{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:44:34Z","timestamp":1787985874079,"version":"build-2784847793"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011262","name":"FP7 Food, Agriculture and Fisheries, Biotechnology","doi-asserted-by":"publisher","award":["ANR-16-0001-COFA"],"award-info":[{"award-number":["ANR-16-0001-COFA"]}],"id":[{"id":"10.13039\/100011262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In fish, minimally invasive blood sampling is widely used to monitor physiological stress with blood plasma biomarkers. As fish blood cells are nucleated, they might be a source a potential new markers derived from \u2018omics technologies. We modified the epiGBS (epiGenotyping By Sequencing) technique to explore changes in genome-wide cytosine methylation in the red blood cells (RBCs) of challenged European sea bass (\n                      <jats:italic>Dicentrarchus labrax<\/jats:italic>\n                      ), a species widely studied in both natural and farmed environments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We retrieved 501,108,033 sequencing reads after trimming, with a mean mapping efficiency of 73.0% (unique best hits). Minor changes in RBC methylome appeared to manifest after the challenge test and a family-effect was detected. Only fifty-seven differentially methylated cytosines (DMCs) close to 51 distinct genes distributed on 17 of 24 linkage groups (LGs) were detected between RBCs of pre- and post-challenge individuals. Thirty-seven of these genes were previously reported as differentially expressed in the brain of zebrafish, most of them involved in stress coping differences. While further investigation remains necessary, few DMC-related genes associated to the Brain Derived Neurotrophic Factor, a protein that favors stress adaptation and fear memory, appear relevant to integrate a centrally produced stress response in RBCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our modified epiGBS protocol was powerful to analyze patterns of cytosine methylation in RBCs of\n                      <jats:italic>D. labrax<\/jats:italic>\n                      and to evaluate the impact of a challenge using minimally invasive blood samples\n                      <jats:italic>.<\/jats:italic>\n                      This study is the first approximation to identify epigenetic biomarkers of exposure to stress in fish.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12864-021-07420-9","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T07:03:39Z","timestamp":1612854219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Family-effects in the epigenomic response of red blood cells to a challenge test in the European sea bass (Dicentrarchus labrax, L.)"],"prefix":"10.1186","volume":"22","author":[{"given":"Madoka Vera","family":"Krick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Desmarais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-7032","authenticated-orcid":false,"given":"Athanasios","family":"Samaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Gu\u00e9ret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadios","family":"Dimitroglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-5032","authenticated-orcid":false,"given":"Michalis","family":"Pavlidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0615-7941","authenticated-orcid":false,"given":"Costas","family":"Tsigenopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6934-1677","authenticated-orcid":false,"given":"Bruno","family":"Guinand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"7420_CR1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/B978-0-12-802728-8.00011-4","volume-title":"Biology of Stress in Fish. Fish Physiology, Vol. 35","author":"NM Sopinka","year":"2016","unstructured":"Sopinka NM, Donaldson MR, O\u2019Connor CM, Suski CD, Cooke SJ. Stress indicators in fish. In: Schreck CB, Tort L, Farrell AP, Brauner CJ, editors. Biology of Stress in Fish. Fish Physiology, Vol. 35. Cambridge: Academic Press; 2016. p. 405\u201362. https:\/\/doi.org\/10.1016\/B978-0-12-802728-8.00011-4."},{"key":"7420_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-12-802728-8.00004-7","volume-title":"Biology of Stress in Fish. Fish Physiology, Vol. 35","author":"E Faught","year":"2016","unstructured":"Faught E, Aluru N, Vijayan MM. The molecular stress response. In: Schreck CB, Tort L, Farrell AP, Brauner CJ, editors. Biology of Stress in Fish. Fish Physiology, Vol. 35. Cambridge: Academic Press; 2016. p. 113\u201366. https:\/\/doi.org\/10.1016\/B978-0-12-802728-8.00004-7."},{"key":"7420_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10695-011-9522-z","volume":"38","author":"P Prunet","year":"2012","unstructured":"Prunet P, Overli \u00d8, Douxfils J, Bernardini G, Kestemont P, Baron D. Fish welfare and genomics. Fish Physiol Biochem. 2012;38:43\u201360. https:\/\/doi.org\/10.1007\/s10695-011-9522-z.","journal-title":"Fish Physiol Biochem"},{"issue":"2\u20133","key":"7420_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ygcen.2009.03.020","volume":"164","author":"N Aluru","year":"2009","unstructured":"Aluru N, Vijayan MM. Stress transcriptomics in fish: a role for genomic cortisol signaling. Gen Comp Endocrinol. 2009;164(2\u20133):142\u201350. https:\/\/doi.org\/10.1016\/j.ygcen.2009.03.020.","journal-title":"Gen Comp Endocrinol"},{"issue":"5","key":"7420_CR5","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1534\/g3.119.400152","volume":"9","author":"NA Robinson","year":"2019","unstructured":"Robinson NA, Johnsen H, Moghadam H, Andersen \u00d8, Tveiten H. Early developmental stress affects subsequent gene expression response to an acute stress in Atlantic salmon: an approach for creating robust fish for aquaculture? G3: genes, genomes. Genetics. 2019;9(5):1597\u2013611. https:\/\/doi.org\/10.1534\/g3.119.400152.","journal-title":"Genetics"},{"issue":"1","key":"7420_CR6","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1038\/s41598-018-37761-7","volume":"9","author":"V Huang","year":"2019","unstructured":"Huang V, Butler AA, Lubin FD. Telencephalon transcriptome analysis of chronically stressed adult zebrafish. Sci Rep. 2019;9(1):1379. https:\/\/doi.org\/10.1038\/s41598-018-37761-7.","journal-title":"Sci Rep"},{"issue":"1","key":"7420_CR7","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s12864-020-6728-4","volume":"21","author":"C Raposo de Magalh\u00e3es","year":"2020","unstructured":"Raposo de Magalh\u00e3es C, Schrama D, Farinha AP, Revets D, Kuehn A, Planchon S, et al. Protein changes as robust signatures of fish chronic stress: a proteomics approach to fish welfare research. BMC Genomics. 2020;21(1):309. https:\/\/doi.org\/10.1186\/s12864-020-6728-4.","journal-title":"BMC Genomics"},{"key":"7420_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aquatox.2014.11.013","volume":"159","author":"KJ Groh","year":"2015","unstructured":"Groh KJ, Suter MJ. Stressor-induced proteome alterations in zebrafish: a meta-analysis of response patterns. Aquat Toxicol. 