{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:26:28Z","timestamp":1793485588269,"version":"4.5.0"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National key research and development program intergovernmental key projects","award":["2023YFE0114300"],"award-info":[{"award-number":["2023YFE0114300"]}]},{"name":"Guangdong Provincial Basic and Applied Basic Research Fund Project","award":["No.2024A1515012697"],"award-info":[{"award-number":["No.2024A1515012697"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["No. 202206010044"],"award-info":[{"award-number":["No. 202206010044"]}]},{"name":"The Joint Funds of the Natural Science Foundation of China","award":["No. U24A20652"],"award-info":[{"award-number":["No. U24A20652"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82272246"],"award-info":[{"award-number":["No. 82272246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04245-4","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:54:03Z","timestamp":1759406043000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Moderate altitude exposure induced gut microbiota enterotype shifts impacting host serum metabolome and phenome"],"prefix":"10.1186","volume":"25","author":[{"given":"Yonghui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"issue":"Suppl 1","key":"4245_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1600-0838.2008.00837.x","volume":"18","author":"P B\u00e4rtsch","year":"2008","unstructured":"B\u00e4rtsch P, Saltin B, Dvorak J. Consensus statement on playing football at different altitude. Scand J Med Sci Sports. 2008;18(Suppl 1):96\u20139. https:\/\/doi.org\/10.1111\/j.1600-0838.2008.00837.x.","journal-title":"Scand J Med Sci Sports"},{"issue":"4","key":"4245_CR2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.14336\/ad.2014.0500274","volume":"5","author":"M Burtscher","year":"2014","unstructured":"Burtscher M. Effects of living at higher altitudes on mortality: a narrative review. Aging Dis. 2014;5(4):274\u201380. https:\/\/doi.org\/10.14336\/ad.2014.0500274.","journal-title":"Aging Dis"},{"issue":"4","key":"4245_CR3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1056\/NEJMra2104829","volume":"386","author":"AM Luks","year":"2022","unstructured":"Luks AM, Hackett PH. Medical conditions and high-altitude travel. N Engl J Med. 2022;386(4):364\u201373. https:\/\/doi.org\/10.1056\/NEJMra2104829.","journal-title":"N Engl J Med"},{"issue":"2","key":"4245_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/08830185.2017.1407763","volume":"37","author":"K Khanna","year":"2018","unstructured":"Khanna K, Mishra KP, Ganju L, Kumar B, Singh SB. High-altitude-induced alterations in gut-immune axis: a review. Int Rev Immunol. 2018;37(2):119\u201326. https:\/\/doi.org\/10.1080\/08830185.2017.1407763.","journal-title":"Int Rev Immunol"},{"issue":"3","key":"4245_CR5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1006\/cyto.1999.0533","volume":"12","author":"G Hartmann","year":"2000","unstructured":"Hartmann G, Tsch\u00f6p M, Fischer R, Bidlingmaier C, Riepl R, Tsch\u00f6p K, et al. High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine. 2000;12(3):246\u201352. https:\/\/doi.org\/10.1006\/cyto.1999.0533.","journal-title":"Cytokine"},{"issue":"3","key":"4245_CR6","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/2211-5463.12587","volume":"9","author":"S He","year":"2019","unstructured":"He S, Li J, Wang J, Zhang Y. Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin-knockout mice. FEBS Open Bio. 2019;9(3):498\u2013509. https:\/\/doi.org\/10.1002\/2211-5463.12587.","journal-title":"FEBS Open Bio"},{"issue":"1","key":"4245_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1089\/152702903321489013","volume":"4","author":"WC Lee","year":"2003","unstructured":"Lee WC, Chen JJ, Ho HY, Hou CW, Liang MP, Shen YW, et al. Short-term altitude mountain living improves glycemic control. High Alt Med Biol. 2003;4(1):81\u201391. https:\/\/doi.org\/10.1089\/152702903321489013.","journal-title":"High Alt Med Biol"},{"issue":"6","key":"4245_CR8","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/s00421-002-0736-8","volume":"88","author":"W Schobersberger","year":"2003","unstructured":"Schobersberger W, Schmid P, Lechleitner M, von Duvillard SP, H\u00f6rtnagl H, Gunga HC, et al. Austrian moderate altitude study 2000 (AMAS 2000). the effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome. Eur J Appl Physiol. 