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Numerous bioactive compounds produced by these organisms can fight off harmful microorganisms. Two marine algae (Chlorophyta: <jats:italic>Ulva lactuca<\/jats:italic>, Rhodophyta: <jats:italic>Pterocladiella capillacea<\/jats:italic>) were screened for their antibacterial activity against distinct multidrug-resistant bacteria <jats:italic>Klebsiella pneumoniae<\/jats:italic>. This efficiency is ascribed to the bioactive substances found in these algae, which have the ability to stop the growth of this harmful bacteria. <jats:italic>Pterocladiella capillacea<\/jats:italic> is a viable target for the development of novel antibacterial medications since its chemicals function by interfering with bacterial processes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A mixture of (<jats:italic>U. lactuca +\u2009P. capillacea.<\/jats:italic> + Nitrofurantoin) increased the inhibition zone on <jats:italic>K. pneumoniae<\/jats:italic> by 100%. Our docking findings demonstrated that benzo[h]quinoline, 2, 4-dimethyl-, and 4, 4\u2019-Bis [4-methyl-2-pyrimidylsulfamido] terephthalanilide have a high affinity (-10 and \u2212\u200911 respectively) to dock with the cell wall proteins of <jats:italic>Klebsiella pneumoniae<\/jats:italic>. It can cause cell lysis and death by interfering with the integrity of bacterial cell walls. Furthermore, it may disrupt DNA replication and vital bacterial enzymes. The molecule 4, 4\u2019-Bis [4-methyl-2-pyrimidylsulfamido] terephthalanilide is a member of the sulfonamide class, which is well-known for its broad-spectrum antibacterial properties. This compound\u2019s capacity to prevent bacteria from synthesizing folic acid is the main source of its antibacterial action. Bacterial cell division and DNA synthesis depend on folic acid. The substance successfully stops bacterial growth and multiplication by blocking this pathway.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These two substances are interesting candidates for the development of novel antimicrobial drugs due to their efficacy against strains of bacteria that are resistant to antibiotics.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12866-025-04102-4","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:54:09Z","timestamp":1750920849000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synergetic effects of Ulva lactuca and Pterocladiella capillacea on the multidrug-resistant Klebsiella pneumoniae"],"prefix":"10.1186","volume":"25","author":[{"given":"Rania M.","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehad M.","family":"Khedr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda M.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Adawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"issue":"2","key":"4102_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.drup.2011.02.001","volume":"14","author":"J Fernebro","year":"2011","unstructured":"Fernebro J. 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