{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:39:32Z","timestamp":1794029972213,"version":"4.8.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103868"],"award-info":[{"award-number":["82103868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8191101420"],"award-info":[{"award-number":["8191101420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Talent Fund of Association for Science and Technology in Shaanxi","award":["20220301"],"award-info":[{"award-number":["20220301"]}]},{"name":"Shaanxi Province Postdoctoral Research Project","award":["2023BSHTBZZ03"],"award-info":[{"award-number":["2023BSHTBZZ03"]}]},{"name":"Shaanxi Provincial Social Science Project","award":["2023P098"],"award-info":[{"award-number":["2023P098"]}]},{"name":"Outstanding Young Scholars Funding","award":["3111500001"],"award-info":[{"award-number":["3111500001"]}]},{"name":"Xi\u2019an Jiaotong University Basic Research and Profession Grant","award":["xtr022019003"],"award-info":[{"award-number":["xtr022019003"]}]},{"name":"Xi\u2019an Jiaotong University Young Talent Support Grant","award":["YX6J004"],"award-info":[{"award-number":["YX6J004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04094-1","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T02:21:58Z","timestamp":1751941318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chronic stress is associated with altered gut microbiota profile and relevant metabolites in adolescents"],"prefix":"10.1186","volume":"25","author":[{"given":"Li","family":"Ying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yuhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yafang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang","family":"Lina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Qinze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chenghai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Shaoxiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Yuexi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Mingwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Zelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Chuangchuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"4094_CR1","unstructured":"WHO. Mental health of adolescents 2021 [Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/adolescent-mental-health."},{"issue":"1","key":"4094_CR2","doi-asserted-by":"publisher","first-page":"e2035487","DOI":"10.1001\/jamanetworkopen.2020.35487","volume":"4","author":"Z Qin","year":"2021","unstructured":"Qin Z, Shi L, Xue Y, Lin H, Zhang J, Liang P, et al. Prevalence and risk factors associated with Self-reported psychological distress among children and adolescents during the COVID-19 pandemic in China. JAMA Netw Open. 2021;4(1):e2035487.","journal-title":"JAMA Netw Open"},{"issue":"1","key":"4094_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s41043-021-00279-2","volume":"40","author":"SK Roy","year":"2021","unstructured":"Roy SK, Jahan K, Alam N, Rois R, Ferdaus A, Israt S, et al. Perceived stress, eating behavior, and overweight and obesity among urban adolescents. J Health Popul Nutr. 2021;40(1):54.","journal-title":"J Health Popul Nutr"},{"issue":"Suppl 2","key":"4094_CR4","first-page":"263","volume":"35","author":"MR Juli","year":"2023","unstructured":"Juli MR, Juli R, Juli G, Juli L. Adolescents and the consequences of COVID-19. Psychiatr Danub. 2023;35(Suppl 2):263\u20135.","journal-title":"Psychiatr Danub"},{"issue":"4","key":"4094_CR5","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The Microbiota-Gut-Brain Axis. Physiol Rev. 2019;99(4):1877\u20132013.","journal-title":"Physiol Rev"},{"issue":"5","key":"4094_CR6","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1053\/j.gastro.2020.10.066","volume":"160","author":"KG Margolis","year":"2021","unstructured":"Margolis KG, Cryan JF, Mayer EA. The Microbiota-Gut-Brain axis: from motility to mood. Gastroenterology. 2021;160(5):1486\u2013501.","journal-title":"Gastroenterology"},{"key":"4094_CR7","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.bbi.2019.05.024","volume":"80","author":"N Michels","year":"2019","unstructured":"Michels N, Van de Wiele T, Fouhy F, O\u2019Mahony S, Clarke G, Keane J. Gut Microbiome patterns depending on children\u2019s psychosocial stress: reports versus biomarkers. Brain Behav Immun. 