{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:19:15Z","timestamp":1783135155267,"version":"3.54.6"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/211.003\/2019"],"award-info":[{"award-number":["E-26\/211.003\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Immunol"],"DOI":"10.1186\/s12865-024-00670-8","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T09:50:30Z","timestamp":1742464230000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HTLV-1-infected cells drive the differentiation of monocytes into macrophages in vitro"],"prefix":"10.1186","volume":"26","author":[{"given":"Sabrina","family":"de Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Affonso","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Cal\u00f4ba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara Salgado","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Vieira","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabianno Ferreira","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Meirelles","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Echevarria-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"issue":"8452","key":"670_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/s0140-6736(85)92734-5","volume":"2","author":"A Gessain","year":"1985","unstructured":"Gessain A, Barin F, Vernant JC, et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 1985;2(8452):407\u201310. https:\/\/doi.org\/10.1016\/s0140-6736(85)92734-5.","journal-title":"Lancet"},{"issue":"12","key":"670_CR2","doi-asserted-by":"publisher","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","volume":"77","author":"BJ Poiesz","year":"1980","unstructured":"Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980;77(12):7415\u20139. https:\/\/doi.org\/10.1073\/pnas.77.12.7415.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"670_CR3","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","volume":"3","author":"A Gessain","year":"2012","unstructured":"Gessain A, Cassar O. Epidemiological aspects and world distribution of HTLV-1 infection. Front Microbiol. 2012;3:388. https:\/\/doi.org\/10.3389\/fmicb.2012.00388.","journal-title":"Front Microbiol"},{"issue":"12","key":"670_CR4","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/S1474-4422(06)70628-7","volume":"5","author":"AQC Araujo","year":"2006","unstructured":"Araujo AQC, Silva MTT. The HTLV-1 neurological complex. Lancet Neurol. 2006;5(12):1068\u201376. https:\/\/doi.org\/10.1016\/S1474-4422(06)70628-7.","journal-title":"Lancet Neurol"},{"key":"670_CR5","unstructured":"Fuzii HT, da Silva Dias GA, de Barros RJ, Falc\u00e3o LF, Quaresma JA. Immunopathogenesis of HTLV-1-assoaciated myelopathy\/tropical spastic paraparesis (HAM\/TSP) - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/24704970\/. Accessed 12 Dec 2023."},{"issue":"5","key":"670_CR6","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/ana.1264","volume":"50","author":"AH Alamy","year":"2001","unstructured":"Alamy AH, Menezes FB, Leite AC, Nascimento OM, Ara\u00fajo AQ. Dysautonomia in human T-cell lymphotrophic virus type I-associated myelopathy\/tropical spastic paraparesis. Ann Neurol. 2001;50(5):681\u20135. https:\/\/doi.org\/10.1002\/ana.1264.","journal-title":"Ann Neurol"},{"issue":"8","key":"670_CR7","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1136\/jnnp.74.8.1085","volume":"74","author":"MTT Silva","year":"2003","unstructured":"Silva MTT, Mattos P, Alfano A, Ara\u00fajo AQC. Neuropsychological assessment in HTLV-1 infection: a comparative study among TSP\/HAM, asymptomatic carriers, and healthy controls. J Neurol Neurosurg Psychiatry. 2003;74(8):1085\u20139. https:\/\/doi.org\/10.1136\/jnnp.74.8.1085.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"670_CR8","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00415-004-0455-7","volume":"251","author":"ACC Leite","year":"2004","unstructured":"Leite ACC, Silva MTT, Alamy AH, et al. Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis\/HTLV-I-associated myelopathy. J Neurol. 