{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T17:32:52Z","timestamp":1768671172255,"version":"3.49.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770398"],"award-info":[{"award-number":["81770398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Planning Project Foundation of Guangzhou","award":["202201020283"],"award-info":[{"award-number":["202201020283"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04027-y","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:34:21Z","timestamp":1747809261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non-alcoholic fatty liver disease enhances the beneficial effect of renal denervation on gut microbiota aberrations in rats with heart failure"],"prefix":"10.1186","volume":"25","author":[{"given":"Fuyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2203-627X","authenticated-orcid":false,"given":"Pingan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"4027_CR1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1001\/jama.2020.13310","volume":"324","author":"JR Baman","year":"2020","unstructured":"Baman JR, Ahmad FS. Heart Failure. JAMA. 2020;324:1015.","journal-title":"JAMA."},{"key":"4027_CR2","doi-asserted-by":"publisher","first-page":"6161","DOI":"10.3390\/ijms21176161","volume":"21","author":"A Drapala","year":"2020","unstructured":"Drapala A, Szudzik M, Chabowski D, Mogilnicka I, Jaworska K, Kraszewska K, et al. Heart failure disturbs gut-blood barrier and increases plasma trimethylamine, a toxic bacterial metabolite. Int J Mol Sci. 2020;21:6161.","journal-title":"Int J Mol Sci."},{"key":"4027_CR3","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.jacc.2007.07.016","volume":"50","author":"A Sandek","year":"2007","unstructured":"Sandek A, Bauditz J, Swidsinski A, Buhner S, Weber-Eibel J, von Haehling S, et al. Altered intestinal function in patients with chronic heart failure. J Am Coll Cardiol. 2007;50:1561\u20139.","journal-title":"J Am Coll Cardiol."},{"key":"4027_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1146\/annurev-physiol-031620-093431","volume":"83","author":"TE Sharp 3rd","year":"2021","unstructured":"Sharp TE 3rd, Lefer DJ. Renal denervation to treat heart failure. Annu Rev Physiol. 2021;83:39\u201358.","journal-title":"Annu Rev Physiol."},{"key":"4027_CR5","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.jacc.2018.08.2186","volume":"72","author":"TE Sharp 3rd","year":"2018","unstructured":"Sharp TE 3rd, Polhemus DJ, Li Z, Spaletra P, Jenkins JS, Reilly JP, et al. Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system. J Am Coll Cardiol. 2018;72:2609\u201321.","journal-title":"J Am Coll Cardiol."},{"key":"4027_CR6","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1161\/HYPERTENSIONAHA.118.11071","volume":"72","author":"H Zheng","year":"2018","unstructured":"Zheng H, Katsurada K, Liu X, Knuepfer MM, Patel KP. Specific afferent renal denervation prevents reduction in neuronal nitric oxide synthase within the paraventricular nucleus in rats with chronic heart failure. Hypertension. 2018;72:667\u201375.","journal-title":"Hypertension."},{"key":"4027_CR7","doi-asserted-by":"publisher","first-page":"118500","DOI":"10.1016\/j.lfs.2020.118500","volume":"262","author":"D Lu","year":"2020","unstructured":"Lu D, Wang J, Zhang H, Shan Q, Zhou B. Renal denervation improves chronic intermittent hypoxia induced hypertension and cardiac fibrosis and balances gut microbiota. Life Sci. 2020;262:118500.","journal-title":"Life Sci."},{"key":"4027_CR8","doi-asserted-by":"publisher","first-page":"1697004","DOI":"10.1155\/2021\/1697004","volume":"2021","author":"Z Guo","year":"2021","unstructured":"Guo Z, Chen Y, Chen S, Liu C, Li S, Chen P. Renal denervation mitigated fecal microbiota aberrations in rats with chronic heart failure. Evid Based Complement Alternat Med. 2021;2021:1697004.","journal-title":"Evid Based Complement Alternat Med."