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However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) and normal controls (normal group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS\/MS) analysis, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that key altered metabolites of 9,10-DiHOME,\n                      <jats:italic>\u03b1<\/jats:italic>\n                      -linolenic acid, ethylparaben, glycocholic acid, pipecolic acid, and 9,12,13-trihydroxy-10(E),15(Z)-octadecadienoic acid, correlating with\n                      <jats:italic>Sneathia (Sneathia_amnii), Lactobacillus<\/jats:italic>\n                      (\n                      <jats:italic>Lactobacillus_iners), Atopobium, Mycoplasma<\/jats:italic>\n                      , and\n                      <jats:italic>Gardnerella<\/jats:italic>\n                      , may be potential biomarkers of HPV infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of current study would help to reveal the association of changes in cervicovaginal microbiota and serum metabolome with HPV infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-024-03244-1","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T06:02:29Z","timestamp":1711087349000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["HPV-associated cervicovaginal microbiome and host metabolome characteristics"],"prefix":"10.1186","volume":"24","author":[{"given":"Yao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"issue":"5","key":"3244_CR1","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/eurpub\/ckz216","volume":"30","author":"C Mattiuzzi","year":"2020","unstructured":"Mattiuzzi C, Lippi G. 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