2004;251(7):877\u201381. https:\/\/doi.org\/10.1007\/s00415-004-0455-7.","journal-title":"J Neurol"},{"issue":"3","key":"670_CR9","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1128\/cdli.1.3.273-282.1994","volume":"1","author":"HE Prince","year":"1994","unstructured":"Prince HE, York J, Golding J, Owen SM, Lal RB. Spontaneous lymphocyte proliferation in human T-cell lymphotropic virus type I (HTLV-I) and HTLV-II infection: T-cell subset responses and their relationships to the presence of provirus and viral antigen production. Clin Diagn Lab Immunol. 1994;1(3):273\u201382. https:\/\/doi.org\/10.1128\/cdli.1.3.273-282.1994.","journal-title":"Clin Diagn Lab Immunol"},{"issue":"10","key":"670_CR10","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1182\/blood.v97.10.3177","volume":"97","author":"J-i Yasunaga","year":"2001","unstructured":"Yasunaga J-i, Sakai T, Nosaka K, et al. Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state. Blood. 2001;97(10):3177\u201383. https:\/\/doi.org\/10.1182\/blood.v97.10.3177.","journal-title":"Blood"},{"issue":"4","key":"670_CR11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nrc2111","volume":"7","author":"M Matsuoka","year":"2007","unstructured":"Matsuoka M, Jeang KT. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer. 2007;7(4):270\u201380. https:\/\/doi.org\/10.1038\/nrc2111.","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"670_CR12","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1002\/ana.10065","volume":"50","author":"M Nagai","year":"2001","unstructured":"Nagai M, Yamano Y, Brennan MB, Mora CA, Jacobson S. Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8\u2009+\u2009T cells in cerebrospinal fluid from patients with HAM\/TSP. Ann Neurol. 2001;50(6):807\u201312. https:\/\/doi.org\/10.1002\/ana.10065.","journal-title":"Ann Neurol"},{"issue":"9","key":"670_CR13","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1089\/aid.1992.8.1699","volume":"8","author":"SE Macatonia","year":"1992","unstructured":"Macatonia SE, Cruickshank JK, Rudge P, Knight SC. Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation. AIDS Res Hum Retroviruses. 1992;8(9):1699\u2013706. https:\/\/doi.org\/10.1089\/aid.1992.8.1699.","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"670_CR14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/viro.2000.0445","volume":"274","author":"M Makino","year":"2000","unstructured":"Makino M, Wakamatsu S, Shimokubo S, Arima N, Baba M. Production of functionally deficient dendritic cells from HTLV-I-infected monocytes: implications for the dendritic cell defect in adult T cell leukemia. Virology. 2000;274(1):140\u20138.","journal-title":"Virology"},{"issue":"5","key":"670_CR15","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/j.1365-2141.2004.04956.x","volume":"125","author":"M Hishizawa","year":"2004","unstructured":"Hishizawa M, Imada K, Kitawaki T, Ueda M, Kadowaki N, Uchiyama T. Depletion and impaired interferon-alpha-producing capacity of blood plasmacytoid dendritic cells in human T-cell leukaemia virus type I-infected individuals. Br J Haematol. 2004;125(5):568\u201375. https:\/\/doi.org\/10.1111\/j.1365-2141.2004.04956.x.","journal-title":"Br J Haematol"},{"issue":"2","key":"670_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1182\/blood-2010-03-272690","volume":"117","author":"CR Nascimento","year":"2011","unstructured":"Nascimento CR, Lima MA, de Andrada Serpa MJ, Espindola O, Leite ACC, Echevarria-Lima J. Monocytes from HTLV-1-infected patients are unable to fully mature into dendritic cells. Blood. 2011;117(2):489\u201399. https:\/\/doi.org\/10.1182\/blood-2010-03-272690.","journal-title":"Blood"},{"issue":"1","key":"670_CR17","doi-asserted-by":"publisher","first-page":"14354","DOI":"10.1038\/s41598-018-32324-2","volume":"8","author":"J Echevarria-Lima","year":"2018","unstructured":"Echevarria-Lima J, de Abreu Pereira D, de Oliveira TS, et al. Protein profile of blood monocytes is altered in HTLV-1 infected patients: implications for HAM\/TSP disease. Sci Rep. 2018;8(1):14354. https:\/\/doi.org\/10.1038\/s41598-018-32324-2.","journal-title":"Sci Rep"},{"issue":"1","key":"670_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2220\/biomedres.31.53","volume":"31","author":"H Takeuchi","year":"2010","unstructured":"Takeuchi H, Takahashi M, Norose Y, Takeshita T, Fukunaga Y, Takahashi H. Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I transmission via breastfeeding. Biomed Res. 2010;31(1):53\u201361. https:\/\/doi.org\/10.2220\/biomedres.31.53.","journal-title":"Biomed Res"},{"key":"670_CR19","doi-asserted-by":"publisher","first-page":"15012","DOI":"10.1038\/nrdp.2015.12","volume":"1","author":"CRM Bangham","year":"2015","unstructured":"Bangham CRM, Araujo A, Yamano Y, Taylor GP. HTLV-1-associated myelopathy\/tropical spastic paraparesis. Nat Rev Dis Primers. 2015;1:15012. https:\/\/doi.org\/10.1038\/nrdp.2015.12.","journal-title":"Nat Rev Dis Primers"},{"issue":"Pt 9","key":"670_CR20","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1093\/brain\/awt183","volume":"136","author":"H Ando","year":"2013","unstructured":"Ando H, Sato T, Tomaru U, et al. Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy. Brain. 2013;136(Pt 9):2876\u201387. https:\/\/doi.org\/10.1093\/brain\/awt183.","journal-title":"Brain"},{"key":"670_CR21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1742-4690-9-16","volume":"9","author":"Y Enose-Akahata","year":"2012","unstructured":"Enose-Akahata Y, Matsuura E, Tanaka Y, Oh U, Jacobson S. Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease. Retrovirology. 2012;9:16. https:\/\/doi.org\/10.1186\/1742-4690-9-16.","journal-title":"Retrovirology"},{"issue":"4","key":"670_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1084\/jem.20132423","volume":"212","author":"L Gao","year":"2015","unstructured":"Gao L, Brenner D, Llorens-Bobadilla E, et al. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med. 2015;212(4):469\u201380. https:\/\/doi.org\/10.1084\/jem.20132423.","journal-title":"J Exp Med"},{"issue":"10","key":"670_CR23","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/nn.2923","volume":"14","author":"M Prinz","year":"2011","unstructured":"Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci. 2011;14(10):1227\u201335. https:\/\/doi.org\/10.1038\/nn.2923.","journal-title":"Nat Neurosci"},{"issue":"4","key":"670_CR24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nm1745","volume":"14","author":"KS Jones","year":"2008","unstructured":"Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med. 2008;14(4):429\u201336. https:\/\/doi.org\/10.1038\/nm1745.","journal-title":"Nat Med"},{"issue":"15","key":"670_CR25","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1182\/blood-2009-02-203042","volume":"114","author":"K Azakami","year":"2009","unstructured":"Azakami K, Sato T, Araya N, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114(15):3208\u201315. https:\/\/doi.org\/10.1182\/blood-2009-02-203042.","journal-title":"Blood"},{"issue":"1","key":"670_CR26","first-page":"1","volume":"49","author":"HW Ziegler-Heitbrock","year":"1989","unstructured":"Ziegler-Heitbrock HW. The biology of the monocyte system. Eur J Cell Biol. 1989;49(1):1\u201312.","journal-title":"Eur J Cell Biol"},{"issue":"6","key":"670_CR27","doi-asserted-by":"publisher","first-page":"e2516","DOI":"10.1371\/journal.pone.0002516","volume":"3","author":"P Ancuta","year":"2008","unstructured":"Ancuta P, Kamat A, Kunstman KJ, et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One. 2008;3(6):e2516. https:\/\/doi.org\/10.1371\/journal.pone.0002516.","journal-title":"PLoS One"},{"issue":"11","key":"670_CR28","doi-asserted-by":"publisher","first-page":"e146215","DOI":"10.1172\/jci.insight.146215","volume":"6","author":"RT Veenhuis","year":"2021","unstructured":"Veenhuis RT, Williams DW, Shirk EN, et al. Higher circulating intermediate monocytes are associated with cognitive function in women with HIV. JCI Insight. 2021;6(11):e146215. https:\/\/doi.org\/10.1172\/jci.insight.146215.","journal-title":"JCI Insight"},{"issue":"5","key":"670_CR29","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1128\/JVI.02735-15","volume":"90","author":"MF de Castro-Amarante","year":"2015","unstructured":"de Castro-Amarante MF, Pise-Masison CA, McKinnon K, et al. Human T cell leukemia virus type 1 infection of the three monocyte subsets contributes to viral burden in humans. J Virol. 