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Animal experiments were conducted under animal protocols approved by the Institutional Animal Care and Use Committee (IACUC) of Linyi University (Approval No. LYU20240206). All animal work was carried out following accordance within the guidelines of the Laboratory Animal Research Center of Linyi University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"526"}}