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The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the aetiological factors of OLP. Although\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection is associated with various oral diseases, the correlation between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and OLP is unclear. This study aimed to investigate the effect of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>\n                      In this study, saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was detected using the carbon-13-labeled urea breath test (UBT). The saliva samples were divided into the following four groups based on the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status:\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive OLP (OLP+),\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive NC (NC+),\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -negative OLP (OLP\u2212), and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -negative NC (NC\u2212). Oral microbiome compositions were significantly different between the OLP and NC groups and between the OLP\u2212 and OLP+ groups. Compared with those in the OLP\u2212 group, those in the OLP+ group had a higher incidence of erosive OLP and higher levels of salivary cytokines. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC\u2212 and NC+ groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first report to demonstrate that\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection is significantly correlated with the pathogenesis of erosive OLP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-021-02188-0","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T08:21:36Z","timestamp":1618906896000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition"],"prefix":"10.1186","volume":"21","author":[{"given":"Shutong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongcheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"2188_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/hel.12405","volume":"22","author":"V Camilo","year":"2017","unstructured":"Camilo V, Sugiyama T, Touati E. 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