2015;90(5):2195\u2013207. https:\/\/doi.org\/10.1128\/JVI.02735-15.","journal-title":"J Virol"},{"issue":"2","key":"670_CR30","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1128\/jvi.77.2.963-969.2003","volume":"77","author":"FJ Kim","year":"2003","unstructured":"Kim FJ, Manel N, Boublik Y, Battini JL, Sitbon M. Human T-cell leukemia virus type 1 envelope-mediated syncytium formation can be activated in resistant mammalian cell lines by a carboxy-terminal truncation of the envelope cytoplasmic domain. J Virol. 2003;77(2):963\u20139. https:\/\/doi.org\/10.1128\/jvi.77.2.963-969.2003.","journal-title":"J Virol"},{"issue":"7","key":"670_CR31","doi-asserted-by":"publisher","first-page":"e69270","DOI":"10.1371\/journal.pone.0069270","volume":"8","author":"DW Williams","year":"2013","unstructured":"Williams DW, Calderon TM, Lopez L, et al. Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14\u2009+\u2009CD16\u2009+\u2009monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis. PLoS One. 2013;8(7):e69270. https:\/\/doi.org\/10.1371\/journal.pone.0069270.","journal-title":"PLoS One"},{"issue":"6","key":"670_CR32","first-page":"978","volume":"72","author":"I Miyoshi","year":"1981","unstructured":"Miyoshi I, Kubonishi I, Yoshimoto S, Shiraishi Y. A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells. Gan. 1981;72(6):978\u201381.","journal-title":"Gan"},{"issue":"1","key":"670_CR33","doi-asserted-by":"publisher","first-page":"e8668","DOI":"10.1371\/journal.pone.0008668","volume":"5","author":"M Daigneault","year":"2010","unstructured":"Daigneault M, Preston JA, Marriott HM, Whyte MKB, Dockrell DH. The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages. PLoS One. 2010;5(1):e8668. https:\/\/doi.org\/10.1371\/journal.pone.0008668.","journal-title":"PLoS One"},{"issue":"6","key":"670_CR34","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/ijc.2910330606","volume":"33","author":"H Yoshikura","year":"1984","unstructured":"Yoshikura H, Nishida J, Yoshida M, Kitamura Y, Takaku F, Ikeda S. Isolation of HTLV derived from Japanese adult T-cell leukemia patients in human diploid fibroblast strain IMR90 and the biological characters of the infected cells. Int J Cancer. 1984;33(6):745\u20139. https:\/\/doi.org\/10.1002\/ijc.2910330606.","journal-title":"Int J Cancer"},{"issue":"6","key":"670_CR35","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1182\/blood.V81.6.1598.1598","volume":"81","author":"T de Revel","year":"1993","unstructured":"de Revel T, Mabondzo A, Gras G, Delord B, Roques P, Boussin F, et al. In vitro infection of human macrophages with human T-cell leukemia virus type 1. Blood. 1993;81(6):1598\u2013606. https:\/\/doi.org\/10.1182\/blood.V81.6.1598.1598.","journal-title":"Blood"},{"issue":"4","key":"670_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 2001;25(4):402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"issue":"1","key":"670_CR37","doi-asserted-by":"publisher","first-page":"e1002480","DOI":"10.1371\/journal.ppat.1002480","volume":"8","author":"S Tattermusch","year":"2012","unstructured":"Tattermusch S, Skinner JA, Chaussabel D, et al. Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy. PLoS Pathog. 2012;8(1):e1002480. https:\/\/doi.org\/10.1371\/journal.ppat.1002480.","journal-title":"PLoS Pathog"},{"issue":"12","key":"670_CR38","doi-asserted-by":"publisher","first-page":"e0208602","DOI":"10.1371\/journal.pone.0208602","volume":"13","author":"KY Gerrick","year":"2018","unstructured":"Gerrick KY, Gerrick ER, Gupta A, Wheelan SJ, Yegnasubramanian S, Jaffee EM. Transcriptional profiling identifies novel regulators of macrophage polarization. PLoS One. 2018;13(12):e0208602. https:\/\/doi.org\/10.1371\/journal.pone.0208602.","journal-title":"PLoS One"},{"issue":"14","key":"670_CR39","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","volume":"23","author":"S Davis","year":"2007","unstructured":"Davis S, Meltzer PS. GEOquery: a bridge between the Gene expression Omnibus (GEO) and BioConductor. Bioinformatics. 