{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:00:51Z","timestamp":1781614851982,"version":"3.54.5"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100022025","name":"South Valley University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Species of\n                      <jats:italic>Candida<\/jats:italic>\n                      are the main cause of aggressive fungal infections in preterm newborns. These infections are linked to significant illness and death. Neonatal thrush is diagnosed by observing white patches on the surfaces of the mucosa of the mouth. Yeast is often associated with it. This study aimed to apply different techniques to characterize the yeasts associated with neonatal mouth thrush. Laboratory-based yeast species identification techniques (morphological and molecular) have been employed. Virulence genes were tested to compare experimental virulence assays and the presence of studied genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results indicated that forty-one isolates out of 79 were identified as\n                      <jats:italic>C. albicans<\/jats:italic>\n                      and confirmed by using (\n                      <jats:italic>CALB1-CALB2<\/jats:italic>\n                      ) specific primers.\n                      <jats:italic>C. dubliniensis<\/jats:italic>\n                      ,\n                      <jats:italic>C. glabrata<\/jats:italic>\n                      (\n                      <jats:italic>Nakaseomyces glabratus<\/jats:italic>\n                      ),\n                      <jats:italic>C. guilliermondii<\/jats:italic>\n                      (\n                      <jats:italic>Meyerozyma guilliermondii<\/jats:italic>\n                      ),\n                      <jats:italic>C. krusei<\/jats:italic>\n                      (\n                      <jats:italic>Pichia kudriavzevii<\/jats:italic>\n                      ),\n                      <jats:italic>C. lusitaniae<\/jats:italic>\n                      (\n                      <jats:italic>Clavispora lusitaniae<\/jats:italic>\n                      ),\n                      <jats:italic>C. parapsilosis<\/jats:italic>\n                      ,\n                      <jats:italic>C. tropicalis<\/jats:italic>\n                      ,\n                      <jats:italic>C. kefyr<\/jats:italic>\n                      (\n                      <jats:italic>Kluyveromyces marxianus<\/jats:italic>\n                      ), and\n                      <jats:italic>Trichosporon asahii<\/jats:italic>\n                      were also verified by applying (\n                      <jats:italic>CandF - CandR<\/jats:italic>\n                      ) primer and Internal transcribed spacer (ITS) sequencing. Thirty-six isolates were active producers of the three tested enzymes: hemolysin, phospholipase, and proteinase. Fifty-five isolates secreted hemolysin, and sixty-four isolates were positive for the presence of the phospholipase B1 (\n                      <jats:italic>PLB1<\/jats:italic>\n                      ) gene. The secreted aspartyl protease 1 (\n                      <jats:italic>SAP1<\/jats:italic>\n                      ) gene was detected in thirty-three isolates, from which thirty-two isolates secreted the proteinase enzyme.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Different techniques were required to diagnose the\n                      <jats:italic>Candida<\/jats:italic>\n                      species and other yeasts associated with neonatal thrush.\n                      <jats:italic>C. albicans<\/jats:italic>\n                      was the dominant species. The identification of two species of\n                      <jats:italic>C. albicans<\/jats:italic>\n                      and\n                      <jats:italic>C. dubliniensis<\/jats:italic>\n                      by specific primer (\n                      <jats:italic>CALB1-CALB2<\/jats:italic>\n                      ), general primer (\n                      <jats:italic>CandF - CandR<\/jats:italic>\n                      ), and sequencing techniques was applied in this study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-025-04075-4","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T02:27:46Z","timestamp":1750904866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization and virulence of yeasts associated with neonatal thrush"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-1018","authenticated-orcid":false,"given":"Eman G. A. M.","family":"El-Dawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Baddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssuf A.","family":"Gherbawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa S.","family":"Yassein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"4075_CR1","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.14219\/jada.archive.1999.0138","volume":"130","author":"HC Slavkin","year":"1999","unstructured":"Slavkin HC. Streptococcus mutans, early childhood caries and new opportunities. J Amer Dent Ass. 1999;130:12: 1787\u201392. https:\/\/doi.org\/10.14219\/jada.archive.1999.0138.","journal-title":"J Amer Dent Ass"},{"key":"4075_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.archoralbio.2004.07.004","volume":"50","author":"T Kadir","year":"2005","unstructured":"Kadir T, Uygun B, Akyuz S. Prevalence of Candida species in Turkish children: relationship between dietary intake and carriage. Arch Oral Biol. 2005;50:33\u20137. https:\/\/doi.org\/10.1016\/j.archoralbio.2004.07.004.","journal-title":"Arch Oral Biol"},{"key":"4075_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.mib.2017.10.020","volume":"40","author":"RA Hall","year":"2017","unstructured":"Hall RA, Noverr MC. Fungal interactions with the human host: exploring the spectrum of symbiosis. Curr Opin Microbiol. 