{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:55:44Z","timestamp":1792076144862,"version":"4.4.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Science and Health Joint Project of Chongqing, China","award":["2023MSXM015"],"award-info":[{"award-number":["2023MSXM015"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]},{"name":"Hospital-managed Project of Southwest Hospital, First Affiliated Hospital of Army Medical University","award":["2024IITZD01"],"award-info":[{"award-number":["2024IITZD01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the association between serum metabolomic profiles and the gut microbiota in patients with neurogenic rosacea. We analyzed the serum metabolites and gut microbial composition in 20 patients with neurogenic rosacea and 14 healthy controls. Metabolomic analysis identified 56 differentially abundant metabolites (DAMs), with benzene and substituted derivatives, carboxylic acids and derivatives, and organophosphates being among the most enriched categories. Gut microbiota analysis revealed significant dysbiosis in patients with neurogenic rosacea, characterized by an increased abundance of\n                    <jats:italic>Lachnospiraceae<\/jats:italic>\n                    ,\n                    <jats:italic>Veillonellaceae<\/jats:italic>\n                    , and\n                    <jats:italic>Clostridiaceae<\/jats:italic>\n                    , and decreased levels of\n                    <jats:italic>Prevotellaceae<\/jats:italic>\n                    and\n                    <jats:italic>Bifidobacteriaceae.<\/jats:italic>\n                    Spearman\u2019s correlation analysis demonstrated significant relationships between specific serum metabolites and gut microbial taxa, including strong positive correlations between 3,4-dihydroxyphenylacetic acid and both\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    (r\u2009=\u20090.7307, padj\u2009=\u20099.25e-07) and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    (r\u2009=\u20090.6898, padj\u2009=\u20096.39e-06). These findings highlight the complex interactions between metabolic dysregulation and gut microbial imbalances in neurogenic rosacea, suggesting a potential role for the gut-skin axis in its pathophysiology. This study paves the way for future therapeutic strategies targeting both metabolic and microbial dysbiosis to manage neurogenic rosacea.\n                  <\/jats:p>","DOI":"10.1186\/s12866-025-04173-3","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T15:04:59Z","timestamp":1752764699000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlations between gut microbiota and serum metabolomics in patients with neurogenic rosacea"],"prefix":"10.1186","volume":"25","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"4173_CR1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/1346-8138.15629","volume":"48","author":"HO Kim","year":"2021","unstructured":"Kim HO, Kang SY, Kim KE, Cho SY, Kim KH, Kim I-H. Neurogenic rosacea in Korea. J Dermatol. 2021;48:49\u201355.","journal-title":"J Dermatol"},{"key":"4173_CR2","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1111\/head.12956","volume":"56","author":"M Rizzi","year":"2016","unstructured":"Rizzi M, Penner F, Messina G, Castelli N, Franzini A, Capella GL. Painful Rosacea as a warning sign of intracranial metastasis of squamous cell carcinoma. Headache. 2016;56:1514\u20136.","journal-title":"Headache"},{"key":"4173_CR3","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1016\/j.jaad.2013.04.045","volume":"69","author":"M Steinhoff","year":"2013","unstructured":"Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol. 2013;69:S15-26.","journal-title":"J Am Acad Dermatol"},{"key":"4173_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.det.2017.11.001","volume":"36","author":"CS Ahn","year":"2018","unstructured":"Ahn CS, Huang WW. Rosacea pathogenesis. Dermatol Clin. 2018;36:81\u20136.","journal-title":"Dermatol Clin"},{"key":"4173_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/jidsymp.2011.6","volume":"15","author":"VD Schwab","year":"2011","unstructured":"Schwab VD, Sulk M, Seeliger S, Nowak P, Aubert J, Mess C, et al. Neurovascular and neuroimmune aspects in the pathophysiology of Rosacea. J Investig Dermatol Symp Proc. 2011;15:53\u201362.","journal-title":"J Investig Dermatol Symp Proc"},{"key":"4173_CR6","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.clindermatol.2021.08.021","volume":"39","author":"S Sinha","year":"2021","unstructured":"Sinha S, Lin G, Ferenczi K. The skin microbiome and the gut-skin axis. Clin Dermatol. 