2007;23(14):1846\u20137. https:\/\/doi.org\/10.1093\/bioinformatics\/btm254.","journal-title":"Bioinformatics"},{"issue":"3","key":"670_CR40","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1002\/imt2.43","volume":"1","author":"Z Gu","year":"2022","unstructured":"Gu Z. Complex heatmap visualization. iMeta. 2022;1(3):e43. https:\/\/doi.org\/10.1002\/imt2.43.","journal-title":"iMeta"},{"issue":"17","key":"670_CR41","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.1093\/bioinformatics\/btac449","volume":"38","author":"Z Gu","year":"2022","unstructured":"Gu Z, H\u00fcbschmann D. Pkgndep: a tool for analyzing dependency heaviness of R packages. Bioinformatics. 2022;38(17):4248\u201351. https:\/\/doi.org\/10.1093\/bioinformatics\/btac449.","journal-title":"Bioinformatics"},{"key":"670_CR42","doi-asserted-by":"publisher","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","volume":"877","author":"C Yunna","year":"2020","unstructured":"Yunna C, Mengru H, Lei W, Weidong C. Macrophage M1\/M2 polarization. Eur J Pharmacol. 2020;877:173090. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173090.","journal-title":"Eur J Pharmacol"},{"issue":"11 Pt A","key":"670_CR43","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1016\/j.bbamcr.2017.05.010","volume":"1864","author":"B Fingleton","year":"2017","unstructured":"Fingleton B. Matrix metalloproteinases as regulators of inflammatory processes. Biochim Biophys Acta Mol Cell Res. 2017;1864(11 Pt A):2036\u201342. https:\/\/doi.org\/10.1016\/j.bbamcr.2017.05.010.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"51","key":"670_CR44","doi-asserted-by":"publisher","first-page":"51340","DOI":"10.1074\/jbc.M310865200","volume":"278","author":"JR Worley","year":"2003","unstructured":"Worley JR, Baugh MD, Hughes DA, et al. Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. J Biol Chem. 2003;278(51):51340\u20136. https:\/\/doi.org\/10.1074\/jbc.M310865200.","journal-title":"J Biol Chem"},{"issue":"11","key":"670_CR45","doi-asserted-by":"publisher","first-page":"a028423","DOI":"10.1101\/cshperspect.a028423","volume":"10","author":"H Negishi","year":"2018","unstructured":"Negishi H, Taniguchi T, Yanai H. The interferon (IFN) class of cytokines and the IFN regulatory factor (IRF) transcription factor family. Cold Spring Harb Perspect Biol. 2018;10(11):a028423. https:\/\/doi.org\/10.1101\/cshperspect.a028423.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"670_CR46","doi-asserted-by":"publisher","first-page":"e01291","DOI":"10.1128\/JVI.01291-18","volume":"93","author":"HC Lee","year":"2019","unstructured":"Lee HC, Lee ES, Uddin MB, et al. Released tryptophanyl-tRNA synthetase stimulates Innate Immune responses against viral infection. J Virol. 2019;93(2):e01291\u201318. https:\/\/doi.org\/10.1128\/JVI.01291-18.","journal-title":"J Virol"},{"issue":"1","key":"670_CR47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1385\/nmm:9:1:55","volume":"9","author":"EL Paley","year":"2007","unstructured":"Paley EL, Denisova G, Sokolova O, Posternak N, Wang X, Brownell AL. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. Neuromolecular Med. 2007;9(1):55\u201382. https:\/\/doi.org\/10.1385\/nmm:9:1:55.","journal-title":"Neuromolecular Med"},{"issue":"5","key":"670_CR48","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1093\/brain\/awx058","volume":"140","author":"PC Tsai","year":"2017","unstructured":"Tsai PC, Soong BW, Mademan I, et al. A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy. Brain. 2017;140(5):1252\u201366. https:\/\/doi.org\/10.1093\/brain\/awx058.","journal-title":"Brain"},{"key":"670_CR49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1742-4690-5-9","volume":"5","author":"JM Bogenberger","year":"2008","unstructured":"Bogenberger JM, Laybourn PJ. Human T lymphotropic virus type 1 protein tax reduces histone levels. Retrovirology. 