2015;159:1\u201312. https:\/\/doi.org\/10.1016\/j.aquatox.2014.11.013.","journal-title":"Aquat Toxicol"},{"key":"7420_CR9","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.1038\/s41598-017-05222-2","volume":"7","author":"HK Moghadam","year":"2017","unstructured":"Moghadam HK, Johnsen H, Robinson N, Andersen O, Jorgensen EH, Johnsen HK, et al. Impacts of early life stress on the methylome and transcriptome of Atlantic salmon. Sci Rep. 2017;7:5023. https:\/\/doi.org\/10.1038\/s41598-017-05222-2.","journal-title":"Sci Rep"},{"issue":"7","key":"7420_CR10","doi-asserted-by":"publisher","first-page":"eaaw7006","DOI":"10.1126\/sciadv.aaw7006","volume":"5","author":"EV Todd","year":"2019","unstructured":"Todd EV, Ortega-Recalde O, Liu H, Lamm MS, Rutherford KM, Cross H, et al. Stress, novel sex genes, and epigenetic reprogramming orchestrate socially controlled sex change. Sci Adv. 2019;5(7):eaaw7006. https:\/\/doi.org\/10.1126\/sciadv.aaw7006.","journal-title":"Sci Adv"},{"issue":"12","key":"7420_CR11","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1080\/15592294.2018.1554520","volume":"13","author":"TM Uren Webster","year":"2018","unstructured":"Uren Webster TM, Rodriguez-Barreto D, Martin SAM, Van Oosterhout C, Orozco-terWengel P, Cable J, et al. Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon. Epigenetics. 2018;13(12):1191\u2013207. https:\/\/doi.org\/10.1080\/15592294.2018.1554520.","journal-title":"Epigenetics"},{"key":"7420_CR12","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.dci.2011.07.002","volume":"35","author":"L Tort","year":"2011","unstructured":"Tort L. Stress and immune modulation in fish. Dev Comp Immunol. 2011;35:1366\u201375. https:\/\/doi.org\/10.1016\/j.dci.2011.07.002.","journal-title":"Dev Comp Immunol"},{"key":"7420_CR13","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.scitotenv.2019.03.275","volume":"670","author":"MA Burgos-Aceves","year":"2019","unstructured":"Burgos-Aceves MA, Lionetti L, Faggio C. Multidisciplinary haematology as prognostic device in environmental and xenobiotic stress-induced response in fish. Sci Tot Environm. 2019;670:1170\u201383. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.03.275.","journal-title":"Sci Tot Environm"},{"key":"7420_CR14","doi-asserted-by":"publisher","first-page":"e26998","DOI":"10.1371\/journal.pone.0026998","volume":"6","author":"D Morera","year":"2011","unstructured":"Morera D, Roher N, Ribas L, Balasch JC, Donate C, Callol A, et al. RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS One. 2011;6:e26998. https:\/\/doi.org\/10.1371\/journal.pone.0026998.","journal-title":"PLoS One"},{"issue":"2","key":"7420_CR15","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.fsi.2015.05.049","volume":"45","author":"MK Dahle","year":"2015","unstructured":"Dahle MK, Wessel \u00d8, Timmerhaus G, Nyman IB, Jorgensen SM, Rimstad E, et al. Transcriptome analyses of Atlantic salmon (Salmo salar L.) erythrocytes infected with piscine orthoreovirus (PRV). Fish Shellfish Immunol. 2015;45(2):780\u201390. https:\/\/doi.org\/10.1016\/j.fsi.2015.05.049.","journal-title":"Fish Shellfish Immunol"},{"issue":"4","key":"7420_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/genes9040202","volume":"9","author":"S Puente-Marin","year":"2018","unstructured":"Puente-Marin S, Nombela I, Ciordia S, Mena MC, Chico V, Coll J, et al. In silico functional networks identified in fish nucleated red blood cells by means of transcriptomic and proteomic profiling. Genes. 2018;9(4):202. https:\/\/doi.org\/10.3390\/genes9040202.","journal-title":"Genes"},{"issue":"11","key":"7420_CR17","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1534\/g3.118.200458","volume":"8","author":"MR Gavery","year":"2018","unstructured":"Gavery MR, Nichols KM, Goetz G, Middleton MA, Swanson P. Characterization of genetic and epigenetic variation in sperm and red blood cells from adult hatchery and natural-origin steelhead, Oncorhynchus mykiss. G3: genes. Genomes, Genetics. 2018;8(11):3723\u201336. https:\/\/doi.org\/10.1534\/g3.118.200458.","journal-title":"Genomes, Genetics"},{"issue":"3","key":"7420_CR18","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/age.12779","volume":"50","author":"M Vandeputte","year":"2019","unstructured":"Vandeputte M, Gagnaire PA, Allal F. The European sea bass: a key marine fish model in the wild and in aquaculture. Anim Genet. 2019;50(3):195\u2013206. https:\/\/doi.org\/10.1111\/age.12779.","journal-title":"Anim Genet"},{"key":"7420_CR19","doi-asserted-by":"publisher","first-page":"5770","DOI":"10.1038\/ncomms6770","volume":"5","author":"M Tine","year":"2014","unstructured":"Tine M, Kuhl H, Gagnaire PA, Louro B, Desmarais E, Martins RST, et al. European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation. Nat Commun. 2014;5:5770. https:\/\/doi.org\/10.1038\/ncomms6770.","journal-title":"Nat Commun"},{"key":"7420_CR20","doi-asserted-by":"publisher","first-page":"e1002447","DOI":"10.1371\/journal.pgen.1002447","volume":"7","author":"L Navarro-Mart\u00edn","year":"2011","unstructured":"Navarro-Mart\u00edn L, Vi\u00f1as J, Ribas L, Diaz N, Gutierrez A, Di Croce L, et al. DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass. PLoS Genet. 2011;7:e1002447. https:\/\/doi.org\/10.1371\/journal.pgen.1002447.","journal-title":"PLoS Genet"},{"key":"7420_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.margen.2011.08.003","volume":"5","author":"F Geay","year":"2012","unstructured":"Geay F, Zambonino-Infante J, Reinhardt R, Kuhl H, Santigosa E, Cahu C, et al. Characteristics of fads2 gene expression and putative promoter in European sea bass (Dicentrarchus labrax): comparison with salmonid species and analysis of CpG methylation. Mar Genomics. 2012;5:7\u201313. https:\/\/doi.org\/10.1016\/j.margen.2011.08.003.","journal-title":"Mar Genomics"},{"issue":"7","key":"7420_CR22","doi-asserted-by":"publisher","first-page":"e0160332","DOI":"10.1371\/journal.pone.0160332","volume":"11","author":"G Terova","year":"2016","unstructured":"Terova G, D\u00edaz N, Rimoldi S, Ceccotti C, Gliozheni E, Piferrer F. Effects of sodium butyrate treatment on histone modifications and the expression of genes related to epigenetic regulatory mechanisms and immune response in European sea bass (Dicentrarchus labrax) fed a plant-based diet. PLoS One. 2016;11(7):e0160332. https:\/\/doi.org\/10.1371\/journal.pone.0160332.","journal-title":"PLoS One"},{"issue":"1","key":"7420_CR23","doi-asserted-by":"publisher","first-page":"12401","DOI":"10.1038\/s41598-017-10861-6","volume":"7","author":"D Anastasiadi","year":"2017","unstructured":"Anastasiadi D, D\u00edaz N, Piferrer F. Small ocean temperature increases elicit stage-dependent changes in DNA methylation and gene expression in a fish, the European sea bass. Sci Rep. 2017;7(1):12401. https:\/\/doi.org\/10.1038\/s41598-017-10861-6.","journal-title":"Sci Rep"},{"issue":"9","key":"7420_CR24","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1080\/15592294.2018.1529504","volume":"13","author":"D Anastasiadi","year":"2018","unstructured":"Anastasiadi D, Vandeputte M, S\u00e1nchez-Baiz\u00e1n N, Allal F, Piferrer F. Dynamic epimarks in sex-related genes predict gonad phenotype in the European sea bass, a fish with mixed genetic and environmental sex determination. Epigenetics. 2018;13(9):988\u20131011. https:\/\/doi.org\/10.1080\/15592294.2018.1529504.","journal-title":"Epigenetics"},{"issue":"6","key":"7420_CR25","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1080\/19396368.2018.1482383","volume":"64","author":"F Barrachina","year":"2018","unstructured":"Barrachina F, Anastasiadi D, Jodar M, Castillo J, Estanyol JM, Piferrer F, et al. Identification of a complex population of chromatin-associated proteins in the European sea bass (Dicentrarchus labrax) sperm. Syst Biol Reprod Med. 2018;64(6):502\u201317. https:\/\/doi.org\/10.1080\/19396368.2018.1482383.","journal-title":"Syst Biol Reprod Med"},{"issue":"10","key":"7420_CR26","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1093\/molbev\/msz153","volume":"36","author":"D Anastasiadi","year":"2019","unstructured":"Anastasiadi D, Piferrer F. Epimutations in developmental genes underlie the onset of domestication in farmed European sea bass. Mol Biol Evol. 2019;36(10):2252\u201364. https:\/\/doi.org\/10.1093\/molbev\/msz153.","journal-title":"Mol Biol Evol"},{"issue":"2","key":"7420_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/1755-0998.13111","volume":"20","author":"D Anastasiadi","year":"2020","unstructured":"Anastasiadi D, Piferrer F. A clockwork fish: age prediction using DNA methylation-based biomarkers in the European seabass. Mol Ecol Resour. 