":"Am J Physiol Ren Physiol"},{"key":"4584_CR42","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-physiol-030212-183750","volume":"75","author":"G Kadamur","year":"2013","unstructured":"Kadamur G, Ross EM. Mammalian phospholipase C. Annu Rev Physiol. 2013;75:127\u201354.","journal-title":"Annu Rev Physiol"},{"key":"4584_CR43","doi-asserted-by":"crossref","unstructured":"Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat. Rev Mol Cell Biol. 2000;1:11\u201321.","DOI":"10.1038\/35036035"},{"key":"4584_CR44","first-page":"71","volume":"51","author":"EA Systems","year":"1991","unstructured":"Systems EA, Analogs A. Protein kinase c. Online. 1991;51:71\u201395.","journal-title":"Online"},{"key":"4584_CR45","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1210\/mend-5-4-605","volume":"5","author":"AV Krishnan","year":"1991","unstructured":"Krishnan AV, Feldman D. Activation of protein kinase-C inhibits vitamin D receptor gene expression. Mol Endocrinol. 1991;5:605\u201312.","journal-title":"Mol Endocrinol"},{"key":"4584_CR46","doi-asserted-by":"publisher","first-page":"E162","DOI":"10.1152\/ajpendo.2001.281.1.E162","volume":"281","author":"W Yang","year":"2001","unstructured":"Yang W, Hyllner SJ, Christakos S. Interrelationship between signal transduction pathways and 1,25(OH)2D3 in UMR106 osteoblastic cells. Am J Physiol Endocrinol Metab. 2001;281:E162\u201370.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"4584_CR47","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/qjmed\/95.1.3","volume":"95","author":"M Mazzali","year":"2002","unstructured":"Mazzali M, Kipari T, Ophascharoensuk V, Wesson JA, Johnson R, Hughes J. Osteopontin--a molecule for all seasons. QJM. 2002;95:3\u201313.","journal-title":"QJM"},{"key":"4584_CR48","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/ki.1995.222","volume":"47","author":"JG Kleinman","year":"1995","unstructured":"Kleinman JG, Beshensky A, Worcester EM, Brown D. Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney. Kidney Int Elsevier Masson SAS. 1995;47:1585\u201396.","journal-title":"Kidney Int Elsevier Masson SAS"},{"key":"4584_CR49","doi-asserted-by":"publisher","first-page":"G96","DOI":"10.1152\/ajpgi.1998.274.1.G96","volume":"274","author":"KL Madsen","year":"1998","unstructured":"Madsen KL, Tavernini MM, Yachimec C, Mendrick DL, Alfonso PJ, Buergin M, et al. Stanniocalcin: a novel protein regulating calcium and phosphate transport across mammalian intestine. Am J Physiol Gastrointest Liver Physiol. 1998;274:G96\u2013102.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4584_CR50","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2003.08.131","volume":"310","author":"K Yahata","year":"2003","unstructured":"Yahata K, Mori K, Mukoyama M, Sugawara A, Suganami T, Makino H, et al. Regulation of stanniocalcin 1 and 2 expression in the kidney by klotho gene. Biochem Biophys Res Commun. 2003;310:128\u201334.","journal-title":"Biochem Biophys Res Commun"},{"key":"4584_CR51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1210\/en.2013-1608","volume":"155","author":"CH Lin","year":"2014","unstructured":"Lin CH, Su CH, Hwang PP. Calcium-sensing receptor mediates Ca2+ homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 2014;155:56\u201367.","journal-title":"Endocrinology"},{"key":"4584_CR52","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1007\/s00424-003-1066-3","volume":"447","author":"SC Hebert","year":"2004","unstructured":"Hebert SC, Mount DB, Gamba G. Molecular physiology of cation-coupled cl- cotransport: the SLC12 family. Pflugers Arch Eur J Physiol. 2004;447:580\u201393.","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"4584_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1152\/physrev.00018.2005","volume":"86","author":"R DiPolo","year":"2006","unstructured":"DiPolo R, Beaug\u00e9 L. Sodium\/calcium exchanger: influence of metabolic regulation on ion carrier interactions. Physiol Rev. 2006;86:155\u2013203.","journal-title":"Physiol Rev"},{"key":"4584_CR54","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1242\/jeb.200.2.295","volume":"302","author":"S Hebert","year":"1997","unstructured":"Hebert S, Brown E, Harris H. Role of the Ca2+\u2212sensing receptor in divalent mineral ion homeostasis. J Exp Biol. 1997;302:295\u2013302.","journal-title":"J Exp Biol"},{"key":"4584_CR55","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1159\/000025892","volume":"21","author":"E Desfleur","year":"1998","unstructured":"Desfleur E, Wittner M, Simeone S, Pajaud S, Moine G, Rajerison R, et al. Calcium-sensing receptor : regulation of electrolyte transport in the thick ascending limb of Henle \u2019 s loop. Kidney Blood Press Res. 1998;21:401\u201312.","journal-title":"Kidney Blood Press Res"},{"key":"4584_CR56","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00424-003-1087-y","volume":"447","author":"RJ Reimer","year":"2004","unstructured":"Reimer RJ, Edwards RH. Organic anion transport is the primary function of the SLC17\/type I phosphate transporter family. Pflugers Arch. Eur. J. Physiol. 