{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:34:20Z","timestamp":1774683260840,"version":"3.50.1"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007525","name":"Universit\u00e9 de Rennes 1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007525","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Florida Department of Health James and Esther King Biomedical Research Program","award":["8JK06"],"award-info":[{"award-number":["8JK06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"DOI":"10.1186\/s12864-025-11960-9","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:36:21Z","timestamp":1758882981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal nicotine exposure induces epigenetic alterations in the Notch signaling genes in the proximal colon in rats"],"prefix":"10.1186","volume":"26","author":[{"given":"Ouzna","family":"Dali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Heitz-Marchaland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Kernanec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Carrion-Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Godin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei","family":"Tevosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasenka","family":"Zubcevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda F.","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Smagulova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"11960_CR1","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1017\/S0033291720003621","volume":"52","author":"P Madley-Dowd","year":"2022","unstructured":"Madley-Dowd P, Kalkbrenner AE, Heuvelman H, Heron J, Zammit S, Rai D, Schendel D. Maternal smoking during pregnancy and offspring intellectual disability: sibling analysis in an intergenerational Danish cohort. Psychol Med. 2022;52:1847\u201356. https:\/\/doi.org\/10.1017\/S0033291720003621.","journal-title":"Psychol Med"},{"key":"11960_CR2","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s12519-021-00501-5","volume":"18","author":"H-K Di","year":"2022","unstructured":"Di H-K, Gan Y, Lu K, Wang C, Zhu Y, Meng X, Xia W-Q, Xu M-Z, Feng J, Tian Q-F, et al. Maternal smoking status during pregnancy and low birth weight in offspring: systematic review and meta-analysis of 55 cohort studies published from 1986 to 2020. World J Pediatr. 2022;18:176\u201385. https:\/\/doi.org\/10.1007\/s12519-021-00501-5.","journal-title":"World J Pediatr"},{"key":"11960_CR3","doi-asserted-by":"publisher","first-page":"L416","DOI":"10.1152\/ajplung.00134.2017","volume":"313","author":"S Sukjamnong","year":"2017","unstructured":"Sukjamnong S, Chan YL, Zakarya R, Saad S, Sharma P, Santiyanont R, Chen H, Oliver BG. Effect of long-term maternal smoking on the offspring\u2019s lung health. Am J Physiol Lung Cell Mol Physiol. 2017;313:L416\u201323. https:\/\/doi.org\/10.1152\/ajplung.00134.2017.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"11960_CR4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/codi.16324","volume":"25","author":"SS Brenne","year":"2023","unstructured":"Brenne SS, Ness-Jensen E, Edna T-H, Lydersen S, Laugsand EA. Risk factors for right colon, left colon and rectal cancers differ between men and women: the population-based HUNT study in Norway. Colorectal Dis. 2023;25:44\u201355. https:\/\/doi.org\/10.1111\/codi.16324.","journal-title":"Colorectal Dis"},{"key":"11960_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/s0009-2797(02)00162-x","volume":"145","author":"CL Crowley-Weber","year":"2003","unstructured":"Crowley-Weber CL, Dvorakova K, Crowley C, Bernstein H, Bernstein C, Garewal H, Payne CM. Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic\/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis. Chem Biol Interact. 2003;145:53\u201366. https:\/\/doi.org\/10.1016\/s0009-2797(02)00162-x.","journal-title":"Chem Biol Interact"},{"key":"11960_CR6","doi-asserted-by":"publisher","first-page":"pkad004","DOI":"10.1093\/jncics\/pkad004","volume":"7","author":"H Li","year":"2023","unstructured":"Li H, Chen X, Hoffmeister M, Brenner H. Associations of smoking with early- and late-onset colorectal cancer. JNCI Cancer Spectr. 2023;7:pkad004. https:\/\/doi.org\/10.1093\/jncics\/pkad004.","journal-title":"JNCI Cancer Spectr"},{"key":"11960_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13072-024-00539-5","volume":"17","author":"O Dali","year":"2024","unstructured":"Dali O, Muriel-Muriel JA, Vargas-Baco A, Tevosian S, Zubcevic J, Smagulova F, Hayward LF. Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat. Epigenetics Chromatin. 2024;17:14. https:\/\/doi.org\/10.1186\/s13072-024-00539-5.","journal-title":"Epigenetics Chromatin"},{"key":"11960_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/bs.apha.2023.08.001","volume":"99","author":"RL Papke","year":"2024","unstructured":"Papke RL. The many enigmas of nicotine. Adv Pharmacol. 