2020;20(2):387\u201397. https:\/\/doi.org\/10.1111\/1755-0998.13111.","journal-title":"Mol Ecol Resour"},{"key":"7420_CR28","volume-title":"FAO Yearbook of Fishery and Aquaculture Statistics","author":"FAO","year":"2020","unstructured":"FAO. FAO Yearbook of Fishery and Aquaculture Statistics. 2020. Available at: http:\/\/www.fao.org\/fishery\/statistics\/yearbook\/en (Accessed 27 Jan 2021)."},{"key":"7420_CR29","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ygcen.2011.06.004","volume":"173","author":"E Fanouraki","year":"2011","unstructured":"Fanouraki E, Mylonas CC, Papandroulakis N, Pavlidis M. Species specificity in the magnitude and duration of the acute stress response in Mediterranean marine fish in culture. Gen Comp Endocrinol. 2011;173:313\u201322. https:\/\/doi.org\/10.1016\/j.ygcen.2011.06.004.","journal-title":"Gen Comp Endocrinol"},{"key":"7420_CR30","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0044-8486(01)00818-3","volume":"210","author":"M Vazzana","year":"2002","unstructured":"Vazzana M, Cammarata M, Cooper EL, Parrinello N. Confinement stress in sea bass (Dicentrarchus labrax) depresses peritoneal leukocyte cytotoxicity. Aquaculture. 2002;210:231\u201343. https:\/\/doi.org\/10.1016\/S0044-8486(01)00818-3.","journal-title":"Aquaculture"},{"key":"7420_CR31","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1051\/alr\/2011130","volume":"24","author":"JL C\u0153urdacier","year":"2011","unstructured":"C\u0153urdacier JL, Dutto G, Gasset E, Blancheton JP. Is total serum protein a good indicator for welfare in reared sea bass (Dicentrarchus labrax)? Aquat Living Resour. 2011;24:124\u20137. https:\/\/doi.org\/10.1051\/alr\/2011130.","journal-title":"Aquat Living Resour"},{"key":"7420_CR32","doi-asserted-by":"publisher","first-page":"34858","DOI":"10.1038\/srep34858","volume":"6","author":"A Samaras","year":"2016","unstructured":"Samaras A, Dimitroglou A, Sarropoulou E, Papaharisis L, Kottaras L, Pavlidis M. Repeatability of cortisol stress response in the European sea bass (Dicentrarchus labrax) and transcription differences between individuals with divergent responses. Sci Rep. 2016;6:34858. https:\/\/doi.org\/10.1038\/srep34858.","journal-title":"Sci Rep"},{"key":"7420_CR33","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2202-11-4","volume":"11","author":"C Tognoli","year":"2010","unstructured":"Tognoli C, Rossi F, Di Cola F, Baj G, Tongiorgi E, Terova G, et al. Acute stress alters transcript expression pattern and reduces processing of proBDNF to mature BDNF in Dicentrarchus labrax. BMC Neurosci. 2010;11:4. https:\/\/doi.org\/10.1186\/1471-2202-11-4.","journal-title":"BMC Neurosci"},{"key":"7420_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nmeth.3763","volume":"13","author":"TP van Gurp","year":"2016","unstructured":"van Gurp TP, Wagemaker NCAM, Wouters B, Vergeer P, Ouborg JNJ, Verhoeven KJS. epiGBS: reference-free reduced representation bisulfite sequencing. Nat Meth. 2016;13:322\u20134. https:\/\/doi.org\/10.1038\/nmeth.3763.","journal-title":"Nat Meth"},{"issue":"8","key":"7420_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrg.2016.59","volume":"17","author":"CD Allis","year":"2016","unstructured":"Allis CD, Jenuwein T. The molecular hallmarks of epigenetic control. Nat Rev Genet. 2016;17(8):487\u2013500. https:\/\/doi.org\/10.1038\/nrg.2016.59.","journal-title":"Nat Rev Genet"},{"key":"7420_CR36","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature14192","volume":"517","author":"D Sch\u00fcbeler","year":"2015","unstructured":"Sch\u00fcbeler D. Function and information content of DNA methylation. Nature. 2015;517:321\u20136. https:\/\/doi.org\/10.1038\/nature14192.","journal-title":"Nature"},{"key":"7420_CR37","doi-asserted-by":"publisher","first-page":"6100","DOI":"10.1111\/mec.12556","volume":"22","author":"S Rey","year":"2013","unstructured":"Rey S, Boltana S, Vargas R, Roher N, MacKenzie S. Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function. Mol Ecol. 2013;22:6100\u201315. https:\/\/doi.org\/10.1111\/mec.12556.","journal-title":"Mol Ecol"},{"issue":"Pt 20","key":"7420_CR38","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1242\/jeb.161406","volume":"220","author":"J Liu","year":"2017","unstructured":"Liu J, Dias K, Plagnes-Juan E, Veron V, Panserat S, Marandel L. Long-term programming effect of embryonic hypoxia exposure and high-carbohydrate diet at first feeding on glucose metabolism in juvenile rainbow trout. J Exp Biol. 2017;220(Pt 20):3686\u201394. https:\/\/doi.org\/10.1242\/jeb.161406.","journal-title":"J Exp Biol"},{"issue":"1","key":"7420_CR39","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12864-015-1626-x","volume":"16","author":"RY Wong","year":"2015","unstructured":"Wong RY, Lamm MS, Godwin J. Characterizing the neurotranscriptomic states in alternative stress coping styles. BMC Genomics. 2015;16(1):425. https:\/\/doi.org\/10.1186\/s12864-015-1626-x.","journal-title":"BMC Genomics"},{"issue":"9","key":"7420_CR40","doi-asserted-by":"publisher","first-page":"e0137726","DOI":"10.1371\/journal.pone.0137726","volume":"10","author":"AK Greenwood","year":"2015","unstructured":"Greenwood AK. Peichel CL social regulation of gene expression in threespine sticklebacks. PLoS One. 2015;10(9):e0137726. https:\/\/doi.org\/10.1371\/journal.pone.0137726.","journal-title":"PLoS One"},{"issue":"2","key":"7420_CR41","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2010.09.042","volume":"68","author":"CA Walsh","year":"2010","unstructured":"Walsh CA, Engle EC. Allelic diversity in human developmental neurogenetics: insights into biology and disease. Neuron. 2010;68(2):245\u201353. https:\/\/doi.org\/10.1016\/j.neuron.2010.09.042.","journal-title":"Neuron"},{"issue":"6\u20137","key":"7420_CR42","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.bbagrm.2013.01.001","volume":"1829","author":"I Vlasova-St Louis","year":"2013","unstructured":"Vlasova-St Louis I, Dickson AM, Bohjanen PR, Wilusz CJ. 2013. CELFish ways to modulate mRNA decay. Biochim Biophys Acta. 2013;1829(6\u20137):695\u2013707. https:\/\/doi.org\/10.1016\/j.bbagrm.2013.01.001.","journal-title":"Biochim Biophys Acta"},{"issue":"13","key":"7420_CR43","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1111\/mec.15131","volume":"28","author":"J Mer\u00f6ndun","year":"2019","unstructured":"Mer\u00f6ndun J, Murray DL, Shafer ABA. Genome-scale sampling suggests cryptic epigenetic structuring and insular divergence in Canada lynx. Mol Ecol. 2019;28(13):3186\u201396. https:\/\/doi.org\/10.1111\/mec.15131.","journal-title":"Mol Ecol"},{"key":"7420_CR44","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2164-14-11","volume":"14","author":"J Wang","year":"2013","unstructured":"Wang J, Xia Y, Li L, Gong DS, Yao Y, Luo HJ, et al. Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing. BMC Genomics. 