{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:14:32Z","timestamp":1788484472453,"version":"build-2803163510"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270440"],"award-info":[{"award-number":["32270440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20192"],"award-info":[{"award-number":["U21A20192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300421024"],"award-info":[{"award-number":["262300421024"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Genomics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Energy allocation between reproduction and survival represents a fundamental life-history challenge for animals in seasonal environments. Using integrated transcriptomics and metabolomics, we investigated\n                      <jats:italic>Nanorana taihangnica<\/jats:italic>\n                      (Anura: Dicroglossidae), a non-amplexus stream frog endemic to China, to elucidate the seasonal morphological and molecular coordination between the testis and abdominal fat body.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Morphological analysis showed that fat body adipocyte cross-sectional area minimized at the end of the breeding season but rapidly recovered thereafter, while testicular volume continued declining post-breeding and only recovered during the non-breeding period. During breeding season, multi-omics analyses revealed that the fat body enhanced fatty acid oxidation, upregulated histidine-carnosine metabolism, activated NAD\n                      <jats:sup>+<\/jats:sup>\n                      metabolism and FOXO3-mediated antioxidative responses to mitigate metabolic stress, and regulated adipocyte survival and apoptosis via sphingolipid signaling. Seasonal testicular development was centrally regulated by the mTOR signaling pathway, whose activity integrated autophagy levels, NAD\n                      <jats:sup>+<\/jats:sup>\n                      availability, and aspartate metabolism to coordinate spermatogonial proliferation and spermatogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that\n                      <jats:italic>N. taihangnica<\/jats:italic>\n                      optimizes seasonal energy storage, allocation, and reproductive investment through molecular and metabolic crosstalk between the fat body and testis, providing empirical insights into the physiological integration of life-history strategies in animals inhabiting fluctuating environments.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12864-026-13080-4","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:16:08Z","timestamp":1782101768000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics unveils seasonal remodeling and metabolic crosstalk between testis and abdominal fat body in a non-amplexus stream frog Nanorana taihangnica (Anura: Dicroglossidae)"],"prefix":"10.1186","volume":"27","author":[{"given":"Yimin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruinan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinmeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"13080_CR1","unstructured":"Stearns SC. The evolution of life histories. Oxford: Oxford University Press; 1992. p. 100\u201322."},{"issue":"4","key":"13080_CR2","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1086\/677926","volume":"184","author":"J Sainmont","year":"2014","unstructured":"Sainmont J, Andersen KH, Varpe O, Visser AW. Capital versus income breeding in a seasonal environment. Am Nat. 2014;184(4):466\u201376. https:\/\/doi.org\/10.1086\/677926.","journal-title":"Am Nat"},{"issue":"3","key":"13080_CR3","doi-asserted-by":"publisher","first-page":"e05900","DOI":"10.1111\/ecog.05900","volume":"45","author":"SW Yanco","year":"2022","unstructured":"Yanco SW, Pierce AK, Wunder MB. Life history diversity in terrestrial animals is associated with metabolic response to seasonally fluctuating resources. Ecography. 2022;45(3):e05900. https:\/\/doi.org\/10.1111\/ecog.05900.","journal-title":"Ecography"},{"issue":"4300","key":"13080_CR4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.327542","volume":"197","author":"ST Emlen","year":"1977","unstructured":"Emlen ST, Oring LW. Ecology, sexual selection, and the evolution of mating systems. Science. 1977;197(4300):215\u201323. https:\/\/doi.org\/10.1126\/science.327542.","journal-title":"Science"},{"issue":"3","key":"13080_CR5","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/0003-3472(77)90118-X","volume":"25","author":"KD Wells","year":"1977","unstructured":"Wells KD. The social behaviour of anuran amphibians. Anim Behav. 1977;25(3):666\u201393. https:\/\/doi.org\/10.1016\/0003-3472(77)90118-X.","journal-title":"Anim Behav"},{"issue":"2","key":"13080_CR6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1677\/joe.0.0780165","volume":"78","author":"M Milone","year":"1978","unstructured":"Milone M, Iela L, Esposito V, Rastogi RK, Chieffi G. Annual variations in the total lipid and protein content of the liver, fat body, ovary and plasma of the female frog (Rana esculenta L.). J Endocrinol. 