2017;40:58\u201364. https:\/\/doi.org\/10.1016\/j.mib.2017.10.020.","journal-title":"Curr Opin Microbiol"},{"key":"4075_CR4","first-page":"1","volume":"2","author":"MI Qadir","year":"2020","unstructured":"Qadir MI, Asif H. An overview to candidiasis-a Candida infection. Int J Advan Res Microbiol Immunol. 2020;2:1.","journal-title":"Int J Advan Res Microbiol Immunol"},{"issue":"6","key":"4075_CR5","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1684\/ejd.2006.0011","volume":"16","author":"E Sarifakioglu","year":"2006","unstructured":"Sarifakioglu E, Gunduz C, Gorpelioglu C. Oral mucosa manifestations in 100 pregnant versus non-pregnant patients: an epidemiological observational study. Eur J Dermatol. 2006;16(6):674\u20136. https:\/\/doi.org\/10.1684\/ejd.2006.0011.","journal-title":"Eur J Dermatol"},{"key":"4075_CR6","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.2147\/DDDT","volume":"10","author":"X Lyu","year":"2016","unstructured":"Lyu X, Zhao C, Yan ZM, Hua H. Efficacy of Nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis. Drug Des Devel Ther. 2016;10:1161\u201371. https:\/\/doi.org\/10.2147\/DDDT. S100795.","journal-title":"Drug Des Devel Ther"},{"key":"4075_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.micpath.2019.03.022","volume":"131","author":"B Khadija","year":"2019","unstructured":"Khadija B, Abbasi A, Khan S, Nadeem M, Badshah L, Faryal R. Isolation of pathogenic Candida species from oral cavity of postpartum females, and its association with obstetric and dental problems. Microb Pathog. 2019;131:40\u20136. https:\/\/doi.org\/10.1016\/j.micpath.2019.03.022.","journal-title":"Microb Pathog"},{"key":"4075_CR8","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1001\/archpedi.1957.04030040016004","volume":"94","author":"B Dobias","year":"1957","unstructured":"Dobias B. Moniliasis in pediatrics. Amer J Dis Child. 1957;94:3: 234\u201351. https:\/\/doi.org\/10.1001\/archpedi.1957.04030040016004.","journal-title":"Amer J Dis Child"},{"issue":"2","key":"4075_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0095-5108(18)30523","volume":"18","author":"JE Baley","year":"1991","unstructured":"Baley JE. Neonatal candidiasis: the current challenge. Clin Perinatol. 1991;18(2):263\u201380. https:\/\/doi.org\/10.1016\/S0095-5108(18)30523-.","journal-title":"Clin Perinatol"},{"key":"4075_CR10","unstructured":"Riordan KJ, Wambach, editors. Breastfeeding and human lactation Jones & Bartlett Learning. J of Med 2010; 120:10: 871\u2013879."},{"issue":"6","key":"4075_CR11","doi-asserted-by":"publisher","first-page":"F429","DOI":"10.1136\/adc.2008.157123","volume":"94","author":"A Howell","year":"2009","unstructured":"Howell A, Isaacs D, Halliday R, Australasian Study Group For Neonatal Infections. Oral Nystatin prophylaxis and neonatal fungal infections. Arch Dis Childhood-Fetal Neonatal Ed. 2009;94(6):F429\u201333. https:\/\/doi.org\/10.1136\/adc.2008.157123.","journal-title":"Arch Dis Childhood-Fetal Neonatal Ed"},{"key":"4075_CR12","doi-asserted-by":"publisher","unstructured":"Ben Abdeljelil J, Saghrouni F, Khammari I, Gheith S, Fathallah A, Ben Said M, Boukadida J. Investigation of a cluster of Candida albicans invasive candidiasis in a neonatal intensive care unit by Pulsed- Field Gel Electrophoresis. The Sci World J. 2012; 2012:1: 138989. https:\/\/doi.org\/10.1100\/2012\/138989","DOI":"10.1100\/2012\/138989"},{"key":"4075_CR13","doi-asserted-by":"publisher","unstructured":"Ben Abdeljelil J, Saghrouni F, Nouri S, Geith S, Khammari I, Fathallah A, Sboui H. & Ben sa\u00efd M. Neonatal invasive candidiasis in Tunisian hospital: incidence, risk factors, distribution of species and antifungal susceptibility. Mycoses 2012b 55:6: 493\u2013500. https:\/\/doi.org\/10.1111\/j.1439-0507.2012.02189.x","DOI":"10.1111\/j.1439-0507.2012.02189.x"},{"key":"4075_CR14","volume-title":"Candida and candidosis: A review and bibliography","author":"FC Odds","year":"1988","unstructured":"Odds FC. Candida and candidosis: A review and bibliography. London: Bailliere Tindall; 1988."},{"key":"4075_CR15","unstructured":"Terezhalmy GT, Huber MA. Oropharyngeal candidiasis: etiology, epidemiology, clinical manifestations, diagnosis, and treatment. Crest Oral-B at Dentalcare.com Contin. Educ Course 2011; p 1\u201316."},{"key":"4075_CR16","doi-asserted-by":"publisher","first-page":"e75490","DOI":"10.7554\/eLife.75490","volume":"11","author":"CM Russell","year":"2022","unstructured":"Russell CM, Schaefer KG, Dixson A, Gray ALH, Pyron RJ, Alves DS, Moore N, Conley EA, Schuck RJ, White TA, Do TD, King GM, Barrera FN. The Candida albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells. Elife. 2022;11:e75490. https:\/\/doi.org\/10.7554\/eLife.75490.","journal-title":"Elife"},{"issue":"1","key":"4075_CR17","doi-asserted-by":"publisher","first-page":"e03510","DOI":"10.1128\/mbio.03510-21","volume":"13","author":"JP Richardson","year":"2022","unstructured":"Richardson JP, Brown R, Kichik N, Lee S, Priest E, Mogavero S, Maufrais C, Wickramasinghe DN, Tsavou A, Kotowicz NK, Hepworth OW, Gallego-Cort\u00e9s A, Ponde NO, Ho J, Moyes DL, Wilson D, D\u2019Enfert C, Hube B, Naglik JR. Candidalysins are a new family of cytolytic fungal peptide toxins. mBio. 2022;13(1):e03510\u201321. https:\/\/doi.org\/10.1128\/mbio.03510-21.","journal-title":"mBio"},{"issue":"3","key":"4075_CR18","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1590\/S1517-83822008000300033","volume":"39","author":"RB Silva","year":"2008","unstructured":"Silva RB, Fusco-Almeida AM, Matsumoto MT, Baeza LC, Benaducci T, Mendes-Giannini MJS. Genetic diversity and antifungal susceptibility testing of trichosporon Asahii isolated of intensive care units patients. Braz J Microbiol. 