2008;5:9. https:\/\/doi.org\/10.1186\/1742-4690-5-9.","journal-title":"Retrovirology"},{"issue":"3\u20134","key":"670_CR50","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.bbagrm.2009.09.002","volume":"1799","author":"JK Nyborg","year":"2010","unstructured":"Nyborg JK, Egan D, Sharma N. The HTLV-1 tax protein: revealing mechanisms of transcriptional activation through histone acetylation and nucleosome disassembly. Biochim Biophys Acta. 2010;1799(3\u20134):266\u201374. https:\/\/doi.org\/10.1016\/j.bbagrm.2009.09.002.","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"670_CR51","doi-asserted-by":"publisher","first-page":"e3399","DOI":"10.1371\/journal.pntd.0003399","volume":"8","author":"CF Amorim","year":"2014","unstructured":"Amorim CF, Souza AS, Diniz AG, Carvalho NB, Santos SB, Carvalho EM. Functional activity of monocytes and macrophages in HTLV-1 infected subjects. PLoS Negl Trop Dis. 2014;8(12):e3399. https:\/\/doi.org\/10.1371\/journal.pntd.0003399.","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"670_CR52","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12977-019-0506-x","volume":"16","author":"B Rocamonde","year":"2019","unstructured":"Rocamonde B, Carcone A, Mahieux R, Dutartre H. HTLV-1 infection of myeloid cells: from transmission to immune alterations. Retrovirology. 2019;16(1):45. https:\/\/doi.org\/10.1186\/s12977-019-0506-x.","journal-title":"Retrovirology"},{"issue":"1","key":"670_CR53","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1038\/s41467-021-25101-9","volume":"12","author":"M Yamagishi","year":"2021","unstructured":"Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, Nakashima M, Makiyama J, Iwanaga M, Fukuda T, Watanabe T, Suzuki Y, Uchimaru K. Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. Nat Commun. 2021;12(1):4821. https:\/\/doi.org\/10.1038\/s41467-021-25101-9.","journal-title":"Nat Commun"},{"issue":"1","key":"670_CR54","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13046-016-0398-8","volume":"35","author":"MP Fuggetta","year":"2016","unstructured":"Fuggetta MP, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali-Fei P, Ensoli F, Ciafr\u00e8 S, Marino-Merlo F, Mastino A, Ravagnan G. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by resveratrol. J Exp Clin Cancer Res. 2016;35(1):118. https:\/\/doi.org\/10.1186\/s13046-016-0398-8.","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"670_CR55","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13577-018-00231-3","volume":"32","author":"H Nomura","year":"2019","unstructured":"Nomura H, Umekita K, Hashikura Y, Umeki K, Yamamoto I, Aratake Y, Saito M, Hasegawa H, Yanagihara K, Okayama A. Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production. Hum Cell. 2019;32(2):185\u201392. https:\/\/doi.org\/10.1007\/s13577-018-00231-3.","journal-title":"Hum Cell"},{"issue":"32","key":"670_CR56","doi-asserted-by":"publisher","first-page":"22284","DOI":"10.1074\/jbc.M114.549659","volume":"289","author":"E Jaworski","year":"2014","unstructured":"Jaworski E, Narayanan A, Van Duyne R, et al. Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein. J Biol Chem. 2014;289(32):22284\u2013305. https:\/\/doi.org\/10.1074\/jbc.M114.549659.","journal-title":"J Biol Chem"},{"key":"670_CR57","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jneuroim.2016.09.014","volume":"304","author":"E Matsuura","year":"2017","unstructured":"Matsuura E, Enose-Akahata Y, Yao K, et al. Dynamic acquisition of HTLV-1 tax protein by mononuclear phagocytes: role in neurologic disease. J Neuroimmunol. 2017;304:43\u201350. https:\/\/doi.org\/10.1016\/j.jneuroim.2016.09.014.","journal-title":"J Neuroimmunol"},{"issue":"7","key":"670_CR58","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1074\/jbc.M109.031476","volume":"285","author":"S Suzuki","year":"2010","unstructured":"Suzuki S, Zhou Y, Refaat A, et al. Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. J Biol Chem. 2010;285(7):4441\u20136. https:\/\/doi.org\/10.1074\/jbc.M109.031476.","journal-title":"J Biol Chem"},{"issue":"2","key":"670_CR59","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1349-7006.2011.02123.x","volume":"103","author":"M Yoshita","year":"2012","unstructured":"Yoshita M, Higuchi M, Takahashi M, Oie M, Tanaka Y, Fujii M. Activation of mTOR by human T-cell leukemia virus type 1 tax is important for the transformation of mouse T cells to interleukin-2-independent growth. Cancer Sci. 2012;103(2):369\u201374. https:\/\/doi.org\/10.1111\/j.1349-7006.2011.02123.x.","journal-title":"Cancer Sci"},{"issue":"3","key":"670_CR60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neurol.2011.12.006","volume":"168","author":"A Gessain","year":"2012","unstructured":"Gessain A, Mahieux R. Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects. Rev Neurol (Paris). 2012;168(3):257\u201369. https:\/\/doi.org\/10.1016\/j.neurol.2011.12.006.","journal-title":"Rev Neurol (Paris)"},{"issue":"9","key":"670_CR61","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.4049\/jimmunol.2001191","volume":"207","author":"N Gajanayaka","year":"2021","unstructured":"Gajanayaka N, Dong SXM, Ali H, et al. TLR-4 agonist induces IFN-\u03b3 production selectively in proinflammatory human M1 macrophages through the PI3K-mTOR- and JNK-MAPK-activated p70S6K pathway. J Immunol. 2021;207(9):2310\u201324. https:\/\/doi.org\/10.4049\/jimmunol.2001191.","journal-title":"J Immunol"},{"issue":"6","key":"670_CR62","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/v8060161","volume":"8","author":"CZ Giam","year":"2016","unstructured":"Giam CZ, Semmes OJ. HTLV-1 infection and adult T-cell leukemia\/lymphoma-a tale of two proteins: tax and HBZ. Viruses. 2016;8(6):161. https:\/\/doi.org\/10.3390\/v8060161.","journal-title":"Viruses"},{"key":"670_CR63","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/978-3-030-57362-1_10","volume":"217","author":"CZ Giam","year":"2021","unstructured":"Giam CZ. HTLV-1 replication and adult T cell leukemia development. Recent Results Cancer Res. 2021;217:209\u201343. https:\/\/doi.org\/10.1007\/978-3-030-57362-1_10.","journal-title":"Recent Results Cancer Res"},{"issue":"1","key":"670_CR64","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1038\/s41467-022-30029-9","volume":"13","author":"M Matsuo","year":"2022","unstructured":"Matsuo M, Ueno T, Monde K, et al. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Nat Commun. 2022;13(1):2405. https:\/\/doi.org\/10.1038\/s41467-022-30029-9.","journal-title":"Nat Commun"},{"issue":"3","key":"670_CR65","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1189\/jlb.1205723","volume":"80","author":"C Grant","year":"2006","unstructured":"Grant C, Jain P, Nonnemacher M, Flaig KE, Irish B, Ahuja J, et al. AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. J Leukoc Biol. 2006;80(3):640\u201350. https:\/\/doi.org\/10.1189\/jlb.1205723.","journal-title":"J Leukoc Biol"},{"issue":"1","key":"670_CR66","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13072-019-0279-4","volume":"12","author":"KF Dekkers","year":"2019","unstructured":"Dekkers KF, Neele AE, Jukema JW, Heijmans BT, de Winther MPJ. Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites. Epigenetics Chromatin. 2019;12(1):34. https:\/\/doi.org\/10.1186\/s13072-019-0279-4.","journal-title":"Epigenetics Chromatin"},{"issue":"6","key":"670_CR67","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/s13365-020-00919-z","volume":"27","author":"M Zarei Ghobadi","year":"2021","unstructured":"Zarei Ghobadi M, Mozhgani SH, Erfani Y. Identification of dysregulated pathways underlying HTLV-1-associated myelopathy\/tropical spastic paraparesis through co-expression network analysis. J Neurovirol. 2021;27(6):820\u201330. https:\/\/doi.org\/10.1007\/s13365-020-00919-z.","journal-title":"J Neurovirol"},{"issue":"12","key":"670_CR68","doi-asserted-by":"publisher","first-page":"7815","DOI":"10.4049\/jimmunol.174.12.7815","volume":"174","author":"F Ossendorp","year":"2005","unstructured":"Ossendorp F, Fu N, Camps M, Granucci F, Gobin SJ, van den Elsen PJ, Schuurhuis D, Adema GJ, Lipford GB, Chiba T, Sijts A, Kloetzel PM, Ricciardi-Castagnoli P, Melief CJ. Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. J Immunol. 