{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T01:00:28Z","timestamp":1780275628853,"version":"3.54.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Graduate Research Innovation Project of Jishou University"},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"DOI":"10.1186\/s12864-026-12844-2","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T23:35:06Z","timestamp":1776641706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A transcriptome analysis revealing the molecular mechanism of light intensity-driven color variation in the skin of Chinese giant salamander (Andrias davidianus)"],"prefix":"10.1186","volume":"27","author":[{"given":"Zhizhi","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"004","key":"12844_CR1","first-page":"1","volume":"05","author":"ARAA Qvarnstr\u00f6m","year":"2013","unstructured":"Qvarnstr\u00f6m ARAA. Adaptive colouration in amphibians. Semin Cell Dev Biol. 2013;05(004):1\u201331.","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"12844_CR2","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/biology13010005","volume":"13","author":"L Ma","year":"2024","unstructured":"Ma L, Zhu Z, Zhang S, et al. Comparative Transcriptome Analysis of the Skin and the Peritoneal Wall Layer of Triplophysa stenura Distributed in High Elevations. Biology. 2024;13(1):5.","journal-title":"Biology"},{"issue":"16","key":"12844_CR3","first-page":"3683","volume":"848","author":"A Ziegelbecker","year":"2021","unstructured":"Ziegelbecker A, Remele K, Pfeifhofer HW, et al. Wasteful carotenoid coloration and its effects on territorial behavior in a cichlid fish. Springer International Publishing. 2021;848(16):3683\u201398.","journal-title":"Springer International Publishing"},{"issue":"4","key":"12844_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/pcmr.12776","volume":"32","author":"GE Bertolesi","year":"2019","unstructured":"Bertolesi GE, Zhang JZ, McFarlane S. Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl. Pigment Cell Melanoma Res. 2019;32(4):510\u201327.","journal-title":"Pigment Cell Melanoma Res"},{"key":"12844_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113662","volume":"301","author":"PG Vissio","year":"2021","unstructured":"Vissio PG, Darias MJ, Di Yorio MP, et al. Fish skin pigmentation in aquaculture: the influence of rearing conditions and its neuroendocrine regulation. Gen Comp Endocrinol. 2021;301:113662.","journal-title":"Gen Comp Endocrinol"},{"issue":"12","key":"12844_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009244","volume":"16","author":"R Madelaine","year":"2020","unstructured":"Madelaine R, Ngo KJ, Skariah G, et al. Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation. PLoS Genet. 2020;16(12):e1009244.","journal-title":"PLoS Genet"},{"issue":"7","key":"12844_CR7","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.190319","volume":"6","author":"J Brejcha","year":"2019","unstructured":"Brejcha J, Bataller JV, Bos\u00e1kov\u00e1 Z, et al. Body coloration and mechanisms of colour production in Archelosauria: the case of deirocheline turtles. R Soc Open Sci. 2019;6(7):190319.","journal-title":"R Soc Open Sci"},{"issue":"1","key":"12844_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/pcmr.12040","volume":"26","author":"H Nilsson Sk Ld","year":"2013","unstructured":"Nilsson Sk Ld H, Aspengren S, Wallin M. Rapid color change in fish and amphibians \u2013 function, regulation, and emerging applications. Pigment Cell Melanoma Res. 2013;26(1):29\u201338.","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"12844_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tig.2010.02.002","volume":"26","author":"JK Hubbard","year":"2010","unstructured":"Hubbard JK, Uy JAC, Hauber ME, et al. Vertebrate pigmentation: from underlying genes to adaptive function. Trends Genet. 