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Understanding the spread, evolution, and distribution of such genes among human populations will help in the development of strategies to diminish their occurrence. To tackle this problem, we investigated the distribution and prevalence of potential mcr genes in the human gut microbiome using a set of bioinformatics tools to screen the Unified Human Gastrointestinal Genome (UHGG) collection for the presence, synteny and phylogeny of putative mcr genes, and co-located antibiotic resistance genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2079 antibiotic resistance genes (ARGs) were classified as\n                      <jats:italic>mcr<\/jats:italic>\n                      genes in 2046 metagenome assembled genomes (MAGs), distributed across 1596 individuals from 41 countries, of which 215 were identified in plasmidial contigs. The genera that presented the largest number of\n                      <jats:italic>mcr<\/jats:italic>\n                      -like genes were\n                      <jats:italic>Suterella<\/jats:italic>\n                      and\n                      <jats:italic>Parasuterella<\/jats:italic>\n                      . Other potential pathogens carrying\n                      <jats:italic>mcr<\/jats:italic>\n                      genes belonged to the genus\n                      <jats:italic>Vibrio<\/jats:italic>\n                      ,\n                      <jats:italic>Escherichia<\/jats:italic>\n                      and\n                      <jats:italic>Campylobacter<\/jats:italic>\n                      . Finally, we identified a total of 22,746 ARGs belonging to 21 different classes in the same 2046 MAGs, suggesting multi-resistance potential in the corresponding bacterial strains, increasing the concern of ARGs impact in the clinical settings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study uncovers the diversity of\n                      <jats:italic>mcr<\/jats:italic>\n                      -like genes in the human gut microbiome. We demonstrated the cosmopolitan distribution of these genes in individuals worldwide and the co-presence of other antibiotic resistance genes, including Extended-spectrum Beta-Lactamases (ESBL). Also, we described\n                      <jats:italic>mcr<\/jats:italic>\n                      -like genes fused to a PAP2-like domain in\n                      <jats:italic>S. wadsworthensis<\/jats:italic>\n                      . These novel sequences increase our knowledge about the diversity and evolution of\n                      <jats:italic>mcr<\/jats:italic>\n                      -like genes. Future research should focus on activity, genetic mobility and a potential colistin resistance in the corresponding strains to experimentally validate those findings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-021-02281-4","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T07:03:04Z","timestamp":1626937384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Putative mobilized colistin resistance genes in the human gut microbiome"],"prefix":"10.1186","volume":"21","author":[{"given":"Bruno G. 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