{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:19:40Z","timestamp":1793715580956,"version":"4.6.1"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"DOI":"10.1186\/s12864-024-10691-7","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:03:10Z","timestamp":1724061790000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A novel mRNA multi-epitope vaccine of Acinetobacter baumannii based on multi-target protein design in immunoinformatic approach"],"prefix":"10.1186","volume":"25","author":[{"given":"Yizhong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyou","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongliu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinhua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"2","key":"10691_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0934-8840(89)80012-X","volume":"272","author":"A Giammanco","year":"1989","unstructured":"Giammanco A, Vieu JF, Bouvet PJ, Sarzana A, Sinatra A. A comparative assay of epidemiological markers for Acinetobacter strains isolated in a hospital. Zentralbl Bakteriol. 1989;272(2):231\u201341.","journal-title":"Zentralbl Bakteriol"},{"issue":"41","key":"10691_CR2","doi-asserted-by":"publisher","first-page":"e202209556","DOI":"10.1002\/anie.202209556","volume":"61","author":"J Sianturi","year":"2022","unstructured":"Sianturi J, Priegue P, Hu J, Yin J, Seeberger PH. Semi-synthetic glycoconjugate vaccine lead against Acinetobacter baumannii 17978. Angew Chem Int Ed Engl. 2022;61(41):e202209556.","journal-title":"Angew Chem Int Ed Engl"},{"issue":"3","key":"10691_CR3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/pro.3826","volume":"29","author":"LM Tillery","year":"2020","unstructured":"Tillery LM, Barrett KF, Dranow DM, Craig J, Shek R, Chun I, Barrett LK, Phan IQ, Subramanian S, Abendroth J, et al. Toward a structome of Acinetobacter baumannii drug targets. Protein Sci. 2020;29(3):789\u2013802.","journal-title":"Protein Sci"},{"issue":"11","key":"10691_CR4","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.3390\/ijms22115641","volume":"22","author":"AA Kasimova","year":"2021","unstructured":"Kasimova AA, Arbatsky NP, Tickner J, Kenyon JJ, Hall RM, Shneider MM, Dzhaparova AA, Shashkov AS, Chizhov AO, Popova AV, et al. Acinetobacter baumannii K106 and K112: two structurally and genetically related 6-deoxy-l-talose-containing capsular polysaccharides. Int J Mol Sci. 2021;22(11):5641.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10691_CR5","doi-asserted-by":"publisher","first-page":"e0179322","DOI":"10.1128\/mbio.01793-22","volume":"13","author":"EA Villa","year":"2022","unstructured":"Villa EA, Escalante-Semerena JC. Acinetobacter baumannii Catabolizes Ethanolamine in the Absence of a Metabolosome and Converts Cobinamide into Adenosylated Cobamides. Bio. 2022;13(4):e0179322.","journal-title":"mBio"},{"issue":"2","key":"10691_CR6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tim.2021.11.008","volume":"30","author":"C Whiteway","year":"2022","unstructured":"Whiteway C, Breine A, Philippe C, Van der Henst C. Acinetobacter baumannii. Trends Microbiol. 2022;30(2):199\u2013200.","journal-title":"Trends Microbiol"},{"key":"10691_CR7","doi-asserted-by":"publisher","unstructured":"Monem S, Furmanek-Blaszk B, Lupkowska A, Kuczynska-Wisnik D, Stojowska-Swedrzynska K, Laskowska E. Mechanisms protecting acinetobacter baumannii against multiple stresses triggered by the host immune response, antibiotics and outside-host environment. Int J Mol Sci. 2020;21(15):5498. https:\/\/doi.org\/10.3390\/ijms21155498.","DOI":"10.3390\/ijms21155498"},{"issue":"6","key":"10691_CR8","doi-asserted-by":"publisher","first-page":"e40019","DOI":"10.1371\/journal.pone.0040019","volume":"7","author":"H Qiu","year":"2012","unstructured":"Qiu H, KuoLee R, Harris G, Van Rooijen N, Patel GB, Chen W. Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection. PLoS ONE. 2012;7(6): e40019.","journal-title":"PLoS ONE"},{"issue":"7","key":"10691_CR9","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.3390\/pharmaceutics14071357","volume":"14","author":"MA Khan","year":"2022","unstructured":"Khan MA, Allemailem KS, Maswadeh H, Younus H: Safety and Prophylactic Efficacy of Liposome-Based Vaccine against the Drug-Resistant Acinetobacter baumannii in Mice. Pharmaceutics 2022, 14(7).","journal-title":"Pharmaceutics"},{"key":"10691_CR10","doi-asserted-by":"publisher","unstructured":"Weng Z, Yang N, Shi S, et al. Outer Membrane Vesicles from Acinetobacter baumannii: Biogenesis, Functions, and Vaccine Application. Vaccines (Basel). 