2024;99:327\u201354. https:\/\/doi.org\/10.1016\/bs.apha.2023.08.001.","journal-title":"Adv Pharmacol"},{"key":"11960_CR9","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuint.2019.02.006","volume":"125","author":"T Alkam","year":"2019","unstructured":"Alkam T, Nabeshima T. Molecular mechanisms for nicotine intoxication. Neurochem Int. 2019;125:117\u201326. https:\/\/doi.org\/10.1016\/j.neuint.2019.02.006.","journal-title":"Neurochem Int"},{"key":"11960_CR10","doi-asserted-by":"publisher","first-page":"dev201164","DOI":"10.1242\/dev.201164","volume":"150","author":"A Murtazina","year":"2023","unstructured":"Murtazina A, Adameyko I. The peripheral nervous system. Development. 2023;150:dev201164. https:\/\/doi.org\/10.1242\/dev.201164.","journal-title":"Development"},{"key":"11960_CR11","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1242\/dev.017418","volume":"135","author":"AJ Barlow","year":"2008","unstructured":"Barlow AJ, Wallace AS, Thapar N, Burns AJ. Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation. Development. 2008;135:1681\u201391. https:\/\/doi.org\/10.1242\/dev.017418.","journal-title":"Development"},{"key":"11960_CR12","doi-asserted-by":"publisher","first-page":"8024171","DOI":"10.1155\/2020\/8024171","volume":"2020","author":"MA Fleming","year":"2020","unstructured":"Fleming MA, Ehsan L, Moore SR, Levin DE. The enteric nervous system and its emerging role as a therapeutic target. Gastroenterol Res Pract. 2020;2020:8024171. https:\/\/doi.org\/10.1155\/2020\/8024171.","journal-title":"Gastroenterol Res Pract"},{"key":"11960_CR13","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1159\/000111623","volume":"9","author":"PG Bannerman","year":"1987","unstructured":"Bannerman PG, Mirsky R, Jessen KR. Analysis of enteric neurons, glia and their interactions using explant cultures of the myenteric plexus. Dev Neurosci. 1987;9:201\u201327. https:\/\/doi.org\/10.1159\/000111623.","journal-title":"Dev Neurosci"},{"key":"11960_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bbr.2006.07.025","volume":"176","author":"DF MacFabe","year":"2007","unstructured":"MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F, Taylor AR, Kavaliers M, Ossenkopp K-P. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res. 2007;176:149\u201369. https:\/\/doi.org\/10.1016\/j.bbr.2006.07.025.","journal-title":"Behav Brain Res"},{"key":"11960_CR15","doi-asserted-by":"publisher","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","volume":"7","author":"NM Vogt","year":"2017","unstructured":"Vogt NM, Kerby RL, Dill-McFarland KA, Harding SJ, Merluzzi AP, Johnson SC, Carlsson CM, Asthana S, Zetterberg H, Blennow K, et al. Gut microbiome alterations in Alzheimer\u2019s disease. Sci Rep. 2017;7:13537. https:\/\/doi.org\/10.1038\/s41598-017-13601-y.","journal-title":"Sci Rep"},{"key":"11960_CR16","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/metabo12080735","volume":"12","author":"J Zubcevic","year":"2022","unstructured":"Zubcevic J, Watkins J, Lin C, Bautista B, Hatch HM, Tevosian SG, Hayward LF. Nicotine exposure during rodent pregnancy alters the composition of maternal gut microbiota and abundance of maternal and amniotic short chain fatty acids. Metabolites. 2022;12:735. https:\/\/doi.org\/10.3390\/metabo12080735.","journal-title":"Metabolites"},{"key":"11960_CR17","doi-asserted-by":"publisher","first-page":"100925","DOI":"10.1016\/j.molmet.2019.12.005","volume":"38","author":"R Fellows","year":"2020","unstructured":"Fellows R, Varga-Weisz P. Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk. Mol Metab. 2020;38:100925. https:\/\/doi.org\/10.1016\/j.molmet.2019.12.005.","journal-title":"Mol Metab"},{"key":"11960_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","volume":"24","author":"ER Mann","year":"2024","unstructured":"Mann ER, Lam YK, Uhlig HH. Short-chain fatty acids: linking diet, the microbiome and immunity. Nat Rev Immunol. 2024;24:577\u201395. https:\/\/doi.org\/10.1038\/s41577-024-01014-8.","journal-title":"Nat Rev Immunol"},{"key":"11960_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0092-8674(78)90305-7","volume":"14","author":"EP Candido","year":"1978","unstructured":"Candido EP, Reeves R, Davie JR. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell. 1978;14:105\u201313. https:\/\/doi.org\/10.1016\/0092-8674(78)90305-7.","journal-title":"Cell"},{"key":"11960_CR20","doi-asserted-by":"publisher","first-page":"111809","DOI":"10.1016\/j.celrep.2022.111809","volume":"41","author":"PJ Lund","year":"2022","unstructured":"Lund PJ, Gates LA, Leboeuf M, Smith SA, Chau L, Lopes M, Friedman ES, Saiman Y, Kim MS, Shoffler CA, et al. Stable isotope tracing in vivo reveals a metabolic bridge linking the microbiota to host histone acetylation. Cell Rep. 2022;41:111809. https:\/\/doi.org\/10.1016\/j.celrep.2022.111809.","journal-title":"Cell Rep"},{"key":"11960_CR21","doi-asserted-by":"publisher","first-page":"2483780","DOI":"10.1080\/19490976.2025.2483780","volume":"17","author":"B Thulasinathan","year":"2025","unstructured":"Thulasinathan B, Suvilesh KN, Maram S, Grossmann E, Ghouri Y, Teixeiro EP, Chan J, Kaif JT, Rachagani S. The impact of gut microbial short-chain fatty acids on colorectal cancer development and prevention. Gut Microbes. 