{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T09:37:53Z","timestamp":1794562673508,"version":"4.9.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073422"],"award-info":[{"award-number":["82073422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072235"],"award-info":[{"award-number":["82072235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018558","name":"Shanghai Shuguang Program","doi-asserted-by":"publisher","award":["21SG17"],"award-info":[{"award-number":["21SG17"]}],"id":[{"id":"10.13039\/501100018558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Atopic dermatitis (AD) is an inflammatory skin condition distinguished by an activated Th2 immune response. The local skin microbial dysbiosis is a contributing factor to the development of AD. The pathogenic coagulase-positive <jats:italic>Staphylococcus aureus<\/jats:italic> is the primary species responsible for the progression of AD. Even though <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> is an animal-origin pathogen, it is increasingly becoming a source of concern in human diseases. As another coagulase-positive <jats:italic>Staphylococci<\/jats:italic>, it is crucial to pay more attention to <jats:italic>S. pseudintermedius<\/jats:italic> isolated from the lesion site.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In our investigation, we presented a case of cheilitis in a patient with atopic dermatitis (AD). We utilized culture and next-generation genomic sequencing (NGS) to identify the bacteria present on the skin swabs taken from the lip sites both prior to and following treatment. Our findings indicated that the predominant bacteria colonizing the lesion site of AD were <jats:italic>S. pseudintermedius<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic>, both of which were eradicated after treatment. The Multi-locus sequence typing (MLST) of <jats:italic>S. pseudintermedius<\/jats:italic> and <jats:italic>S. aureus<\/jats:italic> demonstrated coordinated antibiotic susceptibility, with ST2384 and ST22 being the respective types. Although the skin abscess area resulting from <jats:italic>S. pseudintermediu<\/jats:italic>s infection was significantly smaller than that caused by <jats:italic>S. aureus<\/jats:italic> in mice, the expression of cytokines interleukin-4 (IL-4) and interleukin-5 (IL-5) were significantly higher in the <jats:italic>S. pseudintermedius<\/jats:italic>-infected mice.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The <jats:italic>S. pseudintermedius<\/jats:italic> strain isolated from the lesion site of the AD patient exhibited a higher expression of IL-4 and IL-5 when colonized on mouse skin, as compared to <jats:italic>S. aureus.<\/jats:italic> This observation confirms that <jats:italic>S. pseudintermedius<\/jats:italic> can effectively induce the Th2 response in vivo. Our findings suggest that animal-origin <jats:italic>S. pseudintermedius<\/jats:italic> may play a role in the development of AD when colonized on the skin, emphasizing the importance of taking preventive measures when in contact with animals.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12866-023-02837-6","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T14:24:43Z","timestamp":1684160683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cheilitis in an atopic dermatitis patient associated with co-infection of Staphylococcus pseudintermedius and Staphylococcus aureus"],"prefix":"10.1186","volume":"23","author":[{"given":"Shucui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadira","family":"Nurxat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8897-5117","authenticated-orcid":false,"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3053-2756","authenticated-orcid":false,"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"issue":"1","key":"2837_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","volume":"4","author":"S Weidinger","year":"2018","unstructured":"Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1.","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"2837_CR2","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1056\/NEJMra2023911","volume":"384","author":"S St\u00e4nder","year":"2021","unstructured":"St\u00e4nder S, Atopic Dermatitis. N Engl J Med. 2021;384(12):1136\u201343.","journal-title":"N Engl J Med"},{"issue":"10","key":"2837_CR3","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/1346-8138.15048","volume":"46","author":"TF Tsai","year":"2019","unstructured":"Tsai TF, Rajagopalan M, Chu CY, Encarnacion L, Gerber RA, Santos-Estrella P, Llamado LJQ, Tallman AM. Burden of atopic dermatitis in Asia. J Dermatol. 