},{"key":"4027_CR9","doi-asserted-by":"publisher","first-page":"e0218322","DOI":"10.1128\/spectrum.02183-22","volume":"10","author":"Z Guo","year":"2022","unstructured":"Guo Z, Chen F, Chen Y, Liu C, Li S, Chen P. Inhibiting intestinal Kruppel-Like factor 5 impairs the beneficial role of renal denervation in gut microbiota in rats with heart failure. Microbiol Spectr. 2022;10:e0218322.","journal-title":"Microbiol Spectr."},{"key":"4027_CR10","doi-asserted-by":"publisher","first-page":"101111","DOI":"10.1016\/j.molmet.2020.101111","volume":"50","author":"W Jonas","year":"2021","unstructured":"Jonas W, Schurmann A. Genetic and epigenetic factors determining NAFLD risk. Mol Metab. 2021;50:101111.","journal-title":"Mol Metab."},{"key":"4027_CR11","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/oby.21879","volume":"25","author":"TG Simon","year":"2017","unstructured":"Simon TG, Bamira DG, Chung RT, Weiner RB, Corey KE. Nonalcoholic steatohepatitis is associated with cardiac remodeling and dysfunction. Obesity (Silver Spring). 2017;25:1313\u20136.","journal-title":"Obesity (Silver Spring)."},{"key":"4027_CR12","first-page":"457","volume":"17","author":"H Fotbolcu","year":"2010","unstructured":"Fotbolcu H, Yakar T, Duman D, Karaahmet T, Tigen K, Cevik C, et al. Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease. Cardiol J. 2010;17:457\u201363.","journal-title":"Cardiol J."},{"issue":"17","key":"4027_CR13","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1113\/JP277994","volume":"597","author":"C Hurr","year":"2019","unstructured":"Hurr C, Simonyan H, Morgan DA, Rahmouni K, Young CN. Liver sympathetic denervationreverses obesity-induced hepatic steatosis. J Physiol. 2019;597(17):4565\u201380. https:\/\/doi.org\/10.1113\/JP277994. Epub 2019 Jul 26. PMID: 31278754; PMCID: PMC6716997.","journal-title":"J Physiol"},{"key":"4027_CR14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41575-020-0269-9","volume":"17","author":"J Aron-Wisnewsky","year":"2020","unstructured":"Aron-Wisnewsky J, Vigliotti C, Witjes J, Le P, Holleboom AG, Verheij J, et al. Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders. Nat Rev Gastroenterol Hepatol. 2020;17:279\u201397.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"4027_CR15","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/hep.29588","volume":"67","author":"T Khamphaya","year":"2018","unstructured":"Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell-Richards KA, Robert ME, Mennone A, et al. Nonalcoholic fatty liver disease impairs expression of the type II inositol 1,4,5-trisphosphate receptor. Hepatology. 2018;67:560\u201374.","journal-title":"Hepatology."},{"key":"4027_CR16","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3390\/nu9101072","volume":"9","author":"MA Van Herck","year":"2017","unstructured":"Van Herck MA, Vonghia L, Francque SM. Animal models of nonalcoholic fatty liver disease-a starter\u2019s guide. Nutrients. 2017;9:1072.","journal-title":"Nutrients."},{"key":"4027_CR17","doi-asserted-by":"publisher","first-page":"G987","DOI":"10.1152\/ajpgi.90272.2008","volume":"295","author":"LH Tetri","year":"2008","unstructured":"Tetri LH, Basaranoglu M, Brunt EM, Yerian LM, Neuschwander-Tetri BA. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol. 2008;295:G987-95.","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"4027_CR18","doi-asserted-by":"publisher","first-page":"765591","DOI":"10.3389\/fcvm.2021.765591","volume":"8","author":"Y Chen","year":"2021","unstructured":"Chen Y, Guo Z, Li S, Liu Z, Chen P. Spermidine affects cardiac function in heart failure mice by influencing the gut microbiota and cardiac galectin-3. Front Cardiovasc Med. 2021;8:765591.","journal-title":"Front Cardiovasc Med."