{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:28:35Z","timestamp":1787020115372,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82001749"],"award-info":[{"award-number":["82001749"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04192-0","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:14:05Z","timestamp":1753434845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An untargeted metabolomics analysis in feces and brain of Orthoflaviviruses-infected mice"],"prefix":"10.1186","volume":"25","author":[{"given":"Zhiwei","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningze","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"4192_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.onehlt.2017.06.001","volume":"4","author":"E Gould","year":"2017","unstructured":"Gould E, Pettersson J, Higgs S, Charrel R, de Lamballerie X. Emerging arboviruses: why today?? One Health. 2017;4:1\u201313. https:\/\/doi.org\/10.1016\/j.onehlt.2017.06.001.","journal-title":"One Health"},{"issue":"1","key":"4192_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13071-017-2559-9","volume":"11","author":"L Braack","year":"2018","unstructured":"Braack L, de Gouveia AP, Cornel AJ, Swanepoel R, de Jager C. Mosquito-Borne arboviruses of African origin: review of key viruses and vectors. Parasit Vectors. 2018;11(1):29. https:\/\/doi.org\/10.1186\/s13071-017-2559-9.","journal-title":"Parasit Vectors"},{"key":"4192_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-med-050715-105122","volume":"69","author":"SC Weaver","year":"2018","unstructured":"Weaver SC, Charlier C, Vasilakis N, Lecuit M. Zika, chikungunya, and other emerging Vector-Borne viral diseases. Annu Rev Med. 2018;69:395\u2013408. https:\/\/doi.org\/10.1146\/annurev-med-050715-105122.","journal-title":"Annu Rev Med"},{"issue":"7446","key":"4192_CR4","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GRW, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue. Nature. 2013;496(7446):504\u20137. https:\/\/doi.org\/10.1038\/nature12060.","journal-title":"Nature"},{"issue":"1","key":"4192_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3201\/eid2601.190235","volume":"26","author":"R Kuwata","year":"2020","unstructured":"Kuwata R, Torii S, Shimoda H, Supriyono S, Phichitraslip T, Prasertsincharoen N, Takemae H, Bautista RCJT, Ebora VDBM, Abella JAC, Dargantes AP, Hadi UK, Setiyono A, Baltazar ET, Simborio LT, Agungpriyono S, Jittapalapong S, Rerkamnuaychoke W, Hondo E, Maeda K. Distribution of Japanese encephalitis virus, Japan and Southeast asia, 2016\u20132018. Emerg Infect Dis. 2020;26(1):125\u20138. https:\/\/doi.org\/10.3201\/eid2601.190235.","journal-title":"Emerg Infect Dis"},{"key":"4192_CR6","doi-asserted-by":"publisher","DOI":"10.4103\/JVBD.JVBD_49_24","author":"Q Li","year":"2024","unstructured":"Li Q, Cheng X, Luo M, Shi J. Japanese encephalitis virus: an overview. J Vector Borne Dis. 2024. https:\/\/doi.org\/10.4103\/JVBD.JVBD_49_24.","journal-title":"J Vector Borne Dis"},{"issue":"10","key":"4192_CR7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","volume":"374","author":"J Mlakar","year":"2016","unstructured":"Mlakar J, Korva M, Tul N, Popovi\u0107 M, Polj\u0161ak-Prijatelj M, Mraz J, Kolenc M, Rus KR, Vipotnik TV, Vodu\u0161ek VF, Vizjak A, Pi\u017eem J, Petrovec M, \u017dupanc TA. Zika virus associated with microcephaly. N Engl J Med. 2016;374(10):951\u20138. https:\/\/doi.org\/10.1056\/NEJMoa1600651.","journal-title":"N Engl J Med"},{"key":"4192_CR8","doi-asserted-by":"publisher","unstructured":"Li G-H, Ning Z-J, Liu Y-M, Li X-H. Neurological manifestations of dengue infection. Front Cell Infect Microbiol. 