2025;17:2483780. https:\/\/doi.org\/10.1080\/19490976.2025.2483780.","journal-title":"Gut Microbes"},{"key":"11960_CR22","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.molcel.2012.08.033","volume":"48","author":"DR Donohoe","year":"2012","unstructured":"Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. The warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell. 2012;48:612\u201326. https:\/\/doi.org\/10.1016\/j.molcel.2012.08.033.","journal-title":"Mol Cell"},{"key":"11960_CR23","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676\u201382. https:\/\/doi.org\/10.1038\/nmeth.2019.","journal-title":"Nat Methods"},{"key":"11960_CR24","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/sj.onc.1202458","volume":"18","author":"H Tahara","year":"1999","unstructured":"Tahara H, Yasui W, Tahara E, Fujimoto J, Ito K, Tamai K, Nakayama J, Ishikawa F, Tahara E, Ide T. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. Oncogene. 1999;18:1561\u20137. https:\/\/doi.org\/10.1038\/sj.onc.1202458.","journal-title":"Oncogene"},{"key":"11960_CR25","doi-asserted-by":"publisher","first-page":"100773","DOI":"10.1016\/j.yfrne.2019.100773","volume":"54","author":"T Candler","year":"2019","unstructured":"Candler T, K\u00fchnen P, Prentice AM, Silver M. Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease. Front Neuroendocrinol. 2019;54:100773. https:\/\/doi.org\/10.1016\/j.yfrne.2019.100773.","journal-title":"Front Neuroendocrinol"},{"key":"11960_CR26","doi-asserted-by":"publisher","first-page":"9477","DOI":"10.3390\/ijerph19159477","volume":"19","author":"O White","year":"2022","unstructured":"White O, Roeder N, Blum K, Eiden RD, Thanos PK. Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review. Int J Environ Res Public Health. 2022;19:9477. https:\/\/doi.org\/10.3390\/ijerph19159477.","journal-title":"Int J Environ Res Public Health"},{"key":"11960_CR27","doi-asserted-by":"publisher","first-page":"4898","DOI":"10.1172\/JCI98353","volume":"128","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Federation AJ, Kim S, O\u2019Keefe JP, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018;128:4898\u2013911. https:\/\/doi.org\/10.1172\/JCI98353.","journal-title":"J Clin Invest"},{"key":"11960_CR28","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1365-2362.2006.01617.x","volume":"36","author":"GF K\u00f6rm\u00f6czi","year":"2006","unstructured":"K\u00f6rm\u00f6czi GF, S\u00e4emann MD, Buchta C, Peck-Radosavljevic M, Mayr WR, Schwartz DWM, Dunkler D, Spitzauer S, Panzer S. Influence of clinical factors on the haemolysis marker haptoglobin. Eur J Clin Invest. 2006;36:202\u20139. https:\/\/doi.org\/10.1111\/j.1365-2362.2006.01617.x.","journal-title":"Eur J Clin Invest"},{"key":"11960_CR29","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.molcel.2016.03.014","volume":"62","author":"A Goudarzi","year":"2016","unstructured":"Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte A-L, He T, et al. Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. Mol Cell. 2016;62:169\u201380. https:\/\/doi.org\/10.1016\/j.molcel.2016.03.014.","journal-title":"Mol Cell"},{"key":"11960_CR30","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12943-018-0915-9","volume":"17","author":"B Donati","year":"2018","unstructured":"Donati B, Lorenzini E, Ciarrocchi A. BRD4 and cancer: going beyond transcriptional regulation. Mol Cancer. 2018;17:164. https:\/\/doi.org\/10.1186\/s12943-018-0915-9.","journal-title":"Mol Cancer"},{"key":"11960_CR31","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nrm2298","volume":"8","author":"AJ Ruthenburg","year":"2007","unstructured":"Ruthenburg AJ, Li H, Patel DJ, Allis CD. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol. 2007;8:983\u201394. https:\/\/doi.org\/10.1038\/nrm2298.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"11960_CR32","doi-asserted-by":"publisher","first-page":"642547","DOI":"10.3389\/fonc.2021.642547","volume":"11","author":"B Wang","year":"2021","unstructured":"Wang B, Guo H, Yu H, Chen Y, Xu H, Zhao G. The role of the transcription factor EGR1 in cancer. Front Oncol. 2021;11:642547. https:\/\/doi.org\/10.3389\/fonc.2021.642547.","journal-title":"Front Oncol"},{"key":"11960_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaci.2023.12.013","volume":"154","author":"JI Silverberg","year":"2024","unstructured":"Silverberg JI, Boguniewicz M, Quintana FJ, Clark RA, Gross L, Hirano I, Tallman AM, Brown PM, Fredericks D, Rubenstein DS, et al. Tapinarof validates the aryl hydrocarbon receptor as a therapeutic target: a clinical review. J Allergy Clin Immunol. 2024;154:1\u201310. https:\/\/doi.org\/10.1016\/j.jaci.2023.12.013.","journal-title":"J Allergy Clin Immunol"},{"key":"11960_CR34","doi-asserted-by":"publisher","first-page":"e023539","DOI":"10.1161\/JAHA.121.023539","volume":"10","author":"LM Khachigian","year":"2021","unstructured":"Khachigian LM. Early Growth Response-1, an integrative sensor in cardiovascular and inflammatory disease. J Am Heart Assoc. 