{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:47:18Z","timestamp":1777099638024,"version":"3.51.4"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12865-018-0259-7","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T21:15:27Z","timestamp":1530047727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of differences between total IgG and sum of the IgG subclasses in children with suspected immunodeficiency \u2013 indication of determinants"],"prefix":"10.1186","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-7692","authenticated-orcid":false,"given":"Gerard","family":"Pasternak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Lewandowicz-Uszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Pento\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"issue":"2","key":"259_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1525-1578(10)60493-X","volume":"6","author":"MS Lim","year":"2004","unstructured":"Lim MS, Elenitoba-Johnson KS. The molecular pathology of primary Immunodeficiencies. J Mol Diagn. 2004;6(2):59\u201383.","journal-title":"J Mol Diagn"},{"issue":"3","key":"259_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-2249.1990.tb05339.x","volume":"81","author":"R Jefferis","year":"1990","unstructured":"Jefferis R, Kumararatne DS. Selective IgG subclass deficiency: quantification and clinical relevance. Clin Exp Immunol. 1990;81(3):357\u201367.","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"259_CR3","first-page":"28","volume":"20","author":"TW Kuijpers","year":"1992","unstructured":"Kuijpers TW, Weening RS, Out TA. IgG subclass deficiencies and recurrent pyogenic infections, unresponsiveness against bacterial polysaccharide antigens. Allergol Immunopathol. 1992;20(1):28\u201334.","journal-title":"Allergol Immunopathol"},{"key":"259_CR4","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","volume":"5","author":"G Vidarsson","year":"2014","unstructured":"Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520. \n                    https:\/\/doi.org\/10.3389\/fimmu.2014.00520\n                    \n                  .","journal-title":"Front Immunol"},{"issue":"3","key":"259_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1034\/j.1399-3038.2002.00058.x","volume":"13","author":"C de MoraesLui","year":"2002","unstructured":"de MoraesLui C, Oliveira LC, Diogo CL, Kirschfink M, Grumach AS. Immunoglobulin G subclass concentrations and infections in children and adolescents with severe asthma. Pediatr Allergy Immunol. 2002;13(3):195\u2013202.","journal-title":"Pediatr Allergy Immunol"},{"issue":"11","key":"259_CR6","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1373\/clinchem.2003.022350","volume":"49","author":"U Schauer","year":"2003","unstructured":"Schauer U, Stemberg F, Rieger CH, Borte M, Schubert S, Riedel F, Herz U, Renz H, Wick M, Carr-Smith HD, et al. Clin Chem. 2003;49(11):1924\u20139.","journal-title":"Clin Chem"},{"key":"259_CR7","doi-asserted-by":"publisher","unstructured":"Ludwig-Kraus B, and Kraus FB. Similar but not consistent: Revisiting the pitfalls of measuring IgG subclasses with different assays. J Clin Lab Anal. 2017;31:e22146. \n                    https:\/\/doi.org\/10.1002\/jcla.22146\n                    \n                  .","DOI":"10.1002\/jcla.22146"},{"key":"259_CR8","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.jaci.2005.01.039","volume":"115","author":"X Bossuyt","year":"2005","unstructured":"Bossuyt X, Marien G, Meyts I, Proesmans M, De Boeck K. Determination of IgG subclasses: a need for standardization. J Allergy ClinImmunol. 2005;115:872\u20134.","journal-title":"J Allergy ClinImmunol"},{"key":"259_CR9","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/PAT.0000000000000003","volume":"45","author":"A McLean-Tooke","year":"2013","unstructured":"McLean-Tooke A, O'Sullivan M, Easter T, Loh R. Differences between total IgG and sum of the IgG subclasses in clinical samples. Pathology. 2013;45:675\u20137.","journal-title":"Pathology"}],"container-title":["BMC Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12865-018-0259-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12865-018-0259-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12865-018-0259-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T19:09:23Z","timestamp":1561576163000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/s12865-018-0259-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["259"],"URL":"https:\/\/doi.org\/10.1186\/s12865-018-0259-7","relation":{},"ISSN":["1471-2172"],"issn-type":[{"value":"1471-2172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"assertion":[{"value":"28 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This manuscript complies with the ethical standards. The data was collected retrospectively with the consent of the hospital management and the ethics commission. Personal data of patients remained anonymous. Only the results of diagnostic tests were used. No individual consents obtained, as there was no need. The need for consent was waived by the Bioethics Committee of the Medical University of Wroclaw, and the study was approved as No.KB-638\/2017 by this committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"22"}}