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(Protocol numbers: CIRCB\/14\u2009\u2212\u200911\/DROS631-1112; 2014\/10\/499\/CE\/CNERSH\/SP; 2015\/03\/569\/CE\/CNERSH\/SP). All participants provided written informed consent. Data were processed using specific identifiers for privacy and confidentiality purposes. All methods were carried out in accordance with relevant guidelines and regulations. Clinical data generated during the course of this study were provided free of charge to all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"68"}}