2013;14:11. https:\/\/doi.org\/10.1186\/1471-2164-14-11.","journal-title":"BMC Genomics"},{"key":"7420_CR45","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","volume":"11","author":"F Krueger","year":"2011","unstructured":"Krueger F, Andrews SR. Bismark: A flexible aligner and methylation caller for bisulfite-Seq applications. Bioinformatics. 2011;11:1571\u20132. https:\/\/doi.org\/10.1093\/bioinformatics\/btr167.","journal-title":"Bioinformatics"},{"key":"7420_CR46","doi-asserted-by":"publisher","first-page":"35903","DOI":"10.1038\/srep35903","volume":"6","author":"ZY Wan","year":"2016","unstructured":"Wan ZY, Xia JH, Lin G, Wang L, Lin VCL, Yue GH. Genome-wide methylation analysis identified sexually dimorphic methylated regions in hybrid tilapia. Sci Rep. 2016;6:35903. https:\/\/doi.org\/10.1038\/srep35903.","journal-title":"Sci Rep"},{"issue":"12","key":"7420_CR47","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1111\/mec.15481","volume":"29","author":"WM Berbel-Filho","year":"2020","unstructured":"Berbel-Filho WM, Berry N, Rodr\u00edguez-Barreto D. Texeira SR, de Leaniz CG, Consuegra S. environmental enrichment induces intergenerational behavioural and epigenetic effects on fish. Mol Ecol. 2020;29(12):2888\u2013299. https:\/\/doi.org\/10.1111\/mec.15481.","journal-title":"Mol Ecol"},{"key":"7420_CR48","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.aquaculture.2019.04.073","volume":"508","author":"J Wang","year":"2019","unstructured":"Wang J, Liu Y, Jiang S, Li WH, Gui L, Zhou T, et al. Transcriptomic and epigenomic alterations of Nile tilapia gonads sexually reversed by high temperature. Aquaculture. 2019;508:167\u201377. https:\/\/doi.org\/10.1016\/j.aquaculture.2019.04.073.","journal-title":"Aquaculture"},{"issue":"12","key":"7420_CR49","doi-asserted-by":"publisher","first-page":"eaaz1138","DOI":"10.1126\/sciadv.aaz1138","volume":"6","author":"MJ Heckwolf","year":"2020","unstructured":"Heckwolf MJ, Meyer BS, H\u00e4sler R, Hoppner MP, Eizaguirre MC, Reusch TBH. Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation. Sci Adv. 2020;6(12):eaaz1138. https:\/\/doi.org\/10.1126\/sciadv.aaz1138.","journal-title":"Sci Adv"},{"issue":"15","key":"7420_CR50","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1111\/mec.14771","volume":"27","author":"J Hu","year":"2018","unstructured":"Hu J, P\u00e9rez-Jvostov F, Blondel L, Barrett RDH. Genome-wide DNA methylation signatures of infection status in Trinidadian guppies (Poecilia reticulata). Mol Ecol. 2018;27(15):3087\u2013102. https:\/\/doi.org\/10.1111\/mec.14771.","journal-title":"Mol Ecol"},{"issue":"5","key":"7420_CR51","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2217\/epi.13.43","volume":"5","author":"M Ehrlich","year":"2013","unstructured":"Ehrlich M, Lacey M. DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics. 2013;5(5):553\u201368. https:\/\/doi.org\/10.2217\/epi.13.43.","journal-title":"Epigenomics"},{"issue":"5","key":"7420_CR52","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tig.2015.03.002","volume":"31","author":"G Lev Maor","year":"2015","unstructured":"Lev Maor G, Yearim A, Ast G. The alternative role of DNA methylation in splicing regulation. Trends Genet. 2015;31(5):274\u201380. https:\/\/doi.org\/10.1016\/j.tig.2015.03.002.","journal-title":"Trends Genet"},{"key":"7420_CR53","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nature09165","volume":"466","author":"AK Maunakea","year":"2010","unstructured":"Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D\u2019Souza C, Fouse SD, et al. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 2010;466:253\u20137. https:\/\/doi.org\/10.1038\/nature09165.","journal-title":"Nature"},{"issue":"6","key":"7420_CR54","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1080\/15592294.2018.1486654","volume":"13","author":"B Hing","year":"2018","unstructured":"Hing B, Braun P, Cordner ZA, Ewald ER, Moody L, McKane M, et al. 2018. Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X. Epigenetics. 2018;13(6):627\u201341. https:\/\/doi.org\/10.1080\/15592294.2018.1486654.","journal-title":"Epigenetics"},{"issue":"11","key":"7420_CR55","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1101\/gr.116509.110","volume":"21","author":"M Suzuki","year":"2011","unstructured":"Suzuki M, Oda M, Ramos MP, Pascual M, Lau K, Stasiek E, et al. Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome. Genome Res. 2011;21(11):1833\u201340. https:\/\/doi.org\/10.1101\/gr.116509.110.","journal-title":"Genome Res"},{"key":"7420_CR56","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3390\/genes10050356","volume":"10","author":"MR Gavery","year":"2019","unstructured":"Gavery MR, Nichols KM, Berejikian BA, Tatara CP, Goetz GW, Dickey JT, et al. Temporal dynamics of DNA methylation patterns in response to rearing juvenile steelhead (Oncorhynchus mykiss) in a hatchery versus simulated stream environment. Genes. 2019;10:356. https:\/\/doi.org\/10.3390\/genes10050356.","journal-title":"Genes"},{"issue":"6","key":"7420_CR57","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/acel.12257","volume":"13","author":"M Baumgart","year":"2014","unstructured":"Baumgart M, Groth M, Priebe S, Savino A, Testa G, Dix A, et al. RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell. 2014;13(6):965\u201374. https:\/\/doi.org\/10.1111\/acel.12257.","journal-title":"Aging Cell"},{"issue":"20","key":"7420_CR58","first-page":"1710","volume":"118","author":"XG Nie","year":"2005","unstructured":"Nie XG. Differential expression of Bmp2, Bmp4 and Bmp3 in embryonic development of mouse anterior and posterior palate. Chin Med J. 2005;118(20):1710\u20136. 16313756.","journal-title":"Chin Med J"},{"issue":"1","key":"7420_CR59","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ydbio.2006.03.028","volume":"295","author":"MB Walker","year":"2006","unstructured":"Walker MB, Miller CT, Coffin Talbot J, Stock DW, Kimmel CB. Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev Biol. 2006;295(1):194\u2013205. https:\/\/doi.org\/10.1016\/j.ydbio.2006.03.028.","journal-title":"Dev Biol"},{"issue":"1","key":"7420_CR60","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12041-018-0903-2","volume":"97","author":"PK Kumari","year":"2018","unstructured":"Kumari PK, Ali A, Singh SK, Chaurasia A, Raman R. Genetic heterogeneity in Van der Woude syndrome: identification of NOL4 and IRF6 haplotype from the noncoding region as candidates in two families. J Genet. 2018;97(1):275\u201385 PMID: 2966634.","journal-title":"J Genet"},{"issue":"1","key":"7420_CR61","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1101\/gad.940702","volume":"16","author":"MK Gustafsson","year":"2002","unstructured":"Gustafsson MK, Pan H, Pinney DF, Liu YL, Lewandowski A, Epstein DJ, et al. 2002. Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification. Genes Dev. 2002;16(1):114\u201326. https:\/\/doi.org\/10.1101\/gad.940702.","journal-title":"Genes Dev"},{"issue":"4","key":"7420_CR62","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1089\/zeb.2013.09","volume":"10","author":"CY Lin","year":"2013","unstructured":"Lin CY, Lee HC, Chen HC, Hsieh CC, Tsai HJ. Normal function of Myf5 during gastrulation is required for pharyngeal arch cartilage development in zebrafish embryos. Zebrafish. 2013;10(4):486\u201399. https:\/\/doi.org\/10.1089\/zeb.2013.09.","journal-title":"Zebrafish"},{"issue":"7","key":"7420_CR63","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/dneu.22478","volume":"77","author":"F Friocourt","year":"2017","unstructured":"Friocourt F, Ch\u00e9dotal A. The Robo3 receptor, a key player in the development, evolution, and function of commissural systems. Dev Neurobiol. 