1978;78(2):165\u20139. https:\/\/doi.org\/10.1677\/joe.0.0780165.","journal-title":"J Endocrinol."},{"issue":"8","key":"13080_CR7","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1007\/BF01915320","volume":"34","author":"R Schlaghecke","year":"1978","unstructured":"Schlaghecke R, Bl\u00fcm V. Seasonal variations in fat body metabolism of the green frog Rana esculenta (L.). Experientia. 1978;34(8):1019\u201320. https:\/\/doi.org\/10.1007\/BF01915320.","journal-title":"Experientia."},{"issue":"3","key":"13080_CR8","doi-asserted-by":"publisher","first-page":"151873","DOI":"10.1016\/j.acthis.2022.151873","volume":"124","author":"AB Dias","year":"2022","unstructured":"Dias AB, de Oliveira SA, Cerri PS, Sasso-Cerri E. Bilateral asymmetry in bullfrog testes and fat bodies: correlations with steroidogenic activity, mast cells number and structural proteins. Acta Histochem. 2022;124(3):151873. https:\/\/doi.org\/10.1016\/j.acthis.2022.151873.","journal-title":"Acta Histochem"},{"issue":"2","key":"13080_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/BF00220364","volume":"161","author":"G Chieffi","year":"1975","unstructured":"Chieffi G, Rastogi RK, Iela L, Milone M. The function of fat bodies in relation to the hypothalamo-hypophyseal-gonadal axis in the frog. Rana esculenta Cell Tissue Res. 1975;161(2):157\u201365. https:\/\/doi.org\/10.1007\/BF00220364.","journal-title":"Rana esculenta Cell Tissue Res"},{"issue":"2","key":"13080_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00540598","volume":"51","author":"RC Mac Nally","year":"1981","unstructured":"Mac Nally RC. On the reproductive energetics of chorusing males: Energy depletion profiles, restoration and growth in two sympatric species of Ranidella (Anura). Oecologia. 1981;51(2):181\u20138. https:\/\/doi.org\/10.1007\/BF00540598.","journal-title":"Oecologia"},{"issue":"1\u20132","key":"13080_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1080\/11250007609434893","volume":"43","author":"RK Rastogi","year":"1976","unstructured":"Rastogi RK. Seasonal cycle in anuran (Amphibia) testis: the endocrine and environmental controls. Bolletino di Zoologia. 1976;43(1\u20132):151\u201372. https:\/\/doi.org\/10.1080\/11250007609434893.","journal-title":"Bolletino di Zoologia"},{"issue":"1","key":"13080_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0016-6480(89)90049-x","volume":"73","author":"MJ Delgado","year":"1989","unstructured":"Delgado MJ, Guti\u00e9rrez P, Alonso-Bedate M. Seasonal cycles in testicular activity in the frog. Rana perezi Gen Comp Endocrinol. 1989;73(1):1\u201311. https:\/\/doi.org\/10.1016\/0016-6480(89)90049-x.","journal-title":"Rana perezi Gen Comp Endocrinol"},{"issue":"3","key":"13080_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1006\/gcen.1998.7118","volume":"111","author":"SK Ko","year":"1998","unstructured":"Ko SK, Kang HM, Im WB, Kwon HB. Testicular Cycles in Three Species of Korean Frogs: Rana nigromaculata, Rana rugosa, and Rana dybowskii. Gen Comp Endocrinol. 1998;111(3):347\u201358.","journal-title":"Gen Comp Endocrinol"},{"issue":"10","key":"13080_CR14","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1139\/y92-189","volume":"70","author":"MJ Delgado","year":"1992","unstructured":"Delgado MJ, Alonso-G\u00f3mez AL, Alonso-Bedate M. Role of environmental temperature and photoperiod in regulation of seasonal testicular activity in the frog. Rana perezi Can J Physiol Pharmacol. 1992;70(10):1348\u201352.","journal-title":"Rana perezi Can J Physiol Pharmacol"},{"key":"13080_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jphotobiol.2018.12.005","volume":"191","author":"BK Borah","year":"2019","unstructured":"Borah BK, Renthlei Z, Trivedi AK. Seasonality in terai tree frog (Polypedates teraiensis): Role of light and temperature in regulation of seasonal breeding. J Photochem Photobiol B. 2019;191:44\u201351. https:\/\/doi.org\/10.1016\/j.jphotobiol.2018.12.005.","journal-title":"J Photochem Photobiol B"},{"issue":"4","key":"13080_CR16","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1080\/07420528.2020.1726373","volume":"37","author":"BK Borah","year":"2020","unstructured":"Borah BK, Renthlei Z, Trivedi AK. Hypothalamus but not liver retains daily expression of clock genes during hibernation in terai tree frog (Polypedates teraiensis). Chronobiol Int. 2020;37(4):485\u201392. https:\/\/doi.org\/10.1080\/07420528.2020.1726373.","journal-title":"Chronobiol Int"},{"issue":"3","key":"13080_CR17","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.beproc.2012.08.003","volume":"91","author":"L Zhang","year":"2012","unstructured":"Zhang L, Yang J, Lu Y, Lu X, Chen X. Aquatic eggs are fertilised by multiple males not engaged in amplexus in a stream-breeding frog. Behav Processes. 