2008;39(3):585\u201392. https:\/\/doi.org\/10.1590\/S1517-83822008000300033.","journal-title":"Braz J Microbiol"},{"issue":"2","key":"4075_CR19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","volume":"36","author":"S Silva","year":"2011","unstructured":"Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2011;36(2):288\u2013305. https:\/\/doi.org\/10.1111\/j.1574-6976.2011.00278.x.","journal-title":"FEMS Microbiol Rev"},{"key":"4075_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13412","author":"MR J\u00f8rgensen","year":"2024","unstructured":"J\u00f8rgensen MR. Pathophysiological microenvironments in oral candidiasis. APMIS. 2024. https:\/\/doi.org\/10.1111\/apm.13412.","journal-title":"APMIS"},{"key":"4075_CR21","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1001\/archpedi.1960.02070030214011","volume":"99","author":"CL Taschdjian","year":"1960","unstructured":"Taschdjian CL, Burchall JJ, Kozinn PJ. Rapid identification of Candida albicans by filamentation on serum and serum substitutes. AMA J Dis Child. 1960;99:212\u20135. https:\/\/doi.org\/10.1001\/archpedi.1960.02070030214011.","journal-title":"AMA J Dis Child"},{"key":"4075_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/jof4010010","volume":"4","author":"JV Desai","year":"2018","unstructured":"Desai JV. Candida albicans hyphae: from growth initiation to invasion. J Fungi (Basel). 2018;4:10. https:\/\/doi.org\/10.3390\/jof4010010.","journal-title":"J Fungi (Basel)"},{"key":"4075_CR23","doi-asserted-by":"publisher","unstructured":"Gutierrez J, Morales P, Gonzalez MA, Quindos G. Candida Dubliniensis, a new fungal pathogen. J. of basic microbiol: an int. J. on biochem, physiol, gene, morph, 182 and ecology of microorganisms. 2002; 42:3: 207\u201327. https:\/\/doi.org\/10.1002\/1521-4028","DOI":"10.1002\/1521-4028"},{"key":"4075_CR24","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/j.1567-1364.2009.00570.x","volume":"9","author":"RS Almeida","year":"2009","unstructured":"Almeida RS, Wilson D, Hube B. Candida albicans iron acquisition within the host. FEMS Yeast Res. 2009;9:7:1000\u201312. https:\/\/doi.org\/10.1111\/j.1567-1364.2009.00570.x.","journal-title":"FEMS Yeast Res"},{"key":"4075_CR25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1371\/journal.ppat.1000217","volume":"4","author":"RS Almeida","year":"2008","unstructured":"Almeida RS, Brunke S, Albrecht A, Thewes S, Laue M, Edwards JE, Filler SG, Hube B. The hyphal-associated adhesin and Invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathog. 2008;4:11. https:\/\/doi.org\/10.1371\/journal.ppat.1000217.","journal-title":"PLoS Pathog"},{"key":"4075_CR26","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1099\/00221287-131-5-1217","volume":"131","author":"K Barrett-Bee","year":"1985","unstructured":"Barrett-Bee K, Hayes Y, Wilson RG, et al. A comparison of phospholipase activity, cellular adherence and pathogenicity of yeasts. J Gen Microbiol. 1985;131:1217\u201321. https:\/\/doi.org\/10.1099\/00221287-131-5-1217.","journal-title":"J Gen Microbiol"},{"key":"4075_CR27","first-page":"51","volume-title":"Fungal pathogenesis: principles and clinical applications","author":"PK Mukherjee","year":"2002","unstructured":"Mukherjee PK, Ghannoum MA. Secretory proteins in fungal virulence. In: Calderone RA, Cihlar RL, editors. Fungal pathogenesis: principles and clinical applications. New York: Marcel Dekker; 2002. pp. 51\u201379."},{"issue":"3","key":"4075_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1086\/376536","volume":"188","author":"JR Naglik","year":"2003","unstructured":"Naglik JR, Rodgers CA, Shirlaw PJ, Dobbie JL, Fernandes-Naglik LL, Greenspan D, Agabian N, Challacombe SJ. Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections. J Infect Dis. 2003;188(3):469\u201379. https:\/\/doi.org\/10.1086\/376536.","journal-title":"J Infect Dis"},{"issue":"12","key":"4075_CR29","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1111\/j.1600-0463.2006.apm_479.x","volume":"114","author":"YH Samaranayake","year":"2006","unstructured":"Samaranayake YH, Dassanayake RS, Cheung BPK, Jayatilake JAMS, Yeung KWS, Yau JYY, Samaranayake LP. Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium. APMIS. 2006;114(12):857\u201366. https:\/\/doi.org\/10.1111\/j.1600-0463.2006.apm_479.x.","journal-title":"APMIS"},{"key":"4075_CR30","first-page":"169","volume":"3","author":"AZ Mahmoudabadi","year":"2010","unstructured":"Mahmoudabadi AZ, Zarrin M, Miry S. Phospholipase activity of Candida albicans isolated from vagina and urine samples. Jundishapur J Microbiol. 2010;3:169\u201373.","journal-title":"Jundishapur J Microbiol"},{"issue":"10","key":"4075_CR31","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1099\/jmm.0.47303-0","volume":"56","author":"CSP Tsang","year":"2007","unstructured":"Tsang CSP, Chu FCS, Leung WK, Jin LJ, Samaranayake LP, Siu SC. Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus. J Med Microbiol. 