2021;39:829\u201339.","journal-title":"Clin Dermatol"},{"key":"4173_CR7","doi-asserted-by":"publisher","first-page":"2096995","DOI":"10.1080\/19490976.2022.2096995","volume":"14","author":"MR Mahmud","year":"2022","unstructured":"Mahmud MR, Akter S, Tamanna SK, Mazumder L, Esti IZ, Banerjee S, et al. Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes. 2022;14:2096995.","journal-title":"Gut Microbes."},{"key":"4173_CR8","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/biomedicines10051037","volume":"10","author":"AYK Thye","year":"2022","unstructured":"Thye AYK, Bah YR, Law JWF, Tan LTH, He YW, Wong SH, et al. Gut-skin axis: unravelling the connection between the gut microbiome and psoriasis. Biomedicines. 2022;10:1037.","journal-title":"Biomedicines"},{"key":"4173_CR9","first-page":"3","volume":"2","author":"RD Hills Jr","year":"2022","unstructured":"Hills RD Jr, Pontefract BA, Mishcon HR, Black CA, Sutton SC, Theberge CR. Gut microbiome: profound implications for diet and disease. Kompass Nutrition Dietetics. 2022;2:3\u201318.","journal-title":"Kompass Nutrition Dietetics"},{"key":"4173_CR10","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.3390\/ijerph17207618","volume":"17","author":"Z Al Bander","year":"2020","unstructured":"Al Bander Z, Nitert MD, Mousa A, Naderpoor N. The Gut microbiota and inflammation: an overview. Int J Environ Res Public Health. 2020;17:7618.","journal-title":"Int J Environ Res Public Health"},{"key":"4173_CR11","doi-asserted-by":"crossref","unstructured":"Widhiati S, Purnomosari D, Wibawa T, Soebono H. The role of gut microbiome in inflammatory skin disorders: A systematic review. Dermatol Reports. 2022;14:9188.","DOI":"10.4081\/dr.2022.9188"},{"key":"4173_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/ijd.14802","volume":"59","author":"KG Thompson","year":"2020","unstructured":"Thompson KG, Rainer BM, Kang S, Chien AL. The skin microbiota as a link between rosacea and its systemic comorbidities. Int J Dermatol. 2020;59:513\u20134.","journal-title":"Int J Dermatol"},{"key":"4173_CR13","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.3390\/microorganisms8101587","volume":"8","author":"JY Yoo","year":"2020","unstructured":"Yoo JY, Groer M, Dutra SVO, Sarkar A, McSkimming DI. Gut microbiota and immune system interactions. Microorganisms. 2020;8:1587.","journal-title":"Microorganisms"},{"key":"4173_CR14","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1126\/science.abo0693","volume":"376","author":"TA Harris-Tryon","year":"2022","unstructured":"Harris-Tryon TA, Grice EA. Microbiota and maintenance of skin barrier function. Science. 2022;376:940\u20135.","journal-title":"Science"},{"key":"4173_CR15","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.3390\/ijms24043494","volume":"24","author":"A Stec","year":"2023","unstructured":"Stec A, Sikora M, Maciejewska M, Paralusz-Stec K, Michalska M, Sikorska E, et al. Bacterial metabolites: a link between gut microbiota and dermatological diseases. Int J Mol Sci. 2023;24:3494.","journal-title":"Int J Mol Sci"},{"key":"4173_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrm3314","volume":"13","author":"GJ Patti","year":"2012","unstructured":"Patti GJ, Yanes O, Siuzdak G. Metabolomics: the apogee of the omics trilogy. Nat Rev Mol Cell Biol. 2012;13:263\u20139.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4173_CR17","doi-asserted-by":"crossref","unstructured":"Demurtas A, Pescina S, Nicoli S, Santi P, Ribeiro de Araujo D, Padula C. Validation of a HPLC-UV method for the quantification of budesonide in skin layers. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1164:122512.","DOI":"10.1016\/j.jchromb.2020.122512"},{"key":"4173_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2013","unstructured":"Want EJ, Masson P, Michopoulos F, Wilson ID, Theodoridis G, Plumb RS, et al. Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc. 2013;8:17\u201332.","journal-title":"Nat Protoc"},{"key":"4173_CR19","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1021\/ac8019366","volume":"81","author":"E Zelena","year":"2009","unstructured":"Zelena E, Dunn WB, Broadhurst D, Francis-McIntyre S, Carroll KM, Begley P, et al. Development of a Robust and Repeatable UPLC\u2212MS method for the long-term metabolomic study of human serum. Anal Chem. 2009;81:1357\u201364.","journal-title":"Anal Chem"},{"key":"4173_CR20","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1021\/ac051437y","volume":"78","author":"CA Smith","year":"2006","unstructured":"Smith CA, Want EJ, O\u2019Maille G, Abagyan R, Siuzdak G. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem. 2006;78:779\u201387.","journal-title":"Anal Chem"},{"key":"4173_CR21","doi-asserted-by":"publisher","first-page":"8835","DOI":"10.1007\/s00216-015-9042-2","volume":"407","author":"M Navarro-Reig","year":"2015","unstructured":"Navarro-Reig M, Jaumot J, Garc\u00eda-Reiriz A, Tauler R. Evaluation of changes induced in rice metabolome by Cd and Cu exposure using LC-MS with XCMS and MCR-ALS data analysis strategies. Anal Bioanal Chem. 2015;407:8835\u201347.","journal-title":"Anal Bioanal Chem"},{"issue":"Database issue","key":"4173_CR22","doi-asserted-by":"publisher","first-page":"D521","DOI":"10.1093\/nar\/gkl923","volume":"35","author":"DS Wishart","year":"2007","unstructured":"Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, et al. HMDB: the human metabolome database. Nucleic Acids Res. 2007;35(Database issue):D521-526.","journal-title":"Nucleic Acids Res"},{"key":"4173_CR23","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/jms.1777","volume":"45","author":"H Horai","year":"2010","unstructured":"Horai H, Arita M, Kanaya S, Nihei Y, Ikeda T, Suwa K, et al. MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom. 2010;45:703\u201314.","journal-title":"J Mass Spectrom"},{"issue":"Database issue","key":"4173_CR24","doi-asserted-by":"publisher","first-page":"D527","DOI":"10.1093\/nar\/gkl838","volume":"35","author":"M Sud","year":"2007","unstructured":"Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, et al. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007;35(Database issue):D527-532.","journal-title":"Nucleic Acids Res"},{"key":"4173_CR25","doi-asserted-by":"publisher","first-page":"32548","DOI":"10.1039\/D0RA05326K","volume":"10","author":"S Abdelrazig","year":"2020","unstructured":"Abdelrazig S, Safo L, Rance GA, Fay MW, Theodosiou E, Topham PD, et al. Metabolic characterisation of Magnetospirillum gryphiswaldense MSR-1 using LC-MS-based metabolite profiling. RSC Adv. 2020;10:32548\u201360.","journal-title":"RSC Adv"},{"key":"4173_CR26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","volume":"27","author":"H Ogata","year":"1999","unstructured":"Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 1999;27:29\u201334.","journal-title":"Nucleic Acids Res"},{"key":"4173_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.aca.2016.12.029","volume":"955","author":"Y Gagnebin","year":"2017","unstructured":"Gagnebin Y, Tonoli D, Lescuyer P, Ponte B, de Seigneux S, Martin P-Y, et al. Metabolomic analysis of urine samples by UHPLC-QTOF-MS: Impact of normalization strategies. Anal Chim Acta. 2017;955:27\u201335.","journal-title":"Anal Chim Acta"},{"key":"4173_CR28","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","volume":"14","author":"EA Th\u00e9venot","year":"2015","unstructured":"Th\u00e9venot EA, Roux A, Xu Y, Ezan E, Junot C. Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. J Proteome Res. 2015;14:3322\u201335.","journal-title":"J Proteome Res"},{"key":"4173_CR29","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, et al. Metagenomic biomarker discovery and explanation. Genome Biol. 2011;12:R60.","journal-title":"Genome Biol"},{"key":"4173_CR30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/exd.13143","volume":"26","author":"AD Holmes","year":"2017","unstructured":"Holmes AD, Steinhoff M. Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics. Exp Dermatol. 2017;26:659\u201367.","journal-title":"Exp Dermatol"},{"issue":"1_Supplement","key":"4173_CR31","first-page":"87","volume":"210","author":"M Sur","year":"2023","unstructured":"Sur M, Mone K, Zhang G, Reddy J. Lactose differentially modulates functionalities of antigen-presenting cells and T cells. J Immunol. 2023;210(1_Supplement):87\u201306.","journal-title":"J Immunol"},{"key":"4173_CR32","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1021\/jf011533+","volume":"50","author":"S Sang","year":"2002","unstructured":"Sang S, Lapsley K, Jeong W-S, Lachance PA, Ho C-T, Rosen RT. Antioxidative phenolic compounds isolated from almond skins ( Prunus amygdalus Batsch). J Agric Food Chem. 2002;50:2459\u201363.","journal-title":"J Agric Food Chem"},{"key":"4173_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.fct.2013.12.024","volume":"65","author":"C Mancuso","year":"2014","unstructured":"Mancuso C, Santangelo R. Ferulic acid: Pharmacological and toxicological aspects. Food Chem Toxicol. 