2023;12(1):49. https:\/\/doi.org\/10.3390\/vaccines12010049.","DOI":"10.3390\/vaccines12010049"},{"issue":"4","key":"10691_CR11","first-page":"177","volume":"178","author":"JI Anasagasti","year":"1986","unstructured":"Anasagasti JI, Peralta V, Harto A, Chinchilla A, Ledo A. Study of personality in patients with chronic urticaria using the 16-PF questionnaire. Rev Clin Esp. 1986;178(4):177\u201380.","journal-title":"Rev Clin Esp"},{"issue":"2","key":"10691_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.vaccine.2012.11.008","volume":"31","author":"L Lin","year":"2013","unstructured":"Lin L, Tan B, Pantapalangkoor P, Ho T, Hujer AM, Taracila MA, Bonomo RA, Spellberg B. Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes. Vaccine. 2013;31(2):313\u20138.","journal-title":"Vaccine"},{"key":"10691_CR13","doi-asserted-by":"publisher","first-page":"110650","DOI":"10.1016\/j.intimp.2023.110650","volume":"122","author":"M Mansouri","year":"2023","unstructured":"Mansouri M, Sadeghpoor M, Abdollahi M, Vafaei AJ, Jalali Nadoushan M, Rasooli I. Synergistic immunoprotection by Oma87 and Bap against Acinetobacter baumannii sepsis model. Int Immunopharmacol. 2023;122:110650.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10691_CR14","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1038\/s41598-019-39299-8","volume":"9","author":"V Chauhan","year":"2019","unstructured":"Chauhan V, Rungta T, Goyal K, Singh MP. Designing a multi-epitope based vaccine to combat Kaposi Sarcoma utilizing immunoinformatics approach. Sci Rep. 2019;9(1):2517.","journal-title":"Sci Rep"},{"issue":"6","key":"10691_CR15","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.jiph.2019.05.009","volume":"12","author":"SA Sheweita","year":"2019","unstructured":"Sheweita SA, Batah AM, Ghazy AA, Hussein A, Amara AA. A new strain of Acinetobacter baumannii and characterization of its ghost as a candidate vaccine. J Infect Public Health. 2019;12(6):831\u201342.","journal-title":"J Infect Public Health"},{"key":"10691_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1112816","volume":"14","author":"C Tan","year":"2023","unstructured":"Tan C, Zhu F, Pan P, Wu A, Li C. Development of multi-epitope vaccines against the monkeypox virus based on envelope proteins using immunoinformatics approaches. Front Immunol. 2023;14:1112816.","journal-title":"Front Immunol"},{"issue":"1","key":"10691_CR17","doi-asserted-by":"publisher","first-page":"bbad502","DOI":"10.1093\/bib\/bbad502","volume":"25","author":"M Asadinezhad","year":"2023","unstructured":"Asadinezhad M, Khoshnood S, Asadollahi P, Ghafourian S, Sadeghifard N, Pakzad I, Zeinivand Y, Omidi N, Hematian A, Kalani BS. Development of innovative multi-epitope mRNA vaccine against pseudomonas aeruginosa using in silico approaches. Brief Bioinform. 2023;25(1):bbad502.","journal-title":"Brief Bioinform"},{"issue":"9","key":"10691_CR18","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1016\/j.bbamem.2006.07.007","volume":"1758","author":"V Dhople","year":"2006","unstructured":"Dhople V, Krukemeyer A, Ramamoorthy A. The human beta-defensin-3, an antibacterial peptide with multiple biological functions. Biochim Biophys Acta. 2006;1758(9):1499\u2013512.","journal-title":"Biochim Biophys Acta"},{"issue":"5439","key":"10691_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1126\/science.286.5439.525","volume":"286","author":"D Yang","year":"1999","unstructured":"Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang JM, Howard OM, et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science. 1999;286(5439):525\u20138.","journal-title":"Science"},{"issue":"2","key":"10691_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030839","volume":"7","author":"A Shanmugam","year":"2012","unstructured":"Shanmugam A, Rajoria S, George AL, Mittelman A, Suriano R, Tiwari RK. Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. PLoS ONE. 2012;7(2): e30839.","journal-title":"PLoS ONE"},{"key":"10691_CR21","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.3389\/fimmu.2018.02212","volume":"9","author":"L Antonio-Herrera","year":"2018","unstructured":"Antonio-Herrera L, Badillo-Godinez O, Medina-Contreras O, Tepale-Segura A, Garcia-Lozano A, Gutierrez-Xicotencatl L, Soldevila G, Esquivel-Guadarrama FR, Idoyaga J, Bonifaz LC. The nontoxic cholera B subunit is a potent adjuvant for intradermal DC-targeted vaccination. Front Immunol. 