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The Illumina platform was used to perform WGS of the\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      isolates, and the resistance genes carried by the Carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains were detected via ABRicate software. The phylogenetic tree was constructed by thirty-four strains including twenty-eight strains downloaded from NCBI database and the carbapenem-resistant six\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains in this study. Which based on genomic single nucleotide polymorphism (SNP) to understand the affinities of the carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains were isolated from five different clinical departments using the blood, urine, sputum, and secretion specimens. These infected patients are middle-aged and elderly people with a history of severe trauma, tumors, hypertension, and various other underlying diseases, and invasive procedures. Antimicrobial sensitivity testing showed that all strains presented resistance to ampicillin-sulbactam, ceftazidime, ciprofloxacin, levofloxacin, and ertapenem, whereas they exhibited full susceptibility to cefepime and amikacin. Most strains demonstrated high resistance to \u03b2-lactams, aminoglycosides, and sulfonamides. Thirty-five resistance genes were identified by ABRicate. All carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains carried aminoglycoside, fluoroquinolone, chloramphenicol, rifampicin, sulfonamide, and \u03b2-lactam resistance genes, and most importantly, all strains possessed the carbapenem resistance gene\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>NDM\u22121<\/jats:sub>\n                      . The six\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains in this study and the 28 carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains from the NCBI database were divided into four evolutionary groups. The WF3643, WF3849, WF3822, and WF3821 strains in this study were in the same evolutionary group (clade A), while the closely related WF3099 and WF3279 strains were in different evolutionary groups (clade B and clade D), respectively. The WF3099 strain was distantly related to the other five strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains were mostly isolated from middle-aged and older patients with a history of surgery or serious underlying diseases, and they were found to cause multisystem infections. All Carbapenem-resistant\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains in this study carried\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>NDM\u22121<\/jats:sub>\n                      and multiple antimicrobial drug resistance genes. Furthermore, the\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      strains in this study were closely related, suggesting the possibility of nosocomial infections. Therefore, our study highlights the need for research on\n                      <jats:italic>P. rettgeri<\/jats:italic>\n                      to control the spread of these nosocomial infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-023-03032-3","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:02:21Z","timestamp":1696298541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of resistance genes of carbapenem-resistant Providencia rettgeri using whole genome sequencing"],"prefix":"10.1186","volume":"23","author":[{"given":"Mi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"issue":"7","key":"3032_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1099\/00222615-47-7-629","volume":"47","author":"I Stock","year":"1998","unstructured":"Stock I, Wiedemann B. 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