2005;174(12):7815\u201322. https:\/\/doi.org\/10.4049\/jimmunol.174.12.7815.","journal-title":"J Immunol"},{"issue":"7","key":"670_CR69","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1182\/blood-2010-06-291898","volume":"117","author":"S Kanada","year":"2011","unstructured":"Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K. Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood. 2011;117(7):2211\u201322. https:\/\/doi.org\/10.1182\/blood-2010-06-291898.","journal-title":"Blood"},{"issue":"12","key":"670_CR70","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1093\/intimm\/13.12.1515","volume":"13","author":"J Li","year":"2001","unstructured":"Li J, Schuler-Thurner B, Schuler G, Huber C, Seliger B. Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation. Int Immunol. 2001;13(12):1515\u201323. https:\/\/doi.org\/10.1093\/intimm\/13.12.1515.","journal-title":"Int Immunol"},{"issue":"2","key":"670_CR71","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.humimm.2003.11.002","volume":"65","author":"Y Jin","year":"2004","unstructured":"Jin Y, Fuller L, Ciancio G, et al. Antigen presentation and immune regulatory capacity of immature and mature-enriched antigen presenting (dendritic) cells derived from human bone marrow. Hum Immunol. 2004;65(2):93\u2013103. https:\/\/doi.org\/10.1016\/j.humimm.2003.11.002.","journal-title":"Hum Immunol"},{"key":"670_CR72","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.3389\/fimmu.2019.02499","volume":"10","author":"MF Ferrer","year":"2019","unstructured":"Ferrer MF, Thomas P, L\u00f3pez Ortiz AO, et al. Junin virus triggers macrophage activation and modulates polarization according to viral strain pathogenicity. Front Immunol. 2019;10:2499. https:\/\/doi.org\/10.3389\/fimmu.2019.02499.","journal-title":"Front Immunol"},{"issue":"4","key":"670_CR73","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1159\/000460294","volume":"9","author":"J Feng","year":"2017","unstructured":"Feng J, Cao Z, Wang L, et al. Inducible GBP5 mediates the antiviral response via interferon-related pathways during influenza a virus infection. J Innate Immun. 2017;9(4):419\u201335. https:\/\/doi.org\/10.1159\/000460294.","journal-title":"J Innate Immun"},{"issue":"6080","key":"670_CR74","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.1217141","volume":"336","author":"AR Shenoy","year":"2012","unstructured":"Shenoy AR, Wellington DA, Kumar P, et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 2012;336(6080):481\u20135. https:\/\/doi.org\/10.1126\/science.1217141.","journal-title":"Science"},{"issue":"10","key":"670_CR75","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.3390\/v14102146","volume":"14","author":"NL Freitas","year":"2022","unstructured":"Freitas NL, Gomes YCP, Souza FDS, et al. Lessons from the cerebrospinal fluid analysis of HTLV-1-infected individuals: biomarkers of inflammation for HAM\/TSP development. Viruses. 2022;14(10):2146. https:\/\/doi.org\/10.3390\/v14102146.","journal-title":"Viruses"},{"issue":"7","key":"670_CR76","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.it.2022.04.008","volume":"43","author":"RY Ma","year":"2022","unstructured":"Ma RY, Black A, Qian BZ. Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022;43(7):546\u201363. https:\/\/doi.org\/10.1016\/j.it.2022.04.008.","journal-title":"Trends Immunol"}],"container-title":["BMC Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12865-024-00670-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12865-024-00670-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12865-024-00670-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T09:50:41Z","timestamp":1742464241000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/s12865-024-00670-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1186\/s12865-024-00670-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4359860\/v1","asserted-by":"object"}]},"ISSN":["1471-2172"],"issn-type":[{"value":"1471-2172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,20]]},"assertion":[{"value":"2 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24"}}