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Our aim was to assess characteristics and follow-up of adults hospitalized with invasive\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational cohort study was conducted at a national referral center between 2004 and 2019. Patients with proven invasive listeriosis, defined by the European Centre for Disease Prevention and Control criteria, were included. Data collection and follow-up were performed using the hospital electronic system, up until the last documented visit. The primary outcome was in-hospital all-cause mortality, secondary outcomes included residual neurological symptoms, brain abscess occurrence, and requirement for intensive care unit (ICU) admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 63 cases were identified (57.1% male, median age 58.8\u2009\u00b1\u200921.7 years), and 28\/63 developed a complicated disease course (44.4%). At diagnosis, 38\/63 (60.3%) presented with sepsis, 54\/63 (85.7%) had central nervous system involvement, while 9\/63 (14.3%) presented with isolated bacteremia. Frequent clinical symptoms included fever (53\/63, 84.1%), altered mental state (49\/63, 77.8%), with immunocompromised conditions apparent in 56\/63 (88.9%).\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      was isolated from blood (37\/54, 68.5%) and cerebrospinal fluid (48\/55, 87.3%), showing in vitro full susceptibility to ampicillin and meropenem (100% each), gentamicin (86.0%) and trimethoprim\/sulfamethoxazole (97.7%). In-hospital all-cause mortality was 17\/63 (27.0%), and ICU admission was required in 28\/63 (44.4%). At discharge, residual neurological deficits (11\/46, 23.9%) and brain abscess formation (6\/46, 13.0%) were common.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Among hospitalized adult patients with comorbidities, invasive\n                      <jats:italic>L. monocytogenes<\/jats:italic>\n                      infections are associated with high mortality and neurological complications during follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-024-03478-z","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T03:02:18Z","timestamp":1725591738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and microbiological characteristics and follow-up of invasive Listeria monocytogenes infection among hospitalized patients: real-world experience of 16 years from Hungary"],"prefix":"10.1186","volume":"24","author":[{"given":"Rebeka","family":"Kiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Marosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Kor\u00f3zs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borisz","family":"Petrik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botond","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint Gergely","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"1","key":"3478_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrmicro.2017.126","volume":"16","author":"L Radoshevich","year":"2018","unstructured":"Radoshevich L, Cossart P. 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