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This approach was shown to apply to many different photosensitizers, including the xanthene dye Rose Bengal (RB) excited by green light (540\u00a0nm). Rose Bengal diacetate (RBDA) is a lipophilic RB derivative that is easily taken up by cells and hydrolyzed to produce an active photosensitizer. Because KI is not taken up by microbial cells, it was of interest to see if aPDI mediated by RBDA could also be potentiated by KI. The addition of 100 mM KI strongly potentiated the killing of Gram-positive methicillin-resistant\n                    <jats:italic>Staphylocccus aureus<\/jats:italic>\n                    , Gram-negative\n                    <jats:italic>Eschericia coli<\/jats:italic>\n                    , and fungal yeast\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    when treated with RBDA (up to 15 \u00b5M) for 2 hours followed by green light (540\u00a0nm, 10\u00a0J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ). Both RBDA aPDI regimens (400 \u00b5M RBDA with or without 400 mM KI followed by 20\u00a0J\/cm\n                    <jats:sup>2<\/jats:sup>\n                    green light) accelerated the healing of MRSA-infected excisional wounds in diabetic mice, without damaging the host tissue.\n                  <\/jats:p>","DOI":"10.1186\/s12866-024-03401-6","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T07:01:59Z","timestamp":1720162919000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Rose Bengal diacetate-mediated antimicrobial photodynamic inactivation: potentiation by potassium iodide and acceleration of wound healing in MRSA-infected diabetic mice"],"prefix":"10.1186","volume":"24","author":[{"given":"Danfeng","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Hamblin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Fekrazad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"issue":"3","key":"3401_CR1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/cmr.00134-14","volume":"28","author":"SYC Tong","year":"2015","unstructured":"Tong SYC, Davis JS, Eichenberger E, Holland TL, Fowler VG. 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All animal experiments were approved by the Animal Care and Use Committee of West China Hospital, Sichuan University (No.20220118002). All experiments were performed in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"MRH declares the following potential conflicts of interest. Scientific Advisory Boards: Transdermal Cap Inc, Cleveland, OH; Hologenix Inc. Santa Monica, CA; Vielight, Toronto, Canada; JOOVV Inc, Minneapolis-St. Paul MN; Sunlighten, Kansas City, MO; PBM Healing International, Hong Kong. Consulting; USHIO Corp, Japan; Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany; Klox Asia, Guangzhou, China. Stockholding: Niraxx Light Therapeutics, Inc, Irvine CA; JelikaLite Corp, New York NY; Danvantar Biophotonics Oy, Helsinki, Finland. The other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"246"}}