{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:30:02Z","timestamp":1792654202170,"version":"4.5.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12865-017-0209-9","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T09:32:42Z","timestamp":1496136762000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells"],"prefix":"10.1186","volume":"18","author":[{"given":"Annette","family":"Audig\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Aude","family":"Rochat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ivic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Fahrny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina K. S.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Gers-Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renier","family":"Myburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bredl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Schlaepfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra U.","family":"Scherrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Kuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto F.","family":"Speck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"209_CR1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev-immunol-032712-095921","volume":"31","author":"A Rongvaux","year":"2013","unstructured":"Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG. Human hemato-lymphoid system mice: current use and future potential for medicine. Annu Rev Immunol. 2013;31:635\u201374.","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"209_CR2","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","volume":"100","author":"M Ito","year":"2002","unstructured":"Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, et al. NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100(9):3175\u201382.","journal-title":"Blood"},{"issue":"10","key":"209_CR3","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","volume":"174","author":"LD Shultz","year":"2005","unstructured":"Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S, Kotb M, Gillies SD, King M, Mangada J, et al. Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol. 2005;174(10):6477\u201389.","journal-title":"J Immunol"},{"issue":"5667","key":"209_CR4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1093933","volume":"304","author":"E Traggiai","year":"2004","unstructured":"Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004;304(5667):104\u20137.","journal-title":"Science"},{"key":"209_CR5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-immunol-032713-120142","volume":"32","author":"AN Barclay","year":"2014","unstructured":"Barclay AN, Van den Berg TK. The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target. Annu Rev Immunol. 2014;32:25\u201350.","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"209_CR6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/ni1527","volume":"8","author":"K Takenaka","year":"2007","unstructured":"Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol. 2007;8(12):1313\u201323.","journal-title":"Nat Immunol"},{"issue":"8","key":"209_CR7","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1182\/blood-2012-06-440354","volume":"121","author":"T Yamauchi","year":"2013","unstructured":"Yamauchi T, Takenaka K, Urata S, Shima T, Kikushige Y, Tokuyama T, Iwamoto C, Nishihara M, Iwasaki H, Miyamoto T, et al. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood. 2013;121(8):1316\u201325.","journal-title":"Blood"},{"issue":"8","key":"209_CR8","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1182\/blood-2002-07-1995","volume":"101","author":"T Yahata","year":"2003","unstructured":"Yahata T, Ando K, Sato T, Miyatake H, Nakamura Y, Muguruma Y, Kato S, Hotta T. A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD\/SCID mice bone marrow. Blood. 2003;101(8):2905\u201313.","journal-title":"Blood"},{"issue":"5","key":"209_CR9","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1182\/blood-2005-02-0516","volume":"106","author":"F Ishikawa","year":"2005","unstructured":"Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M. Development of functional human blood and immune systems in NOD\/SCID\/IL2 receptor {gamma} chain(null) mice. Blood. 2005;106(5):1565\u201373.","journal-title":"Blood"},{"issue":"2","key":"209_CR10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2249.2008.03753.x","volume":"154","author":"T Pearson","year":"2008","unstructured":"Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, et al. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol. 2008;154(2):270\u201384.","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"209_CR11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1182\/blood-2010-02-271841","volume":"116","author":"SP McDermott","year":"2010","unstructured":"McDermott SP, Eppert K, Lechman ER, Doedens M, Dick JE. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood. 2010;116(2):193\u2013200.","journal-title":"Blood"},{"issue":"1","key":"209_CR12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.clim.2009.12.008","volume":"135","author":"MA Brehm","year":"2010","unstructured":"Brehm MA, Cuthbert A, Yang C, Miller DM, DiIorio P, Laning J, Burzenski L, Gott B, Foreman O, Kavirayani A, et al. Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol. 2010;135(1):84\u201398.","journal-title":"Clin Immunol"},{"key":"209_CR13","doi-asserted-by":"crossref","unstructured":"Harris DT, Badowski M. Long term human reconstitution and immune aging in NOD-Rag (-)-gamma chain (-) mice. Immunobiology. 2014;219(2):131-7.","DOI":"10.1016\/j.imbio.2013.08.013"},{"key":"209_CR14","doi-asserted-by":"crossref","unstructured":"Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R: Studies of Lymphocyte Reconstitution in a Humanized Mouse Model Reveal a Requirement of T Cells for Human B Cell Maturation. J Immunol. 2013;190(5):2090-01.","DOI":"10.4049\/jimmunol.1202810"},{"issue":"2","key":"209_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exphem.2015.10.008","volume":"44","author":"J Hoggatt","year":"2016","unstructured":"Hoggatt J, Hoggatt AF, Tate TA, Fortman J, Pelus LM. Bleeding the laboratory mouse: Not all methods are equal. Exp Hematol. 2016;44(2):132\u20137. e131.","journal-title":"Exp Hematol"},{"issue":"3","key":"209_CR16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.beha.2008.06.003","volume":"21","author":"KM Williams","year":"2008","unstructured":"Williams KM, Gress RE. Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation. Best Pract Res Clin Haematol. 2008;21(3):579\u201396.","journal-title":"Best Pract Res Clin Haematol"},{"issue":"2-3","key":"209_CR17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.trim.2011.12.003","volume":"26","author":"X Wang","year":"2012","unstructured":"Wang X, Qi Z, Wei H, Tian Z, Sun R. Characterization of human B cells in umbilical cord blood-transplanted NOD\/SCID mice. Transpl Immunol. 2012;26(2-3):156\u201362.","journal-title":"Transpl Immunol"},{"issue":"7","key":"209_CR18","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/intimm\/dxp050","volume":"21","author":"Y Watanabe","year":"2009","unstructured":"Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, et al. The analysis of the functions of human B and T cells in humanized NOD\/shi-scid\/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol. 2009;21(7):843\u201358.","journal-title":"Int Immunol"},{"issue":"3","key":"209_CR19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.trim.2015.03.002","volume":"32","author":"A Tanner","year":"2015","unstructured":"Tanner A, Hallam SJ, Nielsen SJ, Cuadra GI, Berges BK. Development of human B cells and antibodies following human hematopoietic stem cell transplantation to Rag2(-\/-)gammac(-\/-) mice. Transpl Immunol. 2015;32(3):144\u201350.","journal-title":"Transpl Immunol"},{"key":"209_CR20","doi-asserted-by":"crossref","unstructured":"Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK et al: Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol. 2014;32(4):362-72.","DOI":"10.1038\/nbt.2858"},{"issue":"12","key":"209_CR21","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.4049\/jimmunol.0902019","volume":"183","author":"AU Lent van","year":"2009","unstructured":"van Lent AU, Dontje W, Nagasawa M, Siamari R, Bakker AQ, Pouw SM, Maijoor KA, Weijer K, Cornelissen JJ, Blom B, et al. IL-7 Enhances Thymic Human T Cell Development in \u201cHuman Immune System\u201d Rag2-\/-IL-2R{gamma}c-\/- Mice without Affecting Peripheral T Cell Homeostasis. J Immunol. 2009;183(12):7645\u201355.","journal-title":"J Immunol"},{"issue":"11","key":"209_CR22","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood-2010-08-301507","volume":"117","author":"E Billerbeck","year":"2011","unstructured":"Billerbeck E, Barry WT, Mu K, Dorner M, Rice CM, Ploss A. Development of human CD4\u2009+\u2009FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rgamma(null) humanized mice. Blood. 2011;117(11):3076\u201386.","journal-title":"Blood"},{"issue":"2","key":"209_CR23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.stem.2014.06.001","volume":"15","author":"KN Cosgun","year":"2014","unstructured":"Cosgun KN, Rahmig S, Mende N, Reinke S, Hauber I, Schafer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, et al. Kit regulates HSC engraftment across the human-mouse species barrier. Cell Stem Cell. 2014;15(2):227\u201338.","journal-title":"Cell Stem Cell"},{"issue":"4","key":"209_CR24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stemcr.2016.08.005","volume":"7","author":"S Rahmig","year":"2016","unstructured":"Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornhauser M, Gassmann M, Platz A, Ordemann R, Tonn T, et al. Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice. Stem Cell Rep. 2016;7(4):591\u2013601.","journal-title":"Stem Cell Rep"}],"container-title":["BMC Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12865-017-0209-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T09:32:58Z","timestamp":1496136778000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/s12865-017-0209-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["209"],"URL":"https:\/\/doi.org\/10.1186\/s12865-017-0209-9","relation":{},"ISSN":["1471-2172"],"issn-type":[{"value":"1471-2172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]},"article-number":"28"}}