2018;9:2212.","journal-title":"Front Immunol"},{"issue":"6","key":"10691_CR22","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/sj.mt.6300121","volume":"15","author":"CF Hung","year":"2007","unstructured":"Hung CF, Tsai YC, He L, Wu TC. DNA vaccines encoding Ii-PADRE generates potent PADRE-specific CD4+ T-cell immune responses and enhances vaccine potency. Mol Ther. 2007;15(6):1211\u20139.","journal-title":"Mol Ther"},{"issue":"1","key":"10691_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12979-023-00383-3","volume":"20","author":"HJ Kim","year":"2023","unstructured":"Kim HJ, Kim H, Lee JH, Hwangbo C. Toll-like receptor 4 (TLR4): new insight immune and aging. Immun Ageing. 2023;20(1):67.","journal-title":"Immun Ageing"},{"issue":"2","key":"10691_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nprot.2016.169","volume":"12","author":"D Kozakov","year":"2017","unstructured":"Kozakov D, Hall DR, Xia B, Porter KA, Padhorny D, Yueh C, Beglov D, Vajda S. The ClusPro web server for protein-protein docking. Nat Protoc. 2017;12(2):255\u201378.","journal-title":"Nat Protoc"},{"issue":"16","key":"10691_CR25","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D Van Der Spoel","year":"2005","unstructured":"Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ. GROMACS: fast, flexible, and free. J Comput Chem. 2005;26(16):1701\u201318.","journal-title":"J Comput Chem"},{"issue":"15","key":"10691_CR26","doi-asserted-by":"publisher","first-page":"3692","DOI":"10.1021\/acs.jpcb.6b01316","volume":"120","author":"S Boonstra","year":"2016","unstructured":"Boonstra S, Onck PR, Giessen E. CHARMM TIP3P water model suppresses peptide folding by solvating the unfolded state. J Phys Chem B. 2016;120(15):3692\u20138.","journal-title":"J Phys Chem B"},{"issue":"10","key":"10691_CR27","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","volume":"17","author":"MS Valdes-Tresanco","year":"2021","unstructured":"Valdes-Tresanco MS, Valdes-Tresanco ME, Valiente PA, Moreno E. gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS. J Chem Theory Comput. 2021;17(10):6281\u201391.","journal-title":"J Chem Theory Comput"},{"issue":"6","key":"10691_CR28","doi-asserted-by":"publisher","first-page":"e2887","DOI":"10.1002\/jmr.2887","volume":"34","author":"Y Liu","year":"2021","unstructured":"Liu Y, Gong W, Yang Z, Li C. SNB-PSSM: a spatial neighbor-based PSSM used for protein-RNA binding site prediction. J Mol Recognit. 2021;34(6):e2887.","journal-title":"J Mol Recognit"},{"key":"10691_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.imlet.2017.07.007","volume":"190","author":"Y Kou","year":"2017","unstructured":"Kou Y, Xu Y, Zhao Z, Liu J, Wu Y, You Q, Wang L, Gao F, Cai L, Jiang C. Tissue plasminogen activator (tPA) signal sequence enhances immunogenicity of MVA-based vaccine against tuberculosis. Immunol Lett. 2017;190:51\u20137.","journal-title":"Immunol Lett"},{"issue":"1","key":"10691_CR30","doi-asserted-by":"publisher","first-page":"309","DOI":"10.4049\/jimmunol.180.1.309","volume":"180","author":"S Kreiter","year":"2008","unstructured":"Kreiter S, Selmi A, Diken M, Sebastian M, Osterloh P, Schild H, Huber C, Tureci O, Sahin U. Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals. J Immunol. 2008;180(1):309\u201318.","journal-title":"J Immunol"},{"issue":"1","key":"10691_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13273-021-00171-4","volume":"18","author":"SC Kim","year":"2022","unstructured":"Kim SC, Sekhon SS, Shin WR, Ahn G, Cho BK, Ahn JY, Kim YH. Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency. Mol Cell Toxicol. 2022;18(1):1\u20138.","journal-title":"Mol Cell Toxicol"},{"key":"10691_CR32","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.ijbiomac.2022.12.066","volume":"226","author":"N Rcheulishvili","year":"2023","unstructured":"Rcheulishvili N, Mao J, Papukashvili D, Liu C, Wang Z, Zhao J, Xie F, Pan X, Ji Y, He Y, et al. Designing multi-epitope mRNA construct as a universal influenza vaccine candidate for future epidemic\/pandemic preparedness. Int J Biol Macromol. 