},{"key":"4027_CR19","doi-asserted-by":"publisher","first-page":"101867","DOI":"10.1016\/j.mex.2022.101867","volume":"9","author":"JL Kouakou","year":"2022","unstructured":"Kouakou JL, Gonedel\u00e9-Bi S, Assamoi JB, AssanvoN\u2019Guetta SP. Optimization of the Cetyltrimethylammonium bromide (CTAB) DNA extraction protocol using forest elephant dung samples. MethodsX. 2022;9:101867.","journal-title":"MethodsX."},{"key":"4027_CR20","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s10020-020-00164-4","volume":"26","author":"Z Wang","year":"2020","unstructured":"Wang Z, Li S, Wang R, Guo L, Xu D, Zhang T, et al. The protective effects of the \u03b23 adrenergic receptor agonist BRL37344 against liver steatosis and inflammation in a rat model of high-fat diet-induced nonalcoholic fatty liver disease (NAFLD). Mol Med. 2020;26:54.","journal-title":"Mol Med."},{"key":"4027_CR21","first-page":"1","volume":"51","author":"ZH Zhao","year":"2019","unstructured":"Zhao ZH, Xin FZ, Xue Y, Hu Z, Han Y, Ma F, et al. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Exp Mol Med. 2019;51:1\u201314.","journal-title":"Exp Mol Med."},{"key":"4027_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsec\/fiu002","volume":"91","author":"S Michail","year":"2015","unstructured":"Michail S, Lin M, Frey MR, Fanter R, Paliy O, Hilbush B, et al. Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease. FEMS Microbiol Ecol. 2015;91:1\u20139.","journal-title":"FEMS Microbiol Ecol."},{"key":"4027_CR23","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40168-017-0271-9","volume":"5","author":"S Rath","year":"2017","unstructured":"Rath S, Heidrich B, Pieper DH, Vital M. Uncovering the trimethylamine-producing bacteria of the human gut microbiota. Microbiome. 2017;5:54.","journal-title":"Microbiome."},{"key":"4027_CR24","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/cvr\/cvad023","volume":"119","author":"J Zhao","year":"2023","unstructured":"Zhao J, Zhang Q, Cheng W, Dai Q, Wei Z, Guo M, et al. Heart-gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia\/reperfusion. Cardiovasc Res. 2023;119:1390\u2013402.","journal-title":"Cardiovasc Res."},{"key":"4027_CR25","doi-asserted-by":"publisher","first-page":"683743","DOI":"10.3389\/fcimb.2021.683743","volume":"11","author":"X Pan","year":"2021","unstructured":"Pan X, Kaminga AC, Liu A, Wen SW, Luo M, Luo J. Gut microbiota, glucose, lipid, and water-electrolyte metabolism in children with nonalcoholic fatty liver disease. Front Cell Infect Microbiol. 2021;11:683743.","journal-title":"Front Cell Infect Microbiol."},{"key":"4027_CR26","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.1021\/acs.jafc.2c00641","volume":"70","author":"HY Tsai","year":"2022","unstructured":"Tsai HY, Shih YY, Yeh YT, Huang CH, Liao CA, Hu CY, et al. Pterostilbene and its derivative 3\u2019-hydroxypterostilbene ameliorated nonalcoholic fatty liver disease through synergistic modulation of the gut microbiota and SIRT1\/AMPK signaling pathway. J Agric Food Chem. 2022;70:4966\u201380.","journal-title":"J Agric Food Chem."},{"key":"4027_CR27","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1161\/01.CIR.0000143081.13042.04","volume":"110","author":"P Knuefermann","year":"2004","unstructured":"Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, et al. Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation. 2004;110:3693\u20138.","journal-title":"Circulation."},{"key":"4027_CR28","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1136\/gutjnl-2019-318811","volume":"69","author":"S Sookoian","year":"2020","unstructured":"Sookoian S, Salatino A, Castano GO, Landa MS, Fijalkowky C, Garaycoechea M, et al. Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease. Gut. 2020;69:1483\u201391.","journal-title":"Gut."