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It is present in the intestinal tract of animals and humans, and is considered as a major threat to public health. A total of 33 previously identified\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      strains isolated from of broiler chicken (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920) and, humans (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) were tested for their antimicrobial sensitivity and virulence genes detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The antimicrobial sensitivity testing of broiler chickens\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      strains, showed complete phenotypic resistance towards ampicillin (100%), colistin (100%), fosfomycin (100%), trimethoprim\/sulphamethaxole (100%) followed by gentamicin (90%), cefotaxime (90%) and chloramphenicol (75%). However, all the isolates were sensitive to imipenem (100%).\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      human strains showed complete phenotypic resistance to fosfomycin (100%), followed by ampicillin (92.3%), colistin (92.3%), and ciprofloxacin and trimethoprim\/sulfamethaxole (76.9%, each). The resistance gene profiling of the chicken strains was\n                      <jats:italic>cml<\/jats:italic>\n                      A (65%),\n                      <jats:italic>dfr<\/jats:italic>\n                      A1 (65%),\n                      <jats:italic>mcr<\/jats:italic>\n                      1 (60%),\n                      <jats:italic>tet<\/jats:italic>\n                      A (50%),\n                      <jats:italic>fos<\/jats:italic>\n                      A (40%), and\n                      <jats:italic>sul<\/jats:italic>\n                      1 (35%), and the most prevalent virulence gene was\n                      <jats:italic>rmp<\/jats:italic>\n                      A (85%), that was detected either alone in 9 isolates (52.9%), or in combination with the\n                      <jats:italic>mag<\/jats:italic>\n                      A gene in 8 isolates (47.1%), and with\n                      <jats:italic>fim<\/jats:italic>\n                      H gene in 8 isolates (47.1%), followed by\n                      <jats:italic>fim<\/jats:italic>\n                      H (55%) and\n                      <jats:italic>mag<\/jats:italic>\n                      A genes (40%). On the other hand, the human strains gene profiling showed\n                      <jats:italic>mcr<\/jats:italic>\n                      1 (61.5%),\n                      <jats:italic>cml<\/jats:italic>\n                      A (53.8%), and\n                      <jats:italic>sul<\/jats:italic>\n                      1 (46.2%) genes, while\n                      <jats:italic>dfr<\/jats:italic>\n                      A1 was not detected. The most prevalent virulence genes in the human strains were\n                      <jats:italic>rmp<\/jats:italic>\n                      A and\n                      <jats:italic>mag<\/jats:italic>\n                      A genes (46.2%, each), followed by\n                      <jats:italic>fim<\/jats:italic>\n                      H gene (38.5%). Overall, multidrug-resistant (MDR) (33.3%), extensively-drug resistant (XDR) (57.6%) and pan-drug resistant (PDR) (9.1%) isolates were detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The distribution of such virulent and resistant\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      isolates among apparently healthy broiler chicken, highlights their potential role in the transmission of both resistance and virulence attributes to the surrounding environment and human contacts. Moreover, spreading of carbabenem resistant\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      among human isolates, suggest the urgent need for more strict measures for the uncontrolled usage of antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12866-025-04187-x","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T04:00:09Z","timestamp":1753934409000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Emergence of extensively drug-resistant Klebsiella pneumoniae from broiler chickens and clinical samples in Egypt"],"prefix":"10.1186","volume":"25","author":[{"given":"Mohamed E.","family":"Enany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S.","family":"El-Mahallawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa E. 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