{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:11:50Z","timestamp":1745986310472,"version":"3.40.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2023TC196"],"award-info":[{"award-number":["2023TC196"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biological Breeding-National Science and Technology Major Project","award":["2023ZD0407003"],"award-info":[{"award-number":["2023ZD0407003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["32302708","32272844"],"award-info":[{"award-number":["32302708","32272844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"crossref","award":["Qian Kehe Support (2022) Key 032"],"award-info":[{"award-number":["Qian Kehe Support (2022) Key 032"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Earmarked Fund for China Agriculture Research System","award":["No. CARS-pig-35"],"award-info":[{"award-number":["No. CARS-pig-35"]}]},{"name":"the 2115 Talent Development Program of China Agricultural University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"DOI":"10.1186\/s12864-025-11623-9","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:21:22Z","timestamp":1745914882000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic evidence of the blood virome and bacteriome provides insights into prevalence, evolution, and susceptibility-related genes across Eurasian pigs"],"prefix":"10.1186","volume":"26","author":[{"given":"Zhen","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Jia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"11623_CR1","doi-asserted-by":"publisher","first-page":"eabd5758","DOI":"10.1126\/scitranslmed.abd5758","volume":"13","author":"JK Lunney","year":"2021","unstructured":"Lunney JK, Van Goor A, Walker KE, Hailstock T, Franklin J, Dai C. Importance of the pig as a human biomedical model. Sci Transl Med. 2021;13:eabd5758.","journal-title":"Sci Transl Med"},{"key":"11623_CR2","doi-asserted-by":"publisher","first-page":"e1003453","DOI":"10.1371\/journal.pgen.1003453","volume":"9","author":"S Wilkinson","year":"2013","unstructured":"Wilkinson S, Lu ZH, Megens H-J, Archibald AL, Haley C, Jackson IJ, et al. Signatures of diversifying selection in European pig breeds. PLoS Genet. 2013;9:e1003453.","journal-title":"PLoS Genet"},{"key":"11623_CR3","doi-asserted-by":"publisher","first-page":"11495","DOI":"10.1073\/pnas.1806068115","volume":"115","author":"K VanderWaal","year":"2018","unstructured":"VanderWaal K, Deen J. Global trends in infectious diseases of swine. Proc Natl Acad Sci. 2018;115:11495\u2013500.","journal-title":"Proc Natl Acad Sci"},{"key":"11623_CR4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-micro-102215-095431","volume":"70","author":"N Rascovan","year":"2016","unstructured":"Rascovan N, Duraisamy R, Desnues C. Metagenomics and the human Virome in asymptomatic individuals. Annu Rev Microbiol. 2016;70:125\u201341.","journal-title":"Annu Rev Microbiol"},{"key":"11623_CR5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0021-9975(76)90043-8","volume":"86","author":"N Edington","year":"1976","unstructured":"Edington N, Plowright W, Watt R. Generalized Porcine cytomegalic inclusion disease: distribution of cytomegalic cells and virus. J Comp Pathol. 1976;86:191\u2013202.","journal-title":"J Comp Pathol"},{"key":"11623_CR6","unstructured":"Zimmerman JJ. Diseases of swine. Wiley; 2012."},{"key":"11623_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/insects11040239","volume":"11","author":"A Beaurepaire","year":"2020","unstructured":"Beaurepaire A, Piot N, Doublet V, Antunez K, Campbell E, Chantawannakul P, et al. Diversity and global distribution of viruses of the Western honey bee, Apis mellifera. Insects. 2020;11:239.","journal-title":"Insects"},{"key":"11623_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40168-022-01446-1","volume":"11","author":"N Li","year":"2023","unstructured":"Li N, Li C, Hu T, Li J, Zhou H, Ji J, et al. Nationwide genomic surveillance reveals the prevalence and evolution of honeybee viruses in China. Microbiome. 