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Rev-erb\u03b1, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism. Macrophage polarization plays crucial roles in immune tolerance at the maternal-fetus interface, which also modulates the initiation and resolution of inflammation. Alteration of macrophage polarization induces adverse pregnancy outcomes such as infertility, recurrent spontaneous abortion and preterm labor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Decidual macrophages from LPS-induced mice abortion model displayed M1-like bias, accompanied by decreased expression of Rev-erb\u03b1. SR9009, an agonist of Rev-erb\u03b1, may reduce lipopolysaccharide (LPS)-induced M1 polarization of macrophages via activation of PI3K but not NF-\u03baB signaling pathway. Furthermore, SR9009 could reduce M1-like polarization of decidual macrophages induced by LPS and attenuate LPS-induced resorption rates in mice model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both in vivo and in vitro experiments demonstrated that the pharmacological activation of Rev-erb\u03b1 using SR9009 could attenuate the effect of LPS on macrophage polarization and protect pregnancy. This study may provide a potential therapeutic strategy for miscarriage induced by inflammation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12865-021-00438-4","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T16:03:57Z","timestamp":1629129837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacological activation of rev-erb\u03b1 suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss"],"prefix":"10.1186","volume":"22","author":[{"given":"Liyuan","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songcun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"issue":"1","key":"438_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/dvdy.20605","volume":"235","author":"RP Metz","year":"2006","unstructured":"Metz RP, Qu X, Laffin B, Earnest D, Porter WW. 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All animal protocols were approved by Institutional Animal Care and Use Committee at Fudan University, the ethics committee approval code was FE20053. This study does not involve the use of human data or tissue. All experiments were performed in accordance with relevant guidelines and regulations at Obstetrics and Gynecology Hospital of Fudan University. All mice were sacrificed by exsanguination under anesthesia by 5% isoflurane. The sacrificed mice were handed over to special departments for unified treatment. All procedures were approved by Institutional Animal Care and Use Committee at Fudan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors have not any conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}