2012;91(3):304\u20137. https:\/\/doi.org\/10.1016\/j.beproc.2012.08.003.","journal-title":"Behav Processes"},{"issue":"3","key":"13080_CR18","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3109\/19401736.2014.908362","volume":"26","author":"Z Chen","year":"2015","unstructured":"Chen Z, Zhai X, Zhang J, Chen X. The complete mitochondrial genome of Feirana taihangnica (Anura: Dicroglossidae). Mitochondrial DNA. 2015;26(3):485\u20136. https:\/\/doi.org\/10.3109\/19401736.2014.908362.","journal-title":"Mitochondrial DNA"},{"issue":"4","key":"13080_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1046\/j.1365-2362.2002.00972.x","volume":"32","author":"H Yoshimatsu","year":"2002","unstructured":"Yoshimatsu H, Tsuda K, Niijima A, Tatsukawa M, Chiba S, Sakata T. Histidine induces lipolysis through sympathetic nerve in white adipose tissue. Eur J Clin Invest. 2002;32(4):236\u201341. https:\/\/doi.org\/10.1046\/j.1365-2362.2002.00972.x.","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"13080_CR20","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/nu12051414","volume":"12","author":"J Moro","year":"2020","unstructured":"Moro J, Tom\u00e9 D, Schmidely P, Demersay TC, Azzout-Marniche D. Histidine: a systematic review on metabolism and physiological effects in human and different animal species. Nutrients. 2020;12(5):1414. https:\/\/doi.org\/10.3390\/nu12051414.","journal-title":"Nutrients"},{"issue":"1","key":"13080_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1177\/153537020222700111","volume":"227","author":"H Yoshimatsu","year":"2002","unstructured":"Yoshimatsu H, Chiba S, Tajima D, Akehi Y, Sakata T. Histidine suppresses food intake through its conversion into neuronal histamine. Exp Biol Med (Maywood). 2002;227(1):63\u20138. https:\/\/doi.org\/10.1177\/153537020222700111.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"10","key":"13080_CR22","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1210\/en.2003-0222","volume":"144","author":"AK F\u00fcl\u00f6p","year":"2003","unstructured":"F\u00fcl\u00f6p AK, F\u00f6ldes A, Buz\u00e1s E, Hegyi K, Mikl\u00f3s IH, Romics L, et al. Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene. Endocrinology. 2003;144(10):4306\u201314. https:\/\/doi.org\/10.1210\/en.2003-0222.","journal-title":"Endocrinology"},{"issue":"7","key":"13080_CR23","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/nu8070420","volume":"8","author":"YC Li","year":"2016","unstructured":"Li YC, Li CL, Qi JY, et al. Relationships of Dietary Histidine and Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study. Nutrients. 2016;8(7):420. https:\/\/doi.org\/10.3390\/nu8070420.","journal-title":"Nutrients"},{"issue":"3","key":"13080_CR24","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2337\/DC11-1577","volume":"35","author":"SJ Mihalik","year":"2012","unstructured":"Mihalik SJ, Michaliszyn SF, de las Heras J, Bacha F, Lee S, Chace DH, et al. Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation. Diabetes Care. 2012;35(3):605\u201311. https:\/\/doi.org\/10.2337\/DC11-1577.","journal-title":"Diabetes Care."},{"issue":"4","key":"13080_CR25","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1152\/physrev.00039.2012","volume":"93","author":"AA Boldyrev","year":"2013","unstructured":"Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev. 2013;93(4):1803\u201345. https:\/\/doi.org\/10.1152\/physrev.00039.2012.","journal-title":"Physiol Rev"},{"issue":"2","key":"13080_CR26","doi-asserted-by":"publisher","first-page":"R447","DOI":"10.1152\/ajpregu.00275.2004","volume":"288","author":"M Tanida","year":"2005","unstructured":"Tanida M, Niijima A, Fukuda Y, Sawai H, Tsuruoka N, Shen J, et al. Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2005;288(2):R447\u201355. https:\/\/doi.org\/10.1152\/ajpregu.00275.2004.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"13080_CR27","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2008.06.027","volume":"441","author":"J Shen","year":"2008","unstructured":"Shen J, Yao JF, Tanida M, Nagai K. Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue. Neurosci Lett. 2008;441(1):100\u20134. https:\/\/doi.org\/10.1016\/j.neulet.2008.06.027.","journal-title":"Neurosci Lett"},{"key":"13080_CR28","doi-asserted-by":"publisher","first-page":"112138","DOI":"10.1016\/j.mce.2023.112138","volume":"582","author":"NA Grandini","year":"2024","unstructured":"Grandini NA, Costa MR, Gregolin CS, Siqueira JS, Vieira TA, Togneri Ferron AJ, et al. Effects of carnosine supplementation on markers for the pathophysiological development of metabolic dysfunction-associated steatotic liver disease in a diet-induced model. Mol Cell Endocrinol. 2024;582:112138. https:\/\/doi.org\/10.1016\/j.mce.2023.112138.","journal-title":"Mol Cell Endocrinol."