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The ideal growth conditions included 1% (w\/v) starch, diammonium citrate, dibasic sodium phosphate, 5% (v\/v) inoculum, <jats:italic>p<\/jats:italic>H 8, a rotation speed of 150\u00a0rpm, a temperature of 37\u00a0\u00b0C, and an incubation period of 9\u00a0days. Using ethanol as a solvent, the red pigment was effectively recovered. Data indicates that pigment content remained steady at 40 and 50\u00a0\u00b0C. Heating the pigment extract to 60, 70, 80, 90, and 100\u00a0\u00b0C for one hour results in pigment retention of 98%, 96.5%, 95.5%, 94.6%, and 92.6% of its pigment density, respectively. Studies indicate that the pigment extracts exhibited optimal stability at alkaline <jats:italic>p<\/jats:italic>H levels. The findings demonstrate that the red pigment extract has a peak absorbance range of 280\u2013340\u00a0nm, with a \u03bbmax of 300\u00a0nm. GC\/MS analysis revealed that the primary components of the pigment extract were linolenic acid methyl ester and oleic acid methyl ester, constituting 26.41% and 25.25%, respectively. Fabrics dyed with extracted red pigment exhibit excellent fastness when using the comprehensive green method. In comparison to conventional and nanotechnological attributes, printed samples exhibit significant color strength without environmental repercussions. The treatment of cotton, wool, and polyester samples suppressed pathogen growth to differing extents. Polyester had the most important inhibitory effects on <jats:italic>Staphylococcus aureus<\/jats:italic> (50.03%) and <jats:italic>Bacillus cereus<\/jats:italic> (39.49%). The ADME physicochemical properties of the predominant medication were assessed, together with its bioavailability. The radar plot demonstrated ideal parameters for size, polarity, lipophilicity, solubility, and saturation, excluding flexibility. It exhibited intermediate synthetic accessibility, exceptional permeability and absorption, elevated gastrointestinal absorption, and blood\u2013brain barrier penetration; nonetheless, it did not adhere to the medicinal chemistry rule of three.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1186\/s12866-024-03697-4","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:18:37Z","timestamp":1736756317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improving natural red pigment production by Streptomyces phaeolivaceus strain GH27 for functionalization\u00a0of textiles with in silico ADME prediction"],"prefix":"10.1186","volume":"25","author":[{"given":"Gehad H. 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