2014;65:185\u201395.","journal-title":"Food Chem Toxicol"},{"key":"4173_CR34","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1159\/000491755","volume":"31","author":"K Zdu\u0144ska","year":"2018","unstructured":"Zdu\u0144ska K, Dana A, Kolodziejczak A, Rotsztejn H. Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol Physiol. 2018;31:332\u20136.","journal-title":"Skin Pharmacol Physiol"},{"key":"4173_CR35","doi-asserted-by":"publisher","first-page":"106150","DOI":"10.1016\/j.intimp.2019.106150","volume":"80","author":"S Lin","year":"2020","unstructured":"Lin S, Jin P, Shao C, Lu W, Xiang Q, Jiang Z, et al. Lidocaine attenuates lipopolysaccharide-induced inflammatory responses and protects against endotoxemia in mice by suppressing HIF1\u03b1-induced glycolysis. Int Immunopharmacol. 2020;80:106150.","journal-title":"Int Immunopharmacol"},{"key":"4173_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jdent.2008.10.005","volume":"37","author":"HC Caracas","year":"2009","unstructured":"Caracas HC, Maciel JV, Martins PM, de Souza MM, Maia LC. The use of lidocaine as an anti-inflammatory substance: a systematic review. J Dent. 2009;37:93\u20137.","journal-title":"J Dent"},{"key":"4173_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.coi.2020.12.001","volume":"70","author":"A Fiore","year":"2021","unstructured":"Fiore A, Murray PJ. Tryptophan and indole metabolism in immune regulation. Curr Opin Immunol. 2021;70:7\u201314.","journal-title":"Curr Opin Immunol"},{"key":"4173_CR38","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.3390\/ijms24065742","volume":"24","author":"A Tsuji","year":"2023","unstructured":"Tsuji A, Ikeda Y, Yoshikawa S, Taniguchi K, Sawamura H, Morikawa S, et al. The tryptophan and kynurenine pathway involved in the development of immune-related diseases. IJMS. 2023;24:5742.","journal-title":"IJMS"},{"key":"4173_CR39","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/ani12121497","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen Y, Wang J, Fan H, Xia S, Zhao K, Chen G, et al. The multi-omics analysis revealed microbiological regulation of rabbit colon with diarrhea fed an antibiotic-free diet. Animals. 2022;12:1497.","journal-title":"Animals"},{"key":"4173_CR40","doi-asserted-by":"publisher","first-page":"118738","DOI":"10.1016\/j.lfs.2020.118738","volume":"265","author":"Y Wu","year":"2021","unstructured":"Wu Y, Luo Z, Liu C. Variations in fecal microbial profiles of acute exacerbations and stable chronic obstructive pulmonary disease. Life Sci. 2021;265:118738.","journal-title":"Life Sci"},{"key":"4173_CR41","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.chemosphere.2016.06.105","volume":"160","author":"C Jin","year":"2016","unstructured":"Jin C, Zeng Z, Fu Z, Jin Y. Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice. Chemosphere. 2016;160:349\u201358.","journal-title":"Chemosphere"},{"key":"4173_CR42","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3920\/BM2016.0184","volume":"8","author":"K Lippert","year":"2017","unstructured":"Lippert K, Kedenko L, Antonielli L, Kedenko I, Gemeier C, Leitner M, et al. Gut microbiota dysbiosis associated with glucose metabolism disorders and the metabolic syndrome in older adults. Benef Microbes. 2017;8:545\u201356.","journal-title":"Benef Microbes"},{"key":"4173_CR43","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/life13061280","volume":"13","author":"D \u0106esi\u0107","year":"2023","unstructured":"\u0106esi\u0107 D, Lugovi\u0107 Mihi\u0107 L, Ozreti\u0107 P, Lojki\u0107 I, Buljan M, \u0160itum M, et al. Association of Gut Lachnospiraceae and Chronic Spontaneous Urticaria. Life. 2023;13:1280.","journal-title":"Life"},{"key":"4173_CR44","doi-asserted-by":"publisher","first-page":"8427","DOI":"10.3390\/ijms21228427","volume":"21","author":"YR Woo","year":"2020","unstructured":"Woo YR, Han YJ, Kim HS, Cho SH, Lee JD. Updates on the risk of neuropsychiatric and gastrointestinal comorbidities in rosacea and its possible relationship with the Gut\u2013Brain\u2013Skin Axis. Int J Mol Sci. 2020;21:8427.","journal-title":"Int J Mol Sci"},{"key":"4173_CR45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/bjd.20411","volume":"185","author":"OM Moreno\u2010Arrones","year":"2021","unstructured":"Moreno\u2010Arrones OM, Ortega\u2010Quijano D, Perez\u2010Brocal V, Fernandez\u2010Nieto D, Jimenez N, de las Heras E, et al. Dysbiotic gut microbiota in patients with inflammatory rosacea: another clue towards the existence of a brain\u2013gut\u2013skin axis. Br J Dermatol. 