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Our interest in occurrence, clinical manifestation, laboratory identification and molecular characterization of Chinese\n                      <jats:italic>C. gattii<\/jats:italic>\n                      strains leads us to this research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 254 clinical isolates, initially identified as\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                      (\n                      <jats:italic>C. neoformans<\/jats:italic>\n                      ), eight strains were re-identified as\n                      <jats:italic>C. gattii<\/jats:italic>\n                      . Multi-locus sequence typing (MLST) showed genotype VGI accounted for the most (6 \/ 8), the other two strains were genotype VGII (VGIIa and VGIIb respectively) with 3 specific spectra of molecular weight about 4342, 8686, 9611\u2009Da by MALDI-TOF MS. The minimal inhibitory concentrations (MICs) of Fluconazole with Yeast one was 2~4 times higher than that with ATB fungus 3 and MICs of antifungal agents against VGII strains were higher than against VGI strains. Comparative proteome analysis showed that 329 and 180 proteins were highly expressed by\n                      <jats:italic>C. gattii<\/jats:italic>\n                      VGI and VGII respectively. The enrichment of differentially expressed proteins was directed to Golgi complex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Infection by\n                      <jats:italic>C. gattii<\/jats:italic>\n                      in China occurred sparsely. Genotype VGI was predominant but VGII was more resistant to antifungal agents. There was significant difference in protein expression profile between isolates of VGI and VGII\n                      <jats:italic>C. gattii<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01752-4","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T12:04:09Z","timestamp":1585569849000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical and microbiological characteristics of Cryptococcus gattii isolated from 7 hospitals in China"],"prefix":"10.1186","volume":"20","author":[{"given":"Liang","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Rong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ying","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Xia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"issue":"1","key":"1752_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/oxfordjournals.aje.a113861","volume":"120","author":"KJ Kwon-Chung","year":"1984","unstructured":"Kwon-Chung KJ, Bennett JE. 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