{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:30:37Z","timestamp":1791250237521,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanxi \u201c1331 Project\u201d Key Innovative Research Team","award":["TD201809"],"award-info":[{"award-number":["TD201809"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271144"],"award-info":[{"award-number":["81271144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Youth Fund of Shanxi Applied Basic Research","award":["201801D221270"],"award-info":[{"award-number":["201801D221270"]}]},{"name":"Shanxi Medical University School and Hospital of Stomatology Fund","award":["KY201803"],"award-info":[{"award-number":["KY201803"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral microbiota is not only important for maintaining oral health but also plays a role in various oral diseases. However, studies regarding microbiome changes in oral lichen planus (OLP) are very limited. To the best of our knowledge, there has been only two studies investigating salivary microbiome changes in OLP. Therefore, the purpose of this study was to identify the characteristic microbial profile in the saliva of OLP patients, with or without erosive lesions, and compare that with recurrent aphthous ulcer (RAU), a common oral immunological disorder that also shows multiple erosive\/ulcerative lesions. Whole saliva samples were collected from 20 patients with OLP (erosive E, n\u2009=\u200910 and non-erosive NE, n\u2009=\u200910), 10 patients with RAU (U) and 10 healthy controls (C). DNA was extracted from the saliva samples, and the 16S rDNA gene V4 hypervariable region was analyzed using Illumina sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We obtained 4949 operational taxonomic units (OTUs) from the V4 region in all saliva samples. Community composition analysis showed a clear decreased relative abundance of genera\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      and\n                      <jats:italic>Sphingomonas<\/jats:italic>\n                      in saliva from RAU patients when compared to the other three groups. Relative abundance of\n                      <jats:italic>Lautropia<\/jats:italic>\n                      and\n                      <jats:italic>Gemella<\/jats:italic>\n                      were higher in E group, whereas relative abundance of\n                      <jats:italic>Haemophilus<\/jats:italic>\n                      and\n                      <jats:italic>Neisseria<\/jats:italic>\n                      were higher in NE group when compared to C group.\n                      <jats:italic>Abiotrophia<\/jats:italic>\n                      and\n                      <jats:italic>Oribacterium<\/jats:italic>\n                      were higher in OLP (combining E and NE groups), while\n                      <jats:italic>Eikenella<\/jats:italic>\n                      and\n                      <jats:italic>Aggregatibacter<\/jats:italic>\n                      were lower when compared to C group. There was statistically significance in \u03b1-diversity between E and RAU groups(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Significant differences in \u03b2-diversity were detected in bacteria between E and C; NE and C; as well as E and NE groups. The LDA effect size algorithm identified the\n                      <jats:italic>g_Haemophilus<\/jats:italic>\n                      might be the potential biomarker in NE group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that salivary microbiome in erosive OLP was significantly different from that found in RAU; and these changes may be related to the underlying disease process rather than presence of ulcerative\/erosive lesions clinically. In addition, our findings in bacterial relative abundance in OLP were significantly different from the previously reported findings, which points to the need for further research in salivary microbiome of OLP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01733-7","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T06:14:42Z","timestamp":1585894482000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Dysbiosis of saliva microbiome in patients with oral lichen planus"],"prefix":"10.1186","volume":"20","author":[{"given":"Fei Yan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hsin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Shing Lisa","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu Yun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"1733_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/10454411980090010501","volume":"9","author":"C Scully","year":"1998","unstructured":"Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, et al. 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