{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:19:21Z","timestamp":1790756361717,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471600"],"award-info":[{"award-number":["31471600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31530054"],"award-info":[{"award-number":["31530054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12866-016-0895-0","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T08:00:42Z","timestamp":1480060842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The gut microbiota in young and middle-aged rats showed different responses to chicken protein in their diet"],"prefix":"10.1186","volume":"16","author":[{"given":"Yingying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"895_CR1","doi-asserted-by":"crossref","unstructured":"O\u2019Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006;7(7):688\u2013693.","DOI":"10.1038\/sj.embor.7400731"},{"key":"895_CR2","doi-asserted-by":"crossref","unstructured":"Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997;65(5):1397\u20131402.","DOI":"10.1093\/ajcn\/65.5.1397"},{"key":"895_CR3","doi-asserted-by":"crossref","unstructured":"Franceschi C, Bonaf\u00e8 M, Valensin S, Olivieri F, de Luca M, Ottaviani E, et al. Inflamm\u2010aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908(1):244\u2013254.","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"issue":"2","key":"895_CR4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.arr.2007.09.002","volume":"7","author":"A Salminen","year":"2008","unstructured":"Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev. 2008;7(2):83\u2013105.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"895_CR5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/MCO.0b013e3282f2bfdf","volume":"11","author":"Y Guigoz","year":"2008","unstructured":"Guigoz Y, Dor\u00e9 J, Schiffrin EJ. The inflammatory status of old age can be nurtured from the intestinal environment. Curr Opin Clin Nutr. 2008;11(1):13\u201320.","journal-title":"Curr Opin Clin Nutr"},{"issue":"1","key":"895_CR6","first-page":"68","volume":"3","author":"AJ Reber","year":"2012","unstructured":"Reber AJ, Chirkova T, Kim JH, Cao W, Biber R, Shay DK, et al. Immunosenescence and challenges of vaccination against influenza in the aging population. Aging Dis. 2012;3(1):68\u201390.","journal-title":"Aging Dis"},{"issue":"Suppl 2","key":"895_CR7","doi-asserted-by":"crossref","first-page":"B16","DOI":"10.1016\/j.numecd.2010.12.008","volume":"21","author":"JA Gilbert","year":"2011","unstructured":"Gilbert JA, Bendsen NT, Tremblay A, Astrup A. Effect of proteins from different sources on body composition. Nutr Metab Cardiovasc Dis. 2011;21 Suppl 2:B16\u201331.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"895_CR8","doi-asserted-by":"crossref","unstructured":"Schulze MB, Manson JE, Willett WC, Hu FB. Processed meat intake and incidence of Type 2 diabetes in younger and middle-aged women. Diabetologia. 2003;46(11):1465\u20131473.","DOI":"10.1007\/s00125-003-1220-7"},{"key":"895_CR9","unstructured":"Chen J, Stampfer MJ, Hough HL, Garcia-Closas M, Willett WC, Hennekens CH, Kelsey KT, Hunter DJ. A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer. Cancer Res. 1998;58(15):3307\u20133311."},{"key":"895_CR10","doi-asserted-by":"publisher","unstructured":"Zhu Y, Lin X, Zhao F, Shi X, Li H, Li Y, et al. Meat, dairy and plant proteins alter bacterial composition of rat gut bacteria. Sci Rep. 2015;5:15220. doi: 10.1038\/srep15220 .","DOI":"10.1038\/srep15220"},{"key":"895_CR11","unstructured":"Flurkey KM, Currer J, Harrison DE. Chapter 20 - mouse models in aging research A2 - Fox, James G. In: Davisson MT, Quimby FW, Barthold SW, Newcomer CE, Smith AL, editors. The mouse in biomedical research. 2nd ed. Burlington: Academic; 2007. p. 637\u2013672."},{"key":"895_CR12","doi-asserted-by":"crossref","unstructured":"Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123(11):1939\u20131951.","DOI":"10.1093\/jn\/123.11.1939"},{"key":"895_CR13","doi-asserted-by":"publisher","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60. doi: 10.1186\/gb-2011-12-6-r60 .","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"895_CR14","doi-asserted-by":"crossref","unstructured":"Million M, Lagier JC, Yahav D, Paul M. Gut bacterial microbiota and obesity. Clin Microbiol Infect. 