{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:24:17Z","timestamp":1777868657163,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hubei Provincial Natural Science Foundation of China","award":["2026NKYJJ12"],"award-info":[{"award-number":["2026NKYJJ12"]}]},{"name":"Hubei Provincial Natural Science Foundation of China","award":["2024AFB373"],"award-info":[{"award-number":["2024AFB373"]}]},{"name":"Science Foundation Project of Hubei Academy of Agricultural Sciences","award":["2024NKYJJ18"],"award-info":[{"award-number":["2024NKYJJ18"]}]},{"name":"Wuhan science & Technology Commissioner industry-Academia-Research Collaboration Program","award":["2023110201030665"],"award-info":[{"award-number":["2023110201030665"]}]},{"name":"Funds for Supporting High-Quality Development of Seed and Breeding Industry Projects in Hubei Province","award":["HBZY2023B008"],"award-info":[{"award-number":["HBZY2023B008"]}]},{"name":"JD Technology Research and Development Project of Hubei Province, China","award":["2023BAA029"],"award-info":[{"award-number":["2023BAA029"]}]},{"name":"Hubei Provincial Science and Technology Program Project","award":["2025EBA026"],"award-info":[{"award-number":["2025EBA026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"DOI":"10.1186\/s12864-026-12828-2","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:55:24Z","timestamp":1775469324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated multi-omics profiling unveils a network of key signaling pathways governing ovarian function and systemic regulation in high-prolificacy goats"],"prefix":"10.1186","volume":"27","author":[{"given":"Fan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishao","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimiao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaidong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengtao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"12828_CR1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3389\/fgene.2020.00286","volume":"11","author":"J-J Wang","year":"2020","unstructured":"Wang J-J, Zhang T, Chen Q-M, Zhang R-Q, Li L, Cheng S-F, et al. Genomic signatures of selection associated with litter size trait in Jining Gray goat. Front Genet. 2020;11:286.","journal-title":"Front Genet"},{"issue":"6","key":"12828_CR2","doi-asserted-by":"publisher","first-page":"772","DOI":"10.5713\/ajas.2002.772","volume":"15","author":"M Hoque","year":"2002","unstructured":"Hoque M, Amin M, Baik D. Genetic and non-genetic causes of variation in gestation length, litter size and litter weight in goats. Asian-Australas J Anim Sci. 2002;15(6):772\u20136.","journal-title":"Asian-Australas J Anim Sci"},{"key":"12828_CR3","doi-asserted-by":"publisher","first-page":"648256","DOI":"10.3389\/fgene.2021.648256","volume":"12","author":"Z Kang","year":"2021","unstructured":"Kang Z, Bai Y, Lan X, Zhao H. Goat AKAP12: indel mutation detection, association analysis with litter size and alternative splicing variant expression. Front Genet. 2021;12:648256.","journal-title":"Front Genet"},{"issue":"9","key":"12828_CR4","doi-asserted-by":"publisher","first-page":"5104","DOI":"10.1073\/pnas.091577598","volume":"98","author":"P Mulsant","year":"2001","unstructured":"Mulsant P, Lecerf F, Fabre S, Schibler L, Monget P, Lanneluc I, et al. Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Merino ewes. Proc Natl Acad Sci USA. 2001;98(9):5104\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"12828_CR5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/10495398.2016.1167706","volume":"27","author":"S Ahlawat","year":"2016","unstructured":"Ahlawat S, Sharma R, Roy M, Mandakmale S, Prakash V, Tantia M. Genotyping of novel SNPs in BMPR1B, BMP15, and GDF9 genes for association with prolificacy in seven Indian goat breeds. Anim Biotechnol. 2016;27(3):199\u2013207.","journal-title":"Anim Biotechnol"},{"issue":"5","key":"12828_CR6","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.17582\/journal.pjz\/20190226030219","volume":"52","author":"W Chen","year":"2020","unstructured":"Chen W, Tian Z, Lin M, Gan S, Sun W, Chu M. Expression analysis of BMPR1B, BMP15, GDF9, Smad1, Smad5, and Smad9 in rams with different fecundity. Pak J Zool. 2020;52(5):1665.","journal-title":"Pak J Zool"},{"key":"12828_CR7","doi-asserted-by":"crossref","unstructured":"Wang N, Zhang G, Li M. Emerging Trends in Systems Biology: Multi-Omics Integration and Beyond. Computational Molecular Biology. 