2007;56(10):1393\u20138. https:\/\/doi.org\/10.1099\/jmm.0.47303-0.","journal-title":"J Med Microbiol"},{"key":"4075_CR32","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2174\/1389203717666160809155749","volume":"18","author":"S Monika","year":"2017","unstructured":"Monika S, Ma\u0142gorzata B, Zbigniew O. Contribution of aspartic proteases in Candida virulence. Protease inhibitors against Candida infections. Curr Protein Pept Sci. 2017;18:10:1050\u201362. https:\/\/doi.org\/10.2174\/1389203717666160809155749.","journal-title":"Curr Protein Pept Sci"},{"key":"4075_CR33","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4615-5373-1_47","volume":"436","author":"B Hube","year":"1998","unstructured":"Hube B, Ruchel R, Monod M, Sanglard D, Odds FC. Functional aspects of secreted Candida proteinases. Adv Exp Med Biol. 1998;436:339\u201344.","journal-title":"Adv Exp Med Biol"},{"key":"4075_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-2133.1948.tb10992.x","volume":"60","author":"GIM Carlier","year":"1948","unstructured":"Carlier GIM. An All-British mycological culture media. Brit J Derm Syph. 1948;60:2.","journal-title":"Brit J Derm Syph"},{"key":"4075_CR35","unstructured":"Sabouraud R. Contribution a L\u2019etude de La trichophytie Humaine. Etude clinique, microscopique et bacterioloqique Sur La pluralit\u00e9 des trichophytons de L\u2019homme. Annals Dermatology Syphilis. 1892;3:1061\u201387."},{"key":"4075_CR36","unstructured":"Gams W, Hoekstra ES, Aptroot ACBS. Course on Mycology. Centraalbureau voor Schimmelcultures, AG Baarn, the Netherlands; 1998."},{"key":"4075_CR37","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1128\/jcm.32.8.1923-1929.1994","volume":"32","author":"FC Odds","year":"1994","unstructured":"Odds FC, Bernaerts R. CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important yeast species. J Clin Microbiol. 1994;32:1923\u20139. https:\/\/doi.org\/10.1128\/jcm.32.8.1923-1929.1994.","journal-title":"J Clin Microbiol"},{"key":"4075_CR38","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1128\/jcm.34.8.2048-2048.1996","volume":"34","author":"AM Freydi\u00e9re","year":"1996","unstructured":"Freydi\u00e9re AM. Evaluation of CHROMagar Candida plates. J Clin Microbiol. 1996;34:2048.","journal-title":"J Clin Microbiol"},{"key":"4075_CR39","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1128\/jcm.25.12.2424-2425.1987","volume":"25","author":"JL Perry","year":"1987","unstructured":"Perry JL, Miller GR. Umbelliferyl-labeled galactosaminide as an aid in identification of Candida albicans. J Clin Microbiol. 1987;25:12: 2424\u20135. https:\/\/doi.org\/10.1128\/jcm.25.12.2424-2425.1987.","journal-title":"J Clin Microbiol"},{"issue":"12","key":"4075_CR40","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1128\/jcm.32.12.3034-3036.1994","volume":"32","author":"P Rousselle","year":"1994","unstructured":"Rousselle P, Freydiere AM, Couillerot PJ, De Montclos H, Gille Y. Rapid identification of Candida albicans by using Albicans ID and fluoroplate agar plates. J Clin Microbiol. 1994;32(12):3034\u20136. https:\/\/doi.org\/10.1128\/jcm.32.12.3034-3036.1994.","journal-title":"J Clin Microbiol"},{"key":"4075_CR41","first-page":"6","volume":"3","author":"DGE Makwana","year":"2012","unstructured":"Makwana DGE, Gadhavi DH, Sinha DM. Comparison of germ tube production by Candida albicans in various media: comparison of germ tube production by Candida albicans. NJIRM. 2012;3:2:6\u20138.","journal-title":"NJIRM"},{"key":"4075_CR42","first-page":"11","volume":"19","author":"JJ Doyle","year":"1987","unstructured":"Doyle JJ, Doyle JL. A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull. 1987;19:11\u20135.","journal-title":"Phytochem Bull"},{"key":"4075_CR43","doi-asserted-by":"crossref","unstructured":"White TJ, Bruns T, Lee SJWT, Taylor J. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. PCR protocols: a guide to methods and applications. 1990; 18:1: 315\u2013322.","DOI":"10.1016\/B978-0-12-372180-8.50042-1"},{"issue":"2","key":"4075_CR44","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3390\/microorganisms10020374","volume":"10","author":"E Garc\u00eda-Salazar","year":"2022","unstructured":"Garc\u00eda-Salazar E, Acosta-Altamirano G, Betancourt-Cisneros P, Reyes-Montes MDR, Rosas-De-Paz E, Duarte-Escalante E, S\u00e1nchez-Conejo AR. Ocharan Hern\u00e1ndez E, Fr\u00edas-De-Le\u00f3n MG. Detection and molecular identification of eight Candida species in clinical samples by simplex PCR. Microorganisms. 2022;10(2):374. https:\/\/doi.org\/10.3390\/microorganisms10020374.","journal-title":"Microorganisms"},{"issue":"2","key":"4075_CR45","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.pep.2004.02.015","volume":"35","author":"L Zhang","year":"2004","unstructured":"Zhang L, Zhao C, Zhu D, Ohta Y, Wang Y. Purification and characterization of Inulinase from Aspergillus Niger AF10 expressed in Pichia pastoris. Protein Expr Purif. 2004;35(2):272\u20135. https:\/\/doi.org\/10.1016\/j.pep.2004.02.015.","journal-title":"Protein Expr Purif"},{"key":"4075_CR46","unstructured":"Moeller M, Maurer H, Roesler M. MDMA in blood, urine and hair: a forensic case. In Proceedings, 30th TIAAFT Meeting. Fukouka, Japan: Yoyodo Printing Kaisha Ltd. 1992; 56\u201361."},{"issue":"2","key":"4075_CR47","first-page":"95","volume":"41","author":"HK Malcok","year":"2009","unstructured":"Malcok HK, Aktas E, Ayyildiz A, Yigit N, Yazgi H. Hemolytic activities of the Candida species in liquidmedium. Eur J Med. 2009;41(2):95\u20138.","journal-title":"Eur J Med"},{"issue":"1","key":"4075_CR48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/00362178285380031","volume":"20","author":"MF Price","year":"1982","unstructured":"Price MF, Wilkinson ID, Gentry LO. Plate method for detection of phospholipase activity in Candida albicans. Sabouraudia: J Med Veterinary Mycol. 1982;20(1):7\u201314. https:\/\/doi.org\/10.1080\/00362178285380031.","journal-title":"Sabouraudia: J Med Veterinary Mycol"},{"key":"4075_CR49","unstructured":"Paterson RRM, Bridge PD. Biochemical techniques for filamentous fungi (IMI techanical Handbook). Oxford University Press; 1994."},{"key":"4075_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijfoodmicro.2016.08.007","volume":"237","author":"S Ozturkoglu-Budak","year":"2016","unstructured":"Ozturkoglu-Budak S, Wiebenga A, Bron PA, de Vries RP. Protease and lipase activities of fungal and bacterial strains derived from an artisanal Raw Ewe\u2019s milk cheese. Int J Food Microbiol. 