2003;88(6):506\u201314. https:\/\/doi.org\/10.1007\/s00421-002-0736-8.","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"4245_CR9","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1089\/ham.2007.8407","volume":"8","author":"O Castillo","year":"2007","unstructured":"Castillo O, Woolcott OO, Gonzales E, Tello V, Tello L, Villarreal C, et al. Residents at high altitude show a lower glucose profile than sea-level residents throughout 12-hour blood continuous monitoring. High Alt Med Biol. 2007;8(4):307\u201311. https:\/\/doi.org\/10.1089\/ham.2007.8407.","journal-title":"High Alt Med Biol"},{"issue":"4","key":"4245_CR10","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/s0899-9007(00)00551-7","volume":"17","author":"JL Santos","year":"2001","unstructured":"Santos JL, P\u00e9rez-Bravo F, Carrasco E, Calvill\u00e1n M, Albala C. Low prevalence of type 2 diabetes despite a high average body mass index in the Aymara natives from Chile. Nutrition. 2001;17(4):305\u20139. https:\/\/doi.org\/10.1016\/s0899-9007(00)00551-7.","journal-title":"Nutrition"},{"issue":"3","key":"4245_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.tmaid.2016.03.015","volume":"14","author":"G Flaherty","year":"2016","unstructured":"Flaherty G, O\u2019Connor R, Johnston N. Altitude training for elite endurance athletes: a review for the travel medicine practitioner. Travel Med Infect Dis. 2016;14(3):200\u201311. https:\/\/doi.org\/10.1016\/j.tmaid.2016.03.015.","journal-title":"Travel Med Infect Dis"},{"issue":"1","key":"4245_CR12","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jsams.2013.10.247","volume":"18","author":"J Wee","year":"2015","unstructured":"Wee J, Climstein M. Hypoxic training: clinical benefits on cardiometabolic risk factors. J Sci Med Sport. 2015;18(1):56\u201361. https:\/\/doi.org\/10.1016\/j.jsams.2013.10.247.","journal-title":"J Sci Med Sport"},{"issue":"4","key":"4245_CR13","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.cmet.2017.09.008","volume":"26","author":"RS Kootte","year":"2017","unstructured":"Kootte RS, Levin E, Saloj\u00e4rvi J, Smits LP, Hartstra AV, Udayappan SD, et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metab. 2017;26(4):611-9.e6. https:\/\/doi.org\/10.1016\/j.cmet.2017.09.008.","journal-title":"Cell Metab"},{"issue":"8","key":"4245_CR14","doi-asserted-by":"publisher","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","volume":"14","author":"R Sender","year":"2016","unstructured":"Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016;14(8):e1002533. https:\/\/doi.org\/10.1371\/journal.pbio.1002533.","journal-title":"PLoS Biol"},{"issue":"1","key":"4245_CR15","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41522-021-00207-6","volume":"7","author":"N Guo","year":"2021","unstructured":"Guo N, Wu Q, Shi F, Niu J, Zhang T, Degen AA, et al. Seasonal dynamics of diet-gut microbiota interaction in adaptation of yaks to life at high altitude. NPJ Biofilms Microbiomes. 2021;7(1):38. https:\/\/doi.org\/10.1038\/s41522-021-00207-6.","journal-title":"NPJ Biofilms Microbiomes"},{"key":"4245_CR16","doi-asserted-by":"publisher","first-page":"167016","DOI":"10.1016\/j.scitotenv.2023.167016","volume":"905","author":"D Liu","year":"2023","unstructured":"Liu D, Gao X, Huang X, Fan Y, Wang YE, Zhang Y, et al. Moderate altitude exposure impacts host fasting blood glucose and serum metabolome by regulation of the intestinal flora. Sci Total Environ. 2023;905:167016. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.167016.","journal-title":"Sci Total Environ"},{"issue":"6052","key":"4245_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.1208344","volume":"334","author":"GD Wu","year":"2011","unstructured":"Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334(6052):105\u20138. https:\/\/doi.org\/10.1126\/science.1208344.","journal-title":"Science"},{"issue":"7285","key":"4245_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","volume":"464","author":"J Qin","year":"2010","unstructured":"Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59\u201365. https:\/\/doi.org\/10.1038\/nature08821.","journal-title":"Nature"},{"issue":"7346","key":"4245_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","volume":"473","author":"M Arumugam","year":"2011","unstructured":"Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174\u201380. https:\/\/doi.org\/10.1038\/nature09944.","journal-title":"Nature"},{"issue":"15","key":"4245_CR20","doi-asserted-by":"publisher","first-page":"R652","DOI":"10.1016\/j.cub.2015.06.031","volume":"25","author":"J Li","year":"2015","unstructured":"Li J, Powell JE, Guo J, Evans JD, Wu J, Williams P, et al. Two gut community enterotypes recur in diverse bumblebee species. Curr Biol. 2015;25(15):R652\u20133. https:\/\/doi.org\/10.1016\/j.cub.2015.06.031.","journal-title":"Curr Biol"},{"issue":"1","key":"4245_CR21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40168-024-01827-8","volume":"12","author":"C Larzul","year":"2024","unstructured":"Larzul C, Estell\u00e9 J, Borey M, Blanc F, Lemonnier G, Billon Y, et al. Driving gut microbiota enterotypes through host genetics. Microbiome. 2024;12(1):116. https:\/\/doi.org\/10.1186\/s40168-024-01827-8.","journal-title":"Microbiome"},{"issue":"26","key":"4245_CR22","doi-asserted-by":"publisher","first-page":"E2703","DOI":"10.1073\/pnas.1402342111","volume":"111","author":"J Wang","year":"2014","unstructured":"Wang J, Linnenbrink M, K\u00fcnzel S, Fernandes R, Nadeau MJ, Rosenstiel P, et al. Dietary history contributes to enterotype-like clustering and functional metagenomic content in the intestinal microbiome of wild mice. Proc Natl Acad Sci U S A. 2014;111(26):E2703\u201310. https:\/\/doi.org\/10.1073\/pnas.1402342111.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"4245_CR23","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1038\/s41467-021-22510-8","volume":"12","author":"CE Couch","year":"2021","unstructured":"Couch CE, Stagaman K, Spaan RS, Combrink HJ, Sharpton TJ, Beechler BR, et al. Diet and gut microbiome enterotype are associated at the population level in African buffalo. Nat Commun. 2021;12(1):2267. https:\/\/doi.org\/10.1038\/s41467-021-22510-8.","journal-title":"Nat Commun"},{"issue":"1","key":"4245_CR24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12937-020-00630-z","volume":"19","author":"Z Cheng","year":"2020","unstructured":"Cheng Z, Shuai P, Qiao Q, Li T. Validity and reliability of a simplified food frequency questionnaire: a cross sectional study among physical health examination adults in southwest region of China. Nutr J. 2020;19(1):114. https:\/\/doi.org\/10.1186\/s12937-020-00630-z.","journal-title":"Nutr J"},{"issue":"4","key":"4245_CR25","doi-asserted-by":"publisher","first-page":"537","DOI":"10.2337\/diacare.20.4.537","volume":"20","author":"XR Pan","year":"1997","unstructured":"Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537\u201344. https:\/\/doi.org\/10.2337\/diacare.20.4.537.","journal-title":"Diabetes Care."},{"key":"4245_CR26","doi-asserted-by":"publisher","first-page":"103546","DOI":"10.1016\/j.redox.2025.103546","volume":"81","author":"X Chen","year":"2025","unstructured":"Chen X, Zou G, Yang Z, Qi X, Song F, Peng L, et al. Serum metabolomic profiling uncovered metabolic shifts in individuals upon moderate-altitude exposure and identified the potentiality of beta-alanine to ameliorate hyperuricemia. Redox Biol. 2025;81:103546. https:\/\/doi.org\/10.1016\/j.redox.2025.103546.","journal-title":"Redox Biol"},{"issue":"Pt B","key":"4245_CR27","doi-asserted-by":"publisher","first-page":"112176","DOI":"10.1016\/j.foodres.2022.112176","volume":"162","author":"Y Hou","year":"2022","unstructured":"Hou Y, Zhang Z, Cui Y, Peng C, Fan Y, Tan C, et al. Pu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions. Food Res Int. 2022;162(Pt B):112176. https:\/\/doi.org\/10.1016\/j.foodres.2022.112176.","journal-title":"Food Res Int"},{"issue":"1","key":"4245_CR28","doi-asserted-by":"publisher","first-page":"2530660","DOI":"10.1080\/21505594.2025.2530660","volume":"16","author":"X Huang","year":"2025","unstructured":"Huang X, Gao X, Fan Y, Wang D, Chen X, Qi X, et al. Moderate altitude exposure impacts extensive host-microbiota multi-kingdom connectivity with serum metabolome and fasting blood glucose. Virulence. 