2021;10:e023539. https:\/\/doi.org\/10.1161\/JAHA.121.023539.","journal-title":"J Am Heart Assoc"},{"key":"11960_CR35","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/metabo12080735","volume":"12","author":"J Zubcevic","year":"2022","unstructured":"Zubcevic J, Watkins J, Lin C, Bautista B, Hatch HM, Tevosian SG, Hayward LF. Nicotine exposure during rodent pregnancy alters the composition of maternal gut microbiota and abundance of maternal and amniotic short chain fatty acids. Metabolites. 2022;12:735. https:\/\/doi.org\/10.3390\/metabo12080735.","journal-title":"Metabolites"},{"key":"11960_CR36","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.3390\/cells8121559","volume":"8","author":"L Legoff","year":"2019","unstructured":"Legoff L, D\u2019Cruz SC, Tevosian S, Primig M, Smagulova F. Transgenerational inheritance of environmentally induced epigenetic alterations during mammalian development. Cells. 2019;8:1559. https:\/\/doi.org\/10.3390\/cells8121559.","journal-title":"Cells"},{"key":"11960_CR37","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1203\/01.PDR.0000159632.70510.3D","volume":"57","author":"JL Lasky","year":"2005","unstructured":"Lasky JL, Wu H. Notch signaling, brain development, and human disease. Pediatr Res. 2005;57:104\u20139. https:\/\/doi.org\/10.1203\/01.PDR.0000159632.70510.3D.","journal-title":"Pediatr Res"},{"key":"11960_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/cells10010047","volume":"10","author":"V Pawolski","year":"2020","unstructured":"Pawolski V, Schmidt MHH. Neuron-glia interaction in the developing and adult enteric nervous system. Cells. 2020;10:47. https:\/\/doi.org\/10.3390\/cells10010047.","journal-title":"Cells"},{"key":"11960_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000356305","volume":"22","author":"JA Liu","year":"2014","unstructured":"Liu JA, Ngan ES-W. Hedgehog and notch signaling in enteric nervous system development. Neurosignals. 2014;22:1\u201313. https:\/\/doi.org\/10.1159\/000356305.","journal-title":"Neurosignals"},{"key":"11960_CR40","doi-asserted-by":"publisher","first-page":"e99984","DOI":"10.15252\/embj.201899984","volume":"38","author":"D Castillo-Azofeifa","year":"2019","unstructured":"Castillo-Azofeifa D, Fazio EN, Nattiv R, Good HJ, Wald T, Pest MA, de Sauvage FJ, Klein OD, Asfaha S. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration. EMBO J. 2019;38:e99984. https:\/\/doi.org\/10.15252\/embj.201899984.","journal-title":"EMBO J"},{"key":"11960_CR41","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/nature03659","volume":"435","author":"JH van Es","year":"2005","unstructured":"van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, et al. Notch\/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005;435:959\u201363. https:\/\/doi.org\/10.1038\/nature03659.","journal-title":"Nature"},{"key":"11960_CR42","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ydbio.2015.03.012","volume":"402","author":"AJ Carulli","year":"2015","unstructured":"Carulli AJ, Keeley TM, Demitrack ES, Chung J, Maillard I, Samuelson LC. Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration. Dev Biol. 2015;402:98\u2013108. https:\/\/doi.org\/10.1016\/j.ydbio.2015.03.012.","journal-title":"Dev Biol"},{"key":"11960_CR43","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13045-019-0757-y","volume":"12","author":"Y Jia","year":"2019","unstructured":"Jia Y, Chng W-J, Zhou J. Super-enhancers: critical roles and therapeutic targets in hematologic malignancies. J Hematol Oncol. 2019;12:77. https:\/\/doi.org\/10.1186\/s13045-019-0757-y.","journal-title":"J Hematol Oncol"},{"key":"11960_CR44","doi-asserted-by":"publisher","first-page":"D280","DOI":"10.1093\/nar\/gkac968","volume":"51","author":"Y Wang","year":"2023","unstructured":"Wang Y, Song C, Zhao J, Zhang Y, Zhao X, Feng C, Zhang G, Zhu J, Wang F, Qian F, et al. SEdb 2.0: a comprehensive super-enhancer database of human and mouse. Nucleic Acids Res. 2023;51:D280\u201390. https:\/\/doi.org\/10.1093\/nar\/gkac968.","journal-title":"Nucleic Acids Res"},{"key":"11960_CR45","doi-asserted-by":"publisher","first-page":"e202302237","DOI":"10.26508\/lsa.202302237","volume":"7","author":"O Dali","year":"2024","unstructured":"Dali O, D\u2019Cruz S, Legoff L, Lahmidi M, Heitz C, Merret PE, Kernanec PY, Pakdel F, Smagulova F. Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024;7:e202302237. https:\/\/doi.org\/10.26508\/lsa.202302237.","journal-title":"Life Sci Alliance"},{"key":"11960_CR46","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1126\/science.7716513","volume":"268","author":"S Artavanis-Tsakonas","year":"1995","unstructured":"Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science. 1995;268:225\u201332. https:\/\/doi.org\/10.1126\/science.7716513.","journal-title":"Science"},{"key":"11960_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41420-019-0166-6","volume":"5","author":"E Acaz-Fonseca","year":"2019","unstructured":"Acaz-Fonseca E, Ortiz-Rodriguez A, Azcoitia I, Garcia-Segura LM, Arevalo M-A. Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge. Cell Death Discov. 