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The aim of this study was to determine the molecular characteristic, antibiotic resistance pattern and capsular types of invasive\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      in Tehran, Iran.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 44 pneumococcal invasive isolates, 39 (89%) were isolated from children and 5 (11%) from adults. The results show that all pneumococcal isolates were susceptible to linezolid but had varying resistance to trimethoprim-sulfamethoxazole (86%), erythromycin (73%), tetracycline (66%), clindamycin (43%), penicillin (16%), chloramphenicol (14%) and levofloxacin (2%). The range of erythromycin, tetracycline and penicillin MICs were 2 -\u2009\u2265\u2009256\u2009\u03bcg\/mL, 4 -\u2009\u2265\u200948\u2009\u03bcg\/mL, and 0.047 -\u2009\u2265\u2009256 respectively. All of the penicillin resistant isolates were multidrug resistant (MDR) and in addition to penicillin were resistant to tetracycline, erythromycin and trimethoprim-sulfamethoxazole. The most common capsular types detected in 64% of the pneumococcal isolates was 6A\/B, 19A, 15A, 23F. The multilocus sequence typing (MLST) of 10 pneumococcal isolates revealed 9 different sequence types (STs), including ST 15139 (capsular type 19A) and ST 15140 (capsular type 23F), which have not previously been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The study revealed that the\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      isolates belonged to diverse capsular types and clones with high rate of resistance to erythromycin, tetracycline, and penicillin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-020-01855-y","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T10:03:47Z","timestamp":1592301827000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran"],"prefix":"10.1186","volume":"20","author":[{"given":"Maryam","family":"Beheshti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Jabalameli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Feizabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad Bonakdar","family":"Hahsemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Beigverdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Emaneini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"issue":"1","key":"1855_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3346\/jkms.2013.28.1.4","volume":"28","author":"JY Song","year":"2013","unstructured":"Song JY, Nahm MH, Moseley MA. 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