},{"key":"4027_CR29","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.3390\/nu13103453","volume":"13","author":"MN Bin-Jumah","year":"2021","unstructured":"Bin-Jumah MN, Gilani SJ, Hosawi S, Al-Abbasi FA, Zeyadi M, Imam SS, et al. Pathobiological relationship of excessive dietary intake of choline\/L-carnitine: a TMAO precursor-associated aggravation in heart failure in sarcopenic patients. Nutrients. 2021;13:3453.","journal-title":"Nutrients."},{"key":"4027_CR30","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1161\/HYPERTENSIONAHA.120.15123","volume":"76","author":"E Gutierrez-Calabres","year":"2020","unstructured":"Gutierrez-Calabres E, Ortega-Hernandez A, Modrego J, Gomez-Gordo R, Caro-Vadillo A, Rodriguez-Bobada C, et al. Gut microbiota profile identifies transition from compensated cardiac hypertrophy to heart failure in hypertensive rats. Hypertension. 2020;76:1545\u201354.","journal-title":"Hypertension."},{"key":"4027_CR31","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/imm.12760","volume":"151","author":"JM Larsen","year":"2017","unstructured":"Larsen JM. The immune response to prevotella bacteria in chronic inflammatory disease. Immunology. 2017;151:363\u201374.","journal-title":"Immunology."},{"key":"4027_CR32","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1039\/D2FO03181G","volume":"14","author":"X Wu","year":"2023","unstructured":"Wu X, Huang X, Ma W, Li M, Wen J, Chen C, et al. Bioactive polysaccharides promote gut immunity via different ways. Food Funct. 2023;14:1387\u2013400.","journal-title":"Food Funct."},{"key":"4027_CR33","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.jacbts.2021.12.010","volume":"7","author":"AA Challa","year":"2022","unstructured":"Challa AA, Lewandowski ED. Short-chain carbon sources: exploiting pleiotropic effects for heart failure therapy. JACC Basic Transl Sci. 2022;7:730\u201342.","journal-title":"JACC Basic Transl Sci."},{"key":"4027_CR34","doi-asserted-by":"publisher","first-page":"101706","DOI":"10.1016\/j.arr.2022.101706","volume":"81","author":"T Hu","year":"2022","unstructured":"Hu T, Wu Q, Yao Q, Jiang K, Yu J, Tang Q. Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases. Ageing Res Rev. 2022;81:101706.","journal-title":"Ageing Res Rev."},{"key":"4027_CR35","doi-asserted-by":"publisher","first-page":"13777","DOI":"10.1038\/s41598-020-70826-0","volume":"10","author":"J Seo","year":"2020","unstructured":"Seo J, Matthewman L, Xia D, Wilshaw J, Chang YM, Connolly DJ. The gut microbiome in dogs with congestive heart failure: a pilot study. Sci Rep. 2020;10:13777.","journal-title":"Sci Rep."},{"key":"4027_CR36","doi-asserted-by":"publisher","first-page":"14143","DOI":"10.3390\/ijms241814143","volume":"24","author":"J Warme","year":"2023","unstructured":"Warme J, Sundqvist MO, Hjort M, Agewall S, Collste O, Ekenback C, et al. Helicobacter pylori and pro-Inflammatory protein biomarkers in myocardial infarction with and without obstructive coronary artery disease. Int J Mol Sci. 2023;24:14143.","journal-title":"Int J Mol Sci."},{"key":"4027_CR37","doi-asserted-by":"crossref","unstructured":"Mantovani A, Petracca G, Csermely A, Beatrice G, Bonapace S, Rossi A, et al. Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals. Gut. 2022:gutjnl-2022-327672.","DOI":"10.1136\/gutjnl-2022-327672"},{"key":"4027_CR38","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1002\/hep.32072","volume":"74","author":"J Zhou","year":"2021","unstructured":"Zhou J, Bai L, Zhang XJ, Li H, Cai J. Nonalcoholic fatty liver disease and cardiac remodeling risk: pathophysiological mechanisms and clinical implications. Hepatology. 2021;74:2839\u201347.","journal-title":"Hepatology."},{"key":"4027_CR39","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.jhep.2014.11.030","volume":"62","author":"S Petta","year":"2015","unstructured":"Petta S, Argano C, Colomba D, Camma C, Di Marco V, Cabibi D, et al. Epicardial fat, cardiac geometry and cardiac function in patients with non-alcoholic fatty liver disease: association with the severity of liver disease. J Hepatol. 