2019;5:1\u201314. https:\/\/doi.org\/10.1038\/s41420-019-0166-6.","journal-title":"Cell Death Discov"},{"key":"11960_CR48","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1177\/002215540405200409","volume":"52","author":"GR Sander","year":"2004","unstructured":"Sander GR, Powell BC. Expression of notch receptors and ligands in the adult gut. J Histochem Cytochem. 2004;52:509\u201316. https:\/\/doi.org\/10.1177\/002215540405200409.","journal-title":"J Histochem Cytochem"},{"key":"11960_CR49","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1523\/JNEUROSCI.23-08-03272.2003","volume":"23","author":"T Li","year":"2003","unstructured":"Li T, Ma G, Cai H, Price DL, Wong PC. Nicastrin is required for assembly of Presenilin\/\u03b3-secretase complexes to mediate Notch signaling and for processing and trafficking of \u03b2-amyloid precursor protein in mammals. J Neurosci. 2003;23:3272\u20137. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-08-03272.2003.","journal-title":"J Neurosci"},{"key":"11960_CR50","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1242\/dev.062802","volume":"138","author":"T Oyama","year":"2011","unstructured":"Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, et al. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Development. 2011;138:5235\u201346. https:\/\/doi.org\/10.1242\/dev.062802.","journal-title":"Development"},{"key":"11960_CR51","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.3389\/fimmu.2019.02289","volume":"10","author":"L Berkowitz","year":"2019","unstructured":"Berkowitz L, Pardo-Roa C, Salazar GA, Salazar-Echegarai F, Miranda JP, Ram\u00edrez G, Ch\u00e1vez JL, Kalergis AM, Bueno SM, \u00c1lvarez-Lobos M. Mucosal exposure to cigarette components induces intestinal inflammation and alters antimicrobial response in mice. Front Immunol. 2019;10:2289. https:\/\/doi.org\/10.3389\/fimmu.2019.02289.","journal-title":"Front Immunol"},{"key":"11960_CR52","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/jox14030053","volume":"14","author":"M Djouina","year":"2024","unstructured":"Djouina M, Ollivier A, Waxin C, Kervoaze G, Pichavant M, Caboche S, Achour D, Grare C, Beury D, Hot D, et al. Chronic exposure to both electronic and conventional cigarettes alters ileum and colon turnover, immune function, and barrier integrity in mice. J Xenobiot. 2024;14:950\u201369. https:\/\/doi.org\/10.3390\/jox14030053.","journal-title":"J Xenobiot"},{"key":"11960_CR53","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1083\/jcb.146.4.819","volume":"146","author":"E Ferrary","year":"1999","unstructured":"Ferrary E, Cohen-Tannoudji M, Pehau-Arnaudet G, Lapillonne A, Athman R, Ruiz T, Boulouha L, El Marjou F, Doye A, Fontaine JJ, et al. In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. J Cell Biol. 1999;146:819\u201330. https:\/\/doi.org\/10.1083\/jcb.146.4.819.","journal-title":"J Cell Biol"},{"key":"11960_CR54","doi-asserted-by":"publisher","first-page":"E1380","DOI":"10.1073\/pnas.1218446110","volume":"110","author":"F Ubelmann","year":"2013","unstructured":"Ubelmann F, Chamaillard M, El-Marjou F, Simon A, Netter J, Vignjevic D, Nichols BL, Quezada-Calvillo R, Grandjean T, Louvard D, et al. Enterocyte loss of polarity and gut wound healing rely upon the F-actin-severing function of villin. Proc Natl Acad Sci U S A. 2013;110:E1380-1389. https:\/\/doi.org\/10.1073\/pnas.1218446110.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11960_CR55","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1096\/fj.12-220160","volume":"27","author":"D-H Kim","year":"2013","unstructured":"Kim D-H, Wirtz D. Focal adhesion size uniquely predicts cell migration. FASEB J. 2013;27:1351\u201361. https:\/\/doi.org\/10.1096\/fj.12-220160.","journal-title":"FASEB J"},{"key":"11960_CR56","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/s0014-2999(00)00925-0","volume":"411","author":"K Muneoka","year":"2001","unstructured":"Muneoka K, Ogawa T, Kamei K, Mimura Y, Kato H, Takigawa M. Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain. Eur J Pharmacol. 2001;411:279\u201382. https:\/\/doi.org\/10.1016\/s0014-2999(00)00925-0.","journal-title":"Eur J Pharmacol"},{"key":"11960_CR57","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1203\/00006450-200211000-00025","volume":"52","author":"HR Wickstr\u00f6m","year":"2002","unstructured":"Wickstr\u00f6m HR, Mas C, Simonneau M, Holgert H, H\u00f6kfelt T, Lagercrantz H. Perinatal nicotine attenuates the hypoxia-induced up-regulation of tyrosine hydroxylase and galanin mRNA in locus ceruleus of the newborn mouse. Pediatr Res. 2002;52:763\u20139. https:\/\/doi.org\/10.1203\/00006450-200211000-00025.","journal-title":"Pediatr Res"},{"key":"11960_CR58","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1460-9568.2005.04229.x","volume":"22","author":"H Chen","year":"2005","unstructured":"Chen H, Parker SL, Matta SG, Sharp BM. Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats. Eur J Neurosci. 2005;22:380\u20138. https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04229.x.","journal-title":"Eur J Neurosci"},{"key":"11960_CR59","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/syn.20752","volume":"64","author":"MI Naseer","year":"2010","unstructured":"Naseer MI, Lee HY, Kim MO. Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABA(B) receptor and PKA-alpha expression in prenatal rat brain. Synapse. 2010;64:467\u201377. https:\/\/doi.org\/10.1002\/syn.20752.","journal-title":"Synapse"},{"key":"11960_CR60","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00018-011-0805-4","volume":"69","author":"K Parameshwaran","year":"2012","unstructured":"Parameshwaran K, Buabeid MA, Karuppagounder SS, Uthayathas S, Thiruchelvam K, Shonesy B, Dityatev A, Escobar MC, Dhanasekaran M, Suppiramaniam V. Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus. Cell Mol Life Sci. 2012;69:829\u201341. https:\/\/doi.org\/10.1007\/s00018-011-0805-4.","journal-title":"Cell Mol Life Sci"},{"key":"11960_CR61","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1159\/000195206","volume":"51","author":"GS Maritz","year":"1987","unstructured":"Maritz GS. Maternal nicotine exposure and carbohydrate metabolism of fetal and neonatal lung tissue: response to nicotine withdrawal. Respiration. 1987;51:232\u201340. https:\/\/doi.org\/10.1159\/000195206.","journal-title":"Respiration"},{"key":"11960_CR62","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1124\/jpet.301.3.930","volume":"301","author":"BJ Dewar","year":"2002","unstructured":"Dewar BJ, Bradford BU, Thurman RG. Nicotine increases hepatic oxygen uptake in the isolated perfused rat liver by inhibiting glycolysis. J Pharmacol Exp Ther. 2002;301:930\u20137. https:\/\/doi.org\/10.1124\/jpet.301.3.930.","journal-title":"J Pharmacol Exp Ther"},{"key":"11960_CR63","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1017\/S2040174423000326","volume":"14","author":"LL Souza","year":"2023","unstructured":"Souza LL, Rossetti CL, Peixoto TC, Manh\u00e3es AC, de Moura EG, Lisboa PC. Neonatal nicotine exposure affects adult rat hepatic pathways involved in endoplasmic reticulum stress and macroautophagy in a sex-dependent manner. J Dev Orig Health Dis. 2023;14:639\u201347. https:\/\/doi.org\/10.1017\/S2040174423000326.","journal-title":"J Dev Orig Health Dis"},{"key":"11960_CR64","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.psychres.2005.04.003","volume":"135","author":"SY Hill","year":"2005","unstructured":"Hill SY, Shen S, Locke Wellman J, Rickin E, Lowers L. Offspring from families at high risk for alcohol dependence: increased body mass index in association with prenatal exposure to cigarettes but not alcohol. Psychiatry Res. 2005;135:203\u201316. https:\/\/doi.org\/10.1016\/j.psychres.2005.04.003.","journal-title":"Psychiatry Res"},{"key":"11960_CR65","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1210\/en.2016-1269","volume":"157","author":"J Fan","year":"2016","unstructured":"Fan J, Zhang W-X, Rao Y-S, Xue J-L, Wang F-F, Zhang L, Yan Y-E. Perinatal nicotine exposure increases obesity susceptibility in adult male rat offspring by altering early adipogenesis. Endocrinology. 2016;157:4276\u201386. https:\/\/doi.org\/10.1210\/en.2016-1269.","journal-title":"Endocrinology"},{"key":"11960_CR66","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13287-018-0853-x","volume":"9","author":"K Tie","year":"2018","unstructured":"Tie K, Wu M, Deng Y, Wen Y, Dan Xu, Null Chen L, Wang H. Histone hypo-acetylation of Sox9 mediates nicotine-induced weak cartilage repair by suppressing BMSC chondrogenic differentiation. Stem Cell Res Ther. 2018;9:98. https:\/\/doi.org\/10.1186\/s13287-018-0853-x.","journal-title":"Stem Cell Res Ther"},{"key":"11960_CR67","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/metabo12080735","volume":"12","author":"J Zubcevic","year":"2022","unstructured":"Zubcevic J, Watkins J, Lin C, Bautista B, Hatch HM, Tevosian SG, Hayward LF. Nicotine exposure during rodent pregnancy alters the composition of maternal gut microbiota and abundance of maternal and amniotic short chain fatty acids. Metabolites. 2022;12:735. https:\/\/doi.org\/10.3390\/metabo12080735.","journal-title":"Metabolites"},{"key":"11960_CR68","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.nbd.2013.11.005","volume":"63","author":"R Koldamova","year":"2014","unstructured":"Koldamova R, Schug J, Lefterova M, Cronican AA, Fitz NF, Davenport FA, Carter A, Castranio EL, Lefterov I. Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration. Neurobiol Dis. 2014;63:107\u201314. https:\/\/doi.org\/10.1016\/j.nbd.2013.11.005.","journal-title":"Neurobiol Dis"},{"key":"11960_CR69","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1152\/jn.00774.2016","volume":"117","author":"M Cholanian","year":"2017","unstructured":"Cholanian M, Wealing J, Levine RB, Fregosi RF. Developmental nicotine exposure alters potassium currents in hypoglossal motoneurons of neonatal rat. J Neurophysiol. 