2025;16(1):2530660. https:\/\/doi.org\/10.1080\/21505594.2025.2530660.","journal-title":"Virulence"},{"issue":"11","key":"4245_CR29","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1038\/s41587-023-01688-w","volume":"41","author":"A Blanco-M\u00edguez","year":"2023","unstructured":"Blanco-M\u00edguez A, Beghini F, Cumbo F, McIver LJ, Thompson KN, Zolfo M, et al. Extending and improving metagenomic taxonomic profiling with uncharacterized species using metaphlan 4. Nat Biotechnol. 2023;41(11):1633\u201344. https:\/\/doi.org\/10.1038\/s41587-023-01688-w.","journal-title":"Nat Biotechnol"},{"key":"4245_CR30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088","author":"F Beghini","year":"2021","unstructured":"Beghini F, McIver LJ, Blanco-M\u00edguez A, Dubois L, Asnicar F, Maharjan S, et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife. 2021. https:\/\/doi.org\/10.7554\/eLife.65088.","journal-title":"Elife"},{"issue":"8","key":"4245_CR31","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nbt.2942","volume":"32","author":"J Li","year":"2014","unstructured":"Li J, Jia H, Cai X, Zhong H, Feng Q, Sunagawa S, et al. An integrated catalog of reference genes in the human gut microbiome. Nat Biotechnol. 2014;32(8):834\u201341. https:\/\/doi.org\/10.1038\/nbt.2942.","journal-title":"Nat Biotechnol"},{"issue":"8","key":"4245_CR32","doi-asserted-by":"publisher","first-page":"16088","DOI":"10.1038\/nmicrobiol.2016.88","volume":"1","author":"S Vieira-Silva","year":"2016","unstructured":"Vieira-Silva S, Falony G, Darzi Y, Lima-Mendez G, Garcia Yunta R, Okuda S, et al. Species-function relationships shape ecological properties of the human gut microbiome. Nat Microbiol. 2016;1(8):16088. https:\/\/doi.org\/10.1038\/nmicrobiol.2016.88.","journal-title":"Nat Microbiol"},{"issue":"7500","key":"4245_CR33","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nature13178","volume":"509","author":"T Ding","year":"2014","unstructured":"Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body. Nature. 2014;509(7500):357\u201360. https:\/\/doi.org\/10.1038\/nature13178.","journal-title":"Nature"},{"issue":"7418","key":"4245_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","volume":"490","author":"J Qin","year":"2012","unstructured":"Qin J, Li Y, Cai Z, Li S, Zhu J, Zhang F, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55\u201360. https:\/\/doi.org\/10.1038\/nature11450.","journal-title":"Nature"},{"key":"4245_CR35","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1038\/ncomms7528","volume":"6","author":"Q Feng","year":"2015","unstructured":"Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun. 2015;6:6528. https:\/\/doi.org\/10.1038\/ncomms7528.","journal-title":"Nat Commun"},{"issue":"7","key":"4245_CR36","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/s41591-018-0061-3","volume":"24","author":"L Hoyles","year":"2018","unstructured":"Hoyles L, Fern\u00e1ndez-Real JM, Federici M, Serino M, Abbott J, Charpentier J, et al. Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Nat Med. 2018;24(7):1070\u201380. https:\/\/doi.org\/10.1038\/s41591-018-0061-3.","journal-title":"Nat Med"},{"issue":"1","key":"4245_CR37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cmet.2019.11.001","volume":"31","author":"Y Liu","year":"2020","unstructured":"Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, et al. Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention. Cell Metab. 2020;31(1):77-91 e5. https:\/\/doi.org\/10.1016\/j.cmet.2019.11.001.","journal-title":"Cell Metab"},{"issue":"6","key":"4245_CR38","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.18632\/aging.102872","volume":"12","author":"Y Chen","year":"2020","unstructured":"Chen Y, Zhang S, Zeng B, Zhao J, Yang M, Zhang M, et al. Transplant of microbiota from long-living people to mice reduces aging-related indices and transfers beneficial bacteria. Aging (Albany NY). 