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In China, ST11-type CRKP is the most prevalent CRKP, but ST15-type CRKP, a recently prevalent high-risk clone, has emerged widely throughout China, posing a serious public health risk. Therefore, we conducted an epidemiological of an outbreak of ST15 CRKP of producing CTX-M-15, KPC-2 and SHV-106 in a tertiary hospital in Anhui, China, to Understanding the potential risks of the current STT15 CRKP outbreak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From July 2021 to December 2021, 13 ST15 CRKP isolates were identified by collecting non-repeated clinical multidrug-resistant isolates, with all capsular typing of serotype KL19. All ST15 CRKP isolates were resistant to cephalosporins, carbapenems and quinolones, but were sensitive to amikacin, tigecycline and polymyxin B. In addition, isolates carried\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>SHV\u2212106<\/jats:sub>\n                      (100%),\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>KPC\u22122<\/jats:sub>\n                      (69%),\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>CTX\u2212M\u221215<\/jats:sub>\n                      (69%),\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>TEM\u22121B<\/jats:sub>\n                      (69%),\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA\u22121<\/jats:sub>\n                      (62%) and\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>LAP\u22122<\/jats:sub>\n                      (8%), as well as iron chelators (\n                      <jats:italic>iutA<\/jats:italic>\n                      ,\n                      <jats:italic>ybt<\/jats:italic>\n                      ,\n                      <jats:italic>fyuA<\/jats:italic>\n                      ,\n                      <jats:italic>ent<\/jats:italic>\n                      ,\n                      <jats:italic>fepA<\/jats:italic>\n                      ,\n                      <jats:italic>irp1<\/jats:italic>\n                      ,\n                      <jats:italic>irp2<\/jats:italic>\n                      , 100%) were detected. In phenotyping experiments, all ST15 CRKP exhibited lower growth rates than NTUH-K2044, and all ST15 CRKP did not exhibit mucoviscositty characteristics. However, in the\n                      <jats:italic>Galleria mellonella<\/jats:italic>\n                      infection model, isolates 21081212, 21081241\u00a0and 21091216 were more lethal than the hypervirulent isolates NTUH-K2044. Sequencing results showed that the genetic environment surrounding the genes\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>SHV\u2212106<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>KPC\u22122<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>CTX\u2212M\u221215<\/jats:sub>\n                      ,\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>OXA\u22121<\/jats:sub>\n                      and\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>TEM\u22121B<\/jats:sub>\n                      were all identical in the ST15 CRKP isolates. Phylogenetic analysis showed that 13 ST15 CRKP isolates were divided into three subgroups, and when placed in global analysis, 10 of them were highly homologous to isolates from Jiangsu, two were highly homologous to isolates from Zhejiang, and one was homologous to an isolate from an unlabelled region.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our research shows that ST15 CRKP, which carries multiple \u03b2-lactamases genes and siderophores-encoding genes, may be evolving to hypervirulence and may have spread widely in localised areas. Therefore, environmental surveillance and clinical infection control in hospitals should be strengthened to prevent further spread of ST15 CRKP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-022-02672-1","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T04:04:18Z","timestamp":1667275458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Epidemiology of carbapenem-resistant Klebsiella pneumoniae ST15 of producing KPC-2, SHV-106 and CTX-M-15 in Anhui, China"],"prefix":"10.1186","volume":"22","author":[{"given":"Hang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhien","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2672_CR1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cmi.2015.09.025","volume":"22","author":"M Cubero","year":"2016","unstructured":"Cubero M, Grau I, Tubau F, Pallar\u00e9s R, Dominguez MA, Linares J, et al. 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