2017;117:1544\u201352. https:\/\/doi.org\/10.1152\/jn.00774.2016.","journal-title":"J Neurophysiol"},{"key":"11960_CR70","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3892\/or.2021.8120","volume":"46","author":"S Shao","year":"2021","unstructured":"Shao S, Ju M, Lei J, Lu X, Li H, Wang D, Xia C. Egr-1 inhibits colon cancer cell proliferation, migration and invasion via regulating CDKL1 at the transcriptional level. Oncol Rep. 2021;46:169. https:\/\/doi.org\/10.3892\/or.2021.8120.","journal-title":"Oncol Rep"},{"key":"11960_CR71","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1128\/IAI.00236-12","volume":"80","author":"I Ahmed","year":"2012","unstructured":"Ahmed I, Chandrakesan P, Tawfik O, Xia L, Anant S, Umar S. Critical roles of Notch and Wnt\/\u03b2-catenin pathways in the regulation of hyperplasia and\/or colitis in response to bacterial infection. Infect Immun. 2012;80:3107\u201321. https:\/\/doi.org\/10.1128\/IAI.00236-12.","journal-title":"Infect Immun"},{"key":"11960_CR72","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.cell.2015.02.035","volume":"160","author":"CV Theodoris","year":"2015","unstructured":"Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency. Cell. 2015;160:1072\u201386. https:\/\/doi.org\/10.1016\/j.cell.2015.02.035.","journal-title":"Cell"},{"key":"11960_CR73","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/ibd\/izad268","volume":"30","author":"Q Yan Ang","year":"2024","unstructured":"Yan Ang Q, Plichta D, Kim S, Hyun-A Kim I, Gregory S, Xia Y, Lau H, Xavier R, Ananthakrishnan AN. Differential Impact of Smoking on Methylome and Transcriptome in Crohn\u2019s Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2024;30:981\u201391. https:\/\/doi.org\/10.1093\/ibd\/izad268.","journal-title":"Inflamm Bowel Dis"},{"key":"11960_CR74","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1046\/j.1365-3016.2000.00247.x","volume":"14","author":"B Zar\u00e9n","year":"2000","unstructured":"Zar\u00e9n B, Lindmark G, Bakketeig L. Maternal smoking affects fetal growth more in the male fetus. Paediatr Perinat Epidemiol. 2000;14:118\u201326. https:\/\/doi.org\/10.1046\/j.1365-3016.2000.00247.x.","journal-title":"Paediatr Perinat Epidemiol"},{"key":"11960_CR75","doi-asserted-by":"publisher","first-page":"105590","DOI":"10.1016\/j.ebiom.2025.105590","volume":"114","author":"M Mihov","year":"2025","unstructured":"Mihov M, Shoctor H, Douglas A, Hay DC, O\u2019Shaughnessy PJ, Iredale JP, Shaw S, Fowler PA, Grassmann F. Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort. EBioMedicine. 2025;114:105590. https:\/\/doi.org\/10.1016\/j.ebiom.2025.105590.","journal-title":"EBioMedicine"},{"key":"11960_CR76","doi-asserted-by":"publisher","first-page":"113589","DOI":"10.1016\/j.ecoenv.2022.113589","volume":"238","author":"C Yi","year":"2022","unstructured":"Yi C, Wang Q, Qu Y, Niu J, Oliver BG, Chen H. In-utero exposure to air pollution and early-life neural development and cognition. Ecotoxicol Environ Saf. 2022;238:113589. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113589.","journal-title":"Ecotoxicol Environ Saf"},{"key":"11960_CR77","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/ajhb.20995","volume":"22","author":"JG Eriksson","year":"2010","unstructured":"Eriksson JG, Kajantie E, Osmond C, Thornburg K, Barker DJP. Boys live dangerously in the womb. Am J Hum Biol. 2010;22:330\u20135. https:\/\/doi.org\/10.1002\/ajhb.20995.","journal-title":"Am J Hum Biol"},{"key":"11960_CR78","doi-asserted-by":"publisher","first-page":"8003","DOI":"10.1038\/s41598-023-35113-8","volume":"13","author":"M Capriati","year":"2023","unstructured":"Capriati M, Hao C, D\u2019Cruz SC, Monfort C, Chevrier C, Warembourg C, Smagulova F. Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Sci Rep. 2023;13:8003. https:\/\/doi.org\/10.1038\/s41598-023-35113-8.","journal-title":"Sci Rep"},{"key":"11960_CR79","doi-asserted-by":"publisher","first-page":"e79233","DOI":"10.1371\/journal.pone.0079233","volume":"8","author":"S Cvitic","year":"2013","unstructured":"Cvitic S, Longtine MS, Hackl H, Wagner K, Nelson MD, Desoye G, Hiden U. The human placental sexome differs between trophoblast epithelium and villous vessel endothelium. PLoS ONE. 2013;8:e79233. https:\/\/doi.org\/10.1371\/journal.pone.0079233.","journal-title":"PLoS ONE"},{"key":"11960_CR80","doi-asserted-by":"publisher","first-page":"13600","DOI":"10.1523\/JNEUROSCI.5835-12.2013","volume":"33","author":"G-Q Chang","year":"2013","unstructured":"Chang G-Q, Karatayev O, Leibowitz SF. Prenatal exposure to nicotine stimulates neurogenesis of orexigenic peptide-expressing neurons in hypothalamus and amygdala. J Neurosci. 2013;33:13600\u201311. https:\/\/doi.org\/10.1523\/JNEUROSCI.5835-12.2013.","journal-title":"J Neurosci"},{"key":"11960_CR81","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.expneurol.2011.09.006","volume":"232","author":"CR Boychuk","year":"2011","unstructured":"Boychuk CR, Hayward LF. Prenatal nicotine exposure alters postnatal cardiorespiratory integration in young male but not female rats. Exp Neurol. 