2017;7. https:\/\/doi.org\/10.3389\/fcimb.2017.00449.","DOI":"10.3389\/fcimb.2017.00449"},{"issue":"16","key":"4192_CR9","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1056\/NEJMra1602113","volume":"374","author":"LR Petersen","year":"2016","unstructured":"Petersen LR, Jamieson DJ, Powers AM, Honein MA. Zika virus. N Engl J Med. 2016;374(16):1552\u201363. https:\/\/doi.org\/10.1056\/NEJMra1602113.","journal-title":"N Engl J Med"},{"key":"4192_CR11","doi-asserted-by":"publisher","unstructured":"Roberts LD, Souza AL, Gerszten RE, Clish CB. Targeted Metabolomics. Curr Protoc Mol Biol 2012, Chap. 30, Unit 30.2.1\u201324. https:\/\/doi.org\/10.1002\/0471142727.mb3002s98","DOI":"10.1002\/0471142727.mb3002s98"},{"issue":"2","key":"4192_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/ijms18020449","volume":"18","author":"PMP van Oort","year":"2017","unstructured":"van Oort PMP, de Bruin S, Weda H, Knobel HH, Schultz MJ, Bos LD. On behalf of the Mars consortium, null. Exhaled breath metabolomics for the diagnosis of pneumonia in intubated and Mechanically-Ventilated intensive care unit (ICU)-Patients. Int J Mol Sci. 2017;18(2):449. https:\/\/doi.org\/10.3390\/ijms18020449.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4192_CR13","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","volume":"38","author":"EL Pearce","year":"2013","unstructured":"Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity. 2013;38(4):633\u201343. https:\/\/doi.org\/10.1016\/j.immuni.2013.04.005.","journal-title":"Immunity"},{"issue":"7221","key":"4192_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/456443c","volume":"456","author":"AK Arakaki","year":"2008","unstructured":"Arakaki AK, Skolnick J, McDonald JF. Marker metabolites can be therapeutic targets as well. Nature. 2008;456(7221):443. https:\/\/doi.org\/10.1038\/456443c.","journal-title":"Nature"},{"issue":"3","key":"4192_CR15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3390\/v11030225","volume":"11","author":"N Byers","year":"2019","unstructured":"Byers N, Fleshman A, Perera R, Molins C. Metabolomic insights into human arboviral infections: dengue, chikungunya, and Zika viruses. Viruses. 2019;11(3):225. https:\/\/doi.org\/10.3390\/v11030225.","journal-title":"Viruses"},{"key":"4192_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-med-042320-014032","volume":"73","author":"EA Mayer","year":"2022","unstructured":"Mayer EA, Nance K, Chen S. The Gut-Brain Axis. Annu Rev Med. 2022;73:439\u201353. https:\/\/doi.org\/10.1146\/annurev-med-042320-014032.","journal-title":"Annu Rev Med"},{"issue":"1","key":"4192_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/tjb-2023-0095","volume":"49","author":"HO Do\u011fan","year":"2024","unstructured":"Do\u011fan HO, Metabolomics. A review of liquid chromatography mass Spectrometry-Based methods and clinical applications. Turkish J Biochem. 2024;49(1):1\u201314. https:\/\/doi.org\/10.1515\/tjb-2023-0095.","journal-title":"Turkish J Biochem"},{"issue":"7","key":"4192_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1023\/A:1007039825505","volume":"16","author":"L Elling","year":"1999","unstructured":"Elling L, Zervosen A, Guti\u00e9rrez Gallego R, Nieder V, Malissard M, Berger EG, Vliegenthart JFG, Kamerling JP. UDP-N-Acetyl-\u03b1-D-Glucosamine as acceptor substrate of \u03b2-1,4-Galactosyltransferase. Enzymatic synthesis of UDP-N-Acetyllactosamine. Glycoconj J. 1999;16(7):327\u201336. https:\/\/doi.org\/10.1023\/A:1007039825505.","journal-title":"Glycoconj J"},{"key":"4192_CR19","doi-asserted-by":"publisher","unstructured":"The Trypanosome UDP-Glucose Pyrophosphorylase Is Imported by Piggybacking into Glycosomes, Where Unconventional Sugar Nucleotide Synthesis Takes Place. mBio. 2021, 12 (3). https:\/\/doi.org\/10.1128\/mbio.00375-21","DOI":"10.1128\/mbio.00375-21"},{"issue":"1","key":"4192_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S0005-2736(02)00461-3","volume":"1564","author":"J Davidsen","year":"2002","unstructured":"Davidsen J, Mouritsen OG, J\u00f8rgensen K. Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes. Biochim Et Biophys Acta (BBA) - Biomembr. 