2019;46(10):825\u201334.","journal-title":"J Dermatol"},{"key":"2837_CR4","doi-asserted-by":"crossref","unstructured":"Sroka-Tomaszewska J, Trzeciak M. Molecular Mechanisms of Atopic Dermatitis Pathogenesis,Int J Mol Sci22(8) (2021).","DOI":"10.3390\/ijms22084130"},{"key":"2837_CR5","doi-asserted-by":"crossref","unstructured":"Pappa G, Sgouros D, Theodoropoulos K, Kanelleas A, Bozi E, Gregoriou S, Krasagakis K, Katoulis AC. The IL-4\/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis,J Clin Med11(19) (2022).","DOI":"10.3390\/jcm11195633"},{"issue":"7","key":"2837_CR6","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s13555-022-00737-7","volume":"12","author":"EB Haddad","year":"2022","unstructured":"Haddad EB, Cyr SL, Arima K, McDonald RA, Levit NA, Nestle FO. Current and emerging strategies to inhibit type 2 inflammation in atopic dermatitis. Dermatol Ther (Heidelb). 2022;12(7):1501\u201333.","journal-title":"Dermatol Ther (Heidelb)"},{"key":"2837_CR7","doi-asserted-by":"crossref","unstructured":"Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis,Sci Transl Med9(378) (2017).","DOI":"10.1126\/scitranslmed.aah4680"},{"issue":"1","key":"2837_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jaci.2018.11.015","volume":"143","author":"AS Paller","year":"2019","unstructured":"Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD. The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol. 2019;143(1):26\u201335.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2837_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.alit.2019.02.006","volume":"68","author":"K Iwamoto","year":"2019","unstructured":"Iwamoto K, Moriwaki M, Miyake R, Hide M. Staphylococcus aureus in atopic dermatitis: strain-specific cell wall proteins and skin immunity. Allergol Int. 2019;68(3):309\u201315.","journal-title":"Allergol Int"},{"key":"2837_CR10","doi-asserted-by":"crossref","unstructured":"Roetzer A, Model N, Laube J, Unterhumer Y, Haller G, Eibl MM. Functional and Immunological Studies Revealed a Second Superantigen Toxin in Staphylococcal Enterotoxin C Producing Staphylococcus aureus Strains,Toxins (Basel)14(9) (2022).","DOI":"10.3390\/toxins14090595"},{"issue":"5","key":"2837_CR11","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1093\/infdis\/jir389","volume":"204","author":"JJ Nienaber","year":"2011","unstructured":"Nienaber JJ, Sharma Kuinkel BK, Clarke-Pearson M, Lamlertthon S, Park L, Rude TH, Barriere S, Woods CW, Chu VH, Mar\u00edn M, Bukovski S, Garcia P, Corey GR, Korman T, Doco-Lecompte T, Murdoch DR, Reller LB, Fowler VG Jr. Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. J Infect Dis. 2011;204(5):704\u201313.","journal-title":"J Infect Dis"},{"key":"2837_CR12","doi-asserted-by":"crossref","unstructured":"Lynch SA, Helbig KJ. The Complex Diseases of Staphylococcus pseudintermedius in Canines: Where to Next?,Vet Sci8(1) (2021).","DOI":"10.3390\/vetsci8010011"},{"issue":"4","key":"2837_CR13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.diagmicrobio.2016.05.008","volume":"85","author":"R Somayaji","year":"2016","unstructured":"Somayaji R, Priyantha MA, Rubin JE, Church D. Human infections due to Staphylococcus pseudintermedius, an emerging zoonosis of canine origin: report of 24 cases. Diagn Microbiol Infect Dis. 2016;85(4):471\u20136.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"1","key":"2837_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s40168-020-00866-1","volume":"8","author":"Y Liu","year":"2020","unstructured":"Liu Y, Liu Y, Du Z, Zhang L, Chen J, Shen Z, Liu Q, Qin J, Lv H, Wang H, He L, Liu J, Huang Q, Sun Y, Otto M, Li M. Skin microbiota analysis-inspired development of novel anti-infectives. Microbiome. 2020;8(1):85.","journal-title":"Microbiome"},{"key":"2837_CR15","doi-asserted-by":"crossref","unstructured":"Koreen L, Ramaswamy SV, Graviss EA, Naidich S, Musser JM, Kreiswirth BN. spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation, J Clin Microbiol 42(2) (2004) 792-9.","DOI":"10.1128\/JCM.42.2.792-799.2004"},{"issue":"6","key":"2837_CR16","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","volume":"95","author":"MC Maiden","year":"1998","unstructured":"Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou J, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A. 1998;95(6):3140\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2837_CR17","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3389\/fmicb.2016.01599","volume":"7","author":"T Pires Dos Santos","year":"2016","unstructured":"Pires Dos Santos T, Damborg P, Moodley A, Guardabassi L. Systematic review on global epidemiology of Methicillin-Resistant Staphylococcus pseudintermedius: inference of Population structure from Multilocus sequence typing data. Front Microbiol. 2016;7:1599.","journal-title":"Front Microbiol"},{"issue":"12","key":"2837_CR18","doi-asserted-by":"publisher","first-page":"e0021321","DOI":"10.1128\/JCM.00213-21","volume":"59","author":"R Humphries","year":"2021","unstructured":"Humphries R, Bobenchik AM, Hindler JA, Schuetz AN. Overview of changes to the Clinical and Laboratory Standards Institute Performance Standards for Antimicrobial susceptibility testing, M100, 31st Edition. J Clin Microbiol. 