2023;11:6.","journal-title":"Microbiome"},{"key":"11623_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41421-022-00476-1","volume":"8","author":"J Guo","year":"2022","unstructured":"Guo J, Huang X, Zhang C, Huang P, Li Y, Wen F, et al. The blood Virome of 10,585 individuals from the ChinaMAP. Cell Discovery. 2022;8:113.","journal-title":"Cell Discovery"},{"key":"11623_CR10","doi-asserted-by":"publisher","first-page":"e1006292","DOI":"10.1371\/journal.ppat.1006292","volume":"13","author":"A Moustafa","year":"2017","unstructured":"Moustafa A, Xie C, Kirkness E, Biggs W, Wong E, Turpaz Y, et al. The blood DNA Virome in 8,000 humans. PLoS Pathog. 2017;13:e1006292.","journal-title":"PLoS Pathog"},{"key":"11623_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-422X-10-228","volume":"10","author":"S Xiang","year":"2013","unstructured":"Xiang S, Ma Y, Yan Q, Lv M, Zhao X, Yin H, et al. Construction and characterization of an infectious replication competent clone of Porcine endogenous retrovirus from Chinese miniature pigs. Virol J. 2013;10:1\u20139.","journal-title":"Virol J"},{"key":"11623_CR12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s44161-022-00112-x","volume":"1","author":"CE Goerlich","year":"2022","unstructured":"Goerlich CE, Singh AK, Griffith BP, Mohiuddin MM. The immunobiology and clinical use of genetically engineered Porcine hearts for cardiac xenotransplantation. Nat Cardiovasc Res. 2022;1:715\u201326.","journal-title":"Nat Cardiovasc Res"},{"key":"11623_CR13","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1126\/science.aan4187","volume":"357","author":"D Niu","year":"2017","unstructured":"Niu D, Wei H-J, Lin L, George H, Wang T, Lee I-H, et al. Inactivation of Porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science. 2017;357:1303\u20137.","journal-title":"Science"},{"key":"11623_CR14","doi-asserted-by":"crossref","unstructured":"Denner J. Virus safety of xenotransplantation. Viruses. 2022;14:1926.","DOI":"10.3390\/v14091926"},{"key":"11623_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/pathogens7010031","volume":"7","author":"CT Styles","year":"2018","unstructured":"Styles CT, Paschos K, White RE, Farrell PJ. The cooperative functions of the EBNA3 proteins are central to EBV persistence and latency. Pathogens. 2018;7:31.","journal-title":"Pathogens"},{"key":"11623_CR16","unstructured":"Kalchschmidt JS. Molecular insights into host gene regulation by Epstein-Barr virus nuclear antigen EBNA. Volume 3\u00a0C. Imperial College London; 2016."},{"key":"11623_CR17","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.1128\/JVI.79.11.6890-6899.2005","volume":"79","author":"JA Isler","year":"2005","unstructured":"Isler JA, Skalet AH, Alwine JC. Human cytomegalovirus infection activates and regulates the unfolded protein response. J Virol. 2005;79:6890\u20139.","journal-title":"J Virol"},{"key":"11623_CR18","doi-asserted-by":"publisher","first-page":"6712","DOI":"10.1128\/JVI.00200-12","volume":"86","author":"Z Qian","year":"2012","unstructured":"Qian Z, Xuan B, Chapa TJ, Gualberto N, Yu D. Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response. J Virol. 2012;86:6712\u201323.","journal-title":"J Virol"},{"key":"11623_CR19","doi-asserted-by":"crossref","unstructured":"Drew T. The emergence and evolution of swine viral diseases: to what extent have husbandry systems and global trade contributed to their distribution and diversity? Revue scientifique et Technique-OIE. 2011;30:95.","DOI":"10.20506\/rst.30.1.2020"},{"key":"11623_CR20","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1128\/JVI.02307-08","volume":"83","author":"B Xuan","year":"2009","unstructured":"Xuan B, Qian Z, Torigoi E, Yu D. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses Endoplasmic reticulum stress-induced cell death. J Virol. 2009;83:3463\u201374.","journal-title":"J Virol"},{"key":"11623_CR21","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1146\/annurev.cellbio.12.1.627","volume":"12","author":"L Hernandez","year":"1996","unstructured":"Hernandez L, Hoffman L, Wolfsberg T, White J. Virus-cell and cell-cell fusion. Annu Rev Cell Dev Biol. 1996;12:627\u201361.