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The mutation spectrum in this condition is determined amongst sub-populations belonging to the north, south and east India geography, however, sub-populations of west Indian origin, especially Gujarati-Indians, are yet to be studied. We aimed to analyse the variants present in the <jats:italic>GLANS<\/jats:italic> gene amongst the population of Gujarat by sequencing all exons and exon\u2013intron boundaries of the <jats:italic>GALNS<\/jats:italic> gene in patients from 23 unrelated families.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We report 11 variants that include eight missense variants: (p.L36R, p.D39G, p.P77R, p.C79R, pP125L, p.P151L, p.G255A and p.L350P), one splice site variant: (c.121-7C\u2009&gt;\u2009G), one small insertion: (c.1241_1242insA, p.I416HfsTer2) and one small deletion: (c.839_841delACA). Of these, three missense variants (p.D39G, p.G255A and p.L350P), one splice site and the two indels mentioned above are novel. Interestingly, we observed a higher than anticipated prevalence of p.P77R variant in our cohort (<jats:italic>n<\/jats:italic>\u2009=\u200914\/25, 56%). Haplotype analysis in cases with p.P77R variant and 63 ethnicity matched healthy population controls suggested a 4 SNP haplotype block present in cases compared to controls (likelihood ratio test <jats:italic>p<\/jats:italic>-value\u2009=\u20091.16\u2009\u00d7\u200910<jats:sup>\u201313<\/jats:sup>), thereby suggesting p.P77R variant as a founder variant in the Gujarati-Indian population. Furthermore, age of mutation analysis suggested the variant to have arisen approximately 450\u00a0years ago in the population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>p.P77R variant in the <jats:italic>GLANS<\/jats:italic> gene is likely to be a founder variant in MPS IVA patients of Gujarati-Indian ancestry and appeared approximately 450\u00a0years ago in the population. To our knowledge, this is the first variant to be posited as a founder variant in the <jats:italic>GLANS<\/jats:italic> gene in patients with MPS IVA syndrome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12864-022-08693-4","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T08:04:05Z","timestamp":1655798645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The GALNS p.P77R variant is a probable Gujarati-Indian founder mutation causing Mucopolysaccharidosis IVA syndrome"],"prefix":"10.1186","volume":"23","author":[{"given":"Harsh","family":"Sheth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premal","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulin","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Bhavsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadhira","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frenny","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"8693_CR1","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0006-291X(74)91022-5","volume":"61","author":"R Matalon","year":"1974","unstructured":"Matalon R, Arbogast B, Justice P, Brandt IK, Dorfman A. 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This process is in accordance with the Helsinki declaration. An informed consent was obtained from the parents before enrolling the patients for the investigations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"An informed consent for publication of non-identifiable data was also obtained from parents of patients or individuals included in the submission. [This was in accordance with the requirement of the institutional ethics committee].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"458"}}