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The present study aimed at evaluating hospital epidemiology and antifungal susceptibility of all isolates recorded in our clinical database since its implementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data on date of isolation, biological samples, patients\u2019 age and sex, clinical settings, and antifungal susceptibility tests for all\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp. isolated from 2015 to 2022 were extracted from the clinical database. Score test for trend of odds, non-parametric Mann Kendall trend test and logistic regression analysis were used to analyze prevalence, incidence, and seasonality of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp. isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1126\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp. isolates were evaluated.\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      was the most prevalent (44.1%) followed by\n                      <jats:italic>A. niger<\/jats:italic>\n                      (22.3%),\n                      <jats:italic>A. flavus<\/jats:italic>\n                      (17.7%) and\n                      <jats:italic>A. terreus<\/jats:italic>\n                      (10.6%).\n                      <jats:italic>A. niger<\/jats:italic>\n                      prevalence increased over time in intensive care units (\n                      <jats:italic>p<\/jats:italic>\n                      -trend\u2009=\u20090.0051). Overall, 16 (1.5%) were not susceptible to one azole compound, and 108 (10.9%) to amphotericin B, with\n                      <jats:italic>A. niger<\/jats:italic>\n                      showing the highest percentage (21.9%). The risk of detecting\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      was higher\u00a0in June, (OR\u2009=\u20092.14, 95% CI [1.16; 3.98]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and reduced during September (OR\u2009=\u20090.48, 95% CI [0.27; 0.87]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and October as compared to January (OR\u2009=\u20090.39, 95% CI [0.21; 0.70]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002.\n                      <jats:italic>A. niger<\/jats:italic>\n                      showed a reduced risk of isolation from all clinical samples in the month of June as compared to January (OR\u2009=\u20090.34, 95% CI [0.14; 0.79]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Seasonal trend for\n                      <jats:italic>A. flavus<\/jats:italic>\n                      showed a higher risk of detection in September (OR\u2009=\u20092.7, 95% CI [1.18; 6.18]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), October (OR\u2009=\u20092.32, 95% CI [1.01; 5.35]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048) and November (OR\u2009=\u20092.42, 95% CI [1.01; 5.79]\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) as compared to January.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first study to analyze, at once, data regarding prevalence, time trends, seasonality, species distribution and antifungal susceptibility profiles of all\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      spp. isolates over a 8-year period in a tertiary care center. Surprisingly no increase in azole resistance was observed over time.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-024-03267-8","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T07:02:08Z","timestamp":1712127728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hospital distribution, seasonality, time trends and antifungal susceptibility profiles of all Aspergillus species isolated from clinical samples from 2015 to 2022 in a tertiary care hospital"],"prefix":"10.1186","volume":"24","author":[{"given":"Iacopo","family":"Franconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmeri","family":"Rizzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Ghelardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Lupetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"Supplement 1","key":"3267_CR1","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.3109\/13693786.2010.504753","volume":"49","author":"DL Hawksworth","year":"2011","unstructured":"Hawksworth DL. 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This work is a retrospective analysis of data reported by routine examinations performed at Pisa University Hospital, Mycology Unit laboratory, no adjunctive analysis and\/or intervention was applied, no sample was collected and\/or stored specifically for this study, no further microbiological test was performed explicitly for this study, data were extracted and analyzed anonymously. 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