2002;1564(1):256\u201362. https:\/\/doi.org\/10.1016\/S0005-2736(02)00461-3.","journal-title":"Biochim Et Biophys Acta (BBA) - Biomembr"},{"key":"4192_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/978-1-4757-0390-0_18","volume-title":"Purine metabolism in Man-IV","author":"N Kamatani","year":"1984","unstructured":"Kamatani N, Kubota M, Willis EH, Frincke LA, Carson DA. 5\u2032-Methylthioadenosine is the major source of adenine in human cells. In: De Bruyn CH, M. M., Simmonds HA, M\u00fcller MM, editors. Purine metabolism in Man-IV. Advances in Experimental Medicine and Biology. Volume 165. Boston, MA: Springer US; 1984. pp. 83\u20138. https:\/\/doi.org\/10.1007\/978-1-4757-0390-0_18."},{"issue":"6","key":"4192_CR22","doi-asserted-by":"publisher","first-page":"104775","DOI":"10.1016\/j.jbc.2023.104775","volume":"299","author":"C Weigel","year":"2023","unstructured":"Weigel C, Bellaci J, Spiegel S. Sphingosine-1-Phosphate and its receptors in vascular endothelial and lymphatic barrier function. J Biol Chem. 2023;299(6):104775. https:\/\/doi.org\/10.1016\/j.jbc.2023.104775.","journal-title":"J Biol Chem"},{"issue":"5","key":"4192_CR23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/iub.2795","volume":"76","author":"A Modak","year":"2024","unstructured":"Modak A, Mishra SR, Awasthi M, Aravind A, Singh S, Sreekumar E. Fingolimod (FTY720), an FDA-Approved sphingosine 1-Phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue virus serotype 2 infection. IUBMB Life. 2024;76(5):267\u201385. https:\/\/doi.org\/10.1002\/iub.2795.","journal-title":"IUBMB Life"},{"issue":"1","key":"4192_CR24","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1128\/JVI.01849-15","volume":"90","author":"X Carnec","year":"2016","unstructured":"Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Hafirassou ML, Kitaura J, Ramdasi R, Schwartz O, Amara A. The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection. J Virol. 2016;90(1):92\u2013102. https:\/\/doi.org\/10.1128\/JVI.01849-15.","journal-title":"J Virol"},{"issue":"8","key":"4192_CR25","doi-asserted-by":"publisher","first-page":"4275","DOI":"10.1128\/jvi.03287-13","volume":"88","author":"K Morizono","year":"2014","unstructured":"Morizono K, Chen ISY. Role of phosphatidylserine receptors in enveloped virus infection. J Virol. 2014;88(8):4275\u201390. https:\/\/doi.org\/10.1128\/jvi.03287-13.","journal-title":"J Virol"},{"key":"4192_CR26","doi-asserted-by":"publisher","unstructured":"Leonardi R, Jackowski S. Biosynthesis of pantothenic acid and coenzyme A. EcoSal Plus. 2007;2(2). https:\/\/doi.org\/10.1128\/ecosalplus.3.6.3.4.","DOI":"10.1128\/ecosalplus.3.6.3.4"},{"issue":"7","key":"4192_CR27","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1529\/biophysj.108.138123","volume":"95","author":"H Martinez-Seara","year":"2008","unstructured":"Martinez-Seara H, R\u00f3g T, Pasenkiewicz-Gierula M, Vattulainen I, Karttunen M, Reigada R. Interplay of unsaturated phospholipids and cholesterol in membranes: effect of the Double-Bond position. Biophys J. 2008;95(7):3295\u2013305. https:\/\/doi.org\/10.1529\/biophysj.108.138123.","journal-title":"Biophys J"},{"key":"4192_CR28","doi-asserted-by":"publisher","first-page":"198610","DOI":"10.1016\/j.virusres.2021.198610","volume":"307","author":"RDS Peinado","year":"2022","unstructured":"Peinado RDS, Eberle RJ, Pacca CC, Arni RK, Coronado MA. Review of -Omics studies on Mosquito-Borne viruses of the flavivirus genus. Virus Res. 2022;307:198610. https:\/\/doi.org\/10.1016\/j.virusres.2021.198610.","journal-title":"Virus Res"},{"issue":"8","key":"4192_CR29","doi-asserted-by":"publisher","first-page":"e2373","DOI":"10.1371\/journal.pntd.0002373","volume":"7","author":"L Cui","year":"2013","unstructured":"Cui L, Lee YH, Kumar Y, Xu F, Lu K, Ooi EE, Tannenbaum SR, Ong CN. Serum metabolome and lipidome changes in adult patients with primary dengue infection. PLoS Negl Trop Dis. 2013;7(8):e2373. https:\/\/doi.org\/10.1371\/journal.pntd.0002373.","journal-title":"PLoS Negl Trop Dis"},{"issue":"16","key":"4192_CR30","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1128\/JVI.00187-16","volume":"90","author":"T El-Bacha","year":"2016","unstructured":"El-Bacha T, Struchiner CJ, Cordeiro MT, Almeida FCL, Marques ET. Da poian, A. T. 1 H nuclear magnetic resonance metabolomics of plasma unveils liver dysfunction in dengue patients. J Virol. 