{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:29:54Z","timestamp":1780450194314,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Burkholderia cenocepacia<\/jats:italic> is an opportunistic pathogen that can cause acute and chronic infections in patients with weakened immune systems and in patients with cystic fibrosis. <jats:italic>B. cenocepacia<\/jats:italic> is resistant to many antibiotics making treatment challenging. Consequently, there is a critical need for alternative strategies to treat <jats:italic>B. cenocepacia<\/jats:italic> infections such as using bacteriophages and\/or bacteriophages with subinhibitory doses of antibiotic called phage-antibiotic synergy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We isolated a bacteriophage, KP1, from raw sewage that infects <jats:italic>B. cenocepacia<\/jats:italic>. Its morphological characteristics indicate it belongs in the family <jats:italic>Siphoviridae<\/jats:italic>, it has a 52 Kb ds DNA genome, and it has a narrow host range. We determined it rescued infections in <jats:italic>Lemna minor<\/jats:italic> (duckweed) and moderately reduced bacterial populations in our artificial sputum medium model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These results suggest that KP1 phage alone in the duckweed model or in combination with antibiotics in the ASMDM model improves the efficacy of reducing <jats:italic>B. cenocepacia<\/jats:italic> populations.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12866-022-02738-0","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T02:02:47Z","timestamp":1672884167000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Phage-antibiotic synergy reduces Burkholderia cenocepacia population"],"prefix":"10.1186","volume":"23","author":[{"given":"Anna G.","family":"Mankovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Kavanaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Kistler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Muckle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine L.","family":"Weingart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"2738_CR1","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1128\/JCM.39.10.3427-3436.2001","volume":"39","author":"T Coenye","year":"2001","unstructured":"Coenye T, Vandamme P, Govan JR, LiPuma JJ. 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