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This study assessed antibody (IgG) responses against malaria parasite, <jats:italic>Pfs230<\/jats:italic> and PfEBA175-3R and vector, <jats:italic>gSG6-P1<\/jats:italic> in febrile individuals with variant Hb genotypes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study was conducted on symptomatic malaria patients attending various healthcare facilities throughout Ghana. Microscopy and ELISA were used to determine the natural IgG antibody levels of gSG6-P1, PfEBA175-3R &amp; Pfs230, and Capillarys 2 Flex Piercing was used for Hb variants determination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 600 symptomatic malaria patients, 50.0% of the participants had malaria parasites by microscopy. The majority 79.0% (398\/504) of the participants had Hb AA, followed by HbAS variant at 11.3% (57\/504) and HbAC 6.7% (34\/504). There were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) reduced levels of gSG6-P1 IgG in individuals with both HbAC and HbAS genotypes compared to the HbAA genotype. The levels of gSG6-P1 IgG were significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) higher in HbAS compared to HbAC. Similarly, Pfs230 IgG and PfEBA-175-3R IgG distributions observed across the haemoglobin variants were significantly higher in HbAC relative to HbAS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The study has shown that haemoglobin variants significantly influence the pattern of anti-gSG6-P1, Pfs230, and PfEBA-175 IgG levels in malaria-endemic population. The HbAS genotype is suggested to confer protection against malaria infection. Reduced exposure to infection ultimately reduces the induction of antibodies targeted against <jats:italic>P. falciparum<\/jats:italic> antigens.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12865-024-00607-1","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T16:02:13Z","timestamp":1707494533000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Immune responses to P falciparum antibodies in symptomatic malaria patients with variant hemoglobin genotypes in Ghana"],"prefix":"10.1186","volume":"25","author":[{"given":"Kwame Kumi","family":"Asare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Agrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiifi Solomon","family":"Ofori-Acquah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Kudzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nii Ayite","family":"Aryee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Eva","family":"Amoah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"issue":"4","key":"607_CR1","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1007\/s11686-022-00629-y","volume":"67","author":"RC Ehiem","year":"2022","unstructured":"Ehiem RC, Lawson BW, Larbi JA. 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All the methods were straightly carried out as approved by the IRB and in accordance with the relevant guidelines and regulations of the Helsinki Declaration 2013 (64th WMA General Assembly, Fortaleza, Brazil, October 2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}