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Eradication of these carcinogenic bacteria from the gut is one of the challenges for clinicians. The complexity of treatment mainly owes to antibiotic resistance and relapse due to an additional reservoir in the oral cavity. Our study emphases the isolation of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      from distinct habitats of the gut microenvironment (gastric biopsy and gastric juice) and its subsequent characterization. We have also evaluated the effect of various oral rinses on isolated\n                      <jats:italic>H. pylori<\/jats:italic>\n                      from different anatomical locations of included subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The possible strains isolated from two different habitats of the same subject shows a striking difference in their growth pattern. Promisingly, some of the included oral rinses are efficient in growth inhibition as per recommended 30\u2009s treatment. The subsequent evaluation shows that oral rinse B (among A-E) is most effective and down-regulates the expression of one of the potent\n                      <jats:italic>H. pylori<\/jats:italic>\n                      gene, CagA, in the infected gastric adenocarcinoma (AGS) cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study, for the first time, revealed that\n                      <jats:italic>H. pylori,<\/jats:italic>\n                      isolated from the different habitat of the same subject, show a different growth pattern. The expression of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      pathogenic gene (CagA) was down-regulated by the use of oral rinses. Hence, oral rinses will reduce the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      in the oral cavity and help to control its migration from oral to the gastric compartment and may be used as an adjuvant treatment option for its re-infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01728-4","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T06:03:08Z","timestamp":1583301788000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Oral rinses in growth inhibition and treatment of Helicobacter pylori infection"],"prefix":"10.1186","volume":"20","author":[{"given":"Dharmendra","family":"Kashyap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budhadev","family":"Baral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Prakash","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charu","family":"Sonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debi","family":"Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hem C.","family":"Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"1728_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nrgastro.2010.154","volume":"7","author":"Y Yamaoka","year":"2010","unstructured":"Yamaoka Y. 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