{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:45:30Z","timestamp":1791855930573,"version":"4.3.4"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Merino sheep are the most famous fine wool sheep in the world. They have high wool production and excellent wool quality and have attracted worldwide attention. The fleece of the Merino sheep is composed predominantly of wool fibers grown from secondary wool follicles. Therefore, it is necessary to study the development of hair follicles to understand the mechanism of wool production. The hair follicle is a complex biological system involved in a dynamic process governed by gene regulation. The hair follicle development process is very complex and poorly understood. The purpose of our research is to identify candidate genes related to hair follicle development, provide a theoretical molecular breeding basis for the cultivation of fine wool sheep, and provide a reference for the problems of hair loss and alopecia areata that affect human beings.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We analyzed mRNAs data in skin tissues of 18 Merino sheep at four embryonic days (E65, E85, E105 and E135) and two postnatal days (P7 and P30). G1 to G6 represent hair follicles developmental at six stages (i.e. E65 to P30). We identified 7879 differentially expressed genes (DEGs) and 12623 novel DEGs, revealed different expression patterns of these DEGs at six stages of hair follicle development, and demonstrated their complex interactions. DEGs with stage-specific expression were significantly enriched in epidermal differentiation and development, hair follicle development and hair follicle morphogenesis and were enriched in many pathways related to hair follicle development. The key genes (<jats:italic>LAMA5<\/jats:italic>, <jats:italic>WNT10A<\/jats:italic>, <jats:italic>KRT25<\/jats:italic>, <jats:italic>SOSTDC1<\/jats:italic>, <jats:italic>ZDHHC21<\/jats:italic>, <jats:italic>FZD1<\/jats:italic>, <jats:italic>BMP7<\/jats:italic>, <jats:italic>LRP4<\/jats:italic>, <jats:italic>T<\/jats:italic>G<jats:italic>F\u03b22<\/jats:italic>, <jats:italic>TMEM79<\/jats:italic>, <jats:italic>SOX10<\/jats:italic>, <jats:italic>ITGB4<\/jats:italic>, <jats:italic>KRT14<\/jats:italic>, <jats:italic>ITGA6<\/jats:italic>, and <jats:italic>GLI2<\/jats:italic>) affecting hair follicle morphogenesis were identified by network analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study provides a new reference for the molecular basis of hair follicle development and lays a foundation for further improving sheep hair follicle breeding. Candidate genes related to hair follicular development were found, which provided a theoretical basis for molecular breeding for the culture of fine wool sheep. These results are a valuable resource for biological investigations of fleece evolution in animals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12864-022-08552-2","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T01:02:35Z","timestamp":1654650155000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Gene network analysis reveals candidate genes related with the hair follicle development in sheep"],"prefix":"10.1186","volume":"23","author":[{"given":"Junmin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingru","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangbao","family":"Gun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"issue":"1","key":"8552_CR1","doi-asserted-by":"publisher","first-page":"8501","DOI":"10.1038\/s41598-019-44600-w","volume":"9","author":"A Sulayman","year":"2019","unstructured":"Sulayman A, Tian K, Huang X, Tian Y, Xu X, Fu X, et al. 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Collection of all tissue samples was conducted in accordance with the guidelines of the Ethics Committee of the College of Animal Science (approval number: 2006\u2013398) of Gansu Agricultural University. All embryo samples were obtained by cesarean section after 12 ewes were electrocution followed by exsanguination. The skin tissues were collected immediately after euthanasia, used for scientific research. On postnatal days P7 and P30, lamb was observed to lose consciousness after using general anesthetic the skin tissue of postnatal lambs was collected in vivo, with a depth of about 2 cm<sup>2<\/sup>\u2009\u00d7\u20093\u00a0mm. Then skin wounds were quickly sprinkled anti-inflammatory powder and carefully suture. We took good care of the lamb until the wound healed. All efforts were made to minimize animal suffering and discomfort.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"428"}}