2011;232:212\u201321. https:\/\/doi.org\/10.1016\/j.expneurol.2011.09.006.","journal-title":"Exp Neurol"},{"key":"11960_CR82","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1177\/0023677216653984","volume":"51","author":"SJ Jackson","year":"2017","unstructured":"Jackson SJ, Andrews N, Ball D, Bellantuono I, Gray J, Hachoumi L, Holmes A, Latcham J, Petrie A, Potter P, et al. Does age matter? The impact of rodent age on study outcomes. Lab Anim. 2017;51:160\u20139. https:\/\/doi.org\/10.1177\/0023677216653984.","journal-title":"Lab Anim"},{"key":"11960_CR83","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim D, Paggi JM, Park C, Bennett C, Salzberg SL. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol. 2019;37:907\u201315. https:\/\/doi.org\/10.1038\/s41587-019-0201-4.","journal-title":"Nat Biotechnol"},{"issue":"W1","key":"11960_CR84","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","volume":"50","author":"BT Sherman","year":"2022","unstructured":"Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216\u201321. https:\/\/doi.org\/10.1093\/nar\/gkac194.","journal-title":"Nucleic Acids Res"},{"key":"11960_CR85","doi-asserted-by":"publisher","first-page":"W90","DOI":"10.1093\/nar\/gkw377","volume":"44","author":"MV Kuleshov","year":"2016","unstructured":"Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 2016;44:W90-97. https:\/\/doi.org\/10.1093\/nar\/gkw377.","journal-title":"Nucleic Acids Res"},{"key":"11960_CR86","doi-asserted-by":"publisher","first-page":"W345","DOI":"10.1093\/nar\/gkac247","volume":"50","author":"Galaxy Community","year":"2022","unstructured":"Galaxy Community. The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update. Nucleic Acids Res. 2022;50:W345\u201351. https:\/\/doi.org\/10.1093\/nar\/gkac247.","journal-title":"Nucleic Acids Res"},{"key":"11960_CR87","first-page":"17","volume":"56","author":"RJ Callicott","year":"2006","unstructured":"Callicott RJ, Womack JE. Real-time PCR assay for measurement of mouse telomeres. Comp Med. 2006;56:17\u201322.","journal-title":"Comp Med"},{"key":"11960_CR88","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9:R137. https:\/\/doi.org\/10.1186\/gb-2008-9-9-r137.","journal-title":"Genome Biol"},{"key":"11960_CR89","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841\u20132. https:\/\/doi.org\/10.1093\/bioinformatics\/btq033.","journal-title":"Bioinformatics"},{"key":"11960_CR90","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"11960_CR91","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","volume":"31","author":"G Yu","year":"2015","unstructured":"Yu G, Wang L-G, He Q-Y. ChIPseeker: an R\/bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics. 2015;31:2382\u20133. https:\/\/doi.org\/10.1093\/bioinformatics\/btv145.","journal-title":"Bioinformatics"},{"key":"11960_CR92","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson JT, Thorvaldsd\u00f3ttir H, Winckler W, Guttman M, Lander ES, Getz G, Mesirov JP. Integrative genomics viewer. Nat Biotechnol. 2011;29:24\u20136. https:\/\/doi.org\/10.1038\/nbt.1754.","journal-title":"Nat Biotechnol"},{"key":"11960_CR93","doi-asserted-by":"publisher","first-page":"e0294236","DOI":"10.1371\/journal.pone.0294236","volume":"18","author":"D Tang","year":"2023","unstructured":"Tang D, Chen M, Huang X, Zhang G, Zeng L, Zhang G, Wu S, Wang Y. SRplot: a free online platform for data visualization and graphing. PLoS ONE. 2023;18:e0294236. https:\/\/doi.org\/10.1371\/journal.pone.0294236.","journal-title":"PLoS ONE"},{"key":"11960_CR94","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13072-019-0276-7","volume":"12","author":"L Legoff","year":"2019","unstructured":"Legoff L, Dali O, D\u2019Cruz SC, Suglia A, Gely-Pernot A, H\u00e9mery C, Kernanec P-Y, Demmouche A, Kervarrec C, Tevosian S, et al. Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features. Epigenetics Chromatin. 2019;12:29. https:\/\/doi.org\/10.1186\/s13072-019-0276-7.","journal-title":"Epigenetics Chromatin"},{"key":"11960_CR95","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1186\/s12864-015-2095-y","volume":"16","author":"A Gely-Pernot","year":"2015","unstructured":"Gely-Pernot A, Hao C, Becker E, Stuparevic I, Kervarrec C, Chalmel F, Primig M, Jegou B, Smagulova F. The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine. BMC Genomics. 2015;16:885. https:\/\/doi.org\/10.1186\/s12864-015-2095-y.","journal-title":"BMC Genomics"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-025-11960-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-025-11960-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-025-11960-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:36:22Z","timestamp":1758882982000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcgenomics.biomedcentral.com\/articles\/10.1186\/s12864-025-11960-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":95,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11960"],"URL":"https:\/\/doi.org\/10.1186\/s12864-025-11960-9","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"7 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures were approved by the University of Florida Institutional Animal Care and Use Committee (IACUC) before the start of the study (#20180188, Tevosian SG, Associate Professor, The PI).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"836"}}