},{"issue":"9","key":"13080_CR29","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.molmed.2005.07.003","volume":"11","author":"M L\u00f6ffler","year":"2005","unstructured":"L\u00f6ffler M, Fairbanks LD, Zameitat E, Marinaki AM, Simmonds HA. Pyrimidine pathways in health and disease. Trends Mol Med. 2005;11(9):430\u20137. https:\/\/doi.org\/10.1016\/j.molmed.2005.07.003.","journal-title":"Trends Mol Med"},{"issue":"4","key":"13080_CR30","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nri.2016.26","volume":"16","author":"MO Li","year":"2016","unstructured":"Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol. 2016;16(4):220\u201333. https:\/\/doi.org\/10.1038\/nri.2016.26.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"13080_CR31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/nri.2017.75","volume":"17","author":"L Lu","year":"2017","unstructured":"Lu L, Barbi J, Pan F. The regulation of immune tolerance by FOXP3. Nat Rev Immunol. 2017;17(11):703\u201317. https:\/\/doi.org\/10.1038\/nri.2017.75.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"13080_CR32","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12964-022-00849-9","volume":"20","author":"Y Miao","year":"2022","unstructured":"Miao Y, Zhang C, Yang L, Zeng X, Hu Y, Xue X, et al. The activation of PPAR\u03b3 enhances Treg responses through up-regulating CD36\/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of T\u03b2RII\/IL-2R\u03b1. Cell Commun Signal. 2022;20(1):48. https:\/\/doi.org\/10.1186\/s12964-022-00849-9.","journal-title":"Cell Commun Signal"},{"key":"13080_CR33","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.3389\/fimmu.2018.02075","volume":"9","author":"Q Zeng","year":"2018","unstructured":"Zeng Q, Sun X, Xiao L, Xie Z, Bettini M, Deng T. A Unique Population: Adipose-Resident Regulatory T Cells. Front Immunol. 2018;9:2075. https:\/\/doi.org\/10.3389\/fimmu.2018.02075.","journal-title":"Front Immunol"},{"issue":"3","key":"13080_CR34","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/s41590-024-01762-8","volume":"25","author":"M Grusdat","year":"2024","unstructured":"Grusdat M, Brenner D. Adipose Treg cells in charge of metabolism. Nat Immunol. 2024;25(3):392\u20133. https:\/\/doi.org\/10.1038\/s41590-024-01762-8.","journal-title":"Nat Immunol"},{"issue":"2","key":"13080_CR35","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","volume":"22","author":"AJ Covarrubias","year":"2021","unstructured":"Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119\u201341. https:\/\/doi.org\/10.1038\/s41580-020-00313-x.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"13080_CR36","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/s41392-020-00311-7","volume":"5","author":"N Xie","year":"2020","unstructured":"Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther. 2020;5(1):227. https:\/\/doi.org\/10.1038\/s41392-020-00311-7.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"13080_CR37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1179\/1351000212Y.0000000001","volume":"17","author":"H Massudi","year":"2012","unstructured":"Massudi H, Grant R, Guillemin GJ, Braidy N. NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Rep. 2012;17(1):28\u201346. https:\/\/doi.org\/10.1179\/1351000212Y.0000000001.","journal-title":"Redox Rep"},{"issue":"2","key":"13080_CR38","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s11357-020-00165-5","volume":"42","author":"T Kiss","year":"2020","unstructured":"Kiss T, Ny\u00fal-T\u00f3th \u00c1, Balasubramanian P, Tarantini S, Ahire C, Yabluchanskiy A, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527\u201346. https:\/\/doi.org\/10.1007\/s11357-020-00165-5.","journal-title":"Geroscience"},{"issue":"2","key":"13080_CR39","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nrm3507","volume":"14","author":"A Eijkelenboom","year":"2013","unstructured":"Eijkelenboom A, Burgering BM. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol. 2013;14(2):83\u201397. https:\/\/doi.org\/10.1038\/nrm3507.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"13080_CR40","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nrm2190","volume":"8","author":"A van der Horst","year":"2007","unstructured":"van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol. 2007;8(6):440\u201350. https:\/\/doi.org\/10.1038\/nrm2190.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"13080_CR41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s13668-023-00475-y","volume":"12","author":"GFS Alegre","year":"2023","unstructured":"Alegre GFS, Pastore GM. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health. Curr Nutr Rep. 2023;12(3):445\u201364. https:\/\/doi.org\/10.1007\/s13668-023-00475-y.","journal-title":"Curr Nutr Rep"},{"issue":"24","key":"13080_CR42","doi-asserted-by":"publisher","first-page":"14196","DOI":"10.1073\/pnas.95.24.14196","volume":"95","author":"P Xia","year":"1998","unstructured":"Xia P, Gamble JR, Rye KA, Wang L, Hii CS, Cockerill P, et al. Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc Natl Acad Sci USA. 1998;95(24):14196\u2013201. https:\/\/doi.org\/10.1073\/pnas.95.24.14196.","journal-title":"Proc Natl Acad Sci USA"},{"key":"13080_CR43","doi-asserted-by":"publisher","first-page":"872421","DOI":"10.3389\/fphys.2022.872421","volume":"13","author":"S Banaras","year":"2022","unstructured":"Banaras S, Paracha RZ, Nisar M, Arif A, Ahmad J, Tariq Saeed M, et al. System level modeling and analysis of TNF-\u03b1 mediated sphingolipid signaling pathway in neurological disorders for the prediction of therapeutic targets. Front Physiol. 2022;13:872421. https:\/\/doi.org\/10.3389\/fphys.2022.872421.","journal-title":"Front Physiol"},{"issue":"2","key":"13080_CR44","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5483\/bmbrep.2006.39.2.113","volume":"39","author":"TA Taha","year":"2006","unstructured":"Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006;39(2):113\u201331. https:\/\/doi.org\/10.5483\/bmbrep.2006.39.2.113.","journal-title":"J Biochem Mol Biol"},{"issue":"6","key":"13080_CR45","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/s12276-023-01018-9","volume":"55","author":"M Lee","year":"2023","unstructured":"Lee M, Lee SY, Bae YS. Functional roles of sphingolipids in immunity and their implication in disease. Exp Mol Med. 2023;55(6):1110\u201330. https:\/\/doi.org\/10.1038\/s12276-023-01018-9.","journal-title":"Exp Mol Med"},{"issue":"10","key":"13080_CR46","doi-asserted-by":"publisher","first-page":"7996","DOI":"10.1074\/jbc.M111423200","volume":"277","author":"P Xia","year":"2002","unstructured":"Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, et al. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. J Biol Chem. 2002;277(10):7996\u20138003. https:\/\/doi.org\/10.1074\/jbc.M111423200.","journal-title":"J Biol Chem"},{"issue":"6585","key":"13080_CR47","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/381800a0","volume":"381","author":"O Cuvillier","year":"1996","unstructured":"Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S, et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 1996;381(6585):800\u20133. https:\/\/doi.org\/10.1038\/381800a0.","journal-title":"Nature"},{"key":"13080_CR48","doi-asserted-by":"crossref","unstructured":"Thiriet M. Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, Volume 4. New York: Springer; 2011. p. 30\u20131.","DOI":"10.1007\/978-1-4419-9758-6"},{"issue":"1","key":"13080_CR49","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41392-024-01803-6","volume":"9","author":"M Zhang","year":"2024","unstructured":"Zhang M, Chen T, Lu X, Lan X, Chen Z, Lu S. G protein-coupled receptors (GPCRs): advances in structures, mechanisms, and drug discovery. Signal Transduct Target Ther. 2024;9(1):88. https:\/\/doi.org\/10.1038\/s41392-024-01803-6.","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"13080_CR50","doi-asserted-by":"publisher","first-page":"e0214760","DOI":"10.1371\/journal.pone.0214760","volume":"14","author":"TW Jung","year":"2019","unstructured":"Jung TW, Park T, Park J, Kim U, Je HD, Kim HD, et al. Phosphatidylcholine causes adipocyte-specific lipolysis and apoptosis in adipose and muscle tissues. PLoS One. 2019;14(4):e0214760. https:\/\/doi.org\/10.1371\/journal.pone.0214760.","journal-title":"PLoS One"},{"issue":"9","key":"13080_CR51","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.3390\/cells10092288","volume":"10","author":"T R\u00f6szer","year":"2021","unstructured":"R\u00f6szer T. Adipose Tissue Immunometabolism and Apoptotic Cell Clearance. Cells. 2021;10(9):2288. https:\/\/doi.org\/10.3390\/cells10092288.","journal-title":"Cells"},{"issue":"6684","key":"13080_CR52","doi-asserted-by":"publisher","first-page":"eadi3332","DOI":"10.1126\/science.adi3332","volume":"383","author":"J Chen","year":"2024","unstructured":"Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, et al. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024;383(6684):eadi3332. https:\/\/doi.org\/10.1126\/science.adi3332.","journal-title":"Science."},{"issue":"1","key":"13080_CR53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12672-023-00611-8","volume":"14","author":"G Wang","year":"2023","unstructured":"Wang G, Zhang X, Zhou Z, Song C, Jin W, Zhang H, et al. Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K\/AKT\/mTOR pathway. Discov Oncol. 2023;14(1):4. https:\/\/doi.org\/10.1007\/s12672-023-00611-8.","journal-title":"Discov Oncol"},{"issue":"11","key":"13080_CR54","doi-asserted-by":"publisher","first-page":"5172","DOI":"10.7150\/thno.71585","volume":"12","author":"C Zhou","year":"2022","unstructured":"Zhou C, Kuang Y, Li Q, Duan Y, Liu X, Yue J, et al. Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT\/eNOS signaling pathway. Theranostics. 