2019;80:751\u201362.","journal-title":"Brain Behav Immun"},{"key":"4094_CR8","doi-asserted-by":"publisher","first-page":"104469","DOI":"10.1016\/j.psyneuen.2019.104469","volume":"111","author":"LM Mackner","year":"2020","unstructured":"Mackner LM, Hatzakis E, Allen JM, Davies RH, Kim SC, Maltz RM, et al. Fecal microbiota and metabolites are distinct in a pilot study of pediatric crohn\u2019s disease patients with higher levels of perceived stress. Psychoneuroendocrinology. 2020;111:104469.","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"4094_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1869501","volume":"13","author":"Y Deng","year":"2021","unstructured":"Deng Y, Zhou M, Wang J, Yao J, Yu J, Liu W, et al. Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain. Gut Microbes. 2021;13(1):1\u201316.","journal-title":"Gut Microbes"},{"issue":"2","key":"4094_CR10","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1017\/S0954422419000143","volume":"32","author":"N Michels","year":"2019","unstructured":"Michels N. Biological underpinnings from psychosocial stress towards appetite and obesity during youth: research implications towards metagenomics, epigenomics and metabolomics. Nutr Res Rev. 2019;32(2):282\u201393.","journal-title":"Nutr Res Rev"},{"issue":"3","key":"4094_CR11","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00213-021-05958-w","volume":"239","author":"Q Xu","year":"2022","unstructured":"Xu Q, Jiang M, Gu S, Zhang X, Feng G, Ma X, et al. Metabolomics changes in brain-gut axis after unpredictable chronic mild stress. Psychopharmacology. 2022;239(3):729\u201343.","journal-title":"Psychopharmacology"},{"issue":"1","key":"4094_CR12","doi-asserted-by":"publisher","first-page":"18134","DOI":"10.1038\/s41598-020-75114-5","volume":"10","author":"PJ Hamilton","year":"2020","unstructured":"Hamilton PJ, Chen EY, Tolstikov V, Pena CJ, Picone JA, Shah P, et al. Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum. Sci Rep. 2020;10(1):18134.","journal-title":"Sci Rep"},{"key":"4094_CR13","doi-asserted-by":"publisher","first-page":"100348","DOI":"10.1016\/j.ynstr.2021.100348","volume":"15","author":"EJL Coley","year":"2021","unstructured":"Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, et al. Early life adversity predicts brain-gut alterations associated with increased stress and mood. Neurobiol Stress. 2021;15:100348.","journal-title":"Neurobiol Stress"},{"key":"4094_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jad.2020.12.156","volume":"282","author":"Q Chen","year":"2021","unstructured":"Chen Q, Wang XQ, He XX, Ji LJ, Liu MF, Ye BJ. The relationship between search for meaning in life and symptoms of depression and anxiety: key roles of the presence of meaning in life and life events among Chinese adolescents. J Affect Disord. 2021;282:545\u201353.","journal-title":"J Affect Disord"},{"key":"4094_CR15","unstructured":"Lu J. The relationship between academic stress and aggressivity in high grade pupils in primary school. Tianjin Normal Univeristy; 2013."},{"issue":"7","key":"4094_CR16","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1017\/S1368980015002505","volume":"19","author":"G Tabacchi","year":"2016","unstructured":"Tabacchi G, Filippi AR, Amodio E, Jemni M, Bianco A, Firenze A, et al. A meta-analysis of the validity of FFQ targeted to adolescents. Public Health Nutr. 2016;19(7):1168\u201383.","journal-title":"Public Health Nutr"},{"key":"4094_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.aca.2015.02.012","volume":"879","author":"PS Gromski","year":"2015","unstructured":"Gromski PS, Muhamadali H, Ellis DI, Xu Y, Correa E, Turner ML, et al. A tutorial review: metabolomics and partial least squares-discriminant analysis\u2013a marriage of convenience or a shotgun wedding. Anal Chim Acta. 2015;879:10\u201323.","journal-title":"Anal Chim Acta"},{"key":"4094_CR18","doi-asserted-by":"crossref","unstructured":"Silva C, Perestrelo R, Silva P, Tomas H, Camara JS. Breast Cancer metabolomics: from analytical platforms to multivariate data analysis. Rev Metabolites. 2019;9(5):102.","DOI":"10.3390\/metabo9050102"},{"issue":"1","key":"4094_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27\u201330.