2021;59(12):e0021321.","journal-title":"J Clin Microbiol"},{"key":"2837_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jim.2014.04.007","volume":"410","author":"HK Kim","year":"2014","unstructured":"Kim HK, Missiakas D, Schneewind O. Mouse models for infectious diseases caused by Staphylococcus aureus. J Immunol Methods. 2014;410:88\u201399.","journal-title":"J Immunol Methods"},{"issue":"4s","key":"2837_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jaci.2017.01.011","volume":"139","author":"PM Brunner","year":"2017","unstructured":"Brunner PM, Guttman-Yassky E, Leung DY. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol. 2017;139(4s):65\u2013s76.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"2837_CR21","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","volume":"42","author":"T Kobayashi","year":"2015","unstructured":"Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K. Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis. Immunity. 2015;42(4):756\u201366.","journal-title":"Immunity"},{"issue":"6","key":"2837_CR22","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.tim.2017.11.008","volume":"26","author":"JA Geoghegan","year":"2018","unstructured":"Geoghegan JA, Irvine AD, Foster TJ. Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship. Trends Microbiol. 2018;26(6):484\u201397.","journal-title":"Trends Microbiol"},{"issue":"3","key":"2837_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/DER.0000000000000568","volume":"31","author":"L Blicharz","year":"2020","unstructured":"Blicharz L, Usarek P, M\u0142ynarczyk G, Skowro\u0144ski K, Rudnicka L, Samochocki Z. Nasal colonization by Staphylococci and Severity of atopic dermatitis. Dermatitis. 2020;31(3):215\u201322.","journal-title":"Dermatitis"},{"issue":"10","key":"2837_CR24","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/exd.14381","volume":"30","author":"K Bier","year":"2021","unstructured":"Bier K, Schittek B. Beneficial effects of coagulase-negative Staphylococci on Staphylococcus aureus skin colonization. Exp Dermatol. 2021;30(10):1442\u201352.","journal-title":"Exp Dermatol"},{"key":"2837_CR25","doi-asserted-by":"crossref","unstructured":"Bender AC, Faulkner JA, Tulimieri K, Boise TH, Elkins KM. High Resolution Melt Assays to Detect and Identify Vibrio parahaemolyticus, Bacillus cereus, Escherichia coli, and Clostridioides difficile Bacteria,Microorganisms8(4) (2020).","DOI":"10.3390\/microorganisms8040561"},{"issue":"10","key":"2837_CR26","doi-asserted-by":"publisher","first-page":"e1001133","DOI":"10.1371\/journal.ppat.1001133","volume":"6","author":"GY Cheung","year":"2010","unstructured":"Cheung GY, Rigby K, Wang R, Queck SY, Braughton KR, Whitney AR, Teintze M, DeLeo FR, Otto M. Staphylococcus epidermidis strategies to avoid killing by human neutrophils. PLoS Pathog. 2010;6(10):e1001133.","journal-title":"PLoS Pathog"},{"issue":"11","key":"2837_CR27","doi-asserted-by":"publisher","first-page":"e1009026","DOI":"10.1371\/journal.ppat.1009026","volume":"16","author":"MM Brown","year":"2020","unstructured":"Brown MM, Horswill AR. Staphylococcus epidermidisSkin friend or foe? PLoS Pathog. 2020;16(11):e1009026.","journal-title":"PLoS Pathog"},{"issue":"6","key":"2837_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.tim.2019.01.008","volume":"27","author":"CP Parlet","year":"2019","unstructured":"Parlet CP, Brown MM, Horswill AR. Commensal staphylococci influence Staphylococcus aureus skin colonization and disease. Trends Microbiol. 2019;27(6):497\u2013507.","journal-title":"Trends Microbiol"},{"issue":"4","key":"2837_CR29","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s10096-014-2300-y","volume":"34","author":"S B\u00f6rjesson","year":"2015","unstructured":"B\u00f6rjesson S, G\u00f3mez-Sanz E, Ekstr\u00f6m K, Torres C, Gr\u00f6nlund U. Staphylococcus pseudintermedius can be misdiagnosed as Staphylococcus aureus in humans with dog bite wounds. Eur J Clin Microbiol Infect Dis. 2015;34(4):839\u201344.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2837_CR30","doi-asserted-by":"crossref","unstructured":"Ruiz-Ripa L, Sim\u00f3n C, Ceballos S, Ortega C, Zarazaga M, Torres C, G\u00f3mez-Sanz E. S. pseudintermedius and S. aureus lineages with transmission ability circulate as causative agents of infections in pets for years, BMC Vet Res 17(1) (2021) 42.","DOI":"10.1186\/s12917-020-02726-4"},{"key":"2837_CR31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fcimb.2018.00221","volume":"8","author":"Y Maali","year":"2018","unstructured":"Maali Y, Badiou C, Martins-Sim\u00f5es P, Hodille E, Bes M, Vandenesch F, Lina G, Diot A, Laurent F. Trouillet-Assant, understanding the virulence of Staphylococcus pseudintermedius: a major role of pore-forming toxins. Front Cell Infect Microbiol. 