2017;77(7):876\u201390. https:\/\/doi.org\/10.1002\/dneu.22478.","journal-title":"Dev Neurobiol"},{"issue":"5","key":"7420_CR64","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1093\/molbev\/mst023","volume":"30","author":"GB Kamm","year":"2013","unstructured":"Kamm GB, Pisciottano F, Kliger R, Franchini LF. The developmental brain gene NPAS3 contains the largest number of accelerated regulatory sequences in the human genome. Mol Biol Evol. 2013;30(5):1088\u2013102. https:\/\/doi.org\/10.1093\/molbev\/mst023.","journal-title":"Mol Biol Evol"},{"issue":"1794","key":"7420_CR65","doi-asserted-by":"publisher","first-page":"20141146","DOI":"10.1098\/rspb.2014.1146","volume":"281","author":"KE McGhee","year":"2014","unstructured":"McGhee KE, Bell AM. Paternal care in a fish: epigenetics and fitness enhancing effects on offspring anxiety. Proc Biol Sci. 2014;281(1794):20141146. https:\/\/doi.org\/10.1098\/rspb.2014.1146.","journal-title":"Proc Biol Sci"},{"issue":"5","key":"7420_CR66","doi-asserted-by":"publisher","first-page":"E654","DOI":"10.1073\/pnas.1514292113","volume":"113","author":"RF Oliveira","year":"2016","unstructured":"Oliveira RF, Sim\u00f5es JM, Teles MC, Oliveira CR, Becker JD, Lopez JS. Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain. Proc Natl Acad Sci U S A. 2016;113(5):E654\u201361. https:\/\/doi.org\/10.1073\/pnas.1514292113.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"7420_CR67","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.schres.2013.07.030","volume":"150","author":"J Auta","year":"2013","unstructured":"Auta J, Smith RC, Dong E, Tueting P, Sershen H, Boules S, et al. DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients. Schizophr Res. 2013;150(1):312\u20138. https:\/\/doi.org\/10.1016\/j.schres.2013.07.030.","journal-title":"Schizophr Res"},{"issue":"8","key":"7420_CR68","doi-asserted-by":"publisher","first-page":"e1700722","DOI":"10.1002\/mnfr.20170072","volume":"62","author":"J Blaze","year":"2018","unstructured":"Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM. Polyphenolic compounds alter stress-induced patterns of global DNA methylation in brain and blood. Mol Nutr Food Res. 2018;62(8):e1700722. https:\/\/doi.org\/10.1002\/mnfr.20170072.","journal-title":"Mol Nutr Food Res"},{"key":"7420_CR69","doi-asserted-by":"publisher","unstructured":"Vinkers CH, Geuze E, van Rooij SJH, Kennis M, Sch\u00fcr RR, Nispeling DM, et al. Successful treatment of post-traumatic stress disorder reverses DNA methylation marks. Mol Psychiatry. 2019. https:\/\/doi.org\/10.1038\/s41380-019-0549-3.","DOI":"10.1038\/s41380-019-0549-3"},{"key":"7420_CR70","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3389\/fgene.2020.00671","volume":"11","author":"AI Arockiaraj","year":"2020","unstructured":"Arockiaraj AI, Liu D, Shaffer JR, Koleck TA, Crago EA, Weeks DE, Conley YP. Methylation data processing protocol and comparison of blood and cerebral spinal fluid following aneurysmal subarachnoid hemorrhage. Front Genet. 2020;11:671. https:\/\/doi.org\/10.3389\/fgene.2020.00671.","journal-title":"Front Genet"},{"key":"7420_CR71","doi-asserted-by":"publisher","first-page":"508809","DOI":"10.3389\/fgene.2020.508809","volume":"11","author":"F P\u00e9rtille","year":"2020","unstructured":"P\u00e9rtille F, Ibelli AMG, Sharif ME, Poleti MD, Fr\u00f6hlich AS, Rezaei S, et al. Putative epigenetic biomarkers of stress in red blood cells of chickens reared across different biomes. Front Genet. 2020;11:508809. https:\/\/doi.org\/10.3389\/fgene.2020.508809.","journal-title":"Front Genet"},{"issue":"42","key":"7420_CR72","doi-asserted-by":"publisher","first-page":"10576","DOI":"10.1523\/JNEUROSCI.1786-08.2008","volume":"28","author":"FD Lubin","year":"2008","unstructured":"Lubin FD, Roth TL, Sweatt JD. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci. 2008;28(42):10576\u201386. https:\/\/doi.org\/10.1523\/JNEUROSCI.1786-08.2008.","journal-title":"J Neurosci"},{"key":"7420_CR73","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3389\/fnbeh.2019.00101","volume":"13","author":"EJL Coley","year":"2019","unstructured":"Coley EJL, Demaestri C, Ganguly P, Honeycutt JA, Peterzell S, Rose N, et al. Cross-generational transmission of early life stress effects on HPA regulators and Bdnf are mediated by sex, lineage, and upbringing. Front Behav Neurosci. 2019;13:101. https:\/\/doi.org\/10.3389\/fnbeh.2019.00101.","journal-title":"Front Behav Neurosci"},{"issue":"11","key":"7420_CR74","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.3390\/ijms18112312","volume":"18","author":"T Numakawa","year":"2017","unstructured":"Numakawa T, Odaka H, Adachi N. Actions of brain-derived neurotrophic factor and glucocorticoid stress in neurogenesis. Int J Mol Sci. 2017;18(11):2312. https:\/\/doi.org\/10.3390\/ijms18112312.","journal-title":"Int J Mol Sci"},{"key":"7420_CR75","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1038\/s41380-019-0639-2","volume":"25","author":"M Notaras","year":"2020","unstructured":"Notaras M, van den Buuse M. Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders. Mol Psychiatry. 2020;25:2251\u201374. https:\/\/doi.org\/10.1038\/s41380-019-0639-2.","journal-title":"Mol Psychiatry"},{"key":"7420_CR76","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.pnpbp.2015.02.014","volume":"60","author":"M Pavlidis","year":"2015","unstructured":"Pavlidis M, Theodoridi A, Tsalafouta A. Neuroendocrine regulation of the stress response in adult zebrafish, Danio rerio. Prog Neuro-Psychopharmacol Biol Psychiatry. 2015;60:121\u201331. https:\/\/doi.org\/10.1016\/j.pnpbp.2015.02.014.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"1","key":"7420_CR77","doi-asserted-by":"publisher","first-page":"5638","DOI":"10.1038\/s41598-018-23950-x","volume":"8","author":"MA Vindas","year":"2018","unstructured":"Vindas MA, Fokos S, Pavlidis M, Hoglund E, Dyonisopoulou S, Ebbesson LOE, et al. Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping. Sci Rep. 2018;8(1):5638. https:\/\/doi.org\/10.1038\/s41598-018-23950-x.","journal-title":"Sci Rep"},{"key":"7420_CR78","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ygcen.2018.06.001","volume":"267","author":"B Sadoul","year":"2018","unstructured":"Sadoul B, Alfonso S, Bessa E, Bouchareb A, Blondeau-Bidet E, Clair P, et al. Enhanced brain expression of genes related to cell proliferation and neural differentiation is associated with cortisol receptor expression in fishes. Gen Comp Endocrinol. 2018;267:76\u201381. https:\/\/doi.org\/10.1016\/j.ygcen.2018.06.001.","journal-title":"Gen Comp Endocrinol"},{"key":"7420_CR79","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3389\/fendo.2018.00451","volume":"9","author":"A Samaras","year":"2018","unstructured":"Samaras A, Espirito Santo C, Papandroulakis N, Mitrizakis N, Pavlidis M, Hoglund E, et al. Allostatic load and stress physiology in European seabass (Dicentrarchus labrax L.) and gilthead seabream (Sparus aurata L.). Front Endocrinol. 2018;9:451. https:\/\/doi.org\/10.3389\/fendo.2018.00451.","journal-title":"Front Endocrinol"},{"key":"7420_CR80","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.physbeh.2019.04.020","volume":"207","author":"S Alfonso","year":"2019","unstructured":"Alfonso S, Sadoul B, Gesto M, Joassard L, Chatain B, B\u00e9gout ML. Coping styles in European sea bass: the link between boldness, stress response and neurogenesis. Physiol Behav. 