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"4094_CR20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","volume":"25","author":"MT Bailey","year":"2011","unstructured":"Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced Immunomodulation. Brain Behav Immun. 2011;25(3):397\u2013407.","journal-title":"Brain Behav Immun"},{"issue":"6","key":"4094_CR21","doi-asserted-by":"publisher","first-page":"748","DOI":"10.4161\/19490976.2014.972241","volume":"5","author":"JD Galley","year":"2014","unstructured":"Galley JD, Yu Z, Kumar P, Dowd SE, Lyte M, Bailey MT. The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor. Gut Microbes. 2014;5(6):748\u201360.","journal-title":"Gut Microbes"},{"key":"4094_CR22","doi-asserted-by":"crossref","unstructured":"Mohebali N, Weigel M, Hain T, Sutel M, Bull J, Kreikemeyer B, et al. Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg\/Th17 cell balance and intestinal barrier integrity. Volume 167. Biomedicine & pharmacotherapy\u2009=\u2009Biomedecine & pharmacotherapie; 2023. p. 115568.","DOI":"10.1016\/j.biopha.2023.115568"},{"issue":"9","key":"4094_CR23","doi-asserted-by":"publisher","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.122.320184","volume":"131","author":"HB Li","year":"2022","unstructured":"Li HB, Xu ML, Xu XD, Tang YY, Jiang HL, Li L, et al. Faecalibacterium prausnitzii attenuates CKD via Butyrate-Renal GPR43 Axis. Circul Res. 2022;131(9):e120\u201334.","journal-title":"Circul Res"},{"key":"4094_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.psyneuen.2019.02.025","volume":"104","author":"Z Hao","year":"2019","unstructured":"Hao Z, Wang W, Guo R, Liu H. Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats. Psychoneuroendocrinology. 2019;104:132\u201342.","journal-title":"Psychoneuroendocrinology"},{"key":"4094_CR25","doi-asserted-by":"publisher","first-page":"100627","DOI":"10.1016\/j.dcn.2019.100627","volume":"37","author":"CSM Cowan","year":"2019","unstructured":"Cowan CSM, Stylianakis AA, Richardson R. Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats. Dev Cogn Neurosci. 2019;37:100627.","journal-title":"Dev Cogn Neurosci"},{"issue":"10","key":"4094_CR26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","volume":"19","author":"PD Cani","year":"2022","unstructured":"Cani PD, Depommier C, Derrien M, Everard A, de Vos WM. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Reviews Gastroenterol Hepatol. 2022;19(10):625\u201337.","journal-title":"Nat Reviews Gastroenterol Hepatol"},{"key":"4094_CR27","doi-asserted-by":"crossref","unstructured":"Guo H, Liu X, Chen T, Wang X, Zhang X. Akkermansia muciniphila improves Depressive-Like symptoms by modulating the level of 5-HT neurotransmitters in the gut and brain of mice. Mol Neurobiol. 2024;61(2):821\u201334.","DOI":"10.1007\/s12035-023-03602-6"},{"key":"4094_CR28","doi-asserted-by":"crossref","unstructured":"Kirmiz N, Galindo K, Cross KL, Luna E, Rhoades N, Podar M, et al. Comparative genomics guides Elucidation of vitamin B(12) biosynthesis in novel Human-Associated Akkermansia strains. Appl Environ Microbiol. 2020;86(3):e02117\u201319.","DOI":"10.1128\/AEM.02117-19"},{"issue":"2","key":"4094_CR29","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/ismej.2015.127","volume":"10","author":"TW Hoffmann","year":"2016","unstructured":"Hoffmann TW, Pham HP, Bridonneau C, Aubry C, Lamas B, Martin-Gallausiaux C, et al. Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice. ISME J. 2016;10(2):460\u201377.","journal-title":"ISME J"},{"issue":"7285","key":"4094_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J Qin","year":"2010","unstructured":"Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59\u201365.","journal-title":"Nature"},{"issue":"4","key":"4094_CR31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1177\/10998004231168805","volume":"25","author":"SL Davis","year":"2023","unstructured":"Davis SL, Latimer M, Rice M. Biomarkers of stress and inflammation in children. Biol Res Nurs. 2023;25(4):559\u201370.","journal-title":"Biol Res Nurs"},{"key":"4094_CR32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jad.2023.02.123","volume":"329","author":"Y Li","year":"2023","unstructured":"Li Y, Jia W, Yan N, Hua Y, Han T, Yang J, et al. Associations between chronic stress and hair cortisol in children: A systematic review and meta-analysis. J Affect Disord. 