2018;8:221.","journal-title":"Front Cell Infect Microbiol"},{"issue":"6","key":"2837_CR32","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1093\/jac\/dkq078","volume":"65","author":"V Perreten","year":"2010","unstructured":"Perreten V, Kadlec K, Schwarz S, Gr\u00f6nlund Andersson U, Finn M, Greko C, Moodley A, Kania SA, Frank LA, Bemis DA, Franco A, Iurescia M, Battisti A, Duim B, Wagenaar JA, van Duijkeren E, Weese JS, Fitzgerald JR, Rossano A, Guardabassi L. Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: an international multicentre study. J Antimicrob Chemother. 2010;65(6):1145\u201354.","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"2837_CR33","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1093\/jac\/dkq241","volume":"65","author":"R Stegmann","year":"2010","unstructured":"Stegmann R, Burnens A, Maranta CA, Perreten V. Human infection associated with methicillin-resistant Staphylococcus pseudintermedius ST71. J Antimicrob Chemother. 2010;65(9):2047\u20138.","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"2837_CR34","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1128\/JCM.00703-14","volume":"52","author":"G Starlander","year":"2014","unstructured":"Starlander G, B\u00f6rjesson S, Gr\u00f6nlund-Andersson U, Tellgren-Roth C, Melhus A. Cluster of infections caused by methicillin-resistant Staphylococcus pseudintermedius in humans in a tertiary hospital. J Clin Microbiol. 2014;52(8):3118\u201320.","journal-title":"J Clin Microbiol"},{"key":"2837_CR35","doi-asserted-by":"crossref","unstructured":"Wegener A, Broens EM, van der Graaf-van L, Bloois AL, Zomer CE, Visser J, van Zeijl C, van der Meer JG, Kusters AW, Friedrich GA, Kampinga GJ, Sips L, Smeets MEJ, van Kerckhoven AJ, Timmerman JA, Wagenaar B, Duim. Absence of Host-Specific Genes in Canine and Human Staphylococcus pseudintermedius as Inferred from Comparative Genomics,Antibiotics (Basel)10(7) (2021).","DOI":"10.3390\/antibiotics10070854"},{"key":"2837_CR36","doi-asserted-by":"crossref","unstructured":"Bexley J, Nuttall TJ, Hammerberg B, Fitzgerald JR, Halliwell RE. Serum anti-Staphylococcus pseudintermedius IgE and IgG antibodies in dogs with atopic dermatitis and nonatopic dogs, Vet Dermatol 24(1) (2013) 19\u201324.e5-6.","DOI":"10.1111\/j.1365-3164.2012.01109.x"},{"issue":"1","key":"2837_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/bjd.15139","volume":"177","author":"L Hepburn","year":"2017","unstructured":"Hepburn L, Hijnen DJ, Sellman BR, Mustelin T, Sleeman MA, May RD, Strickland I. The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies. Br J Dermatol. 2017;177(1):63\u201371.","journal-title":"Br J Dermatol"},{"key":"2837_CR38","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.2147\/IDR.S212358","volume":"12","author":"N Xiao","year":"2019","unstructured":"Xiao N, Yang J, Duan N, Lu B, Wang L. Community-associated Staphylococcus aureus PVL(+) ST22 predominates in skin and soft tissue infections in Beijing, China. Infect Drug Resist. 2019;12:2495\u2013503.","journal-title":"Infect Drug Resist"},{"issue":"2","key":"2837_CR39","doi-asserted-by":"publisher","first-page":"151550","DOI":"10.1016\/j.ijmm.2022.151550","volume":"312","author":"Z Yang","year":"2022","unstructured":"Yang Z, Qiu B, Cheng D, Zhao N, Liu Y, Li M, Liu Q. Virulent Staphylococcus aureus colonizes pediatric nares by resisting killing of human antimicrobial peptides. Int J Med Microbiol. 2022;312(2):151550.","journal-title":"Int J Med Microbiol"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-023-02837-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-023-02837-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-023-02837-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T14:25:09Z","timestamp":1684160709000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-023-02837-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2837"],"URL":"https:\/\/doi.org\/10.1186\/s12866-023-02837-6","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"7 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods followed in this work comply with the guidelines and regulations. This study has been reviewed and approved by the Ethics Committee of Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. The legal guardian of the young patient provided informed consent. All animal experiments were performed following the Guide for the Care and Use of Laboratory Animals of the Chinese Association for Laboratory Animal Sciences (CALAS) and approved by the ethics committee of Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. all methods are reported in accordance with ARRIVE guidelines () for the reporting of animal experiments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent from a parent for both study participation and publication of identifying information\/images in an online open-access publication has been obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"130"}}