2019;207:67\u201385. https:\/\/doi.org\/10.1016\/j.physbeh.2019.04.020.","journal-title":"Physiol Behav"},{"issue":"12","key":"7420_CR81","doi-asserted-by":"publisher","first-page":"a011148","DOI":"10.1101\/cshperspect.a011148","volume":"4","author":"P Sassone-Corsi","year":"2012","unstructured":"Sassone-Corsi P. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012;4(12):a011148. https:\/\/doi.org\/10.1101\/cshperspect.a011148.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"7","key":"7420_CR82","doi-asserted-by":"publisher","first-page":"369","DOI":"10.5483\/bmbrep.2014.47.7.086","volume":"47","author":"EH Lee","year":"2014","unstructured":"Lee EH, Seo SR. Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases. BMB Rep. 2014;47(7):369\u201375. https:\/\/doi.org\/10.5483\/bmbrep.2014.47.7.086.","journal-title":"BMB Rep"},{"issue":"2","key":"7420_CR83","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tem.2013.10.006","volume":"25","author":"K Marosi","year":"2014","unstructured":"Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2014;25(2):89\u201398. https:\/\/doi.org\/10.1016\/j.tem.2013.10.006.","journal-title":"Trends Endocrinol Metab"},{"key":"7420_CR84","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pneurobio.2013.10.005","volume":"112","author":"MR Bennett","year":"2014","unstructured":"Bennett MR, Lagopoulos J. Stress and trauma: BDNF control of dendritic-spine formation and regression. Prog Neurobiol. 2014;112:80\u201399. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.10.005.","journal-title":"Prog Neurobiol"},{"key":"7420_CR85","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.bcp.2019.08.003","volume":"168","author":"JM Buck","year":"2019","unstructured":"Buck JM, O\u2019Neill HC, Stitzel JA. Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice. Biochem Pharmacol. 2019;168:438\u201351. https:\/\/doi.org\/10.1016\/j.bcp.2019.08.003.","journal-title":"Biochem Pharmacol"},{"issue":"13","key":"7420_CR86","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1007\/s00018-017-2742-3","volume":"75","author":"B Zhu","year":"2018","unstructured":"Zhu B, Zhao L, Luo D, Xue DM, Tan T, Dong ZF, et al. Furin promotes dendritic morphogenesis and learning and memory in transgenic mice. Cell Mol Life Sci. 2018;75(13):2473\u201388. https:\/\/doi.org\/10.1007\/s00018-017-2742-3.","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"7420_CR87","doi-asserted-by":"crossref","first-page":"287","DOI":"10.55782\/ane-1996-1134","volume":"56","author":"M Marcinkiewicz","year":"1996","unstructured":"Marcinkiewicz M, Seidah NG, Chr\u00e9tien M. Implications of the subtilisin\/kexin-like precursor convertases in the development and function of nervous tissues. Acta Neurobiol Exp. 1996;56(1):287\u201398 PMID: 8787188.","journal-title":"Acta Neurobiol Exp"},{"issue":"1","key":"7420_CR88","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/jnr.23455","volume":"93","author":"Y Chen","year":"2015","unstructured":"Chen Y, Zhang J, Deng M. Furin mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation. J Neurosci Res. 2015;93(1):189\u201394. https:\/\/doi.org\/10.1002\/jnr.23455.","journal-title":"J Neurosci Res"},{"issue":"6","key":"7420_CR89","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128605","volume":"10","author":"FC Yeh","year":"2015","unstructured":"Yeh FC, Kao CF, Kuo PH. Explore the features of brain-derived neurotrophic factor in mood disorders. PLoS One. 2015;10(6):e0128605. https:\/\/doi.org\/10.1371\/journal.pone.0128605.","journal-title":"PLoS One"},{"key":"7420_CR90","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.1100135","volume":"306","author":"PT Pang","year":"2004","unstructured":"Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K, Zhen SH, et al. Cleavage of proBDNF by tPA\/plasmin is essential for long-term hippocampal plasticity. Science. 2004;306:487\u201391. https:\/\/doi.org\/10.1126\/science.1100135.","journal-title":"Science"},{"issue":"2\u20133","key":"7420_CR91","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","volume":"583","author":"BS McEwen","year":"2008","unstructured":"McEwen BS. Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008;583(2\u20133):174\u201385. https:\/\/doi.org\/10.1016\/j.ejphar.2007.11.071.","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"7420_CR92","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1073\/pnas.1114122109","volume":"109","author":"FD Jeanneteau","year":"2012","unstructured":"Jeanneteau FD, Lambert WM, Ismaili N, Bath KG, Lee FS, Garabedian MJ, et al. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A. 2012;109(4):1305\u201310. https:\/\/doi.org\/10.1073\/pnas.1114122109.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"7420_CR93","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.febslet.2008.02.026","volume":"582","author":"K Gray","year":"2008","unstructured":"Gray K, Ellis V. Activation of pro-BDNF by the pericellular serine protease plasmin. FEBS Lett. 2008;582(6):907\u201310. https:\/\/doi.org\/10.1016\/j.febslet.2008.02.026.","journal-title":"FEBS Lett"},{"issue":"5","key":"7420_CR94","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/j.1538-7836.2004.00694.x","volume":"2","author":"N Wang","year":"2004","unstructured":"Wang N, Zhang L, Miles L, Hoover-Plow J. Plasminogen regulates pro-opiomelanocortin processing. J Thromb Haemost. 2004;2(5):785\u201396. https:\/\/doi.org\/10.1111\/j.1538-7836.2004.00694.x.","journal-title":"J Thromb Haemost"},{"key":"7420_CR95","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-981-13-7647-4_3","volume":"1141","author":"X Liu","year":"2019","unstructured":"Liu X. SLC family transporters. Adv Exp Med Biol. 2019;1141:101\u2013202. https:\/\/doi.org\/10.1007\/978-981-13-7647-4_3.","journal-title":"Adv Exp Med Biol"},{"key":"7420_CR96","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fnins.2015.00021","volume":"9","author":"N Strazielle","year":"2015","unstructured":"Strazielle N, Ghersi-Egea JF. Efflux transporters in blood-brain interfaces of the developing brain. Front Neurosci. 2015;9:21. https:\/\/doi.org\/10.3389\/fnins.2015.00021.","journal-title":"Front Neurosci"},{"issue":"7","key":"7420_CR97","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/mp.2014.86","volume":"20","author":"T Courouss\u00e9","year":"2015","unstructured":"Courouss\u00e9 T, Bacq A, Belzung C, Guiard B, Balasse L, Louis F, et al. Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3\u03b2 signaling. Mol Psychiatry. 2015;20(7):889\u2013900. https:\/\/doi.org\/10.1038\/mp.2014.86.","journal-title":"Mol Psychiatry"},{"key":"7420_CR98","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pharmthera.2014.09.008","volume":"146","author":"T Courouss\u00e9","year":"2015","unstructured":"Courouss\u00e9 T, Gautron S. Role of organic cation transporters (OCTs) in the brain. Pharmacol Ther. 2015;146:94\u2013103. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.09.008.","journal-title":"Pharmacol Ther"},{"issue":"3","key":"7420_CR99","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.neuron.2016.03.017","volume":"90","author":"Y Gai","year":"2016","unstructured":"Gai Y, Liu Z, Cervantes-Sandoval I, Davis RL. Drosophila SLC22A transporter is a memory suppressor gene that influences cholinergic neurotransmission to the mushroom bodies. Neuron. 2016;90(3):581\u201395. https:\/\/doi.org\/10.1016\/j.neuron.2016.03.017.","journal-title":"Neuron"},{"issue":"37","key":"7420_CR100","doi-asserted-by":"publisher","first-page":"13648","DOI":"10.1073\/pnas.0405310101","volume":"101","author":"C Erbel-Sieler","year":"2004","unstructured":"Erbel-Sieler C, Dudley C, Zhou Y, Wu XL, Estill SJ, Han T, et al. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A. 2004;101(37):13648\u201353. https:\/\/doi.org\/10.1073\/pnas.0405310101.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"7420_CR101","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.psychres.2018.04.063","volume":"265","author":"LM Luoma","year":"2018","unstructured":"Luoma LM, Macintyre G, Tibbo PG, Wild TC, Colman I, Purdon SE. NPAS3 exonic SNP genotype is linked to working memory performance in healthy young adults. Psychiatry Res. 2018;265:263\u20134. https:\/\/doi.org\/10.1016\/j.psychres.2018.04.063.","journal-title":"Psychiatry Res"},{"key":"7420_CR102","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fnmol.2016.00109","volume":"9","author":"D Yang","year":"2016","unstructured":"Yang D, Zhang W, Padhiar A, Yue Y, Shi YH, Zheng TZ, et al. NPAS3 regulates transcription and expression of VGF: implications for neurogenesis and psychiatric disorders. Front Mol Neurosci. 2016;9:109. https:\/\/doi.org\/10.3389\/fnmol.2016.00109.","journal-title":"Front Mol Neurosci"},{"issue":"8","key":"7420_CR103","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/mp.2008.56","volume":"14","author":"C Lavedan","year":"2009","unstructured":"Lavedan C, Licamele L, Volpi S, Hamilton J, Heaton C, Mack K, et al. 2009. Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study. Mol Psychiatry. 2009;14(8):804\u201319. https:\/\/doi.org\/10.1038\/mp.2008.56.","journal-title":"Mol Psychiatry"},{"key":"7420_CR104","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1111\/tra.12089","volume":"14","author":"L Walch","year":"2013","unstructured":"Walch L. Emerging role of the scaffolding protein Dlg1 in vesicle trafficking. Traffic. 2013;14:964\u201373. https:\/\/doi.org\/10.1111\/tra.12089.","journal-title":"Traffic"},{"issue":"2","key":"7420_CR105","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuron.2016.12.039","volume":"93","author":"Y Liu","year":"2017","unstructured":"Liu Y, Cui L, Schwarz MK, Fog Y, Schl\u00fcter OM. Adrenergic gate release for spike timing-dependent synaptic potentiation. Neuron 18. 2017;93(2):394\u2013408. https:\/\/doi.org\/10.1016\/j.neuron.2016.12.039.","journal-title":"Neuron 18"},{"issue":"2","key":"7420_CR106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057124","volume":"8","author":"H Jourdi","year":"2013","unstructured":"Jourdi H, Kabbaj M. Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression. PLoS One. 2013;8(2):e57124. https:\/\/doi.org\/10.1371\/journal.pone.0057124.","journal-title":"PLoS One"},{"issue":"2","key":"7420_CR107","doi-asserted-by":"publisher","first-page":"e1008590","DOI":"10.1371\/journal.pgen.1008590","volume":"16","author":"MD Singh","year":"2020","unstructured":"Singh MD, Jensen M, Lasser M, Huber E, Yusuff T, Pizzo L, et al. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. PLoS Genet. 2020;16(2):e1008590. https:\/\/doi.org\/10.1371\/journal.pgen.1008590.","journal-title":"PLoS Genet"},{"issue":"9","key":"7420_CR108","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.tips.2017.05.007","volume":"38","author":"VM Lauschke","year":"2017","unstructured":"Lauschke VM, Ivanov M, Ingelman-Sundberg M. Pitfalls and opportunities for epigenomic analyses focused on disease diagnosis, prognosis, and therapy. Trends Pharmacol Sci. 2017;38(9):765\u201370. https:\/\/doi.org\/10.1016\/j.tips.2017.05.007.","journal-title":"Trends Pharmacol Sci"},{"key":"7420_CR109","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jaut.2017.12.006","volume":"87","author":"JP van Hamburg","year":"2018","unstructured":"van Hamburg JP, Tas SW. Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis. J Autoimmun. 2018;87:69\u201381. https:\/\/doi.org\/10.1016\/j.jaut.2017.12.006.","journal-title":"J Autoimmun"},{"issue":"2","key":"7420_CR110","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bbrc.2006.02.177","volume":"343","author":"D Haasch","year":"2006","unstructured":"Haasch D, Berg C, Clampit JE, Pederson T, Frost L, Kroeger P, et al. PKCtheta is a key player in the development of insulin resistance. Biochem Biophys Res Commun. 2006;343(2):361\u20138. https:\/\/doi.org\/10.1016\/j.bbrc.2006.02.177.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"7420_CR111","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1038\/s41598-017-04053-5","volume":"7","author":"A Zanin-Zhorov","year":"2017","unstructured":"Zanin-Zhorov A, Kumari S, Hippen KL, Merkel SC, MacMillan ML, Blazar BR, Dustin ML. Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-\u03b8 restrained suppressive activity. Sci Rep. 2017;7(1):4258. https:\/\/doi.org\/10.1038\/s41598-017-04053-5 Erratum in: Sci Rep. 2020;10(1): 3317.","journal-title":"Sci Rep"},{"issue":"22","key":"7420_CR112","doi-asserted-by":"publisher","first-page":"16167","DOI":"10.1074\/jbc.M113.460246","volume":"288","author":"DM Erion","year":"2013","unstructured":"Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, et al. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis. J Biol Chem. 2013;288(22):16167\u201376. https:\/\/doi.org\/10.1074\/jbc.M113.460246.","journal-title":"J Biol Chem"},{"key":"7420_CR113","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/bs.ircmb.2015.05.004","volume":"318","author":"K Anyamaneeratch","year":"2015","unstructured":"Anyamaneeratch K, Rojvirat P, Sukjoi W, Jitrapakdee S. Insights into transcriptional regulation of hepatic glucose production. Int Rev Cell Mol Biol. 2015;318:203\u201353. https:\/\/doi.org\/10.1016\/bs.ircmb.2015.05.004.","journal-title":"Int Rev Cell Mol Biol"},{"issue":"43","key":"7420_CR114","doi-asserted-by":"publisher","first-page":"25997","DOI":"10.1074\/jbc.M115.679266","volume":"290","author":"MF Hogan","year":"2015","unstructured":"Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, et al. Hepatic insulin resistance following chronic activation of the CREB Coactivator CRTC2. J Biol Chem. 2015;290(43):25997\u20136006. https:\/\/doi.org\/10.1074\/jbc.M115.679266.","journal-title":"J Biol Chem"},{"issue":"1","key":"7420_CR115","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1210\/me.2015-1237","volume":"30","author":"MJ Hill","year":"2016","unstructured":"Hill MJ, Suzuki S, Segars JH, Kino T. CRTC2 is a Coactivator of GR and couples GR and CREB in the regulation of hepatic gluconeogenesis. Mol Endocrinol. 2016;30(1):104\u201317. https:\/\/doi.org\/10.1210\/me.2015-1237.","journal-title":"Mol Endocrinol"},{"issue":"3","key":"7420_CR116","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1093\/gbe\/evy034","volume":"10","author":"DCH Metzger","year":"2018","unstructured":"Metzger DCH, Schulte PM. The DNA methylation landscape of stickleback reveals patterns of sex chromosome evolution and effects of environmental salinity. Genome Biol Evol. 2018;10(3):775\u201385. https:\/\/doi.org\/10.1093\/gbe\/evy034.","journal-title":"Genome Biol Evol"},{"issue":"8","key":"7420_CR117","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1093\/molbev\/msaa084","volume":"37","author":"K Sagonas","year":"2020","unstructured":"Sagonas K, Meyer BS, Kaufmann J, Lenz TL, H\u00e4sler R, Eizaguirre C. Experimental parasite infection causes genome-wide changes in DNA methylation. Mol Biol Evol. 2020;37(8):2287\u201399. https:\/\/doi.org\/10.1093\/molbev\/msaa084.","journal-title":"Mol Biol Evol"},{"key":"7420_CR118","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3389\/fgene.2019.00847","volume":"10","author":"Y Xiu","year":"2019","unstructured":"Xiu Y, Shao C, Zhu Y, Li YZ, Gan T, Xu WT, et al. Differences in DNA methylation between disease-resistant and disease-susceptible Chinese tongue sole (Cynoglossus semilaevis) families. Front Genet. 