2023;226:885\u201399.","journal-title":"Int J Biol Macromol"},{"issue":"8","key":"10691_CR33","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.ymthe.2019.05.012","volume":"27","author":"Y Rybakova","year":"2019","unstructured":"Rybakova Y, Kowalski PS, Huang Y, Gonzalez JT, Heartlein MW, DeRosa F, Delcassian D, Anderson DG. mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo. Mol Ther. 2019;27(8):1415\u201323.","journal-title":"Mol Ther"},{"issue":"5","key":"10691_CR34","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1007\/s11033-019-04994-2","volume":"46","author":"L Lei","year":"2019","unstructured":"Lei L, Yang F, Zou J, Jing H, Zhang J, Xu W, Zou Q, Zhang J, Wang X. DNA vaccine encoding OmpA and Pal from Acinetobacter baumannii efficiently protects mice against pulmonary infection. Mol Biol Rep. 2019;46(5):5397\u2013408.","journal-title":"Mol Biol Rep"},{"issue":"2","key":"10691_CR35","doi-asserted-by":"publisher","first-page":"110590","DOI":"10.1016\/j.ygeno.2023.110590","volume":"115","author":"X Zeng","year":"2023","unstructured":"Zeng X, Wang N, Xiang C, Liu Q, Li D, Zhou Y, Zhang X, Xie Y, Zhang W, Yang H, et al. Peptidoglycan-associated lipoprotein contributes to the virulence of Acinetobacter baumannii and serves as a vaccine candidate. Genomics. 2023;115(2):110590.","journal-title":"Genomics"},{"key":"10691_CR36","doi-asserted-by":"publisher","first-page":"105138","DOI":"10.1016\/j.meegid.2021.105138","volume":"96","author":"S Beiranvand","year":"2021","unstructured":"Beiranvand S, Doosti A, Mirzaei SA. Putative novel B-cell vaccine candidates identified by reverse vaccinology and genomics approaches to control Acinetobacter baumannii serotypes. Infect Genet Evol. 2021;96:105138.","journal-title":"Infect Genet Evol"},{"issue":"2 Pt B","key":"10691_CR37","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.molimm.2015.07.031","volume":"67","author":"F Badmasti","year":"2015","unstructured":"Badmasti F, Ajdary S, Bouzari S, Fooladi AA, Shahcheraghi F, Siadat SD. Immunological evaluation of OMV(PagL)+Bap(1\u2013487aa) and AbOmpA(8\u2013346aa)+Bap(1\u2013487aa) as vaccine candidates against Acinetobacter baumannii sepsis infection. Mol Immunol. 2015;67(2 Pt B):552\u20138.","journal-title":"Mol Immunol"},{"key":"10691_CR38","doi-asserted-by":"publisher","first-page":"105346","DOI":"10.1016\/j.micpath.2021.105346","volume":"162","author":"Z Raoufi","year":"2022","unstructured":"Raoufi Z, Abdollahi S, Armand R. DcaP porin and its epitope-based subunit promise effective vaccines against Acinetobacter baumannii; in-silico and in-vivo approaches. Microb Pathog. 2022;162:105346.","journal-title":"Microb Pathog"},{"key":"10691_CR39","doi-asserted-by":"publisher","first-page":"104114","DOI":"10.1016\/j.micpath.2020.104114","volume":"143","author":"S Fereshteh","year":"2020","unstructured":"Fereshteh S, Abdoli S, Shahcheraghi F, Ajdary S, Nazari M, Badmasti F. New putative vaccine candidates against Acinetobacter baumannii using the reverse vaccinology method. Microb Pathog. 2020;143:104114.","journal-title":"Microb Pathog"},{"issue":"1","key":"10691_CR40","doi-asserted-by":"publisher","first-page":"10852","DOI":"10.1038\/s41598-022-14877-5","volume":"12","author":"MR Rahbar","year":"2022","unstructured":"Rahbar MR, Mubarak SMH, Hessami A, Khalesi B, Pourzardosht N, Khalili S, Zanoos KA, Jahangiri A. A unique antigen against SARS-CoV-2, Acinetobacter baumannii, and Pseudomonas aeruginosa. Sci Rep. 2022;12(1):10852.","journal-title":"Sci Rep"},{"key":"10691_CR41","doi-asserted-by":"publisher","first-page":"108731","DOI":"10.1016\/j.intimp.2022.108731","volume":"108","author":"Z Akbari","year":"2022","unstructured":"Akbari Z, Rasooli I, Ghaini MH, Chaudhuri S, Farshchi Andisi V, Jahangiri A, Ramezanalizadeh F, Schryvers AB. BauA and Omp34 surface loops trigger protective antibodies against Acinetobacter baumannii in a murine sepsis model. Int Immunopharmacol. 2022;108:108731.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10691_CR42","doi-asserted-by":"publisher","first-page":"19909","DOI":"10.1038\/s41598-022-24163-z","volume":"12","author":"F Ramezanalizadeh","year":"2022","unstructured":"Ramezanalizadeh F, Rasooli I, Owlia P, Darvish Alipour Astaneh S, Abdolhamidi R. Vaccination with a combination of planktonic and biofilm virulence factors confers protection against carbapenem-resistant Acinetobacter baumannii strains. Sci Rep. 2022;12(1):19909.","journal-title":"Sci Rep"},{"issue":"4\u20135","key":"10691_CR43","doi-asserted-by":"publisher","first-page":"104801","DOI":"10.1016\/j.micinf.2021.104801","volume":"23","author":"AE Vieira de Araujo","year":"2021","unstructured":"Vieira de Araujo AE, Conde LV, da Silva Junior HC, de Almeida Machado L, Lara FA, Chapeaurouge A, Pauer H, Pires Hardoim CC, Martha Antunes LC, D\u2019Alincourt Carvalho-Assef AP, et al. Cross-reactivity and immunotherapeutic potential of BamA recombinant protein from Acinetobacter baumannii. Microbes Infect. 