2024; 14.","DOI":"10.5376\/cmb.2024.14.0024"},{"key":"12828_CR8","doi-asserted-by":"publisher","first-page":"1595291","DOI":"10.3389\/frai.2025.1595291","volume":"8","author":"D Selby","year":"2025","unstructured":"Selby D, Jakhmola R, Sprang M, Gro\u00dfmann G, Raki H, Maani N, et al. Visible neural networks for multi-omics integration: a critical review. Front Artif Intell. 2025;8:1595291.","journal-title":"Front Artif Intell"},{"key":"12828_CR9","doi-asserted-by":"publisher","first-page":"148891","DOI":"10.1016\/j.gene.2024.148891","volume":"931","author":"A Shangguan","year":"2024","unstructured":"Shangguan A, Xiang C, Deng Z, Zhang N, Yu M, Zhang F, et al. Genome-wide association study of growth and reproductive traits based on low-coverage whole-genome sequencing in a Chubao black-head goat population. Gene. 2024;931:148891.","journal-title":"Gene"},{"issue":"7","key":"12828_CR10","doi-asserted-by":"publisher","first-page":"988","DOI":"10.3390\/ani14070988","volume":"14","author":"Y Lin","year":"2024","unstructured":"Lin Y, Sun L, Dai J, Lv Y, Liao R, Shen X, et al. Characterization and comparative analysis of whole-transcriptome sequencing in high-and low-fecundity Chongming White Goat ovaries during the estrus phase. Animals. 2024;14(7):988.","journal-title":"Animals"},{"issue":"1","key":"12828_CR11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12864-017-4400-4","volume":"19","author":"K Pokharel","year":"2018","unstructured":"Pokharel K, Peippo J, Honkatukia M, Sepp\u00e4l\u00e4 A, Rautiainen J, Ghanem N, et al. Integrated ovarian mRNA and miRNA transcriptome profiling characterizes the genetic basis of prolificacy traits in sheep (Ovis aries). BMC Genomics. 2018;19(1):104.","journal-title":"BMC Genomics"},{"issue":"1","key":"12828_CR12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s40104-023-00941-1","volume":"14","author":"T Ge","year":"2023","unstructured":"Ge T, Wen Y, Li B, Huang X, Jiang S, Zhang E. Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes. J Animal Sci Biotechnol. 2023;14(1):144.","journal-title":"J Animal Sci Biotechnol"},{"issue":"3","key":"12828_CR13","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.3390\/cimb46030147","volume":"46","author":"S Zhang","year":"2024","unstructured":"Zhang S, Wei Y, Gao X, Song Y, Huang Y, Jiang Q. Unveiling the ovarian cell characteristics and molecular mechanism of prolificacy in goats via single-nucleus transcriptomics data analysis. Curr Issues Mol Biol. 2024;46(3):2301\u201319.","journal-title":"Curr Issues Mol Biol"},{"key":"12828_CR14","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/ijms25020910","volume":"2","author":"Y Song","year":"2024","unstructured":"Song Y, Zhang N, Zhang Y, Wang J, Lv Q, Zhang J. Single-cell transcriptome analysis reveals development-specific networks at distinct antral follicle stages in sheep oocytes. Int J Mol Sci. 2024;2:910.","journal-title":"Int J Mol Sci"},{"key":"12828_CR15","doi-asserted-by":"crossref","unstructured":"Liu Z, Fu S, He X, Dai L, Liu X, Narisu, Shi C, Gu M, Wang Y, Manda. Integrated multi-tissue transcriptome profiling characterizes the genetic basis and biomarkers affecting reproduction in sheep (Ovis Aries). Genes. 2023; 14(10):1881.","DOI":"10.3390\/genes14101881"},{"key":"12828_CR16","doi-asserted-by":"publisher","first-page":"1565807","DOI":"10.3389\/fvets.2025.1565807","volume":"12","author":"C ShI","year":"2025","unstructured":"ShI C, Liu Q, Wang W, He Q, Zhao J, Zhang F, et al. Transcriptome and proteome of ovarian revealed the differences in the ovaries of dairy goats during the breeding and non-breeding seasons. Front Vet Sci. 2025;12:1565807.","journal-title":"Front Vet Sci"},{"key":"12828_CR17","doi-asserted-by":"publisher","first-page":"9240045","DOI":"10.26599\/FSAP.2023.9240045","volume":"1","author":"A Shari","year":"2023","unstructured":"Shari A, Yu M, Ren X. Analysis of differential colostrum metabolism in high and low yielding Guanzhong dairy goats. Food Science of Animal Products. 