2016;237:17\u201327. https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2016.08.007.","journal-title":"Int J Food Microbiol"},{"key":"4075_CR51","unstructured":"Kumar M. Thrush. Background, pathophysiology, epidemiology. Available from: http:\/\/emedicine.medscape.com\/article\/969147-overview. Published January 6, 2017. Accessed September 26, 2016."},{"issue":"8","key":"4075_CR52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/pathogens13080660","volume":"6","author":"N Dermitzaki","year":"2024","unstructured":"Dermitzaki N, Baltogianni M, Tsekoura E, Giapros V. Invasive Candida infections in neonatal intensive care units: risk factors and new insights in prevention. Pathogens. 2024;6(8):13. https:\/\/doi.org\/10.3390\/pathogens13080660.","journal-title":"Pathogens"},{"key":"4075_CR53","doi-asserted-by":"publisher","first-page":"7309","DOI":"10.3389\/fimmu.2016.00309","volume":"18","author":"AJ Battersby","year":"2016","unstructured":"Battersby AJ, Khara J, Wright VJ, Levy O, Kampmann B. Antimicrobial proteins and peptides in early life: ontogeny and translational opportunities. Front Immunol. 2016;18:7309. https:\/\/doi.org\/10.3389\/fimmu.2016.00309.","journal-title":"Front Immunol"},{"key":"4075_CR54","doi-asserted-by":"publisher","unstructured":"Benjamin DK Jr, Stoll BJ, Gantz MG, Walsh MC, S\u00e1nchez PJ, Das A, Shankaran S, Higgins RD, Auten KJ, Miller NA, Walsh TJ. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010;1(1264):e865\u201373. https:\/\/doi.org\/10.1542\/peds.2009-3412.","DOI":"10.1542\/peds.2009-3412"},{"key":"4075_CR55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12281-023-00455-3","volume":"17","author":"M Sharma","year":"2023","unstructured":"Sharma M, Chakrabarti A. Candidiasis and other emerging yeasts. Cur Fung Infect Rep. 2023;17:1:15\u201324. https:\/\/doi.org\/10.1007\/s12281-023-00455-3.","journal-title":"Cur Fung Infect Rep"},{"key":"4075_CR56","unstructured":"Berkhout. De schimmelgesl. Monilia, oidium, oospora En Torula. Disset Ultrecht. 1923; 44."},{"key":"4075_CR57","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3314\/mmj.22.004","volume":"63:4","author":"M Takashima","year":"2022","unstructured":"Takashima M, Sugita T. Taxonomy of pathogenic yeasts Candida, Cryptococcus, Malassezia, and Trichosporon current status, future perspectives, and proposal for transfer of six Candida species to the genus Nakaseomyces. Med Mycol J. 2022;63:4:119\u201332. https:\/\/doi.org\/10.3314\/mmj.22.004.","journal-title":"Med Mycol J"},{"key":"4075_CR58","unstructured":"Behrend G. Ueber trichomycosis nodosa (Juhel-R\u00e9noy): Piedra (Osorio). Berliner Klinische Wochenschrift. 1890; 27: 464\u20137."},{"key":"4075_CR59","doi-asserted-by":"publisher","first-page":"e393","DOI":"10.1016\/S1473-3099(17)30442-5","volume":"17","author":"D Armstrong-James","year":"2017","unstructured":"Armstrong-James D, Brown GD, Netea MG, Zelante T, Gresnigt M, van de Veerdonk F, et al. Immunotherapeutic approaches to treatment of fungal diseases. Lancet Infect Dis. 2017;17:e393\u2013402. https:\/\/doi.org\/10.1016\/S1473-3099(17)30442-5.","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"4075_CR60","doi-asserted-by":"publisher","first-page":"195","DOI":"10.21608\/aunj.2023.202022.1047","volume":"52","author":"NA Hussein","year":"2023","unstructured":"Hussein NA, Abdel-Sater MA, Edrees MF, Nasr AM, Danial AW. Mycobiota associated with teeth and oral cavity and their relevant to dental and periodontal diseases. Assiut Univ J Multidisciplinary Sci Res. 2023;52(2):195\u2013231. https:\/\/doi.org\/10.21608\/aunj.2023.202022.1047.","journal-title":"Assiut Univ J Multidisciplinary Sci Res"},{"issue":"1","key":"4075_CR61","doi-asserted-by":"publisher","first-page":"e03510","DOI":"10.1128\/mbio.03510-21","volume":"13","author":"JP Richardson","year":"2022","unstructured":"Richardson JP, Brown R, Kichik N, Lee S, Priest E, Mogavero S, Maufrais C, Wickramasinghe DN, Tsavou A, Kotowicz NK, et al. Candidalysins are a new family of cytolytic fungal peptide toxins. MBio. 2022;13(1):e03510\u201321. https:\/\/doi.org\/10.1128\/mbio.03510-21.","journal-title":"MBio"},{"key":"4075_CR62","doi-asserted-by":"publisher","first-page":"e75490","DOI":"10.7554\/eLife.75490","volume":"2911","author":"CM Russell","year":"2022","unstructured":"Russell CM, Schaefer KG, Dixson A, Gray AL, Pyron RJ, Alves DS, Moore N, Conley EA, Schuck RJ, White TA, Do TD. The Candida albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells. Elife. 2022;2911:e75490. https:\/\/doi.org\/10.7554\/eLife.75490.","journal-title":"Elife"},{"issue":"4","key":"4075_CR63","doi-asserted-by":"publisher","first-page":"375","DOI":"10.33640\/2405-609X.1984","volume":"6","author":"AIE Al-laaeiby","year":"2020","unstructured":"Al-laaeiby AIE, Al-Mousawi AA, Alrubayae I, Al-Saadoon A, Almayahi M. Innate pathogenic traits in oral yeasts. Karbala Int J Mod Sci. 2020;6(4):375\u201384. https:\/\/doi.org\/10.33640\/2405-609X.1984.","journal-title":"Karbala Int J Mod Sci"},{"issue":"4","key":"4075_CR64","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1128\/jcm.43.4.1818-1828.2005","volume":"43","author":"C Girmenia","year":"2005","unstructured":"Girmenia C, Pagano L, Martino B, D\u2019Antonio D, Fanci R, Specchia G, Melillo L, Buelli M, Pizzarelli G, Venditti M, Martino P. Invasive infections caused by trichosporon species and geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J Clin Microb. 