2016;90(16):7429\u201343. https:\/\/doi.org\/10.1128\/JVI.00187-16.","journal-title":"J Virol"},{"issue":"8","key":"4192_CR31","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/s42255-021-00437-0","volume":"3","author":"H Pang","year":"2021","unstructured":"Pang H, Jiang Y, Li J, Wang Y, Nie M, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Li P, Song L, Lan X, Xu Z, Hu Z. Aberrant NAD\u2009+\u2009Metabolism underlies Zika Virus\u2013Induced microcephaly. Nat Metab. 2021;3(8):1109\u201324. https:\/\/doi.org\/10.1038\/s42255-021-00437-0.","journal-title":"Nat Metab"},{"key":"4192_CR32","doi-asserted-by":"publisher","unstructured":"Ghosh Roy S. Chapter Five - TAM Receptors: A Phosphatidylserine Receptor Family and Its Implications in Viral Infections. In International Review of Cell and Molecular Biology; Davra, V., Galluzzi, L., Eds.; TAM Receptors in Health and Disease; Academic Press, 2020; Vol. 357, pp 81\u2013122. https:\/\/doi.org\/10.1016\/bs.ircmb.2020.09.003","DOI":"10.1016\/bs.ircmb.2020.09.003"},{"key":"4192_CR33","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9794","author":"I Cervenka","year":"2017","unstructured":"Cervenka I, Agudelo LZ, Ruas JL, Kynurenines. Tryptophan\u2019s metabolites in exercise, inflammation, and mental health. Science. 2017. https:\/\/doi.org\/10.1126\/science.aaf9794.","journal-title":"Science"},{"issue":"9","key":"4192_CR34","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1016\/j.celrep.2017.02.014","volume":"18","author":"M Cortese","year":"2017","unstructured":"Cortese M, Goellner S, Acosta EG, Neufeldt CJ, Oleksiuk O, Lampe M, Haselmann U, Funaya C, Schieber N, Ronchi P, Schorb M, Pruunsild P, Schwab Y, Chatel-Chaix L, Ruggieri A, Bartenschlager R. Ultrastructural characterization of Zika virus replication factories. Cell Rep. 2017;18(9):2113\u201323. https:\/\/doi.org\/10.1016\/j.celrep.2017.02.014.","journal-title":"Cell Rep"},{"issue":"4","key":"4192_CR35","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.chom.2012.08.009","volume":"12","author":"L Meertens","year":"2012","unstructured":"Meertens L, Carnec X, Lecoin MP, Ramdasi R, Guivel-Benhassine F, Lew E, Lemke G, Schwartz O, Amara A. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe. 2012;12(4):544\u201357. https:\/\/doi.org\/10.1016\/j.chom.2012.08.009.","journal-title":"Cell Host Microbe"},{"issue":"15","key":"4192_CR36","doi-asserted-by":"publisher","first-page":"8327","DOI":"10.1128\/jvi.01025-13","volume":"87","author":"S Moller-Tank","year":"2013","unstructured":"Moller-Tank S, Kondratowicz AS, Davey RA, Rennert PD, Maury W. Role of the phosphatidylserine receptor TIM-1 in Enveloped-Virus entry. J Virol. 2013;87(15):8327\u201341. https:\/\/doi.org\/10.1128\/jvi.01025-13.","journal-title":"J Virol"},{"issue":"4","key":"4192_CR37","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.chom.2011.03.012","volume":"9","author":"K Morizono","year":"2011","unstructured":"Morizono K, Xie Y, Olafsen T, Lee B, Dasgupta A, Wu AM, Chen ISY. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe. 2011;9(4):286\u201398. https:\/\/doi.org\/10.1016\/j.chom.2011.03.012.","journal-title":"Cell Host Microbe"},{"issue":"47","key":"4192_CR38","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1073\/pnas.1508095112","volume":"112","author":"AS Richard","year":"2015","unstructured":"Richard AS, Zhang A, Park S-J, Farzan M, Zong M, Choe H. Virion-Associated phosphatidylethanolamine promotes TIM1-Mediated infection by ebola, dengue, and West nile viruses. Proc Natl Acad Sci U S A. 2015;112(47):14682\u20137. https:\/\/doi.org\/10.1073\/pnas.1508095112.