2010;26(5):231\u20139.","journal-title":"Trends Genet"},{"key":"12844_CR10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.cbpb.2017.12.011","volume":"217","author":"D Cao","year":"2018","unstructured":"Cao D, Gong S, Yang J, et al. Melanin deposition ruled out as cause of color changes in the red-eared sliders (Trachemys scripta elegans). Comp Biochem Physiol B: Biochem Mol Biol. 2018;217:79\u201385.","journal-title":"Comp Biochem Physiol B: Biochem Mol Biol"},{"issue":"288","key":"12844_CR11","first-page":"20210454","volume":"2021","author":"J Schligler","year":"1952","unstructured":"Schligler J, Cortese D, Beldade R, et al. Long-term exposure to artificial light at night in the wild decreases survival and growth of a coral reef fish. Proc Biol Sci. 1952;2021(288):20210454.","journal-title":"Proc Biol Sci"},{"issue":"8","key":"12844_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081546","volume":"12","author":"P Yin","year":"2023","unstructured":"Yin P, Saito T, Fjelldal PG, et al. Seasonal changes in photoperiod: effects on growth and redox signaling patterns in Atlantic salmon postsmolts. Antioxidants. 2023;12(8):1546.","journal-title":"Antioxidants"},{"issue":"Suppl1","key":"12844_CR13","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1134\/S0012496623700850","volume":"513","author":"MV Kuznetsova","year":"2023","unstructured":"Kuznetsova MV, Rodin MA, N. S N S K. Activities of Energy Metabolism Enzymes in Atlantic Salmon Salmo salar L. Smolts and Parr Grown under Different Light Regimens. Doklady Biol Sci. 2023;513(Suppl1):S22\u20137.","journal-title":"Doklady Biol Sci"},{"issue":"6729","key":"12844_CR14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1126\/science.adj9687","volume":"387","author":"A Fukuda","year":"2025","unstructured":"Fukuda A, Sato K, Fujimori C, et al. Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation. Science. 2025;387(6729):43\u20138.","journal-title":"Science"},{"issue":"2","key":"12844_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1670\/20-093","volume":"55","author":"M Mack","year":"2021","unstructured":"Mack M, Beaty L. The influence of environmental and physiological factors on variation in American toad (Anaxyrus americanus) dorsal coloration. J Herpetol. 2021;55(2):119\u201326.","journal-title":"J Herpetol"},{"issue":"4","key":"12844_CR16","first-page":"1229","volume":"40","author":"HS Shin","year":"2014","unstructured":"Shin HS, Choi CY. The stimulatory effect of LED light spectra on genes related to photoreceptors and skin pigmentation in goldfish (Carassius auratus). Fish Physiol Biochem. 2014;40(4):1229\u201338.","journal-title":"Fish Physiol Biochem"},{"issue":"1","key":"12844_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31262-y","volume":"13","author":"C Park","year":"2023","unstructured":"Park C, No S, Yoo S, et al. Testing multiple hypotheses on the colour change of treefrogs in response to various external conditions. Sci Rep. 2023;13(1):4203.","journal-title":"Sci Rep"},{"issue":"1","key":"12844_CR18","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12983-023-00486-z","volume":"20","author":"TB Radovanovi\u0107","year":"2023","unstructured":"Radovanovi\u0107 TB, Petrovi\u0107 TG, Gavrilovi\u0107 BR, et al. What coloration brings: Implications of background adaptation to oxidative stress in anurans. Front Zool. 2023;20(1):6.","journal-title":"Front Zool"},{"issue":"2","key":"12844_CR19","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/jzo.13131","volume":"322","author":"P Aguilar","year":"2024","unstructured":"Aguilar P, P\u00e9rez I, De Lanuza G, Mart\u00ednez Gil H, et al. Color morphs of the fire salamander are discriminated at night by conspecifics and predators. J Zool. 2024;322(2):141\u201355.","journal-title":"J Zool"},{"issue":"1","key":"12844_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17471-2","volume":"7","author":"H Biland\u017eija","year":"2017","unstructured":"Biland\u017eija H, Laslo M, Porter ML, et al. Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species. Sci Rep. 2017;7(1):17148.","journal-title":"Sci Rep"},{"issue":"1","key":"12844_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.13220","volume":"38","author":"GE Bertolesi","year":"2025","unstructured":"Bertolesi GE, Debnath N, Heshami N, et al. Interplay of light, melatonin, and circadian genes in skin pigmentation regulation. Pigment Cell Melanoma Res. 2025;38(1):e13220.","journal-title":"Pigment Cell Melanoma Res"},{"issue":"1","key":"12844_CR22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ygcen.2009.06.014","volume":"165","author":"MC Isoldi","year":"2010","unstructured":"Isoldi MC, Provencio I, Castrucci AMDL. Light modulates the melanophore response to \u03b1-MSH in Xenopus laevis: an analysis of the signal transduction crosstalk mechanisms involved. Gen Comp Endocrinol. 2010;165(1):104\u201310.","journal-title":"Gen Comp Endocrinol"},{"key":"12844_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118075","volume":"294","author":"T Xiaolong","year":"2025","unstructured":"Xiaolong T, Juan W, Haoqi Z, et al. UVB radiation and amphibian resilience Analyzing skin color, immune suppression and oxidative stress in Rana kukunoris from different elevations. Ecotoxicol Environ Saf. 2025;294:118075.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"12844_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39107-4","volume":"13","author":"HC Liedtke","year":"2023","unstructured":"Liedtke HC, Lopez-Hervas K, Galv\u00e1n I, et al. Background matching through fast and reversible melanin-based pigmentation plasticity in tadpoles comes with morphological and antioxidant changes. Sci Rep. 2023;13(1):12064.","journal-title":"Sci Rep"},{"issue":"5","key":"12844_CR25","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20210427","volume":"41","author":"Y Lu","year":"2021","unstructured":"Lu Y, Tonissen KF, Di Trapani G. Modulating skin colour: role of the thioredoxin and glutathione systems in regulating melanogenesis. Biosci Rep. 2021;41(5):BSR20210427.","journal-title":"Biosci Rep"},{"issue":"7","key":"12844_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ani13071181","volume":"13","author":"Y Guo","year":"2023","unstructured":"Guo Y, Wu W, Yang X. Coordinated microRNA\/mRNA expression profiles reveal unique skin color regulatory mechanisms in Chinese giant salamander (Andrias davidianus). Animals. 2023;13(7):1181.","journal-title":"Animals"},{"issue":"1","key":"12844_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09153-3","volume":"24","author":"HY Wu","year":"2023","unstructured":"Wu HY, Chen KS, Huang YS, et al. Correction: comparative transcriptome analysis of skin color-associated genes in leopard coral grouper (Plectropomus leopardus). BMC Genomics. 2023;24(1):1.","journal-title":"BMC Genomics"},{"key":"12844_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2023.101165","volume":"49","author":"L Wu","year":"2024","unstructured":"Wu L, Sun W, Zhou J, et al. Comparative transcriptome analysis reveals growth and molecular pathway of body color regulation in turbot (Scophthalmus maximus) exposed to different light spectrum. Comp Biochem Physiol D Genomics Proteomics. 2024;49:101165.","journal-title":"Comp Biochem Physiol D Genomics Proteomics"},{"issue":"23","key":"12844_CR29","doi-asserted-by":"publisher","first-page":"16940","DOI":"10.3390\/ijms242316940","volume":"24","author":"Y Markitantova","year":"2023","unstructured":"Markitantova Y, Fokin A, Boguslavsky D, et al. Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl. Int J Mol Sci. 2023;24(23):16940.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"12844_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115640","volume":"44","author":"N Lu","year":"2025","unstructured":"Lu N, Zhu W, Tang C, et al. Genome of a stage-dependent cave-dwelling frog reveals the genetic mechanism of an extremely divergent biphasic life cycle. Cell Rep. 2025;44(5):115640.","journal-title":"Cell Rep"},{"issue":"1","key":"12844_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1034\/j.1601-5223.2002.1360112.x","volume":"136","author":"B Zhu","year":"2010","unstructured":"Zhu B, Feng Z, Ai QU, et al. The karyotype of the caudate amphibian Andrias davidianus. Hereditas. 