2021;23(4\u20135):104801.","journal-title":"Microbes Infect"},{"key":"10691_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejps.2019.02.023","volume":"132","author":"S Ahmad","year":"2019","unstructured":"Ahmad S, Ranaghan KE, Azam SS. Combating tigecycline resistant Acinetobacter baumannii: a leap forward towards multi-epitope based vaccine discovery. Eur J Pharm Sci. 2019;132:1\u201317.","journal-title":"Eur J Pharm Sci"},{"issue":"5","key":"10691_CR45","doi-asserted-by":"publisher","first-page":"e0002323","DOI":"10.1128\/iai.00023-23","volume":"91","author":"V Solanki","year":"2023","unstructured":"Solanki V, Tiwari M, Tiwari V. Investigation of peptidoglycan-associated lipoprotein of Acinetobacter baumannii and its interaction with fibronectin to find its therapeutic potential. Infect Immun. 2023;91(5):e0002323.","journal-title":"Infect Immun"},{"key":"10691_CR46","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.micpath.2018.03.009","volume":"118","author":"S Abdollahi","year":"2018","unstructured":"Abdollahi S, Rasooli I, Mousavi Gargari SL. An in silico structural and physicochemical characterization of TonB-dependent copper receptor in A. baumannii. Microb Pathog. 2018;118:18\u201331.","journal-title":"Microb Pathog"},{"key":"10691_CR47","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.2147\/IJN.S296527","volume":"16","author":"X Du","year":"2021","unstructured":"Du X, Xue J, Jiang M, Lin S, Huang Y, Deng K, Shu L, Xu H, Li Z, Yao J, et al. A multiepitope peptide, rOmp22, encapsulated in chitosan-PLGA nanoparticles as a candidate vaccine against acinetobacter baumannii Infection. Int J Nanomedicine. 2021;16:1819\u201336.","journal-title":"Int J Nanomedicine"},{"issue":"10","key":"10691_CR48","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1128\/IAI.06096-11","volume":"80","author":"LV Bentancor","year":"2012","unstructured":"Bentancor LV, Routray A, Bozkurt-Guzel C, Camacho-Peiro A, Pier GB, Maira-Litran T. Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections. Infect Immun. 2012;80(10):3381\u20138.","journal-title":"Infect Immun"},{"issue":"1","key":"10691_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029446","volume":"7","author":"G Luo","year":"2012","unstructured":"Luo G, Lin L, Ibrahim AS, Baquir B, Pantapalangkoor P, Bonomo RA, Doi Y, Adams MD, Russo TA, Spellberg B. Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection. PLoS ONE. 2012;7(1): e29446.","journal-title":"PLoS ONE"},{"key":"10691_CR50","doi-asserted-by":"publisher","first-page":"1064053","DOI":"10.3389\/fcimb.2022.1064053","volume":"12","author":"A Tajuelo","year":"2022","unstructured":"Tajuelo A, Terron MC, Lopez-Siles M, McConnell MJ. Role of peptidoglycan recycling enzymes AmpD and AnmK in Acinetobacter baumannii virulence features. Front Cell Infect Microbiol. 2022;12:1064053.","journal-title":"Front Cell Infect Microbiol"},{"issue":"34","key":"10691_CR51","doi-asserted-by":"publisher","first-page":"5436","DOI":"10.1016\/j.vaccine.2020.06.052","volume":"38","author":"F Ramezanalizadeh","year":"2020","unstructured":"Ramezanalizadeh F, Owlia P, Rasooli I. Type I pili, CsuA\/B and FimA induce a protective immune response against Acinetobacter baumannii. Vaccine. 2020;38(34):5436\u201346.","journal-title":"Vaccine"},{"issue":"12","key":"10691_CR52","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/apm.12992","volume":"127","author":"Z Aghajani","year":"2019","unstructured":"Aghajani Z, Rasooli I, Mousavi Gargari SL. Exploitation of two siderophore receptors, BauA and BfnH, for protection against Acinetobacter baumannii infection. APMIS. 2019;127(12):753\u201363.","journal-title":"APMIS"},{"issue":"2","key":"10691_CR53","first-page":"155","volume":"31","author":"SJ Guo","year":"2018","unstructured":"Guo SJ, Ren S, Xie YE. Evaluation of the protective efficacy of a fused OmpK\/Omp22 protein vaccine candidate against acinetobacter baumannii infection in mice. Biomed Environ Sci. 2018;31(2):155\u20138.","journal-title":"Biomed Environ Sci"},{"issue":"5","key":"10691_CR54","first-page":"537","volume":"20","author":"K Mehdinejadiani","year":"2021","unstructured":"Mehdinejadiani K, Hashemi A, Bandehpour M, Rahmani H, Ranjbar MM, Yardel V, Jalali SA, Mosaffa N. Evaluationof the new outer membrane protein a epitope-based vaccines for mice model of Acinetobacter baumannii associated pneumonia and sepsis infection. Iran J Allergy Asthma Immunol. 