2023;329:438\u201347.","journal-title":"J Affect Disord"},{"issue":"13","key":"4094_CR33","doi-asserted-by":"publisher","first-page":"2728","DOI":"10.1016\/j.cell.2023.05.029","volume":"186","author":"H Hajjo","year":"2023","unstructured":"Hajjo H, Shouval DS, Gefen T, Geva-Zatorsky N. A sound Mind in a sound body: Stress-induced glucocorticoids exacerbate gut inflammation. Cell. 2023;186(13):2728\u201330.","journal-title":"Cell"},{"key":"4094_CR34","doi-asserted-by":"publisher","first-page":"1183184","DOI":"10.3389\/fnmol.2023.1183184","volume":"16","author":"B Bigio","year":"2023","unstructured":"Bigio B, Sagi Y, Barnhill O, Dobbin J, El Shahawy O, de Angelis P, et al. Epigenetic embedding of childhood adversity: mitochondrial metabolism and neurobiology of stress-related CNS diseases. Front Mol Neurosci. 2023;16:1183184.","journal-title":"Front Mol Neurosci"},{"key":"4094_CR35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.yfrne.2017.11.001","volume":"49","author":"BS McEwen","year":"2018","unstructured":"McEwen BS. Redefining neuroendocrinology: epigenetics of brain-body communication over the life course. Front Neuroendocr. 2018;49:8\u201330.","journal-title":"Front Neuroendocr"},{"issue":"4","key":"4094_CR36","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.3892\/etm.2017.4878","volume":"14","author":"F Wu","year":"2017","unstructured":"Wu F, Guo X, Zhang J, Zhang M, Ou Z, Peng Y. Phascolarctobacterium faecium abundant colonization in human Gastrointestinal tract. Exp Ther Med. 2017;14(4):3122\u20136.","journal-title":"Exp Ther Med"},{"issue":"1","key":"4094_CR37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.celrep.2018.12.028","volume":"26","author":"K Wang","year":"2019","unstructured":"Wang K, Liao M, Zhou N, Bao L, Ma K, Zheng Z, et al. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Rep. 2019;26(1):222\u201335. e5.","journal-title":"Cell Rep"},{"issue":"7","key":"4094_CR38","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nm.4358","volume":"23","author":"R Liu","year":"2017","unstructured":"Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut Microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859\u201368.","journal-title":"Nat Med"},{"issue":"1","key":"4094_CR39","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1038\/s41467-018-05767-4","volume":"9","author":"A Kindt","year":"2018","unstructured":"Kindt A, Liebisch G, Clavel T, Haller D, Hormannsperger G, Yoon H, et al. The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice. Nat Commun. 2018;9(1):3760.","journal-title":"Nat Commun"},{"issue":"7","key":"4094_CR40","doi-asserted-by":"publisher","first-page":"660","DOI":"10.5551\/jat.RV17006","volume":"24","author":"H Ohira","year":"2017","unstructured":"Ohira H, Tsutsui W, Fujioka Y. Are short chain fatty acids in gut microbiota defensive players for inflammation and atherosclerosis?? J Atheroscler Thromb. 2017;24(7):660\u201372.","journal-title":"J Atheroscler Thromb"},{"issue":"4","key":"4094_CR41","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/med.20071","volume":"27","author":"V Capra","year":"2007","unstructured":"Capra V, Thompson MD, Sala A, Cole DE, Folco G, Rovati GE. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev. 2007;27(4):469\u2013527.","journal-title":"Med Res Rev"},{"issue":"6","key":"4094_CR42","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1007\/s10787-024-01557-1","volume":"32","author":"V Sharma","year":"2024","unstructured":"Sharma V, Sharma P, Singh TG. Leukotriene signaling in neurodegeneration: implications for treatment strategies. Inflammopharmacology. 2024;32(6):3571\u201384.","journal-title":"Inflammopharmacology"},{"issue":"1","key":"4094_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5851\/kosfa.2015.35.1.1","volume":"35","author":"P Bondue","year":"2015","unstructured":"Bondue P, Delcenserie V. Genome of bifidobacteria and carbohydrate metabolism. Korean J Food Sci Anim Resour. 2015;35(1):1\u20139.","journal-title":"Korean J Food Sci Anim Resour"},{"key":"4094_CR44","doi-asserted-by":"publisher","first-page":"149631","DOI":"10.1016\/j.bbrc.2024.149631","volume":"702","author":"K Morito","year":"2024","unstructured":"Morito K, Yamagata M, Naka F, Kobayashi K, Ueda H, Morimoto H, et al. Sub-chronic and mild social defeat stress exposure to C57BL\/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver. Biochem Biophys Res Commun. 