2005;43(4):1818\u201328. https:\/\/doi.org\/10.1128\/jcm.43.4.1818-1828.2005.","journal-title":"J Clin Microb"},{"key":"4075_CR65","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/S1567","volume":"4","author":"DJ Sullivan","year":"2004","unstructured":"Sullivan DJ, Moran GP, Pinjon E, Al-Mosaid A, Stokes C, Vaughan C, Coleman DC. Comparison of the epidemiology, drug resistance mechanisms, and virulence of Candida Dubliniensis and Candida albicans. FEMS Yeast Res. 2004;4:4\u20135. https:\/\/doi.org\/10.1016\/S1567-. 1356(03)00240-X.","journal-title":"FEMS Yeast Res"},{"key":"4075_CR66","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1128\/jcm.38.6.2423-2426.2000","volume":"38","author":"MA Jabra-Rizk","year":"2000","unstructured":"Jabra-Rizk MA, Falkler WA Jr, Merz WG, Baqui AA, Kelley JI, Meiller TF. Retrospective identification and characterization of Candida Dubliniensis isolates among Candida albicans clinical laboratory isolates from human immunodeficiency virus (HIV)- infected and non-HIV-infected individuals. J Clin Microbiol. 2000;38:2423\u20136. https:\/\/doi.org\/10.1128\/jcm.38.6.2423-2426.2000.","journal-title":"J Clin Microbiol"},{"issue":"1","key":"4075_CR67","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3109\/13693780802713224","volume":"48","author":"K Ozcan","year":"2010","unstructured":"Ozcan K, Ilkit M, Ates A, Turac-Bicer A, Demirhindi H. Performance of chromogenic Candida agar and CHROMagar Candida in recovery and presumptive identification of monofungal and polyfungal vaginal isolates. Med Myco. 2010;48(1):29\u201334. https:\/\/doi.org\/10.3109\/13693780802713224.","journal-title":"Med Myco"},{"issue":"8","key":"4075_CR68","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1128\/jcm.40.8.2860-2865.2002","volume":"40","author":"G Luo","year":"2002","unstructured":"Luo G, Mitchell TG. Rapid identification of pathogenic fungi directly from cultures by using multiplex PCR. J Clin Microbiol. 2002;40(8):2860\u20135. https:\/\/doi.org\/10.1128\/jcm.40.8.2860-2865.2002.","journal-title":"J Clin Microbiol"},{"issue":"4","key":"4075_CR69","doi-asserted-by":"publisher","first-page":"124","DOI":"10.36346\/sarjps.2024.v06i04.002","volume":"6","author":"HS Hussein","year":"2024","unstructured":"Hussein HS. Isolating and diagnosing some types of Candida spp yeast and studying their sensitivity to some antifungals. South Asian Res J Pharma Sci. 2024;6(4):124\u201330. https:\/\/doi.org\/10.36346\/sarjps.2024.v06i04.002.","journal-title":"South Asian Res J Pharma Sci"},{"issue":"2","key":"4075_CR70","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1128\/jcm.36.2.329-334.1998","volume":"36","author":"D Sullivan","year":"1998","unstructured":"Sullivan D, Coleman D. Candida Dubliniensis: characteristics and identification. J Clin Microbiol. 1998;36(2):329\u201334. https:\/\/doi.org\/10.1128\/jcm.36.2.329-334.1998.","journal-title":"J Clin Microbiol"},{"key":"4075_CR71","unstructured":"Islam A. Characterizing genes of Candida albicans involved in invasiveness, mating and genotoxic stress response (Doctoral dissertation, Concordia University); 2018."},{"key":"4075_CR72","doi-asserted-by":"publisher","first-page":"e33818","DOI":"10.1371\/journal.pone.0033818","volume":"7","author":"CJ Ingham","year":"2012","unstructured":"Ingham CJ, Boonstra S, Levels S, de Lange M, Meis JF, Schneeberger PM. Rapid susceptibility testing and microcolony analysis of Candida spp. Cultured and imaged on porous aluminum oxide. PLoS ONE. 2012;7:3: e33818. https:\/\/doi.org\/10.1371\/journal.pone.0033818.","journal-title":"PLoS ONE"},{"key":"4075_CR73","doi-asserted-by":"crossref","unstructured":"Humaid ARA, Al-Ghalibi SMS, Abdel-Sater MA, Salahaddin RH. Proteases and lipases activity of fungi isolated from local cheese, Republic of Yemen. Ass Univ Bull Environ Res. 2020; 23.","DOI":"10.21608\/auber.2020.112657"},{"issue":"3","key":"4075_CR74","doi-asserted-by":"publisher","first-page":"0778","DOI":"10.21123\/bsj.2022.6744","volume":"20","author":"ER Alwaily","year":"2023","unstructured":"Alwaily ER, Flaih MH, Abood MS, Hussein KR. Determination of fungal and parasitic infections caused vaginitis: molecular identification of Candida parapsilosis in Al-Nasiriyah City, Iraq. Bagh Sci J. 2023;20(3):0778\u20130778. https:\/\/doi.org\/10.21123\/bsj.2022.6744.","journal-title":"Bagh Sci J"},{"issue":"10","key":"4075_CR75","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1086\/323812","volume":"15","author":"DP Kontoyiannis","year":"2001","unstructured":"Kontoyiannis DP, Vaziri I, Hanna HA, Boktour M, Thornby J, Hachem R, Bodey GP, Raad II. Risk factors for Candida tropicalis fungemia in patients with cancer. Clin Infect Dis. 2001;15(10):33. https:\/\/doi.org\/10.1086\/323812.","journal-title":"Clin Infect Dis"},{"issue":"8","key":"4075_CR76","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1099\/00221287-147-8-1997","volume":"147","author":"B Hube","year":"2001","unstructured":"Hube B, Naglik J. Candida albicans proteinases: resolving the mystery of a gene family. Microbiology. 2001;147(8):1997\u20132005. https:\/\/doi.org\/10.1099\/00221287-147-8-1997.","journal-title":"Microbiology"},{"issue":"4","key":"4075_CR77","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/jb\/mvr073","volume":"1","author":"W Aoki","year":"2011","unstructured":"Aoki W, Kitahara N, Miura N, Morisaka H, Yamamoto Y, Kuroda K, Ueda M. Comprehensive characterization of secreted aspartic proteases encoded by a virulence gene family in Candida albicans. J Biochem. 2011;1(4):431\u20138. https:\/\/doi.org\/10.1093\/jb\/mvr073.","journal-title":"J Biochem"},{"key":"4075_CR78","doi-asserted-by":"publisher","unstructured":"Koelsch G, Tang J, Loy JA, Monod M, Jackson K, Foundling SI, Lin X. Enzymic characteristics of secreted aspartic proteases of Candida albicans. Biochimica et biophysica acta (BBA)-Protein structure and molecul enzymo. 