2021;20(5):537\u201349.","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10691_CR55","doi-asserted-by":"publisher","first-page":"105882","DOI":"10.1016\/j.micpath.2022.105882","volume":"174","author":"S Fereshteh","year":"2023","unstructured":"Fereshteh S, Ajdary S, Sepehr A, Bolourchi N, Barzi SM, Haririzadeh Jouriani F, Riazi-Rad F, Shahcheraghi F, Badmasti F. Immunization with recombinant DcaP-like protein and AbOmpA revealed protections against sepsis infection of multi-drug resistant Acinetobacter baumannii ST2(Pas) in a C57BL\/6 mouse model. Microb Pathog. 2023;174:105882.","journal-title":"Microb Pathog"},{"key":"10691_CR56","doi-asserted-by":"publisher","first-page":"884555","DOI":"10.3389\/fimmu.2022.884555","volume":"13","author":"P Sun","year":"2022","unstructured":"Sun P, Li X, Pan C, Liu Z, Wu J, Wang H, Zhu L. A short peptide of autotransporter ata is a promising protective antigen for vaccination against Acinetobacter baumannii. Front Immunol. 2022;13:884555.","journal-title":"Front Immunol"},{"key":"10691_CR57","doi-asserted-by":"publisher","first-page":"109013","DOI":"10.1016\/j.intimp.2022.109013","volume":"110","author":"F Golestani","year":"2022","unstructured":"Golestani F, Malekan M, Rasooli I, Jahangiri A, Ramezanalizadeh F, Chaudhuri S, Farshchi Andisi V, Schryvers AB. Immunogenicity of loop 3 of Omp34 from A. Baumannii in loopless C-lobe of TbpB of N. meningitidis. Int Immunopharmacol. 2022;110:109013.","journal-title":"Int Immunopharmacol"},{"issue":"Pt B","key":"10691_CR58","doi-asserted-by":"publisher","first-page":"105291","DOI":"10.1016\/j.micpath.2021.105291","volume":"161","author":"A Naghipour Erami","year":"2021","unstructured":"Naghipour Erami A, Rasooli I, Jahangiri A, Darvish Alipour Astaneh S. Anti-Omp34 antibodies protect against Acinetobacter baumannii in a murine sepsis model. Microb Pathog. 2021;161(Pt B):105291.","journal-title":"Microb Pathog"},{"key":"10691_CR59","doi-asserted-by":"publisher","unstructured":"Viale AM, Evans BA. Microevolution in the major outer membrane protein OmpA of Acinetobacter baumannii. Microb Genom. 2020;6(6):e000381. https:\/\/doi.org\/10.1099\/mgen.0.000381.","DOI":"10.1099\/mgen.0.000381"},{"issue":"1","key":"10691_CR60","doi-asserted-by":"publisher","first-page":"12576","DOI":"10.1038\/s41598-022-16894-w","volume":"12","author":"A Ranjbar","year":"2022","unstructured":"Ranjbar A, Rasooli I, Jahangiri A, Ramezanalizadeh F. Specific egg yolk antibody raised to biofilm associated protein (Bap) is protective against murine pneumonia caused by Acinetobacter baumannii. Sci Rep. 2022;12(1):12576.","journal-title":"Sci Rep"},{"key":"10691_CR61","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.mimet.2017.11.008","volume":"144","author":"A Jahangiri","year":"2018","unstructured":"Jahangiri A, Rasooli I, Owlia P, Imani Fooladi AA, Salimian J. Highly conserved exposed immunogenic peptides of Omp34 against Acinetobacter baumannii: an innovative approach. J Microbiol Methods. 2018;144:79\u201385.","journal-title":"J Microbiol Methods"},{"key":"10691_CR62","doi-asserted-by":"publisher","first-page":"933445","DOI":"10.3389\/fimmu.2022.933445","volume":"13","author":"S Chaudhuri","year":"2022","unstructured":"Chaudhuri S, Rasooli I, Oskouei RH, Pishgahi M, Jahangir A, Andisi VF, Schryvers AB. Hybrid antigens expressing surface loops of BauA from Acinetobacter baumannii are capable of inducing protection against infection. Front Immunol. 2022;13:933445.","journal-title":"Front Immunol"},{"issue":"1","key":"10691_CR63","doi-asserted-by":"publisher","first-page":"12411","DOI":"10.1038\/s41598-017-12789-3","volume":"7","author":"R Singh","year":"2017","unstructured":"Singh R, Capalash N, Sharma P. Immunoprotective potential of BamA, the outer membrane protein assembly factor, against MDR Acinetobacter baumannii. Sci Rep. 2017;7(1):12411.","journal-title":"Sci Rep"},{"issue":"2","key":"10691_CR64","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10441-015-9251-2","volume":"63","author":"F Sefid","year":"2015","unstructured":"Sefid F, Rasooli I, Jahangiri A, Bazmara H. Functional exposed amino acids of BauA as potential immunogen against Acinetobacter baumannii. Acta Biotheor. 