2024;702:149631.","journal-title":"Biochem Biophys Res Commun"},{"key":"4094_CR45","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbr.2019.01.045","volume":"363","author":"C Zhang","year":"2019","unstructured":"Zhang C, Kalueff AV, Song C. Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress. Behav Brain Res. 2019;363:109\u201317.","journal-title":"Behav Brain Res"},{"key":"4094_CR46","doi-asserted-by":"crossref","unstructured":"Hidalgo-Cantabrana C, Delgado S, Ruiz L, Ruas-Madiedo P, Sanchez B, Margolles A. Bifidobacteria and their Health-Promoting effects. Microbiol Spectr. 2017;5(3):bad-0010-2016.","DOI":"10.1128\/microbiolspec.BAD-0010-2016"},{"issue":"1","key":"4094_CR47","doi-asserted-by":"publisher","first-page":"8770","DOI":"10.1038\/s41598-017-09395-8","volume":"7","author":"D Fang","year":"2017","unstructured":"Fang D, Shi D, Lv L, Gu S, Wu W, Chen Y, et al. Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota. Sci Rep. 2017;7(1):8770.","journal-title":"Sci Rep"},{"issue":"1","key":"4094_CR48","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12866-022-02573-3","volume":"22","author":"J Liu","year":"2022","unstructured":"Liu J, Li W, Yao C, Yu J, Zhang H. Comparative genomic analysis revealed genetic divergence between Bifidobacterium catenulatum subspecies present in infant versus adult guts. BMC Microbiol. 2022;22(1):158.","journal-title":"BMC Microbiol"},{"key":"4094_CR49","doi-asserted-by":"crossref","unstructured":"Kim H, Jeong Y, Kang S, You HJ, Ji GE. Co-Culture with Bifidobacterium catenulatum improves the growth, gut colonization, and butyrate production of Faecalibacterium prausnitzii: in vitro and in vivo studies. Microorganisms. 2020;8(5):788.","DOI":"10.3390\/microorganisms8050788"},{"key":"4094_CR50","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fendo.2020.00025","volume":"11","author":"YP Silva","year":"2020","unstructured":"Silva YP, Bernardi A, Frozza RL. The role of Short-Chain fatty acids from gut microbiota in gut-Brain communication. Front Endocrinol (Lausanne). 2020;11:25.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"4094_CR51","doi-asserted-by":"publisher","first-page":"2371950","DOI":"10.1080\/19490976.2024.2371950","volume":"16","author":"KA Conn","year":"2024","unstructured":"Conn KA, Borsom EM, Cope EK. Implications of microbe-derived \u0263-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in alzheimer\u2019s disease. Gut Microbes. 2024;16(1):2371950.","journal-title":"Gut Microbes"},{"issue":"5","key":"4094_CR52","first-page":"355","volume":"29","author":"X Xin","year":"2015","unstructured":"Xin X, Yao S. Validity and reliability of the adolescent Self-rating life events checklist in middle school students. Chin Mental Health J. 2015;29(5):355\u201360.","journal-title":"Chin Mental Health J"},{"key":"4094_CR53","doi-asserted-by":"publisher","first-page":"980104","DOI":"10.3389\/fpubh.2022.980104","volume":"10","author":"Y Tang","year":"2022","unstructured":"Tang Y, Ma Y, Zhang J, Wang H. The relationship between negative life events and quality of life in adolescents: mediated by resilience and social support. Front Public Health. 2022;10:980104.","journal-title":"Front Public Health"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04094-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04094-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04094-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:37:18Z","timestamp":1752140238000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04094-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4094"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04094-1","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,8]]},"assertion":[{"value":"11 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board at Xi\u2019an Jiaotong University Health Science Center (Approval No.: 2021 \u2212\u20091389) and conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained from all adolescent participants and their parents\/legal guardians, which specifically granted permission for fecal sample collection in both home and school settings.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"423"}}