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"11623_CR22","doi-asserted-by":"publisher","first-page":"e54305","DOI":"10.15252\/embr.202154305","volume":"23","author":"G Jocher","year":"2022","unstructured":"Jocher G, Grass V, Tschirner SK, Riepler L, Breimann S, Kaya T, et al. ADAM10 and ADAM17 promote SARS-CoV\u20102 cell entry and Spike protein\u2010mediated lung cell fusion. EMBO Rep. 2022;23:e54305.","journal-title":"EMBO Rep"},{"key":"11623_CR23","volume-title":"Investigating the regulation of B cell growth and survival genes by","author":"SJ Khasnis","year":"2019","unstructured":"Khasnis SJ. Investigating the regulation of B cell growth and survival genes by. Epstein-Barr virus: University of Sussex; 2019."},{"key":"11623_CR24","doi-asserted-by":"publisher","first-page":"e1005383","DOI":"10.1371\/journal.ppat.1005383","volume":"12","author":"JS Kalchschmidt","year":"2016","unstructured":"Kalchschmidt JS, Gillman AC, Paschos K, Bazot Q, Kempkes B, Allday MJ. EBNA3C directs recruitment of RBPJ (CBF1) to chromatin during the process of gene repression in EBV infected B cells. PLoS Pathog. 2016;12:e1005383.","journal-title":"PLoS Pathog"},{"key":"11623_CR25","doi-asserted-by":"publisher","first-page":"10137","DOI":"10.1038\/s41467-024-54471-z","volume":"15","author":"H Du","year":"2024","unstructured":"Du H, Zhou L, Liu Z, Zhuo Y, Zhang M, Huang Q, et al. The 1000 Chinese Indigenous pig genomes project provides insights into the genomic architecture of pigs. Nat Commun. 2024;15:10137.","journal-title":"Nat Commun"},{"key":"11623_CR26","doi-asserted-by":"publisher","first-page":"110782","DOI":"10.1016\/j.ygeno.2024.110782","volume":"116","author":"H Du","year":"2024","unstructured":"Du H, Diao C, Zhuo Y, Zheng X, Hu Z, Lu S, et al. Assembly of novel sequences for Chinese domestic pigs reveals new genes and regulatory variants providing new insights into their diversity. Genomics. 2024;116:110782.","journal-title":"Genomics"},{"key":"11623_CR27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41597-020-0453-3","volume":"7","author":"I Harris","year":"2020","unstructured":"Harris I, Osborn TJ, Jones P, Lister D. Version 4 of the CRU TS monthly high-resolution gridded multivariate climate dataset. Sci Data. 2020;7:109.","journal-title":"Sci Data"},{"key":"11623_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"Martin MJEj","year":"2011","unstructured":"Martin MJEj. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17:10\u20132.","journal-title":"EMBnet J"},{"key":"11623_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with bowtie 2. Nat Methods. 2012;9:357\u20139.","journal-title":"Nat Methods"},{"key":"11623_CR30","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The sequence alignment\/map format and samtools. Bioinformatics. 2009;25:2078\u20139.","journal-title":"Bioinformatics"},{"key":"11623_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-019-1891-0","volume":"20","author":"DE Wood","year":"2019","unstructured":"Wood DE, Lu J, Langmead B. Improved metagenomic analysis with kraken 2. Genome Biol. 2019;20:1\u201313.","journal-title":"Genome Biol"},{"key":"11623_CR32","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1038\/s41596-022-00738-y","volume":"17","author":"J Lu","year":"2022","unstructured":"Lu J, Rincon N, Wood DE, Breitwieser FP, Pockrandt C, Langmead B, et al. Metagenome analysis using the kraken software suite. Nat Protoc. 2022;17:2815\u201339.","journal-title":"Nat Protoc"},{"key":"11623_CR33","doi-asserted-by":"publisher","first-page":"W5","DOI":"10.1093\/nar\/gkn201","volume":"36","author":"M Johnson","year":"2008","unstructured":"Johnson M, Zaretskaya I, Raytselis Y, Merezhuk Y, McGinnis S, Madden TL. NCBI BLAST: a better web interface. Nucleic Acids Res. 2008;36:W5\u20139.","journal-title":"Nucleic Acids Res"},{"key":"11623_CR34","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, et al. The genome analysis toolkit: a mapreduce framework for analyzing next-generation DNA sequencing data. Genome Res. 2010;20:1297\u2013303.","journal-title":"Genome Res"},{"key":"11623_CR35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559\u201375.","journal-title":"Am J Hum Genet"},{"key":"11623_CR36","unstructured":"Felsenstein J. PHYLIP (phylogeny inference package), version 3.5 c. Produced and distributed by author\/Department of Genetics, University of Washington. 