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The isolation rate of\n                      <jats:italic>Listeria monocytogenes<\/jats:italic>\n                      in fishery products has always been high. And the pore-forming toxin listeriolysin O (LLO) is one of the most important virulence factors of\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      . LLO can promote cytosolic bacterial proliferation and help the pathogen evade attacks from the host immune system. In addition,\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      infection can trigger a series of severe inflammatory reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Here, we further confirmed that morin lacking anti-\n                      <jats:italic>Listeria<\/jats:italic>\n                      activity could inhibit LLO oligomerization. We also found that morin can effectively alleviate the inflammation induced by\n                      <jats:italic>Listeria<\/jats:italic>\n                      in vivo and in vitro and exerted an obvious protective effect on infected cells and mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Morin does not possess anti-\n                      <jats:italic>Listeria<\/jats:italic>\n                      activity, neither does it interfere with secretion of LLO. However, morin inhibits oligomerisation of LLO and morin does reduce the inflammation caused during\n                      <jats:italic>Listeria<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01807-6","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T07:06:13Z","timestamp":1589267173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation"],"prefix":"10.1186","volume":"20","author":[{"given":"Gen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"issue":"8","key":"1807_CR1","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1128\/AAC.02396-14","volume":"58","author":"DA Pensinger","year":"2014","unstructured":"Pensinger DA, Aliota MT, Schaenzer AJ, Boldon KM, Ansari IU, Vincent WJB, Knight B, Reniere ML, Striker R, Sauer JD. 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