2000; 14;1480(1\u20132):117\u201331. https:\/\/doi.org\/10.1016\/S0167-4838(00)00068-6","DOI":"10.1016\/S0167-4838(00)00068-6"},{"issue":"2","key":"4075_CR79","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1074\/jbc.M509297200","volume":"13","author":"A Albrecht","year":"2006","unstructured":"Albrecht A, Felk A, Pichova I, Naglik JR, Schaller M, de Groot P, MacCallum D, Odds FC, Sch\u00e4fer W, Klis F, Monod M. Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. J Biol Chem. 2006;13(2):281. https:\/\/doi.org\/10.1074\/jbc.M509297200.","journal-title":"J Biol Chem"},{"issue":"1","key":"4075_CR80","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1128\/ec.00210-10","volume":"10","author":"L Schild","year":"2011","unstructured":"Schild L, Heyken A, de Groot PW, Hiller E, Mock M, de Koster C, Horn U, Rupp S, Hube B. Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and SAP10. Euk Cell. 2011;10(1):98\u2013109. https:\/\/doi.org\/10.1128\/ec.00210-10.","journal-title":"Euk Cell"},{"issue":"9","key":"4075_CR81","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.3390\/ijms25094775","volume":"27","author":"G Bras","year":"2024","unstructured":"Bras G, Satala D, Juszczak M, Kulig K, Wronowska E, Bednarek A, Zawrotniak M, Rapala-Kozik M, Karkowska-Kuleta J. Secreted aspartic proteinases: key factors in Candida infections and host-pathogen interactions. Int J Mole Sci. 2024;27(9):4775. https:\/\/doi.org\/10.3390\/ijms25094775.","journal-title":"Int J Mole Sci"},{"key":"4075_CR82","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1365-2958.1994.tb00429.x","volume":"13","author":"M Monod","year":"1994","unstructured":"Monod M, Togni G, Hube B, Sangland D. Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol Microbiol. 1994;13:357\u201368. https:\/\/doi.org\/10.1111\/j.1365-2958.1994.tb00429.x.","journal-title":"Mol Microbiol"},{"issue":"4","key":"4075_CR83","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1099\/00221287-144-4-829","volume":"144","author":"D Gilfillan","year":"1998","unstructured":"Gilfillan D, Derek G, Parkinson JS, Coleman T, Gow DC. Candida Dubliniensis: phylogeny and putative virulence factors. Microb. 1998;144(4):829\u201338. https:\/\/doi.org\/10.1099\/00221287-144-4-829.","journal-title":"Microb"},{"key":"4075_CR84","doi-asserted-by":"publisher","unstructured":"Rossoni RD, Barbosa JO, Vilela SFG, Jorge AOC, Junqueira JC. Comparison of the hemolytic activity between C. albicans and nonalbicans Candida species. Braz Oral Res. 2013;27(6):484\u20139. https:\/\/doi.org\/10.1590\/S1806-83242013000600007.","DOI":"10.1590\/S1806-83242013000600007"},{"issue":"7","key":"4075_CR85","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/aac.00099-17","volume":"61","author":"LJ Marcos-Zambrano","year":"2017","unstructured":"Marcos-Zambrano LJ, Puig-Asensio M, P\u00e9rez-Garc\u00eda F, Escribano P, S\u00e1nchez-Carrillo C, Zaragoza O, Padilla B, Cuenca-Estrella M, Almirante B, Mart\u00edn-G\u00f3mez MT, Mu\u00f1oz P, Bouza E, Guinea J. Candida guilliermondii complex is characterized by high antifungal resistance but low mortality in 22 cases of candidemia. Antimicrob Agents Chemother. 2017;61(7):10\u20131128. https:\/\/doi.org\/10.1128\/aac.00099-17.","journal-title":"Antimicrob Agents Chemother"},{"key":"4075_CR86","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.4014\/jmb.1504.04009","volume":"25","author":"RH Bassyouni","year":"2015","unstructured":"Bassyouni RH, Wegdan AA, Abdelmoneim A, Said W, AboElnaga F. Phospholipase and aspartyl proteinase activities of Candida species causing vulvovaginal candidiasis in patients with type 2 diabetes mellitus. J Microbiol Biotech. 2015;25:10: 1734\u201341. https:\/\/doi.org\/10.4014\/jmb.1504.04009.","journal-title":"J Microbiol Biotech"},{"key":"4075_CR87","doi-asserted-by":"publisher","unstructured":"Shrief R, Zaki ME, El-Sehsah EM, Ghaleb S, Mofreh M. Study of antifungal susceptibility, virulence genes and biofilm formation in Candida albicans. The Open Microb J. 2019; 30;13(1). https:\/\/doi.org\/10.2174\/1874285801913010241","DOI":"10.2174\/1874285801913010241"},{"key":"4075_CR88","doi-asserted-by":"publisher","unstructured":"Tun\u00e7 B, Demiray G\u00fcrb\u00fcz EB, Doluca Dereli M. Investigation of phospholipase activity in Candida albicans strains isolated from blood and oral cavity specimens. T\u00fcrk Mikrobiyoloji Cemiyeti Dergisi. 2021;51(1). https:\/\/doi.org\/10.5222\/tmcd.2021.84429.","DOI":"10.5222\/tmcd.2021.84429"},{"key":"4075_CR89","doi-asserted-by":"publisher","unstructured":"Lopes JP, Lionakis MS. Pathogenesis and virulence of Candida albicans. Virulence. 2022 31;13(1):89\u2013121. https:\/\/doi.org\/10.1080\/21505594.2021.2019950","DOI":"10.1080\/21505594.2021.2019950"},{"key":"4075_CR90","doi-asserted-by":"publisher","unstructured":"Navarro-Garc\u00eda F, S\u00e1nchez M, Nombela C, Pla J. Virulence genes in the pathogenic yeast Candida albicans. FEMS microb rev. 2001; 1;25(2):245\u201368. https:\/\/doi.org\/10.1111\/j.1574-6976.2001.tb00577.x","DOI":"10.1111\/j.1574-6976.2001.tb00577.x"},{"key":"4075_CR91","doi-asserted-by":"publisher","first-page":"58","DOI":"10.19106\/JMedSci004801201606","volume":"48","author":"T Wibawa","year":"2016","unstructured":"Wibawa T. The role of virulence factors in Candida albicans pathogenicity. J Med Sci. 2016;48:58\u201368. https:\/\/doi.org\/10.19106\/JMedSci004801201606.","journal-title":"J Med Sci"},{"issue":"72","key":"4075_CR92","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jof7020079","volume":"22","author":"J Talapko","year":"2021","unstructured":"Talapko J, Juzba\u0161i\u0107 M, Matijevi\u0107 T, Pustijanac E, Beki\u0107 S, Kotris I, \u0160krlec I. Candida albicans\u2014the virulence factors and clinical manifestations of infection. J Fun. 2021;22(72):79. https:\/\/doi.org\/10.3390\/jof7020079.","journal-title":"J Fun"},{"issue":"12\u201313","key":"4075_CR93","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.micinf.2011.06.009","volume":"13","author":"JR Naglik","year":"2011","unstructured":"Naglik JR, Moyes DL, W\u00e4chtler B, Hube B. Candida albicans interactions with epithelial cells and mucosal immunity. Microb Infect. 