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The pathogenicity of TD is under extensive research but is yet not fully understood. Several studies have linked it to apoptosis and non-vascularization in the tibial growth plate (GP). We conceived the idea to find the differentially expressed genes (DEGs) in chicken erythrocytes which vary in expression over time using a likelihood-ratio test (LRT). Thiram was used to induce TD in chickens, and then injected Ex-FABP protein at 0, 20, and 50 \u03bcg<jats:sup>.<\/jats:sup>kg<jats:sup>-1<\/jats:sup> to evaluate its therapeutic effect on 30 screened immunity and angiogenesis-related genes using quantitative PCR (qPCR). The histopathology was also performed in TD chickens to explore the shape, circularity, arrangements of chondrocytes and blood vessels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Clinical lameness was observed in TD chickens, which decreased with the injection of Ex-FABP. Histopathological findings support Ex-FABP as a therapeutic agent for the morphology and vascularization of affected chondrocytes in TD chickens. qPCR results of 10 immunity (<jats:italic>TLR<\/jats:italic>2, <jats:italic>TLR<\/jats:italic>3, <jats:italic>TLR<\/jats:italic>4, <jats:italic>TLR<\/jats:italic>5, <jats:italic>TLR<\/jats:italic>7, <jats:italic>TLR<\/jats:italic>15, <jats:italic>IL<\/jats:italic>-7, <jats:italic>MyD<\/jats:italic>88, <jats:italic>MHC<\/jats:italic>II, and <jats:italic>TRAF<\/jats:italic>6) and 20 angiogenesis-related genes (<jats:italic>ITGAV<\/jats:italic>, <jats:italic>ITGA<\/jats:italic>2, <jats:italic>ITGB<\/jats:italic>2, <jats:italic>ITGB<\/jats:italic>3, <jats:italic>ITGA<\/jats:italic>5, <jats:italic>IL1R<\/jats:italic>1, <jats:italic>TBXA2<\/jats:italic>R, <jats:italic>RPL<\/jats:italic>17, <jats:italic>F13A<\/jats:italic>1, <jats:italic>CLU<\/jats:italic>, <jats:italic>RAC<\/jats:italic>2, <jats:italic>RAP1<\/jats:italic>B, <jats:italic>GIT<\/jats:italic>1, <jats:italic>FYN<\/jats:italic>, <jats:italic>IQGAP<\/jats:italic>2, <jats:italic>PTCH<\/jats:italic>1, <jats:italic>NCOR<\/jats:italic>2, <jats:italic>VAV-like<\/jats:italic>, <jats:italic>PTPN<\/jats:italic>11, <jats:italic>MAML<\/jats:italic>3) regulated when Ex-FABP is injected to TD chickens.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Immunity and angiogenesis-related genes can be responsible for apoptosis of chondrocytes and vascularization in tibial GP. Injection of Ex-FABP protein to thiram induced TD chickens decrease the chondrocytes damage and improves vascularization.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12864-022-08494-9","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T18:02:42Z","timestamp":1650650562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transcriptome-based biomarker gene screening and evaluation of the extracellular fatty acid-binding protein (Ex-FABP) on immune and angiogenesis-related genes in chicken erythrocytes of tibial dyschondroplasia"],"prefix":"10.1186","volume":"23","author":[{"given":"Ali Raza","family":"Jahejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayyad Ali Raza","family":"Bukhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazeer Hussain","family":"Kalhoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imdad Hussain","family":"Leghari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed Haidar Abbas","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-xia","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"8494_CR1","doi-asserted-by":"publisher","first-page":"28264","DOI":"10.1007\/s11356-018-2824-2","volume":"25","author":"H Zhang","year":"2018","unstructured":"Zhang H, Mehmood K, Jiang X, Yao W, Iqbal M, Waqas M, et al. 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