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4192_CR39","doi-asserted-by":"publisher","first-page":"e1002584","DOI":"10.1371\/journal.ppat.1002584","volume":"8","author":"R Perera","year":"2012","unstructured":"Perera R, Riley C, Isaac G, Hopf-Jannasch AS, Moore RJ, Weitz KW, Pasa-Tolic L, Metz TO, Adamec J, Kuhn RJ. Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog. 2012;8(3):e1002584. https:\/\/doi.org\/10.1371\/journal.ppat.1002584.","journal-title":"PLoS Pathog"},{"issue":"1","key":"4192_CR40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev.cb.05.110189.001335","volume":"5","author":"G van Meer","year":"1989","unstructured":"van Meer G. Lipid traffic in animal cells. Annu Rev Cell Dev Biol. 1989;5(1):247\u201375. https:\/\/doi.org\/10.1146\/annurev.cb.05.110189.001335.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"4","key":"4192_CR41","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chom.2009.03.007","volume":"5","author":"S Welsch","year":"2009","unstructured":"Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CKE, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. Composition and Three-Dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 2009;5(4):365\u201375. https:\/\/doi.org\/10.1016\/j.chom.2009.03.007.","journal-title":"Cell Host Microbe"},{"key":"4192_CR42","volume-title":"Comprehensive guidelines for prevention And control of dengue And dengue haemorrhagic Fever, rev. And expanded. Ed","year":"2011","unstructured":"World Health Organization, editor. Comprehensive guidelines for prevention And control of dengue And dengue haemorrhagic Fever, rev. And expanded. Ed. SEARO Technical publication series. New Delhi, India: World Health Organization Regional Office for South-East Asia; 2011."},{"issue":"2","key":"4192_CR43","doi-asserted-by":"publisher","first-page":"L176","DOI":"10.1152\/ajplung.00003.2005","volume":"289","author":"F Huang","year":"2005","unstructured":"Huang F, Subbaiah PV, Holian O, Zhang J, Johnson A, Gertzberg N, Lum H. Lysophosphatidylcholine increases endothelial permeability: role of PKC\u03b1 and RhoA cross talk. Am J Physiology-Lung Cell Mol Physiol. 2005;289(2):L176\u201385. https:\/\/doi.org\/10.1152\/ajplung.00003.2005.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"4192_CR44","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1146\/annurev.physiol.65.092101.142459","volume":"65","author":"K Balasubramanian","year":"2003","unstructured":"Balasubramanian K, Schroit AJ, Aminophospholipid Asymmetry. A matter of life and death. Annu Rev Physiol. 2003;65:701\u201334. https:\/\/doi.org\/10.1146\/annurev.physiol.65.092101.142459.","journal-title":"Annu Rev Physiol"},{"issue":"4","key":"4192_CR45","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1182\/blood.V89.4.1121","volume":"89","author":"RF Zwaal","year":"1997","unstructured":"Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood. 1997;89(4):1121\u201332.","journal-title":"Blood"},{"issue":"1","key":"4192_CR46","doi-asserted-by":"publisher","first-page":"H242","DOI":"10.1152\/ajpheart.1998.274.1.H242","volume":"274","author":"N Maulik","year":"1998","unstructured":"Maulik N, Kagan VE, Tyurin VA, Das DK. Redistribution of phosphatidylethanolamine and phosphatidylserine precedes Reperfusion-Induced apoptosis. Am J Physiol Heart Circ Physiol. 1998;274(1):H242\u20138. https:\/\/doi.org\/10.1152\/ajpheart.1998.274.1.H242.