2023;1:9240045.","journal-title":"Food Science of Animal Products"},{"issue":"3","key":"12828_CR18","doi-asserted-by":"publisher","first-page":"msae058","DOI":"10.1093\/molbev\/msae058","volume":"41","author":"B Han","year":"2024","unstructured":"Han B, Tian D, Li X, Liu S, Tian F, Liu D, et al. Multiomics analyses provide new insight into genetic variation of reproductive adaptability in tibetan sheep. Mol Biol Evol. 2024;41(3):msae058.","journal-title":"Mol Biol Evol"},{"issue":"15","key":"12828_CR19","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30(15):2114\u201320.","journal-title":"Bioinformatics"},{"issue":"4","key":"12828_CR20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12(4):357\u201360.","journal-title":"Nat Methods"},{"issue":"2","key":"12828_CR21","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W. HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics. 2015;31(2):166\u20139.","journal-title":"Bioinformatics"},{"issue":"12","key":"12828_CR22","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.","journal-title":"Genome Biol"},{"issue":"1","key":"12828_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"12828_CR24","doi-asserted-by":"publisher","first-page":"W317","DOI":"10.1093\/nar\/gkab447","volume":"49","author":"D Bu","year":"2021","unstructured":"Bu D, Luo H, Huo P, Wang Z, Zhang S, He Z, et al. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res. 2021;49(W1):W317\u201325.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"12828_CR25","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.cell.2020.06.013","volume":"182","author":"MA Gillette","year":"2020","unstructured":"Gillette MA, Satpathy S, Cao S, Dhanasekaran SM, Vasaikar SV, Krug K, et al. Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma. Cell. 2020;182(1):200-225. e235.","journal-title":"Cell."},{"key":"12828_CR26","doi-asserted-by":"crossref","unstructured":"Demichev V, Messner CB, Vernardis SI, Lilley KS, Ralser M. DIA-NN: Neural networks and interference correction enable deep coverage in high-throughput proteomics. Nat Methods. 2020:282699.","DOI":"10.1038\/s41592-019-0638-x"},{"issue":"D1","key":"12828_CR27","doi-asserted-by":"publisher","first-page":"D808","DOI":"10.1093\/nar\/gks1094","volume":"41","author":"A Franceschini","year":"2012","unstructured":"Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 2012;41(D1):D808\u201315.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"12828_CR28","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2013","unstructured":"Want EJ, Masson P, Michopoulos F, Wilson ID, Theodoridis G, Plumb RS, et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc. 2013;8(1):17\u201332.","journal-title":"Nat Protoc"},{"issue":"D1","key":"12828_CR29","doi-asserted-by":"publisher","first-page":"D801","DOI":"10.1093\/nar\/gks1065","volume":"41","author":"DS Wishart","year":"2012","unstructured":"Wishart DS, Jewison T, Guo AC, Wilson M, Knox C, Liu Y, et al. HMDB 3.0\u2014the human metabolome database in 2013. Nucleic Acids Res. 2012;41(D1):D801\u20137.","journal-title":"Nucleic Acids Res"},{"issue":"suppl_1","key":"12828_CR30","doi-asserted-by":"publisher","first-page":"D527","DOI":"10.1093\/nar\/gkl838","volume":"35","author":"M Sud","year":"2007","unstructured":"Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, et al. Lmsd: Lipid maps structure database. Nucleic Acids Res. 2007;35(suppl_1):D527\u201332.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"12828_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12859-017-1579-y","volume":"18","author":"B Wen","year":"2017","unstructured":"Wen B, Mei Z, Zeng C, Liu S. metaX: a flexible and comprehensive software for processing metabolomics data. BMC Bioinformatics. 2017;18(1):183.","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"12828_CR32","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkae253","volume":"52","author":"Z Pang","year":"2024","unstructured":"Pang Z, Lu Y, Zhou G, Hui F, Xu L, Viau C, et al. MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation. Nucleic Acids Res. 2024;52(W1):W398\u2013406.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"12828_CR33","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1095\/biolreprod12.2.293","volume":"12","author":"N Jane Friedley","year":"1975","unstructured":"Jane Friedley N, Rosen S. Carbonic anhydrase activity in the mammalian ovary, Fallopian tube, and uterus: histochemical and biochemical studies1. Biol Reprod. 1975;12(2):293\u2013304.","journal-title":"Biol Reprod"},{"issue":"1","key":"12828_CR34","doi-asserted-by":"publisher","first-page":"6547","DOI":"10.1038\/s41467-021-26826-3","volume":"12","author":"D Nabi","year":"2021","unstructured":"Nabi D, Drechsler H, Pschirer J, Korn F, Schuler N, Diez S, et al. CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes. Nat Commun. 