2004;447:629\u201335.","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"4584_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0029483","volume":"7","author":"T Suyama","year":"2012","unstructured":"Suyama T, Okada S, Ishijima T, Iida K, Abe K, Nakai Y. High phosphorus diet-induced changes in NaPi-IIb phosphate transporter expression in the rat kidney: DNA microarray analysis. PLoS One. 2012;7:1\u20139.","journal-title":"PLoS One"},{"key":"4584_CR58","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1136\/gut.2004.051169","volume":"54","author":"C Bourgier","year":"2005","unstructured":"Bourgier C, Haydont V, Milliat F, Fran\u00e7ois A, Holler V, Lasser P, et al. Inhibition of rho kinase modulates radiation induced fibrogenic phenotype in intestinal smooth muscle cells through alteration of the cytoskeleton and connective tissue growth factor expression. Gut. 2005;54:336\u201343.","journal-title":"Gut"},{"key":"4584_CR59","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1086\/590112","volume":"198","author":"J Estes","year":"2008","unstructured":"Estes J, Baker JV, Brenchley JM, Khoruts A, Barthold JL, Bantle A, et al. Collagen deposition limits immune reconstitution in the gut. J Infect Dis. 2008;198:456\u201364.","journal-title":"J Infect Dis"},{"key":"4584_CR60","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.abb.2004.09.004","volume":"432","author":"GD Kutuzova","year":"2004","unstructured":"Kutuzova GD, DeLuca HF. Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D 3 stimulated calcium absorption and clarify its immunomodulatory properties. Arch Biochem Biophys. 2004;432:152\u201366.","journal-title":"Arch Biochem Biophys"},{"key":"4584_CR61","first-page":"785","volume":"11","author":"D Ricklin","year":"2010","unstructured":"Ricklin D, Hajishengallis G, Yang K, Complement LJD. A key system for immune surveillance and homeostasis. Nat. Immunol. Nat Publ Group. 2010;11:785\u201397.","journal-title":"Nat Publ Group"},{"key":"4584_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2012.00267","volume":"3","author":"WM Rauw","year":"2012","unstructured":"Rauw WM. Immune response from a resource allocation perspective. Front Genet. 2012;3:1\u201314.","journal-title":"Front Genet"},{"key":"4584_CR63","doi-asserted-by":"publisher","first-page":"F345","DOI":"10.1152\/ajprenal.00509.2006","volume":"294","author":"HI Abdullah","year":"2008","unstructured":"Abdullah HI, Pedraza PL, McGiff JC, Ferreri NR. CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism. Am J Physiol Renal Physiol. 2008;294:F345\u201354.","journal-title":"Am J Physiol Renal Physiol"},{"key":"4584_CR64","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nri1632","volume":"5","author":"F Maci\u00e1n","year":"2005","unstructured":"Maci\u00e1n F. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 2005;5:472\u201384.","journal-title":"Nat. Rev. Immunol."},{"key":"4584_CR65","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0092-8674(02)00767-5","volume":"109","author":"F Maci\u00e1n","year":"2002","unstructured":"Maci\u00e1n F, Garc\u00eda-C\u00f3zar F, Im SH, Horton HF, Byrne MC, Rao A. Transcriptional mechanisms underlying lymphocyte tolerance. Cell. 2002;109:719\u201331.","journal-title":"Cell"},{"key":"4584_CR66","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.bbrc.2003.09.174","volume":"311","author":"S Feske","year":"2003","unstructured":"Feske S, Okamura H, Hogan PG, Rao A. Ca2+\/calcineurin signalling in cells of the immune system. Biochem Biophys Res Commun. 2003;311:1117\u201332.","journal-title":"Biochem Biophys Res Commun"},{"key":"4584_CR67","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.1128\/MCB.15.10.5789","volume":"15","author":"I Alroy","year":"1995","unstructured":"Alroy I, Towers TL, Freedman LP. Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp\/AP-1 complex formation by a nuclear hormone receptor. Mol Cell Biol. 1995;15:5789\u201399.","journal-title":"Mol Cell Biol"},{"key":"4584_CR68","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4049\/jimmunol.160.1.209","volume":"160","author":"A Takeuchi","year":"1998","unstructured":"Takeuchi A, Reddy GS, Kobayashi T, Okano T, Park J, Sharma S. Nuclear factor of activated T cells (NFAT) as a molecular target for 1alpha,25-dihydroxyvitamin D3-mediated effects. J Immunol. 1998;160:209\u201318.","journal-title":"J Immunol"},{"key":"4584_CR69","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/ni.1851","volume":"11","author":"MR von Essen","year":"2010","unstructured":"von Essen MR, Kongsbak M, Schjerling P, Olgaard K, \u00d8dum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344\u20139.","journal-title":"Nat Immunol"},{"key":"4584_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2013.00148","volume":"4","author":"M Kongsbak","year":"2013","unstructured":"Kongsbak M, Levring TB, Geisler C, von Essen MR. The vitamin D receptor and T cell function. Front Immunol. 2013;4:1\u201310.","journal-title":"Front Immunol"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-018-4584-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12864-018-4584-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-018-4584-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T22:31:25Z","timestamp":1693607485000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-018-4584-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4584"],"URL":"https:\/\/doi.org\/10.1186\/s12864-018-4584-2","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]},"assertion":[{"value":"2 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Animals were provided by the Leibniz Institute for Farm Animal Biology (FBN). The experimental protocol was approved by the ethics committee of the federal state of Mecklenburg-Western Pomerania, Germany (Landesamt f\u00fcr Landwirtschaft, Lebensmittelsicherheit und Fischerei; LALLF MV 7221.3\u20131-053\/15).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No conflicts of interest, financial or otherwise, are declared by the authors","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"207"}}