2015;62:928\u201333.","journal-title":"J Hepatol."},{"key":"4027_CR40","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1053\/j.ajkd.2022.03.015","volume":"80","author":"J Rey-Garcia","year":"2022","unstructured":"Rey-Garcia J, Townsend RR. Renal denervation: a review. Am J Kidney Dis. 2022;80:527\u201335.","journal-title":"Am J Kidney Dis."},{"key":"4027_CR41","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/hep.31889","volume":"74","author":"F Barrow","year":"2021","unstructured":"Barrow F, Khan S, Wang H, Revelo XS. The emerging role of B cells in the pathogenesis of NAFLD. Hepatology. 2021;74:2277\u201386.","journal-title":"Hepatology."},{"key":"4027_CR42","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1161\/CIRCRESAHA.118.313234","volume":"124","author":"E Brandsma","year":"2019","unstructured":"Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, et al. A proinflammatory gut microbiota increases systemic inflammation and accelerates atherosclerosis. Circ Res. 2019;124:94\u2013100.","journal-title":"Circ Res."},{"key":"4027_CR43","doi-asserted-by":"publisher","first-page":"e02566","DOI":"10.1128\/mBio.02566-18","volume":"10","author":"NT Baxter","year":"2019","unstructured":"Baxter NT, Schmidt AW, Venkataraman A, Kim KS, Waldron C, Schmidt TM. Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers. mBio. 2019;10:e02566-18.","journal-title":"mBio."},{"key":"4027_CR44","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.3168\/jds.2021-21345","volume":"105","author":"J He","year":"2022","unstructured":"He J, Guo K, Chen Q, Wang Y, Jirimutu. Camel milk modulates the gut microbiota and has anti-inflammatory effects in a mouse model of colitis. J Dairy Sci. 2022;105:3782\u201393.","journal-title":"J Dairy Sci."},{"key":"4027_CR45","doi-asserted-by":"publisher","first-page":"eabg733","DOI":"10.1126\/sciadv.abg5733","volume":"7","author":"C Adori","year":"2021","unstructured":"Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, Yoshitake T, et al. Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging. Sci Adv. 2021;7:eabg733.","journal-title":"Sci Adv."},{"key":"4027_CR46","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/jdi.13373","volume":"12","author":"T Chen","year":"2021","unstructured":"Chen T, Zhang Y, Zhang Y, Shan C, Zhang Y, Fang K, et al. Relationships between gut microbiota, plasma glucose and gestational diabetes mellitus. J Diabetes Investig. 2021;12:641\u201350.","journal-title":"J Diabetes Investig."},{"key":"4027_CR47","doi-asserted-by":"publisher","first-page":"7511","DOI":"10.1038\/s41467-023-43119-z","volume":"14","author":"F Khan","year":"2023","unstructured":"Khan F, Elgeti M, Grandfield S, Paz A, Naughton FB, Marcoline FV, et al. Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na\/glucose symporter vSGLT. Nat Commun. 2023;14:7511.","journal-title":"Nat Commun."}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04027-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04027-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04027-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:03:09Z","timestamp":1747814589000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04027-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4027"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04027-y","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"23 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research animals were treated and manipulated following the ARRIVE guidelines (). The investigation was approved by the institutional ethics committee of Guangzhou First People\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"311"}}