2022;12(11):5172\u201388. https:\/\/doi.org\/10.7150\/thno.71585.","journal-title":"Theranostics"},{"issue":"5822","key":"13080_CR55","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1126\/science.113922","volume":"316","author":"R Pappu","year":"2007","unstructured":"Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007;316(5822):295\u20138. https:\/\/doi.org\/10.1126\/science.113922.","journal-title":"Science"},{"key":"13080_CR56","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cellsig.2017.03.002","volume":"34","author":"SN Patmanathan","year":"2017","unstructured":"Patmanathan SN, Wang W, Yap LF, Herr DR, Paterson IC. Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. Cell Signal. 2017;34:66\u201375. https:\/\/doi.org\/10.1016\/j.cellsig.2017.03.002.","journal-title":"Cell Signal"},{"issue":"4","key":"13080_CR57","doi-asserted-by":"publisher","first-page":"a026609","DOI":"10.1101\/cshperspect.a026609","volume":"7","author":"BA Hemmings","year":"2015","unstructured":"Hemmings BA, Restuccia DF. The PI3K-PKB\/Akt pathway. Cold Spring Harb Perspect Biol. 2015;7(4):a026609. https:\/\/doi.org\/10.1101\/cshperspect.a026609.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"13080_CR58","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/sj.onc.1207188","volume":"23","author":"X Liu","year":"2004","unstructured":"Liu X, Yan S, Zhou T, Terada Y, Erikson RL. The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene. 2004;23(3):763\u201376. https:\/\/doi.org\/10.1038\/sj.onc.1207188.","journal-title":"Oncogene"},{"issue":"1","key":"13080_CR59","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1042\/BST20110609","volume":"40","author":"E Aksamitiene","year":"2012","unstructured":"Aksamitiene E, Kiyatkin A, Kholodenko BN. Cross-talk between mitogenic Ras\/MAPK and survival PI3K\/Akt pathways: a fine balance. Biochem Soc Trans. 2012;40(1):139\u201346. https:\/\/doi.org\/10.1042\/BST20110609.","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"13080_CR60","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1042\/EBC20170027","volume":"61","author":"Y Rabanal-Ruiz","year":"2017","unstructured":"Rabanal-Ruiz Y, Otten EG, Korolchuk VI. mTORC1 as the main gateway to autophagy. Essays Biochem. 2017;61(6):565\u201384. https:\/\/doi.org\/10.1042\/EBC20170027.","journal-title":"Essays Biochem"},{"issue":"1","key":"13080_CR61","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrm3249","volume":"13","author":"P Codogno","year":"2011","unstructured":"Codogno P, Mehrpour M, Proikas-Cezanne T. Canonical and non-canonical autophagy: variations on a common theme of self-eating? Nat Rev Mol Cell Biol. 2011;13(1):7\u201312. https:\/\/doi.org\/10.1038\/nrm3249.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"13080_CR62","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017;168(6):960\u201376. https:\/\/doi.org\/10.1016\/j.cell.2017.02.004.","journal-title":"Cell"},{"issue":"3","key":"13080_CR63","doi-asserted-by":"publisher","first-page":"e0300337","DOI":"10.1371\/journal.pone.0300337","volume":"19","author":"M Cl\u00e9mot","year":"2024","unstructured":"Cl\u00e9mot M, D\u2019Alterio C, Kwang AC, Jones DL. mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis. PLoS One. 2024;19(3):e0300337. https:\/\/doi.org\/10.1371\/journal.pone.0300337.","journal-title":"PLoS One"},{"issue":"1","key":"13080_CR64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ydbio.2015.08.004","volume":"407","author":"JT Busada","year":"2015","unstructured":"Busada JT, Niedenberger BA, Velte EK, Keiper BD, Geyer CB. Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo. Dev Biol. 2015;407(1):90\u2013102. https:\/\/doi.org\/10.1016\/j.ydbio.2015.08.004.","journal-title":"Dev Biol"},{"issue":"2","key":"13080_CR65","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.rbmo.2015.11.007","volume":"32","author":"H Xu","year":"2016","unstructured":"Xu H, Shen L, Chen X, Ding Y, He J, Zhu J, et al. mTOR\/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats. Reprod Biomed Online. 2016;32(2):207\u201317. https:\/\/doi.org\/10.1016\/j.rbmo.2015.11.007.","journal-title":"Reprod Biomed Online"},{"issue":"1","key":"13080_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1095\/biolreprod.115.138016","volume":"95","author":"A Boyer","year":"2016","unstructured":"Boyer A, Girard M, Thimmanahalli DS, Levasseur A, C\u00e9leste C, Paquet M, et al. mTOR Regulates Gap Junction Alpha-1 Protein Trafficking in Sertoli Cells and Is Required for the Maintenance of Spermatogenesis in Mice. Biol Reprod. 2016;95(1):13. https:\/\/doi.org\/10.1095\/biolreprod.115.138016.","journal-title":"Biol Reprod"},{"key":"13080_CR67","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.micron.2019.03.006","volume":"121","author":"A Haseeb","year":"2019","unstructured":"Haseeb A, Tarique I, Bai X, Yang P, Ali Vistro W, Huang Y, et al. Inhibition of autophagy impairs acrosome and mitochondrial crista formation during spermiogenesis in turtle: Ultrastructural evidence. Micron. 