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"4192_CR47","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1056\/NEJM199009063231006","volume":"323","author":"A Lewis Robert","year":"1990","unstructured":"Lewis Robert A, Austen K, Frank; Soberman Roy J. Leukotrienes and other products of the 5-Lipoxygenase pathway. N Engl J Med. 1990;323(10):645\u201355. https:\/\/doi.org\/10.1056\/NEJM199009063231006.","journal-title":"N Engl J Med"},{"issue":"5","key":"4192_CR48","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1096\/fj.11-0502ufm","volume":"25","author":"CN Serhan","year":"2011","unstructured":"Serhan CN. The resolution of inflammation: the devil in the flask and in the details. FASEB J. 2011;25(5):1441\u20138. https:\/\/doi.org\/10.1096\/fj.11-0502ufm.","journal-title":"FASEB J"},{"issue":"10","key":"4192_CR49","doi-asserted-by":"publisher","first-page":"e0164377","DOI":"10.1371\/journal.pone.0164377","volume":"11","author":"CFOR Melo","year":"2016","unstructured":"Melo CFOR, De Oliveira DN, Lima EDO, Guerreiro TM, Esteves CZ, Beck RM, Padilla MA, Milanez GP, Arns CW, Proen\u00e7a-Modena JL, Souza-Neto JA, Catharino RR. A lipidomics approach in the characterization of Zika-Infected mosquito cells: potential targets for breaking the transmission cycle. PLoS ONE. 2016;11(10):e0164377. https:\/\/doi.org\/10.1371\/journal.pone.0164377.","journal-title":"PLoS ONE"},{"key":"4192_CR50","doi-asserted-by":"publisher","first-page":"559035","DOI":"10.3389\/fmicb.2020.559035","volume":"11","author":"MG Onyango","year":"2020","unstructured":"Onyango MG, Attardo GM, Kelly ET, Bialosuknia SM, Stout J, Banker E, Kuo L, Ciota AT, Kramer LD. Zika virus infection results in biochemical changes associated with RNA editing, inflammatory and antiviral responses in Aedes Albopictus. Front Microbiol. 2020;11:559035. https:\/\/doi.org\/10.3389\/fmicb.2020.559035.","journal-title":"Front Microbiol"},{"key":"4192_CR51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/bs.ampbs.2022.10.001","volume":"82","author":"X Cao","year":"2023","unstructured":"Cao X, van Putten JPM, W\u00f6sten MMSM. Biological functions of bacterial lysophospholipids. Adv Microb Physiol. 2023;82:129\u201354. https:\/\/doi.org\/10.1016\/bs.ampbs.2022.10.001.","journal-title":"Adv Microb Physiol"},{"issue":"6","key":"4192_CR53","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.3390\/cells9061515","volume":"9","author":"A Lucaciu","year":"2020","unstructured":"Lucaciu A, Brunkhorst R, Pfeilschifter JM, Pfeilschifter W, Subburayalu J. The S1P-S1PR Axis in neurological Disorders-Insights into current and future therapeutic perspectives. Cells. 2020;9(6):1515. https:\/\/doi.org\/10.3390\/cells9061515.","journal-title":"Cells"},{"key":"4192_CR54","doi-asserted-by":"publisher","first-page":"105018","DOI":"10.1016\/j.neuint.2021.105018","volume":"146","author":"P Xiang","year":"2021","unstructured":"Xiang P, Chew WS, Seow WL, Lam BWS, Ong W-Y, Herr DR. The S1P2 receptor regulates Blood-Brain barrier integrity and leukocyte extravasation with implications for neurodegenerative disease. Neurochem Int. 2021;146:105018. https:\/\/doi.org\/10.1016\/j.neuint.2021.105018.","journal-title":"Neurochem Int"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04192-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04192-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04192-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T23:14:03Z","timestamp":1757286843000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04192-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4192"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04192-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6668187\/v1","asserted-by":"object"}]},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were approved by the Institutional Animal Care and Use Committee of Beijing Friendship Hospital, Capital Medical University, and the Institute of Biophysics, Chinese Academy of Sciences (approval numbers: 20-2013, ABSL-2-2022015).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"452"}}