2010;136(1):85\u20138.","journal-title":"Hereditas"},{"issue":"8","key":"12844_CR32","doi-asserted-by":"publisher","first-page":"BSR20210511","DOI":"10.1042\/BSR20210511","volume":"41","author":"Y Bai","year":"2021","unstructured":"Bai Y, Meng Y, Luo J, et al. Full-length transcriptome assembly ofandrias davidianus (amphibia: caudata) skin via hybrid sequencing. Biosci Rep. 2021;41(8):BSR20210511.","journal-title":"Biosci Rep"},{"issue":"3","key":"12844_CR33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3390\/fishes8030121","volume":"8","author":"J Deng","year":"2023","unstructured":"Deng J, Han M, Ma H, et al. Identification of Novel Mutations in the Tyrosinase Gene (TYR) Associated with Pigmentation in Chinese Giant Salamanders (Andrias davidianus). Fishes. 2023;8(3):121.","journal-title":"Fishes"},{"key":"12844_CR34","unstructured":"Deng J, Jiang W, Zhang H, et al. Application of molecular markers based on TYRP1 gene in the breeding of giant salamander body color. China Patent. 2022. CN114150075A [P]."},{"key":"12844_CR35","first-page":"24","volume":"10","author":"J Deng","year":"2020","unstructured":"Deng J, Wei X, Zhang H, et al. Cloning, sequence analysis and expression of the MC1R gene in Chinese giant salamander (Andrias davidianus) . Hebei Fisheries. 2020;10:24\u20139.","journal-title":"Hebei Fisheries"},{"issue":"02","key":"12844_CR36","first-page":"121","volume":"38","author":"J Wei","year":"2019","unstructured":"Wei J, Jie D, Qijun W, et al. Cloning and Polymorphism of Agouti Gene and Its Expression in Different Skin Color Phenotypes in Andrias davidianus. Sichuan Journal of Zoology. 2019;38(02):121\u20139.","journal-title":"Sichuan Journal of Zoology"},{"issue":"Z3","key":"12844_CR37","first-page":"2959","volume":"40","author":"Z Hu","year":"2021","unstructured":"Hu Z, Jie D, Qijun W, et al. Cloning, Sequence Analysis and Expression Analysis of MITF in Giant Salamanders (Andrias davidianus). Genomics and Applied Biology. 2021;40(Z3):2959\u201364.","journal-title":"Genomics and Applied Biology"},{"issue":"11","key":"12844_CR38","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.3390\/ani15111526","volume":"15","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Wang Z, Luo Q, et al. Circadian Rhythm of Body Color Change in the Juvenile Chinese Giant Salamander (Andrias davidianus) Under Different Photoperiods. Animals. 2025;15(11):1526.","journal-title":"Animals"},{"key":"12844_CR39","volume-title":"The effect of ultraviolet radiation on the physiological indicators of two toads at differentaltitudes[D]","author":"Y Liu","year":"2022","unstructured":"Liu Y. The effect of ultraviolet radiation on the physiological indicators of two toads at differentaltitudes[D]. Qinghai: Qinghai Normal University; 2022."},{"issue":"1","key":"12844_CR40","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s12864-018-4790-y","volume":"19","author":"Z Wei","year":"2018","unstructured":"Wei Z, Lusha L, Xungang W, et al. Transcriptomics reveals the molecular processes of light-induced rapid darkening of the non-obligate cave dweller Oreolalax rhodostigmatus (Megophryidae, Anura) and their genetic basis of pigmentation strategy. BMC Genomics. 2018;19(1):422.","journal-title":"BMC Genomics"},{"issue":"1","key":"12844_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00059.2017","volume":"99","author":"L D Alba","year":"2019","unstructured":"D Alba L, Shawkey MD. Melanosomes: biogenesis, properties, and evolution of an ancient organelle. Physiol Rev. 2019;99(1):1\u201319.","journal-title":"Physiol Rev"},{"issue":"3","key":"12844_CR42","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1097\/JD9.0000000000000135","volume":"4","author":"J Jin","year":"2021","unstructured":"Jin J, Jiang Y, Wang Y, et al. Oxyresveratrol-induced Activation of Nrf2\/HO-1 Signaling Pathway Enhances Ability of Resveratrol to Inhibit UVB-induced Melanin. International Journal of Dermatology and Venereology. 