2011;13(12\u201313):963\u201376. https:\/\/doi.org\/10.1016\/j.micinf.2011.06.009.","journal-title":"Microb Infect"},{"issue":"1","key":"4075_CR94","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1038\/s41467-019-09915-2","volume":"24","author":"J Ho","year":"2019","unstructured":"Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C. Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nat Communic. 2019;24(1):2297. https:\/\/doi.org\/10.1038\/s41467-019-09915-2.","journal-title":"Nat Communic"},{"key":"4075_CR95","doi-asserted-by":"publisher","first-page":"1499461","DOI":"10.3389\/fcimb.2024.1499461","volume":"14","author":"K Kulig","year":"2025","unstructured":"Kulig K, Wronowska E, Juszczak M, Zawrotniak M, Karkowska-Kuleta J, Rapala-Kozik M. Host cell responses to Candida albicans biofilm-derived extracellular vesicles. Front Cell Infect Microb. 2025;14:1499461. https:\/\/doi.org\/10.3389\/fcimb.2024.1499461.","journal-title":"Front Cell Infect Microb"},{"key":"4075_CR96","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/sj.bdj.2017.886","volume":"223","author":"MAO Lewis","year":"2017","unstructured":"Lewis MAO, Williams DW. Diagnosis and management of oral candidosis. Br Dent J. 2017;223:675\u201381. https:\/\/doi.org\/10.1038\/sj.bdj.2017.886.","journal-title":"Br Dent J"},{"key":"4075_CR97","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12866-017-1064-9","volume":"17","author":"BA Peters","year":"2017","unstructured":"Peters BA, Wu J, Hayes RB, Ahn J. The oral fungal mycobiome: characteristics and relation to periodontitis in a pilot study. BMC Microbiol. 2017;17:157. https:\/\/doi.org\/10.1186\/s12866-017-1064-9.","journal-title":"BMC Microbiol"},{"key":"4075_CR98","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12879-017-2916-5","volume":"18","author":"N Aslani","year":"2018","unstructured":"Aslani N, Janbabaei G, Abastabar M, Meis JF, Babaeian M, Khodavaisy S, Boekhout T, Badali H. Identification of uncommon oral yeasts from cancer patients by MALDI-TOF mass spectrometry. BMC Infect Dis. 2018;18:24. https:\/\/doi.org\/10.1186\/s12879-017-2916-5.","journal-title":"BMC Infect Dis"},{"key":"4075_CR99","doi-asserted-by":"publisher","first-page":"252","DOI":"10.17294\/2330-0698.1705","volume":"6","author":"DJ Baumgardner","year":"2019","unstructured":"Baumgardner DJ. Oral fungal microbiota: to thrush and beyond. J. Patient-Cent. Res Rev. 2019;6:252\u201361. https:\/\/doi.org\/10.17294\/2330-0698.1705.","journal-title":"Res Rev"},{"key":"4075_CR100","doi-asserted-by":"publisher","first-page":"e700","DOI":"10.4317\/medoral.23719","volume":"25","author":"J Serrano","year":"2020","unstructured":"Serrano J, L\u00f3pez-Pintor RM, Ram\u00edrez L, Fern\u00e1ndez-Castro M, Sanz M, Melchor S, Peiteado D, Hern\u00e1ndez G. Risk factors related to oral candidiasis in patients with primary Sj\u00f6gren\u2019s syndrome. Med Oral Patol Oral Cir Bucal. 2020;25:e700\u20135. https:\/\/doi.org\/10.4317\/medoral.23719.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"6","key":"4075_CR101","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.3390\/jcm13061586","volume":"13","author":"R Sokou","year":"2024","unstructured":"Sokou R, Palioura AE, Kopanou Taliaka P, Konstantinidi A, Tsantes AG, Piovani D, Tsante KA, Gounari EA, Iliodromiti Z, Boutsikou T, et al. Candida auris infection, a rapidly emerging threat in the neonatal intensive care units: A systematic review. J Clinicl Med. 2024;13(6):1586. https:\/\/doi.org\/10.3390\/jcm13061586.","journal-title":"J Clinicl Med"},{"issue":"5","key":"4075_CR102","doi-asserted-by":"publisher","first-page":"e91556","DOI":"10.5812\/jjm.91556","volume":"12","author":"M Maheronnagsh","year":"2019","unstructured":"Maheronnagsh M, Fatahinia M, Dehghan P, Mahmoudabadi AZ, Kheirkhah M. Comparison of virulence factors of different Candida species isolated from the oral cavity of cancer patients and normal individuals. Jundishapur J Microbiol. 2019;12(5):e91556. https:\/\/doi.org\/10.5812\/jjm.91556.","journal-title":"Jundishapur J Microbiol"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04075-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04075-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04075-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:42:39Z","timestamp":1781613759000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12866-025-04075-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":102,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4075"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04075-4","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"12 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Our study was performed in conformity with the Helsinki guidelines and approved by the Research Ethics Committee of the Faculty of Science, South Valley University, Egypt (Reference No.: 022\/03\/2023). Written informed consents with detailed explanations were obtained from all newborns\u2019 parents. All methods were completed following the applicable guidelines and protocols in ethics approval and consent to participate. The investigation procedure does not interfere with patient care or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"366"}}