2020;12(6):4778\u201393. https:\/\/doi.org\/10.18632\/aging.102872.","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"4245_CR39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.chom.2018.07.002","volume":"24","author":"A Jacobson","year":"2018","unstructured":"Jacobson A, Lam L, Rajendram M, Tamburini F, Honeycutt J, Pham T, et al. A Gut commensal-produced metabolite mediates colonization resistance to salmonella infection. Cell Host Microbe. 2018;24(2):296-307 e7. https:\/\/doi.org\/10.1016\/j.chom.2018.07.002.","journal-title":"Cell Host Microbe"},{"key":"4245_CR40","unstructured":"Cohen J. Statistical power analysis for the behavioral sciences (2nd ed. Statistical power analysis for the behavioral sciences). 1988."},{"issue":"1","key":"4245_CR41","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41564-017-0072-8","volume":"3","author":"PI Costea","year":"2018","unstructured":"Costea PI, Hildebrand F, Arumugam M, B\u00e4ckhed F, Blaser MJ, Bushman FD, et al. Enterotypes in the landscape of gut microbial community composition. Nat Microbiol. 2018;3(1):8\u201316. https:\/\/doi.org\/10.1038\/s41564-017-0072-8.","journal-title":"Nat Microbiol"},{"issue":"1","key":"4245_CR42","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s13059-021-02463-3","volume":"22","author":"L Xiao","year":"2021","unstructured":"Xiao L, Wang J, Zheng J, Li X, Zhao F. Deterministic transition of enterotypes shapes the infant gut microbiome at an early age. Genome Biol. 2021;22(1):243. https:\/\/doi.org\/10.1186\/s13059-021-02463-3.","journal-title":"Genome Biol"},{"issue":"5091","key":"4245_CR43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87\u201391. https:\/\/doi.org\/10.1126\/science.7678183.","journal-title":"Science"},{"issue":"1","key":"4245_CR44","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cmet.2019.11.001","volume":"31","author":"Y Liu","year":"2020","unstructured":"Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, et al. Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention. Cell Metab. 2020;31(1):77-91.e5. https:\/\/doi.org\/10.1016\/j.cmet.2019.11.001.","journal-title":"Cell Metab"},{"issue":"Pt 2","key":"4245_CR45","doi-asserted-by":"publisher","first-page":"114206","DOI":"10.1016\/j.envres.2022.114206","volume":"215","author":"H Zuo","year":"2022","unstructured":"Zuo H, Zheng T, Wu K, Yang T, Wang L, Nima Q, et al. High-altitude exposure decreases bone mineral density and its relationship with gut microbiota: results from the China multi-ethnic cohort (CMEC) study. Environ Res. 2022;215(Pt 2):114206. https:\/\/doi.org\/10.1016\/j.envres.2022.114206.","journal-title":"Environ Res"},{"key":"4245_CR46","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1038\/srep14682","volume":"5","author":"L Li","year":"2015","unstructured":"Li L, Zhao X. Comparative analyses of fecal microbiota in Tibetan and Chinese Han living at low or high altitude by barcoded 454 pyrosequencing. Sci Rep. 2015;5:14682. https:\/\/doi.org\/10.1038\/srep14682.","journal-title":"Sci Rep"},{"issue":"1","key":"4245_CR47","doi-asserted-by":"publisher","first-page":"16982","DOI":"10.1038\/s41598-017-17194-4","volume":"7","author":"D Lan","year":"2017","unstructured":"Lan D, Ji W, Lin B, Chen Y, Huang C, Xiong X, et al. Correlations between gut microbiota community structures of Tibetans and geography. Sci Rep. 2017;7(1):16982. https:\/\/doi.org\/10.1038\/s41598-017-17194-4.","journal-title":"Sci Rep"},{"issue":"16","key":"4245_CR48","doi-asserted-by":"publisher","first-page":"4850","DOI":"10.1111\/febs.16409","volume":"289","author":"Y Wang","year":"2022","unstructured":"Wang Y, Shi Y, Li W, Wang S, Zheng J, Xu G, et al. Gut microbiota imbalance mediates intestinal barrier damage in high-altitude exposed mice. FEBS J. 2022;289(16):4850\u201368. https:\/\/doi.org\/10.1111\/febs.16409.","journal-title":"FEBS J"},{"issue":"4","key":"4245_CR49","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12088-018-0746-9","volume":"58","author":"S Kalyana Chakravarthy","year":"2018","unstructured":"Kalyana Chakravarthy S, Jayasudha R, Sai Prashanthi G, Ali MH, Sharma S, Tyagi M, et al. Dysbiosis in the gut bacterial microbiome of patients with uveitis, an inflammatory disease of the eye. Indian J Microbiol. 