2019;10:847. https:\/\/doi.org\/10.3389\/fgene.2019.00847.","journal-title":"Front Genet"},{"key":"7420_CR119","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13072-016-0081-5","volume":"9","author":"KA Triantaphyllopoulos","year":"2016","unstructured":"Triantaphyllopoulos KA, Ikonomopoulos I, Bannister AJ. Epigenetics and inheritance of phenotype variation in livestock. Epigenetics Chromatin. 2016;9:31. https:\/\/doi.org\/10.1186\/s13072-016-0081-5.","journal-title":"Epigenetics Chromatin"},{"key":"7420_CR120","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1242\/jeb.107318","volume":"218","author":"WW Burggren","year":"2015","unstructured":"Burggren WW. Dynamics of epigenetic phenomena: intergenerational and intragenerational phenotype 'washout'. J Exp Biol. 2015;218:80\u20137. https:\/\/doi.org\/10.1242\/jeb.107318.","journal-title":"J Exp Biol"},{"issue":"3","key":"7420_CR121","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/epigenomes1030017","volume":"1","author":"AF Trollope","year":"2017","unstructured":"Trollope AF, Mifsud KR, Saunderson EA, Reul JMHM. Molecular and epigenetic mechanisms underlying cognitive and adaptive responses to stress. Epigenomes. 2017;1(3):17. https:\/\/doi.org\/10.3390\/epigenomes1030017.","journal-title":"Epigenomes"},{"issue":"9","key":"7420_CR122","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1101\/gr.232587.117","volume":"28","author":"M Suzuki","year":"2018","unstructured":"Suzuki M, Liao W, Wos F, Johnston AD, DeGrazia J, Ishii J, et al. Whole-genome bisulfite sequencing with improved accuracy and cost. Genome Res. 2018;28(9):1364\u201371. https:\/\/doi.org\/10.1101\/gr.232587.117.","journal-title":"Genome Res"},{"key":"7420_CR123","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3389\/fpls.2020.00694","volume":"11","author":"O Werner","year":"2020","unstructured":"Werner O, Prudencio \u00c1S, de la Cruz-Martinez E, Nieto-Lugilde M, Martinez-Gomez P, Ros RM. A cost-reduced variant of epi-genotyping by sequencing for studying DNA methylation in non-model organisms. Front Plant Sci. 2020;11:694. https:\/\/doi.org\/10.3389\/fpls.2020.00694.","journal-title":"Front Plant Sci"},{"issue":"11","key":"7420_CR124","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.3390\/ijms19113542","volume":"19","author":"\u00c1S Prudencio","year":"2018","unstructured":"Prudencio \u00c1S, Werner O, Mart\u00ednez-Garc\u00eda PJ, Dicenta F, Ros RM, Martinez-Gomez P. DNA methylation analysis of dormancy release in almond (Prunus dulcis) flower buds using epi-genotyping by sequencing. Int J Mol Sci. 2018;19(11):3542. https:\/\/doi.org\/10.3390\/ijms19113542.","journal-title":"Int J Mol Sci"},{"key":"7420_CR125","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/2041-210X.13395","volume":"11","author":"M Crotti","year":"2020","unstructured":"Crotti M, Adams CE, Elmer KR. Population genomic SNPs from epigenetic RADs: gaining genetic and epigenetic data from a single established next-generation sequencing approach. Methods Ecol Evol. 2020;11:839\u201349. https:\/\/doi.org\/10.1111\/2041-210X.13395.","journal-title":"Methods Ecol Evol"},{"issue":"1","key":"7420_CR126","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12711-016-0217-x","volume":"48","author":"P Suravajhala","year":"2016","unstructured":"Suravajhala P, Kogelman LJ, Kadarmideen HN. Multi-omic data integration and analysis using systems genomics approaches: methods and applications in animal production, health and welfare. Genet Sel Evol. 2016;48(1):38. https:\/\/doi.org\/10.1186\/s12711-016-0217-x.","journal-title":"Genet Sel Evol"},{"issue":"1","key":"7420_CR127","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/icb\/icaa026","volume":"60","author":"TS Schwartz","year":"2020","unstructured":"Schwartz TS. The promises and the challenges of integrating multi-omics and systems biology in comparative stress biology. Integr Comp Biol. 2020;60(1):89\u201397. https:\/\/doi.org\/10.1093\/icb\/icaa026.","journal-title":"Integr Comp Biol"},{"key":"7420_CR128","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/nprot.2010.190","volume":"6","author":"H Gu","year":"2011","unstructured":"Gu H, Smith ZD, Bock C, Boyle P, Gnirke A, Meissner A. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protocols. 2011;6:468\u201381. https:\/\/doi.org\/10.1038\/nprot.2010.190.","journal-title":"Nat Protocols"},{"key":"7420_CR129","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1111\/1755-0998.12273","volume":"14","author":"O Lepais","year":"2014","unstructured":"Lepais O, Weir JT. SimRAD: an R package for simulation-based prediction of the number of loci expected in RADseq and similar genotyping by sequencing approaches. Mol Ecol Resour. 2014;14:1314\u201321. https:\/\/doi.org\/10.1111\/1755-0998.12273.","journal-title":"Mol Ecol Resour"},{"key":"7420_CR130","doi-asserted-by":"publisher","unstructured":"Catchen J, Hohenlohe P. Bassham S, Amoros A, Cresko WA. Stacks: an analysis tool set for population genomics. Mol Ecol 2013; 22(11): 3124\u20133140. doi: https:\/\/doi.org\/10.1111\/mec.12354.","DOI":"10.1111\/mec.12354"},{"key":"7420_CR131","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-R87","volume":"13","author":"A Akalin","year":"2012","unstructured":"Akalin A, Kormaksson M, Li S, Garrett-Bakelman FE, Figueroa ME, Melnick A, et al. MethylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol. 2012;13:R87. https:\/\/doi.org\/10.1186\/gb-2012-13-10-R87.","journal-title":"Genome Biol"},{"issue":"1","key":"7420_CR132","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar R, Domarachev M, Lash AE. Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 2002;30(1):207\u20131.","journal-title":"Nucleic Acids Res"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-021-07420-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12864-021-07420-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-021-07420-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T18:26:58Z","timestamp":1724437618000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-021-07420-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":132,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["7420"],"URL":"https:\/\/doi.org\/10.1186\/s12864-021-07420-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-48905\/v3","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-48905\/v2","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-48905\/v1","asserted-by":"object"}]},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,9]]},"assertion":[{"value":"24 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experiments were performed in accordance with relevant guidelines and regulations. Nireus S.A. research facilities are certified and have obtained the codes for the rearing and use of fish for scientific purposes (EL04-BIOexp-01). All procedures on fish used in this study were approved by the Departmental Animal Care Committee following the Three Rs principle, in accordance with Greek (PD 56\/2013) and EU (Directive 63\/2010) legislation on the care and use of experimental animals. All sample procedures were performed by FELASA certified researchers (\n                      \n                      ).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None declared.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"111"}}