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Hence, an anti-cariogen effective against both bacteria and fungi would be valuable in the management of S-ECC.\n                    <\/jats:p>\n                    <jats:p>\n                      Here we evaluate the antifungal effect of silver diamine fluoride (SDF) against 35-clinical yeast isolates (Ten-each of\n                      <jats:italic>C. albicans<\/jats:italic>\n                      ,\n                      <jats:italic>C. krusei, C. tropicalis<\/jats:italic>\n                      and five\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      strains) from dentinal caries-lesions from S-ECC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Disc-diffusion and time-kill assays as well as MIC\n                      <jats:sub>50<\/jats:sub>\n                      and MIC\n                      <jats:sub>90<\/jats:sub>\n                      evaluations against therapeutic concentrations confirmed the broad-spectrum anti-candidal potency of SDF. Ultrastructural images revealed morphologic aberrations of yeast-cell walls on exposure to SDF. All\n                      <jats:italic>C. krusei<\/jats:italic>\n                      and\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      isolates were significantly more sensitive to SDF, relative to the standard antifungal fluconazole. Further, SDF appears to effectively abrogate filamentation of\n                      <jats:italic>C. albicans<\/jats:italic>\n                      even at very low concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data, for the first time, elucidate the antifungal potency of SDF, in addition to its known antibacterial activity, in the management of S-ECC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01776-w","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T13:02:39Z","timestamp":1586955759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Silver diamine fluoride (SDF) used in childhood caries management has potent antifungal activity against oral Candida species"],"prefix":"10.1186","volume":"20","author":[{"given":"Kausar Sadia","family":"Fakhruddin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Egusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Chi","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chamila","family":"Panduwawala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siripen","family":"Pesee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thenmozhi","family":"Venkatachalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshman Perera","family":"Samaranayake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"issue":"5","key":"1776_CR1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1177\/0022034515573272","volume":"94","author":"NJ Kassebaum","year":"2015","unstructured":"Kassebaum NJ, Bernabe E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. 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We obtained written informed consent at recruitment and before sample collection from the parents\/guardians of child participants. All samples taken from patients were obtained as part of standard care and all tests ran on them were also part of the standard care procedure.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Contributing authors declared no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"95"}}