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Interleukin (IL)-35 is a novel anti-inflammatory cytokine that mainly produced by regulatory T (Treg). This study was performed to analyze whether IL-35 was correlated with obesity in RA and investigate the correlation between other Th1\/Th2\/Th17-related cytokines and obesity in RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The serum IL-35 level was analyzed in RA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981) and healthy donors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953) by ELISA assay, and was compared between three groups (body mass index (BMI) &lt;\u200918.5,\u226518.5 to 25, &gt;\u200925). Serum cytokines including IL-2, IL-4, IL-10, IL-17, INF-\u03b3, TNF-\u03b1 levels were measured using Flowcytometry assay. Clinical information was extracted from medical records. Serum IL-35 level in overweight patients were significantly decreased than those in lean patients. Furthermore, Th1\/Th2\/Th17-related cytokines from overweight patients with RA showed the characteristic immunological features. Serum IL-6, IL-17 and TNF-\u03b1 levels were positively correlated with BMI. However, serum IL-2, IL-4, IL-10 and IFN-\u03b3 concentrations were not correlated with BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quantitative changes in serum IL-35 level were characteristic in overweight patients with RA. These findings indicate that IL-35 plays an important role in the development of RA and may prove to be a potential biomarker of active RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12865-021-00431-x","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T09:02:27Z","timestamp":1624784547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Serum IL-35 is decreased in overweight patients with rheumatoid arthritis: its correlation with Th1\/Th2\/Th17-related cytokines"],"prefix":"10.1186","volume":"22","author":[{"given":"Yuxuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"issue":"2","key":"431_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/art.30136","volume":"63","author":"R Klaasen","year":"2011","unstructured":"Klaasen R, Wijbrandts CA, Gerlag DM, Tak PP. 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