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There is evidence that they affect the physiology of the pancreas, but research in this area remains limited. Therefore, the aim of the study was to determine the effects of PET microplastics on the global proteomic profile of the pancreas using LC\u2013MS\/MS analysis, with the pig as a model organism. The pigs were treated either with a low (0.1\u00a0g\/day) or a high dose (1\u00a0g\/day) of PET microplastics for four weeks. The analysis revealed that PET microplastics affected protein abundance in a dose-dependent manner \u2013 the low dose altered the abundance of 7 proteins, while the high dose \u2013 17. The differentially regulated proteins were involved in fatty acid biosynthesis (FASN, KAS), lipid peroxidation (CBR1) and digestive enzyme production (trypsinogen). Complementary colorimetric assays confirmed a significant increase in free fatty acids under the influence of a high dose of PET microplastics. Taken together, these results indicate that PET microplastics may affect oxidative status, induce lipotoxic stress and impair pancreatic exocrine function, suggesting a novel pathway through which microplastics may cause metabolic disturbances.<\/jats:p>","DOI":"10.1186\/s12864-025-12507-8","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T03:16:33Z","timestamp":1767755793000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PET microplastics induce lipotoxicity in the porcine pancreas"],"prefix":"10.1186","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-7862","authenticated-orcid":false,"given":"Karol","family":"Mierzejewski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kurzy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Golubska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stryi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismena","family":"Ga\u0142\u0119cka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Ca\u0142ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Borrajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Bogacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"12507_CR1","doi-asserted-by":"publisher","first-page":"eadl2746","DOI":"10.1126\/science.adl2746","volume":"386","author":"RC Thompson","year":"2024","unstructured":"Thompson RC, Courtene-Jones W, Boucher J, Pahl S, Raubenheimer K, Koelmans AA. 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