2021;185:655\u20137.","journal-title":"Br J Dermatol"},{"key":"4173_CR46","doi-asserted-by":"crossref","unstructured":"Gunter NV, Teh SS, Lim YM, Mah SH. Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application. Front Pharmacol. 2020;11:594202.","DOI":"10.3389\/fphar.2020.594202"},{"key":"4173_CR47","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1194\/jlr.M031427","volume":"54","author":"H Yu","year":"2013","unstructured":"Yu H, Valerio M, Bielawski J. Fenretinide inhibited de novo ceramide synthesis and proinflammatory cytokines induced by Aggregatibacter actinomycetemcomitans. J Lipid Res. 2013;54:189\u2013201.","journal-title":"J Lipid Res"},{"key":"4173_CR48","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1080\/14786419.2017.1342090","volume":"32","author":"A Pagoni","year":"2018","unstructured":"Pagoni A, Vassiliou S. A novel and efficient synthesis of 3,4-dihydroxyphenylacetic ester and amide derivatives\/conjugates and assessment of their antioxidant activity. Nat Prod Res. 2018;32:1267\u201373.","journal-title":"Nat Prod Res"},{"key":"4173_CR49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s12275-018-8024-4","volume":"56","author":"AJ La Reau","year":"2018","unstructured":"La Reau AJ, Suen G. The Ruminococci: key symbionts of the gut ecosystem. J Microbiol. 2018;56:199\u2013208.","journal-title":"J Microbiol"},{"key":"4173_CR50","doi-asserted-by":"publisher","first-page":"16860","DOI":"10.1021\/jp103590d","volume":"114","author":"E Erdtman","year":"2010","unstructured":"Erdtman E, Bushnell EAC, Gauld JW, Eriksson LA. Computational insights into the mechanism of porphobilinogen synthase. J Phys Chem B. 2010;114:16860\u201370.","journal-title":"J Phys Chem B"},{"key":"4173_CR51","doi-asserted-by":"publisher","first-page":"9713","DOI":"10.1021\/jp104137p","volume":"114","author":"Q Li","year":"2010","unstructured":"Li Q, Batchelor-McAuley C, Compton RG. Electrooxidative decarboxylation of vanillylmandelic acid: voltammetric differentiation between the structurally related compounds homovanillic acid and vanillylmandelic acid. J Phys Chem B. 2010;114:9713\u20139.","journal-title":"J Phys Chem B"},{"key":"4173_CR52","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1016\/j.ijcard.2012.05.109","volume":"167","author":"M Shimabukuro","year":"2013","unstructured":"Shimabukuro M, Higa M, Yamakawa K, Masuzaki H, Sata M. Miglitol, \u03b1-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: a randomized comparable study. Int J Cardiol. 2013;167:2108\u201313.","journal-title":"Int J Cardiol"},{"key":"4173_CR53","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2147\/DDDT.S49763","volume":"7","author":"V Prachayasittikul","year":"2013","unstructured":"Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. DDDT. 2013;7:1157\u201378.","journal-title":"DDDT"},{"key":"4173_CR54","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.celrep.2017.02.018","volume":"18","author":"AM James","year":"2017","unstructured":"James AM, Hoogewijs K, Logan A, Hall AR, Ding S, Fearnley IM, et al. Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II. Cell Rep. 2017;18:2105\u201312.","journal-title":"Cell Rep"},{"key":"4173_CR55","doi-asserted-by":"publisher","first-page":"620143","DOI":"10.3389\/fgene.2020.620143","volume":"11","author":"X Xu","year":"2020","unstructured":"Xu X, Xie Z, Yang Z, Li D, Xu X. A t-SNE based classification approach to compositional microbiome data. Front Genet. 2020;11:620143.","journal-title":"Front Genet"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04173-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04173-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04173-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T14:06:32Z","timestamp":1757253992000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04173-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4173"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04173-3","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"2 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. The protocol was reviewed and approved by the Ethics Committee of Southwest Hospital, First Affiliated Hospital of Army Medical University (Approval No. (A)KY2023192). Written informed consent was obtained from all participants prior to their enrollment in the study. Participants were informed of their right to withdraw from the study at any time without consequences. All data were anonymized to protect participant confidentiality.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"441"}}