2015;63(2):129\u201349.","journal-title":"Acta Biotheor"},{"key":"10691_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/srep20724","volume":"6","author":"W Huang","year":"2016","unstructured":"Huang W, Yao Y, Wang S, Xia Y, Yang X, Long Q, Sun W, Liu C, Li Y, Chu X, et al. Immunization with a 22-kDa outer membrane protein elicits protective immunity to multidrug-resistant Acinetobacter baumannii. Sci Rep. 2016;6:20724.","journal-title":"Sci Rep"},{"issue":"6","key":"10691_CR66","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.micpath.2011.09.004","volume":"51","author":"Y Fattahian","year":"2011","unstructured":"Fattahian Y, Rasooli I, Mousavi Gargari SL, Rahbar MR, Darvish Alipour Astaneh S, Amani J. Protection against Acinetobacter baumannii infection via its functional deprivation of biofilm associated protein (Bap). Microb Pathog. 2011;51(6):402\u20136.","journal-title":"Microb Pathog"},{"issue":"2","key":"10691_CR67","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/jam.14135","volume":"126","author":"A Jahangiri","year":"2019","unstructured":"Jahangiri A, Owlia P, Rasooli I, Salimian J, Derakhshanifar E, Naghipour Erami A, Darzi Eslam E, Darvish Alipour Astaneh S. Specific egg yolk antibodies (IgY) confer protection against Acinetobacter baumannii in a murine pneumonia model. J Appl Microbiol. 2019;126(2):624\u201332.","journal-title":"J Appl Microbiol"},{"key":"10691_CR68","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.micpath.2017.02.028","volume":"105","author":"A Jahangiri","year":"2017","unstructured":"Jahangiri A, Rasooli I, Owlia P, Fooladi AA, Salimian J. In silico design of an immunogen against Acinetobacter baumannii based on a novel model for native structure of outer membrane protein A. Microb Pathog. 2017;105:201\u201310.","journal-title":"Microb Pathog"},{"key":"10691_CR69","doi-asserted-by":"publisher","unstructured":"Dey J, Mahapatra SR, Raj TK, Misra N, Suar M. Identification of potential flavonoid compounds as antibacterial therapeutics against Klebsiella pneumoniae infection using structure-based virtual screening and molecular dynamics simulation. Mol Divers. 2023. https:\/\/doi.org\/10.1007\/s11030-023-10738-z.","DOI":"10.1007\/s11030-023-10738-z"},{"issue":"4","key":"10691_CR70","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s12026-023-09374-4","volume":"71","author":"J Dey","year":"2023","unstructured":"Dey J, Mahapatra SR, Singh PK, Prabhuswamimath SC, Misra N, Suar M. Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction-based approaches. Immunol Res. 2023;71(4):639\u201362.","journal-title":"Immunol Res"},{"issue":"1","key":"10691_CR71","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13099-022-00495-z","volume":"14","author":"J Dey","year":"2022","unstructured":"Dey J, Mahapatra SR, Raj TK, Kaur T, Jain P, Tiwari A, Patro S, Misra N, Suar M. Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium. Gut Pathog. 2022;14(1):21.","journal-title":"Gut Pathog"},{"issue":"28","key":"10691_CR72","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1002\/jcc.25555","volume":"39","author":"X Xu","year":"2018","unstructured":"Xu X, Yan C, Zou X. MDockPeP: An ab-initio protein-peptide docking server. J Comput Chem. 2018;39(28):2409\u201313.","journal-title":"J Comput Chem"},{"issue":"12","key":"10691_CR73","doi-asserted-by":"publisher","first-page":"124102","DOI":"10.1063\/1.2710272","volume":"126","author":"T Yanao","year":"2007","unstructured":"Yanao T, Koon WS, Marsden JE, Kevrekidis IG. Gyration-radius dynamics in structural transitions of atomic clusters. J Chem Phys. 2007;126(12):124102.","journal-title":"J Chem Phys"},{"key":"10691_CR74","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fcimb.2017.00055","volume":"7","author":"CR Lee","year":"2017","unstructured":"Lee CR, Lee JH, Park M, Park KS, Bae IK, Kim YB, Cha CJ, Jeong BC, Lee SH. Biology of Acinetobacter baumannii: pathogenesis, antibiotic resistance mechanisms, and prospective treatment options. Front Cell Infect Microbiol. 2017;7:55.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"10691_CR75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ijantimicag.2012.09.008","volume":"41","author":"R Zarrilli","year":"2013","unstructured":"Zarrilli R, Pournaras S, Giannouli M, Tsakris A. Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages. Int J Antimicrob Agents. 