2021;4(3):152\u201362.","journal-title":"International Journal of Dermatology and Venereology"},{"issue":"7","key":"12844_CR43","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/ijms17071144","volume":"17","author":"SA D'Mello","year":"2016","unstructured":"D\u2019Mello SA, Finlay GJ, Baguley BC, et al. Signaling Pathways in Melanogenesis. Int J Mol Sci. 2016;17(7):1144.","journal-title":"Int J Mol Sci"},{"key":"12844_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2025.111819","volume":"302","author":"TG Petrovi\u0107","year":"2025","unstructured":"Petrovi\u0107 TG, Gavri\u0107-\u010campar JP, Burraco P, et al. Developing under artificial light is not so bright: Oxidative stress as a physiological response to light pollution across amphibian life stages. Comp Biochem Physiol A: Mol Integr Physiol. 2025;302:111819.","journal-title":"Comp Biochem Physiol A: Mol Integr Physiol"},{"issue":"24","key":"12844_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ani13243799","volume":"13","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Liu J, Zhuo H, et al. Differential toxicity responses between hepatopancreas and gills in Litopenaeus vannamei under chronic ammonia-N exposure. Animals (Basel). 2023;13(24):3799.","journal-title":"Animals (Basel)"},{"issue":"11","key":"12844_CR46","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1128\/MCB.01421-12","volume":"33","author":"J Lee","year":"2013","unstructured":"Lee J, Moulik M, Fang Z, et al. Bmal1 and \u03b2-Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced \u03b2-Cell Failure in Mice. Mol Cell Biol. 2013;33(11):2327.","journal-title":"Mol Cell Biol"},{"key":"12844_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00208","volume":"11","author":"X Geng","year":"2020","unstructured":"Geng X, Guo J, Zhang L, et al. Differential proteomic analysis of Chinese giant salamander liver in response to fasting. Front Physiol. 2020;11:208.","journal-title":"Front Physiol"},{"issue":"3","key":"12844_CR48","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3390\/molecules28031053","volume":"28","author":"AM Ferreira","year":"2023","unstructured":"Ferreira AM, de Souza AA, Koga R, et al. Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model. Molecules. 2023;28(3):1053.","journal-title":"Molecules"},{"issue":"275","key":"12844_CR49","doi-asserted-by":"publisher","first-page":"1441589","DOI":"10.3389\/fmars.2024.1441589","volume":"11","author":"M Yang","year":"2024","unstructured":"Yang M, Huang J, Zheng D, et al. ERK1\/2 regulates melanin synthesis in fish: a case study on a colourful variety, leopard coral grouper (Plectropomus leopardus) . Front Mar Sci. 2024;11(275):1441589.","journal-title":"Front Mar Sci"},{"key":"12844_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147508","volume":"876","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Mei Y, Cao A, et al. Transcriptome analyses of betta fish (Betta splendens) provide novel insights into fin regeneration and color-related genes. Gene. 2023;876:147508.","journal-title":"Gene"},{"key":"12844_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2024.112861","volume":"252","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Shi C, Han J, et al. Nonvisual system-mediated body color change in fish reveals nonvisual function of Opsin 3 in skin. J Photochem Photobiol, B. 2024;252:112861.","journal-title":"J Photochem Photobiol, B"},{"issue":"11","key":"12844_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002895","volume":"22","author":"J Tanwar","year":"2024","unstructured":"Tanwar J, Ahuja K, Sharma A, et al. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. PLoS Biol. 2024;22(11):e3002895.","journal-title":"PLoS Biol"},{"issue":"3","key":"12844_CR53","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/cbf.3465","volume":"38","author":"Q Jia","year":"2020","unstructured":"Jia Q, Hu S, Jiao D, et al. Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca 2+ influx via TRPM1 channels. Cell Biochem Funct. 2020;38(3):275\u201382.","journal-title":"Cell Biochem Funct"},{"issue":"3","key":"12844_CR54","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.biocel.2009.07.006","volume":"42","author":"M Wegner","year":"2010","unstructured":"Wegner M. All purpose Sox: the many roles of Sox proteins in gene expression. Int J Biochem Cell Biol. 2010;42(3):381\u201390.","journal-title":"Int J Biochem Cell Biol"},{"issue":"24","key":"12844_CR55","doi-asserted-by":"publisher","first-page":"9081","DOI":"10.1073\/pnas.0603114103","volume":"103","author":"L Hou","year":"2006","unstructured":"Hou L, Arnheiter H, Pavan WJ. Interspecies difference in the regulation of melanocyte development by SOX10 and MITF. Proc Natl Acad Sci U S A. 2006;103(24):9081\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"12844_CR56","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1600-0749.2004.00154.x","volume":"17","author":"Z Jiao","year":"2004","unstructured":"Jiao Z, Mollaaghababa R, Pavan WJ, et al. Direct interaction of Sox10 with the promoter of murine Dopachrome Tautomerase (Dct) and synergistic activation of Dct expression with Mitf. Pigment Cell Res. 2004;17(4):352\u201362.","journal-title":"Pigment Cell Res"},{"issue":"2","key":"12844_CR57","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.ydbio.2006.05.011","volume":"298","author":"F Murisier","year":"2006","unstructured":"Murisier F, Guichard S, Beermann F. A conserved transcriptional enhancer that specifies Tyrp1 expression to melanocytes. Dev Biol. 2006;298(2):644\u201355.","journal-title":"Dev Biol"},{"issue":"4","key":"12844_CR58","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/j.1755-148X.2010.00711.x","volume":"23","author":"ML Harris","year":"2010","unstructured":"Harris ML, Baxter LL, Loftus SK, et al. Sox proteins in melanocyte development and melanoma. Pigment Cell Melanoma Res. 2010;23(4):496\u2013513.","journal-title":"Pigment Cell Melanoma Res"},{"issue":"12","key":"12844_CR59","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.1016\/j.celrep.2019.02.068","volume":"26","author":"AH Cheng","year":"2019","unstructured":"Cheng AH, Bouchard-Cannon P, Hegazi S, et al. SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker. Cell reports (Cambridge). 2019;26(12):3191\u2013202.","journal-title":"Cell reports (Cambridge)"},{"issue":"1","key":"12844_CR60","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1172\/JCI82755","volume":"126","author":"M Dudek","year":"2016","unstructured":"Dudek M, Gossan N, Yang N, et al. The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest. 2016;126(1):365\u201376.","journal-title":"J Clin Invest"},{"issue":"1","key":"12844_CR61","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/jid.2009.334","volume":"130","author":"MC Garrido","year":"2010","unstructured":"Garrido MC, Bastian BC. Kit as a therapeutic target in melanoma. J Invest Dermatol. 2010;130(1):20\u20137.","journal-title":"J Invest Dermatol"},{"issue":"4","key":"12844_CR62","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00403-009-1007-x","volume":"302","author":"Y Mizutani","year":"2010","unstructured":"Mizutani Y, Hayashi N, Kawashima M, et al. A single UVB exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38\/CREB. Arch Dermatol Res. 2010;302(4):283\u201394.","journal-title":"Arch Dermatol Res"},{"key":"12844_CR63","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.9402","volume":"8","author":"S Hu","year":"2020","unstructured":"Hu S, Chen Y, Zhao B, et al. Kit is involved in melanocyte proliferation, apoptosis and melanogenesis in the Rex Rabbit. PeerJ. 2020;8:e9402.","journal-title":"PeerJ"},{"key":"12844_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00095","volume":"7","author":"EM Wolf Horrell","year":"2016","unstructured":"Wolf Horrell EM, Boulanger MC, D\u2019Orazio JA. Melanocortin 1 receptor: structure, function, and regulation. Front Genet. 