2021;12(1):6547.","journal-title":"Nat Commun"},{"issue":"5","key":"12828_CR35","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1111\/rda.12165","volume":"48","author":"R Pramod","year":"2013","unstructured":"Pramod R, Sharma S, Singhi A, Pan S, Mitra A. Differential ovarian morphometry and follicular expression of BMP 15, GDF 9 and BMPR 1B influence the prolificacy in goat. Reprod Domest Anim. 2013;48(5):803\u20139.","journal-title":"Reprod Domest Anim"},{"issue":"1","key":"12828_CR36","doi-asserted-by":"publisher","first-page":"7069","DOI":"10.1038\/s41467-024-50809-9","volume":"15","author":"D Wang","year":"2024","unstructured":"Wang D, Tan L, Zhi Y, Bu L, Wang Y, Wang Z, et al. Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens. Nat Commun. 2024;15(1):7069.","journal-title":"Nat Commun"},{"issue":"6","key":"12828_CR37","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3390\/genes13061031","volume":"13","author":"Z Sun","year":"2022","unstructured":"Sun Z, Zhang Z, Liu Y, Ren C, He X, Jiang Y, et al. Integrated analysis of mRNAs and long non-coding RNAs expression of oviduct that provides novel insights into the prolificacy mechanism of goat (Capra hircus). Genes. 2022;13(6):1031.","journal-title":"Genes"},{"issue":"5","key":"12828_CR38","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.3390\/ijms26051989","volume":"26","author":"D Li","year":"2025","unstructured":"Li D, Wu X, Chen Y, Wu Y, Abudureyimu G, Liang H, et al. Exploration of conditions for the scaled application of laparoscopic ovum pick-up in sheep and comparison of follicular development differences among breeds. Int J Mol Sci. 2025;26(5):1989.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"12828_CR39","doi-asserted-by":"publisher","first-page":"e0185045","DOI":"10.1371\/journal.pone.0185045","volume":"12","author":"G Mamede","year":"2017","unstructured":"Mamede G, Silveira JCD, Perrini C, Collado MD, Perecin F. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PLoS ONE. 2017;12(9):e0185045.","journal-title":"PLoS ONE"},{"key":"12828_CR40","doi-asserted-by":"publisher","first-page":"639030","DOI":"10.3389\/fgene.2021.639030","volume":"12","author":"W Zhang","year":"2021","unstructured":"Zhang W, Xu M, Wang J, Wang S, Wang X, Yang J, et al. Comparative transcriptome analysis of key genes and pathways activated in response to fat deposition in two sheep breeds with distinct tail phenotype. Front Genet. 2021;12:639030.","journal-title":"Front Genet"},{"issue":"1","key":"12828_CR41","doi-asserted-by":"publisher","first-page":"21915","DOI":"10.1038\/s41598-020-79086-4","volume":"10","author":"R Liu","year":"2020","unstructured":"Liu R, Liu X, Bai X, Xiao C, Dong Y. Different expression of lipid metabolism-related genes in Shandong black cattle and Luxi cattle based on transcriptome analysis. Sci Rep. 2020;10(1):21915.","journal-title":"Sci Rep"},{"issue":"4","key":"12828_CR42","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.gpb.2021.08.001","volume":"19","author":"T Chen","year":"2021","unstructured":"Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, et al. The genome sequence archive family: toward explosive data growth and diverse data types. Genomics Proteomics Bioinformatics. 2021;19(4):578\u201383.","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"12828_CR43","unstructured":"Database resources of the national genomics data center, China national center for bioinformation in 2025. Nucleic Acids Res. 2025;53(D1):D30-44."}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-026-12828-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-12828-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-12828-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:21:08Z","timestamp":1777551668000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12864-026-12828-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["12828"],"URL":"https:\/\/doi.org\/10.1186\/s12864-026-12828-2","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental protocols were conformed to \u201cThe Instructive Notions with Respect to Caring for Laboratory Animals\u201d issued by the Ministry of Science and Technology of the People\u2019s Republic of China, and approved by the Animal Care and Use Committee of Hubei Academy of Agricultural Sciences (HBAAS-2023\u2013014).All animal experiments were conducted with the informed consent of the owner of the lower goat farm of Hubei Academy of Agricultural Sciences.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"425"}}