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Carbapenemase gene\n                      <jats:italic>blaNDM-1<\/jats:italic>\n                      was the most commonly detected, accounting for 86.56% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009380), followed by\n                      <jats:italic>blaKPC-2<\/jats:italic>\n                      (9.11%, 40) and\n                      <jats:italic>blaIMP-4<\/jats:italic>\n                      (4.33%, 19). MLST analysis showed 17 different STs detected within CPKP isolates, with ST20, ST2068, ST36 and ST17 being the most frequently isolated types. Eleven STs were identified within CPEC isolates, with ST325 being the dominant types. Eight isolates of NDM-1 producing KP, belonging to ST23, were identified as having hypervirulent traits. The main infections caused by CPE were pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200990) and sepsis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916). All infected patients received monotherapy, with meropenem and ciprofloxacin being the most commonly used antibiotics. All pneumonia patients were cured or improved after treatment. Of the 16 patients with sepsis, 9 were cured or improved, 3 died, and 4 abandoned treatment without any clinical improvement. The rectal prevalences of CPE in the 0\u20133\u00a0days old (DO), the 4\u201328 DO, and the 29 DO-1\u00a0year old groups were decreased from 15.31%, 27.37% and 14.29% in the first stool screening period to 11.78%, 19.59% and 4.07% in the second stool screening period, respectively. Multivariate analysis showed that cesarean section, acidosis, respiration\u00a0failure, gastric lavage and enema were independent risk factors for rectal colonization in the 0\u20133 DO group, whereas cesarean section, cephalosporins, gastric lavage and residence in rural area were independently associated with rectal colonization in the 4\u201328 DO group. The implementation of a series of evidence-based control measures eventually contained the CPE transmission.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Continued vigilance, epidemiological studies, and multimodal infection prevention strategies are urgently needed due to frequent importations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-022-02585-z","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T14:03:06Z","timestamp":1657634586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Epidemiology and clinical characteristics of infection\/colonization due to carbapenemase-producing Enterobacterales in neonatal patients"],"prefix":"10.1186","volume":"22","author":[{"given":"Jiansheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanpeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"issue":"6","key":"2585_CR1","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1093\/cid\/cis543","volume":"55","author":"LK Logan","year":"2012","unstructured":"Logan LK. 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