2013;19(4):305\u2013313.","DOI":"10.1111\/1469-0691.12172"},{"key":"895_CR15","doi-asserted-by":"crossref","unstructured":"Song S, Hooiveld GJEJ, Li M, Zhao F, Zhang W, Xu X, et al. Distinct physiological, plasma amino acid, and liver transcriptome responses to purified dietary beef, chicken, fish, and pork proteins in young rats. Mol Nutr Food Res. 2016;60:1199\u20131205.","DOI":"10.1002\/mnfr.201500789"},{"key":"895_CR16","doi-asserted-by":"crossref","unstructured":"Zhao L. The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol. 2013;11:639\u2013647.","DOI":"10.1038\/nrmicro3089"},{"key":"895_CR17","doi-asserted-by":"crossref","unstructured":"Schwiertz A, Taras D, Schafer K, Beijer S, Bos NA, Donus C, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity. 2010;18(1):190\u2013195.","DOI":"10.1038\/oby.2009.167"},{"key":"895_CR18","doi-asserted-by":"crossref","unstructured":"Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr. 2008;88(4):894\u2013899.","DOI":"10.1093\/ajcn\/88.4.894"},{"key":"895_CR19","doi-asserted-by":"crossref","unstructured":"Lee BJ, Bak YT. Irritable bowel syndrome, gut microbiota and probiotics. J Neurogastroenterol Motil. 2011;17(3):252\u2013266.","DOI":"10.5056\/jnm.2011.17.3.252"},{"key":"895_CR20","doi-asserted-by":"crossref","unstructured":"Marco ML, de Vries MC, Wels M, Molenaar D, Mangell P, Ahrne S, et al. Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice. ISME J. 2010;4(11):1481\u20131484.","DOI":"10.1038\/ismej.2010.61"},{"key":"895_CR21","doi-asserted-by":"crossref","unstructured":"Zweigner J, Schumann RR, Weber JR. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect. 2006;8(3):946\u2013952.","DOI":"10.1016\/j.micinf.2005.10.006"},{"key":"895_CR22","doi-asserted-by":"crossref","unstructured":"Martens EC, Koropatkin NM, Smith TJ, Gordon JI. Complex glycan catabolism by the human gut microbiota: the Bacteroidetes Sus-like paradigm. J Biol Chem. 2009;284(37):24673\u201324677.","DOI":"10.1074\/jbc.R109.022848"},{"key":"895_CR23","doi-asserted-by":"crossref","unstructured":"Leitch EC, Walker AW, Duncan SH, Holtrop G, Flint HJ. Selective colonization of insoluble substrates by human faecal bacteria. Environ Microbiol. 2007;9(3):667\u2013679.","DOI":"10.1111\/j.1462-2920.2006.01186.x"},{"issue":"7","key":"895_CR24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrmicro3050","volume":"11","author":"AE Kaoutari","year":"2013","unstructured":"Kaoutari AE, Armougom F, Gordon JI, Raoult D, Henrissat B. The abundance and variety of carbohydrate-active enzymes in the human gut microbiota. Nat Rev Microbiol. 2013;11(7):497\u2013504.","journal-title":"Nat Rev Microbiol"},{"key":"895_CR25","doi-asserted-by":"crossref","unstructured":"Ze X, Duncan SH, Louis P, Flint HJ. Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon. ISME J. 2012;6(8):1535\u20131543.","DOI":"10.1038\/ismej.2012.4"},{"issue":"1","key":"895_CR26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.phrs.2012.10.005","volume":"69","author":"E Biagi","year":"2013","unstructured":"Biagi E, Candela M, Turroni S, Garagnani P, Franceschi C, Brigidi P. Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res. 2013;69(1):11\u201320.","journal-title":"Pharmacol Res"},{"key":"895_CR27","doi-asserted-by":"crossref","unstructured":"Paddon-Jones D, Campbell WW, Jacques PF, Kritchevsky SB, Moore LL, Rodriguez NR, et al. Protein and healthy aging. Am J Clin Nutr. 2015;101(6):1339S\u20131345S.","DOI":"10.3945\/ajcn.114.084061"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-016-0895-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T19:53:08Z","timestamp":1568577188000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-016-0895-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,25]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["895"],"URL":"https:\/\/doi.org\/10.1186\/s12866-016-0895-0","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,25]]},"article-number":"281"}}