2019;121:84\u20139. https:\/\/doi.org\/10.1016\/j.micron.2019.03.006.","journal-title":"Micron"},{"key":"13080_CR68","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.theriogenology.2021.12.032","volume":"181","author":"N Ye","year":"2022","unstructured":"Ye N, Lv Z, Huang Z, Cheng Y, Wei Q, Shi F. Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters. Theriogenology. 2022;181:8\u201315. https:\/\/doi.org\/10.1016\/j.theriogenology.2021.12.032.","journal-title":"Theriogenology"},{"issue":"3","key":"13080_CR69","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00441-019-03111-w","volume":"379","author":"A Tabecka-Lonczynska","year":"2020","unstructured":"Tabecka-Lonczynska A, Mytych J, Solek P, Koziorowski M. Autophagy as a consequence of seasonal functions of testis and epididymis in adult male European bison (Bison bonasus, Linnaeus 1758). Cell Tissue Res. 2020;379(3):613\u201324. https:\/\/doi.org\/10.1007\/s00441-019-03111-w.","journal-title":"Cell Tissue Res"},{"issue":"1","key":"13080_CR70","doi-asserted-by":"publisher","first-page":"e0191126","DOI":"10.1371\/journal.pone.0191126","volume":"13","author":"CR Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez CR, Muscarsel Isla ML, Vitullo AD. The balance between apoptosis and autophagy regulates testis regression and recrudescence in the seasonal-breeding South American plains vizcacha, Lagostomus maximus. PLoS One. 2018;13(1):e0191126. https:\/\/doi.org\/10.1371\/journal.pone.0191126.","journal-title":"PLoS One"},{"issue":"5","key":"13080_CR71","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1080\/07853890701408194","volume":"39","author":"N Dali-Youcef","year":"2007","unstructured":"Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J. Sirtuins: the \u201cmagnificent seven\u201d, function, metabolism and longevity. Ann Med. 2007;39(5):335\u201345. https:\/\/doi.org\/10.1080\/07853890701408194.","journal-title":"Ann Med"},{"key":"13080_CR72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1478-811X-9-11","volume":"9","author":"S Rahman","year":"2011","unstructured":"Rahman S, Islam R. Mammalian Sirt1: insights on its biological functions. Cell Commun Signal. 2011;9:11. https:\/\/doi.org\/10.1186\/1478-811X-9-11.","journal-title":"Cell Commun Signal"},{"issue":"3","key":"13080_CR73","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jmb.2013.10.009","volume":"426","author":"AM Davenport","year":"2014","unstructured":"Davenport AM, Huber FM, Hoelz A. Structural and functional analysis of human SIRT1. J Mol Biol. 2014;426(3):526\u201341. https:\/\/doi.org\/10.1016\/j.jmb.2013.10.009.","journal-title":"J Mol Biol"},{"issue":"12","key":"13080_CR74","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1002\/jcp.24399","volume":"228","author":"F Ng","year":"2013","unstructured":"Ng F, Tang BL. Sirtuins\u2019 modulation of autophagy. J Cell Physiol. 2013;228(12):2262\u201370. https:\/\/doi.org\/10.1002\/jcp.24399.","journal-title":"J Cell Physiol"},{"issue":"1","key":"13080_CR75","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s13238-020-00771-1","volume":"12","author":"MB Khawar","year":"2021","unstructured":"Khawar MB, Liu C, Gao F, Gao H, Liu W, Han T, et al. Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy. Protein Cell. 2021;12(1):67\u201375. https:\/\/doi.org\/10.1007\/s13238-020-00771-1.","journal-title":"Protein Cell"},{"issue":"10","key":"13080_CR76","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.devcel.2022.04.018","volume":"57","author":"RE Oberkersch","year":"2022","unstructured":"Oberkersch RE, Pontarin G, Astone M, Spizzotin M, Arslanbaeva L, Tosi G, et al. Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis. Dev Cell. 2022;57(10):1241-1256.e8. https:\/\/doi.org\/10.1016\/j.devcel.2022.04.018.","journal-title":"Dev Cell"},{"key":"13080_CR77","doi-asserted-by":"publisher","first-page":"4755514","DOI":"10.1155\/2022\/4755514","volume":"2022","author":"H Song","year":"2022","unstructured":"Song H, Park HJ, Lee WY, Lee KH. Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals. Stem Cells Int. 2022;2022:4755514. https:\/\/doi.org\/10.1155\/2022\/4755514. Published 2022 May 31.","journal-title":"Stem Cells Int."},{"issue":"6","key":"13080_CR78","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/ng1366","volume":"36","author":"FW Buaas","year":"2004","unstructured":"Buaas FW, Kirsh AL, Sharma M, McLean DJ, Morris JL, Griswold MD, et al. Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet. 2004;36(6):647\u201352. https:\/\/doi.org\/10.1038\/ng1366.","journal-title":"Nat Genet"},{"issue":"6","key":"13080_CR79","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/ng1367","volume":"36","author":"JA Costoya","year":"2004","unstructured":"Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, et al. Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet. 2004;36(6):653\u20139. https:\/\/doi.org\/10.1038\/ng1367.","journal-title":"Nat Genet"},{"issue":"2","key":"13080_CR80","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1095\/biolreprod.111.091330","volume":"85","author":"MJ Oatley","year":"2011","unstructured":"Oatley MJ, Kaucher AV, Racicot KE, Oatley JM. Inhibitor of DNA binding 4 is expressed selectively by single spermatogonia in the male germline and regulates the self-renewal of spermatogonial stem cells in mice. Biol Reprod. 2011;85(2):347\u201356. https:\/\/doi.org\/10.1095\/biolreprod.111.091330.","journal-title":"Biol Reprod"},{"issue":"4","key":"13080_CR81","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1242\/dev.146928","volume":"144","author":"AR Helsel","year":"2017","unstructured":"Helsel AR, Yang QE, Oatley MJ, Lord T, Sablitzky F, Oatley JM. ID4 levels dictate the stem cell state in mouse spermatogonia. Development. 2017;144(4):624\u201334. https:\/\/doi.org\/10.1242\/dev.146928.","journal-title":"Development"},{"key":"13080_CR82","doi-asserted-by":"publisher","first-page":"17594","DOI":"10.1038\/srep17594","volume":"5","author":"F Sun","year":"2015","unstructured":"Sun F, Xu Q, Zhao D, Degui Chen C. Id4 Marks Spermatogonial Stem Cells in the Mouse Testis. Sci Rep. 2015;5:17594. https:\/\/doi.org\/10.1038\/srep17594. Published 2015 Dec 1.","journal-title":"Sci Rep."},{"issue":"2","key":"13080_CR83","doi-asserted-by":"publisher","first-page":"e20190557","DOI":"10.1590\/0001-3765202120190557","volume":"93","author":"MG Moreira","year":"2021","unstructured":"Moreira MG, Benetti EJ, Rebelo ACS, Sousa GC, Medeiros MVM, Vieira LG, et al. Morphological characterization of blue-and-yellow macaw (Ara ararauna) seasonal testicular variations in captivity. An Acad Bras Cienc. 2021;93(2):e20190557. https:\/\/doi.org\/10.1590\/0001-3765202120190557.","journal-title":"An Acad Bras Cienc"},{"issue":"2","key":"13080_CR84","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/gcb.13390","volume":"23","author":"DM Green","year":"2017","unstructured":"Green DM. Amphibian breeding phenology trends under climate change: predicting the past to forecast the future. Glob Chang Biol. 2017;23(2):646\u201356. https:\/\/doi.org\/10.1111\/gcb.13390.","journal-title":"Glob Chang Biol"},{"key":"13080_CR85","doi-asserted-by":"publisher","unstructured":"Arietta AZA, Freidenburg LK, Urban MC, Rodrigues SB, Rubinstein A, Skelly DK. Phenological delay despite warming in wood frog Rana sylvatica reproductive timing: a 20\u2010year study[J]. Ecography. 2020. https:\/\/doi.org\/10.1111\/ecog.05297.","DOI":"10.1111\/ecog.05297"},{"key":"13080_CR86","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1111\/ddi.13610","volume":"28","author":"LR Forti","year":"2022","unstructured":"Forti LR, Hepp F, de Souza JM, Protazio A, Szabo JK. Climate drives anuran breeding phenology in a continental perspective as revealed by citizen-collected data. Divers Distrib. 2022;28:2094\u2013109. https:\/\/doi.org\/10.1111\/ddi.13610.","journal-title":"Divers Distrib"},{"key":"13080_CR87","doi-asserted-by":"publisher","unstructured":"Ethier JP, Habib N, Mazerolle MJ, Trudeau VL. Warm Spring Weather Alters Calling Phenology of Four Sympatric Early-Breeding Anurans. Integr Zool. https:\/\/doi.org\/10.1111\/1749-4877.70090. Published online March 29, 2026.","DOI":"10.1111\/1749-4877.70090"},{"key":"13080_CR88","first-page":"478","volume-title":"Colored Atlas of Chinese Amphibians and Their Distributions [Zhongguo Liangqi Dongwu Ji Qi Fenbu Caise Tujian]","author":"L Fei","year":"2012","unstructured":"Fei L, Ye CY, Jiang JP. Colored Atlas of Chinese Amphibians and Their Distributions [Zhongguo Liangqi Dongwu Ji Qi Fenbu Caise Tujian]. Chengdu: Sichuan Science and Technology Press; 2012. p. 478."},{"issue":"6","key":"13080_CR89","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative CT method. Nat Protoc. 2008;3(6):1101\u20138. https:\/\/doi.org\/10.1038\/nprot.2008.73.","journal-title":"Nat Protoc."}],"container-title":["BMC Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12864-026-13080-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-13080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12864-026-13080-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:06:23Z","timestamp":1788483983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12864-026-13080-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["13080"],"URL":"https:\/\/doi.org\/10.1186\/s12864-026-13080-4","relation":{},"ISSN":["1471-2164"],"issn-type":[{"value":"1471-2164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"assertion":[{"value":"28 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors confirm that the sampling and animal-use protocols of this study were conducted in accordance with all the ethical guidelines and legal requirements in China, and were approved by the Institutional Care and Ethics Committee of Henan Normal University (Approval No. HNSD-2026\u201304-062). The study complies with the ARRIVE guidelines for reporting in Vivo Experiments.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"734"}}