{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:41:15Z","timestamp":1784770875210,"version":"3.55.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Factors associated with IgG levels in adults with IgG subclass deficiency (IgGSD) are incompletely understood. We studied adults with IgGSD with subnormal IgG1 only, subnormal IgG1\/IgG3, or subnormal IgG3 only without other subnormal IgG subclasses, IgA, or IgM. We compiled: age; sex; autoimmune condition(s) (AC); atopy; IgG, IgG subclasses, IgA, IgM; IgGsum (IgG1\u2009+\u2009IgG2\u2009+\u2009IgG3\u2009+\u2009IgG4); and D (percentage difference between IgGsum and IgG). We compared attributes of patients with\/without subnormal IgG (&lt;\u20097.00\u00a0g\/L; subnormal IgG1 subclass groups only) and analyzed IgGsum and IgG relationships. We performed backward stepwise regressions on IgG using independent variables IgG subclasses, age, and sex and on D using independent variables age and sex.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were 39 patients with subnormal IgG1 only (89.7% women), 53 with subnormal IgG1\/IgG3 (88.7% women), and 115 with subnormal IgG3 only (91.3% women). Fifteen patients (38.5%) and 32 patients (60.4%) in the respective subnormal IgG1 subclass groups had subnormal IgG. Attributes of patients with\/without IgG\u2009&lt;\u20097.00\u00a0g\/L were similar, except that AC prevalence was lower in patients with subnormal IgG1 only and IgG\u2009&lt;\u20097.00\u00a0g\/L than\u2009\u2265\u20097.00\u00a0g\/L (<jats:italic>p<\/jats:italic>\u2009=\u20090.0484). Mean\/median IgG1 and IgG2 were significantly lower in patients with IgG\u2009&lt;\u20097.00\u00a0g\/L in both subnormal IgG1 subclass groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001, all comparisons). Regressions on IgG in three subclass groups revealed positive associations with IgG1 and IgG2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 each association). Regressions on D revealed no significant association. IgG1 percentages of IgGsum were lower and IgG2 percentages were higher in patients with subnormal IgG1 subclass levels than subnormal IgG3 only (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 all comparisons).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We conclude that both IgG1 and IgG2 are major determinants of IgG in patients with subnormal IgG1, combined subnormal IgG1\/IgG3, or subnormal IgG3 and that in patients with subnormal IgG1 or combined subnormal IgG1\/IgG3, median IgG2 levels are significantly lower in those with IgG\u2009&lt;\u20097.00\u00a0g\/L than those with IgG\u2009\u2265\u20097.00\u00a0g\/L.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12865-021-00447-3","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T12:05:10Z","timestamp":1628510710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Factors associated with IgG levels in adults with IgG subclass deficiency"],"prefix":"10.1186","volume":"22","author":[{"given":"James C.","family":"Barton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Clayborn","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi F.","family":"Bertoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald T.","family":"Acton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"447_CR1","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","volume":"5","author":"G Vidarsson","year":"2014","unstructured":"Vidarsson G, Dekkers G, Rispens T. 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