1993."},{"key":"11623_CR37","doi-asserted-by":"crossref","unstructured":"Liu G, Li Z, Pan M, Ge M, Wang Y, Gao Y, editors. Genetic prevalence of porcine endogenous retrovirus in chinese experimental miniature pigs. Transplantation proceedings; 2011: Elsevier.","DOI":"10.1016\/j.transproceed.2011.06.061"},{"key":"11623_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2875-5-1","volume":"5","author":"ID Ferreira","year":"2006","unstructured":"Ferreira ID, Do Ros\u00e1rio VE, Cravo PV. Real-time quantitative PCR with SYBR green I detection for estimating copy numbers of nine drug resistance candidate genes in plasmodium falciparum. Malar J. 2006;5:1\u20136.","journal-title":"Malar J"},{"key":"11623_CR39","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Durbin R. Fast and accurate short read alignment with Burrows\u2013Wheeler transform. Bioinformatics. 2009;25:1754\u201360.","journal-title":"Bioinformatics"},{"key":"11623_CR40","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/cmb.2012.0021","volume":"19","author":"A Bankevich","year":"2012","unstructured":"Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19:455\u201377.","journal-title":"J Comput Biol"},{"key":"11623_CR41","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1093\/nar\/gkh340","volume":"32","author":"RC Edgar","year":"2004","unstructured":"Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004;32:1792\u20137.","journal-title":"Nucleic Acids Res"},{"key":"11623_CR42","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/molbev\/msu300","volume":"32","author":"L-T Nguyen","year":"2015","unstructured":"Nguyen L-T, Schmidt HA, Von Haeseler A, Minh BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. 2015;32:268\u201374.","journal-title":"Mol Biol Evol"},{"key":"11623_CR43","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ng.2310","volume":"44","author":"X Zhou","year":"2012","unstructured":"Zhou X, Stephens M. Genome-wide efficient mixed-model analysis for association studies. Nat Genet. 2012;44:821\u20134.","journal-title":"Nat Genet"},{"key":"11623_CR44","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s12864-024-10259-5","volume":"25","author":"H Du","year":"2024","unstructured":"Du H, Liu Z, Lu S-Y, Jiang L, Zhou L, Liu J-F. Genomic evidence for human-mediated introgressive hybridization and selection in the developed breed. BMC Genomics. 2024;25:331.","journal-title":"BMC Genomics"},{"key":"11623_CR45","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.gpb.2020.10.007","volume":"19","author":"L Yin","year":"2021","unstructured":"Yin L, Zhang H, Tang Z, Xu J, Yin D, Zhang Z, et al. rMVP: a memory-efficient, visualization-enhanced, and parallel-accelerated tool for genome-wide association study. Genomics Proteom Bioinf. 2021;19:619\u201328.","journal-title":"Genomics Proteom Bioinf"},{"key":"11623_CR46","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263\u20135.","journal-title":"Bioinformatics"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-025-11623-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-025-11623-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-025-11623-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:21:27Z","timestamp":1745914887000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-025-11623-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11623"],"URL":"https:\/\/doi.org\/10.1186\/s12864-025-11623-9","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"23 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that this study was based on publicly available data and did not involve animal experiments.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"413"}}