2016;7:95.","journal-title":"Front Genet"},{"issue":"5","key":"12844_CR65","first-page":"15","volume":"37","author":"PR Upadhyay","year":"2024","unstructured":"Upadhyay PR, Swope VB, Starner RJ, et al. Journey through the spectacular landscape of melanocortin 1 receptor. Pigment Cell Res. 2024;37(5):15.","journal-title":"Pigment Cell Res"},{"issue":"11","key":"12844_CR66","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1021\/pr060363j","volume":"5","author":"A Chi","year":"2006","unstructured":"Chi A, Valencia JC, Hu Z, et al. Proteomic and Bioinformatic Characterization of the Biogenesis and Function of Melanosomes. J Proteome Res. 2006;5(11):3135\u201344.","journal-title":"J Proteome Res"},{"issue":"1","key":"12844_CR67","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1755-148X.2008.00518.x","volume":"22","author":"SK Loftus","year":"2010","unstructured":"Loftus SK, Antonellis A, Matera I, et al. Gpnmb is a melanoblast-expressed, MITF-dependent gene. Pigment Cell Melanoma Res. 2010;22(1):99\u2013110.","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"12844_CR68","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1034\/j.1600-0749.2000.130502.x","volume":"13","author":"R Fujii","year":"2000","unstructured":"Fujii R. The regulation of motile activity in fish chromatophores. Pigment Cell Res. 2000;13(5):300\u201319.","journal-title":"Pigment Cell Res"},{"issue":"11","key":"12844_CR69","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116199","volume":"25","author":"AA Ascsillan","year":"2024","unstructured":"Ascsillan AA, Kemeny LV. The skin-brain axis: from UV and pigmentation to behaviour modulation. Int J Mol Sci. 2024;25(11):6199.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"12844_CR70","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1034\/j.1600-0749.2001.140502.x","volume":"14","author":"N Oshima","year":"2001","unstructured":"Oshima N. Direct reception of light by chromatophores of lower vertebrates. Pigment Cell Res. 2001;14(5):312\u20139.","journal-title":"Pigment Cell Res"},{"key":"12844_CR71","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ng.3732","volume":"49","author":"C Shao","year":"2017","unstructured":"Shao C, Bao B, Xie Z, et al. The genome and transcriptome of Japanese flounder provide insights into flatfish asymmetry. Nat Genet. 2017;49:119\u201324.","journal-title":"Nat Genet"},{"key":"12844_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40166-4","volume":"14","author":"LE Schweikert","year":"2023","unstructured":"Schweikert LE, Bagge LE, Naughton LF, et al. Dynamic light filtering over dermal opsin as a sensory feedback system in fish color change. Nat Commun. 2023;14:4642.","journal-title":"Nat Commun"},{"issue":"4","key":"12844_CR73","first-page":"323","volume":"12","author":"Z Yuhui","year":"1991","unstructured":"Yuhui Z, Pipeng L, Rongsheng F, et al. Study of retina in Andrias davidianus with IM and SEM. Zool Res. 1991;12(4):323\u20138.","journal-title":"Zool Res"}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-026-12844-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-12844-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-12844-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:01:49Z","timestamp":1780272109000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12864-026-12844-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["12844"],"URL":"https:\/\/doi.org\/10.1186\/s12864-026-12844-2","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"17 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Experiment animals in this study were conducted in accordance with the New International Guiding Principles for Biomedical Research Involving Animals (\n                      \n                      ) and were approved by the Animals Research and Ethics Committee of Jishou University (Approval code is: JSDX-2023\u20130038).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"510"}}