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The experimental protocols were approved by the ethical guidelines of the Animal Care and Use Committee of Lanzhou University (Ethic approval No: 2010-1 and 2010-2). This study was designed and conducted according to the ARRIVE guidelines 2.0.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"165"}}