2013;41(1):11\u20139.","journal-title":"Int J Antimicrob Agents"},{"issue":"18","key":"10691_CR76","doi-asserted-by":"publisher","first-page":"6582","DOI":"10.3390\/ijms21186582","volume":"21","author":"S Xu","year":"2020","unstructured":"Xu S, Yang K, Li R, Zhang L. mRNA vaccine era-mechanisms, drug platform and clinical prospection. Int J Mol Sci. 2020;21(18):6582.","journal-title":"Int J Mol Sci"},{"key":"10691_CR77","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.copbio.2021.09.016","volume":"73","author":"E Kon","year":"2022","unstructured":"Kon E, Elia U, Peer D. Principles for designing an optimal mRNA lipid nanoparticle vaccine. Curr Opin Biotechnol. 2022;73:329\u201336.","journal-title":"Curr Opin Biotechnol"},{"issue":"11","key":"10691_CR78","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1016\/j.immuni.2022.10.014","volume":"55","author":"R Verbeke","year":"2022","unstructured":"Verbeke R, Hogan MJ, Lore K, Pardi N. Innate immune mechanisms of mRNA vaccines. Immunity. 2022;55(11):1993\u20132005.","journal-title":"Immunity"},{"issue":"24","key":"10691_CR79","doi-asserted-by":"publisher","first-page":"e153201","DOI":"10.1172\/jci.insight.153201","volume":"6","author":"S Sureshchandra","year":"2021","unstructured":"Sureshchandra S, Lewis SA, Doratt BM, Jankeel A, Coimbra Ibraim I, Messaoudi I. Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine. JCI Insight. 2021;6(24):e153201.","journal-title":"JCI Insight"},{"key":"10691_CR80","doi-asserted-by":"publisher","unstructured":"Lau YT, Tan HS. Acinetobacter baumannii subunit vaccines: recent progress and challenges. Crit Rev Microbiol. 2024;50(4):434\u201349. https:\/\/doi.org\/10.1080\/1040841X.2023.2215303.\u00a0","DOI":"10.1080\/1040841X.2023.2215303"},{"key":"10691_CR81","doi-asserted-by":"publisher","first-page":"103675","DOI":"10.1016\/j.fm.2020.103675","volume":"95","author":"A Carvalheira","year":"2021","unstructured":"Carvalheira A, Silva J, Teixeira P. Acinetobacter spp. in food and drinking water - a review. Food Microbiol. 2021;95:103675.","journal-title":"Food Microbiol"},{"key":"10691_CR82","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cytogfr.2016.03.011","volume":"30","author":"A Sahoo","year":"2016","unstructured":"Sahoo A, Wali S, Nurieva R. T helper 2 and T follicular helper cells: regulation and function of interleukin-4. Cytokine Growth Factor Rev. 2016;30:29\u201337.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10691_CR83","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00018-019-03277-0","volume":"77","author":"D Fang","year":"2020","unstructured":"Fang D, Zhu J. Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells. Cell Mol Life Sci. 2020;77(2):289\u2013303.","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10691_CR84","doi-asserted-by":"publisher","first-page":"653","DOI":"10.4168\/aair.2022.14.6.653","volume":"14","author":"Z Deng","year":"2022","unstructured":"Deng Z, Ding W, Li F, Shen S, Huang C, Lai K. Pulmonary IFN-gamma causes lymphocytic inflammation and cough hypersensitivity by increasing the number of IFN-gamma-secreting T lymphocytes. Allergy Asthma Immunol Res. 2022;14(6):653\u201373.","journal-title":"Allergy Asthma Immunol Res"},{"issue":"6","key":"10691_CR85","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/toxins13060378","volume":"13","author":"C Lingwood","year":"2021","unstructured":"Lingwood C. Therapeutic uses of bacterial subunit toxins. Toxins (Basel). 2021;13(6):378.","journal-title":"Toxins (Basel)."},{"key":"10691_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102743","volume":"55","author":"E Kim","year":"2020","unstructured":"Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, Raj VS, Epperly MW, Klimstra WB, Haagmans BL, et al. Microneedle array delivered recombinant coronavirus vaccines: immunogenicity and rapid translational development. EBioMedicine. 2020;55: 102743.","journal-title":"EBioMedicine"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-024-10691-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-024-10691-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-024-10691-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T11:02:55Z","timestamp":1724065375000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-024-10691-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10691"],"URL":"https:\/\/doi.org\/10.1186\/s12864-024-10691-7","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"13 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participants"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"791"}}