2018;58(4):457\u201369. https:\/\/doi.org\/10.1007\/s12088-018-0746-9.","journal-title":"Indian J Microbiol"},{"issue":"1","key":"4245_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1848158","volume":"13","author":"H Zafar","year":"2021","unstructured":"Zafar H, Saier MH Jr. Gut Bacteroides species in health and disease. Gut Microbes. 2021;13(1):1\u201320. https:\/\/doi.org\/10.1080\/19490976.2020.1848158.","journal-title":"Gut Microbes"},{"issue":"4","key":"4245_CR51","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1210\/jc.2017-02114","volume":"103","author":"F Ottosson","year":"2018","unstructured":"Ottosson F, Brunkwall L, Ericson U, Nilsson PM, Almgren P, Fernandez C, et al. Connection between BMI-related plasma metabolite profile and gut microbiota. J Clin Endocrinol Metab. 2018;103(4):1491\u2013501. https:\/\/doi.org\/10.1210\/jc.2017-02114.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"4245_CR52","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/gutjnl-2022-328185","volume":"72","author":"FF Anh\u00ea","year":"2023","unstructured":"Anh\u00ea FF, Zlitni S, Zhang SY, Choi BS, Chen CY, Foley KP, et al. Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity. Gut. 2023;72(3):460\u201371. https:\/\/doi.org\/10.1136\/gutjnl-2022-328185.","journal-title":"Gut"},{"issue":"1","key":"4245_CR53","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41467-023-35861-1","volume":"14","author":"M Yang","year":"2023","unstructured":"Yang M, Qi X, Li N, Kaifi JT, Chen S, Wheeler AA, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023;14(1):228. https:\/\/doi.org\/10.1038\/s41467-023-35861-1.","journal-title":"Nat Commun"},{"issue":"1","key":"4245_CR54","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s40168-022-01331-x","volume":"10","author":"CG Gonzalez","year":"2022","unstructured":"Gonzalez CG, Mills RH, Zhu Q, Sauceda C, Knight R, Dulai PS, et al. Location-specific signatures of Crohn\u2019s disease at a multi-omics scale. Microbiome. 2022;10(1):133. https:\/\/doi.org\/10.1186\/s40168-022-01331-x.","journal-title":"Microbiome"},{"issue":"1","key":"4245_CR55","doi-asserted-by":"publisher","first-page":"2348441","DOI":"10.1080\/19490976.2024.2348441","volume":"16","author":"Y Lu","year":"2024","unstructured":"Lu Y, Cui A, Zhang X. Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis. Gut Microbes. 2024;16(1):2348441. https:\/\/doi.org\/10.1080\/19490976.2024.2348441.","journal-title":"Gut Microbes"},{"issue":"12","key":"4245_CR56","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1111\/obr.12750","volume":"19","author":"ICL van den Munckhof","year":"2018","unstructured":"van den Munckhof ICL, Kurilshikov A, Ter Horst R, Riksen NP, Joosten LAB, Zhernakova A, et al. Role of gut microbiota in chronic low-grade inflammation as potential driver for atherosclerotic cardiovascular disease: a systematic review of human studies. Obes Rev. 2018;19(12):1719\u201334. https:\/\/doi.org\/10.1111\/obr.12750.","journal-title":"Obes Rev"},{"key":"4245_CR57","doi-asserted-by":"publisher","first-page":"102590","DOI":"10.1016\/j.ebiom.2019.11.051","volume":"51","author":"M Gurung","year":"2020","unstructured":"Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, et al. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020;51:102590. https:\/\/doi.org\/10.1016\/j.ebiom.2019.11.051.","journal-title":"EBioMedicine"},{"issue":"6","key":"4245_CR58","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1002\/art.40827","volume":"71","author":"EHP van Dijkhuizen","year":"2019","unstructured":"van Dijkhuizen EHP, Del Chierico F, Malattia C, Russo A, Pires Marafon D, Ter Haar NM, et al. Microbiome analytics of the gut microbiota in patients with juvenile idiopathic arthritis: a longitudinal observational cohort study. Arthritis Rheumatol. 2019;71(6):1000\u201310. https:\/\/doi.org\/10.1002\/art.40827.","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"4245_CR59","doi-asserted-by":"publisher","first-page":"e0166026","DOI":"10.1371\/journal.pone.0166026","volume":"11","author":"H Zheng","year":"2016","unstructured":"Zheng H, Liang H, Wang Y, Miao M, Shi T, Yang F, et al. Altered gut microbiota composition associated with eczema in infants. PLoS ONE. 2016;11(11):e0166026. https:\/\/doi.org\/10.1371\/journal.pone.0166026.","journal-title":"PLoS ONE"},{"issue":"1","key":"4245_CR60","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s40168-018-0472-x","volume":"6","author":"MKW Crusell","year":"2018","unstructured":"Crusell MKW, Hansen TH, Nielsen T, Allin KH, R\u00fchlemann MC, Damm P, et al. Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum. Microbiome. 2018;6(1):89. https:\/\/doi.org\/10.1186\/s40168-018-0472-x.","journal-title":"Microbiome"},{"key":"4245_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121349","author":"E Maier","year":"2017","unstructured":"Maier E, Anderson RC, Roy NC. Live Faecalibacterium prausnitzii does not enhance epithelial barrier integrity in an apical anaerobic co-culture model of the Large Intestine. Nutrients. 2017. https:\/\/doi.org\/10.3390\/nu9121349.","journal-title":"Nutrients"},{"issue":"3","key":"4245_CR62","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41591-022-01698-2","volume":"28","author":"JA McCulloch","year":"2022","unstructured":"McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, et al. Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1. Nat Med. 2022;28(3):545\u201356. https:\/\/doi.org\/10.1038\/s41591-022-01698-2.","journal-title":"Nat Med"},{"issue":"44","key":"4245_CR63","doi-asserted-by":"publisher","first-page":"eadi7337","DOI":"10.1126\/sciadv.adi7337","volume":"9","author":"S Huang","year":"2023","unstructured":"Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J, et al. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci Adv. 2023;9(44):eadi7337. https:\/\/doi.org\/10.1126\/sciadv.adi7337.","journal-title":"Sci Adv"},{"issue":"3","key":"4245_CR64","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.chom.2018.08.009","volume":"24","author":"AD Truax","year":"2018","unstructured":"Truax AD, Chen L, Tam JW, Cheng N, Guo H, Koblansky AA, et al. The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host Microbe. 2018;24(3):364-78.e6. https:\/\/doi.org\/10.1016\/j.chom.2018.08.009.","journal-title":"Cell Host Microbe"},{"issue":"1","key":"4245_CR65","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13073-021-00856-4","volume":"13","author":"C Alvarez-Silva","year":"2021","unstructured":"Alvarez-Silva C, Kashani A, Hansen TH, Pinna NK, Anjana RM, Dutta A, et al. Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India. Genome Med. 2021;13(1):37. https:\/\/doi.org\/10.1186\/s13073-021-00856-4.","journal-title":"Genome Med"},{"issue":"1","key":"4245_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1840765","volume":"12","author":"X Wang","year":"2020","unstructured":"Wang X, Liu H, Li Y, Huang S, Zhang L, Cao C, et al. Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus. Gut Microbes. 2020;12(1):1\u201313. https:\/\/doi.org\/10.1080\/19490976.2020.1840765.","journal-title":"Gut Microbes"},{"issue":"2","key":"4245_CR67","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2022.12.013","volume":"35","author":"T Takeuchi","year":"2023","unstructured":"Takeuchi T, Kameyama K, Miyauchi E, Nakanishi Y, Kanaya T, Fujii T, et al. Fatty acid overproduction by gut commensal microbiota exacerbates obesity. Cell Metab. 2023;35(2):361-75.e9. https:\/\/doi.org\/10.1016\/j.cmet.2022.12.013.","journal-title":"Cell Metab"},{"issue":"4","key":"4245_CR68","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1128\/cmr.00008-07","volume":"20","author":"HM Wexler","year":"2007","unstructured":"Wexler HM. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007;20(4):593\u2013621. https:\/\/doi.org\/10.1128\/cmr.00008-07.","journal-title":"Clin Microbiol Rev"},{"issue":"7122","key":"4245_CR69","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022\u20133. https:\/\/doi.org\/10.1038\/4441022a.","journal-title":"Nature"},{"issue":"7122","key":"4245_CR70","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"PJ Turnbaugh","year":"2006","unstructured":"Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027\u201331. https:\/\/doi.org\/10.1038\/nature05414.","journal-title":"Nature"},{"issue":"2","key":"4245_CR71","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cmet.2019.11.019","volume":"31","author":"P Petrus","year":"2020","unstructured":"Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, et al. Glutamine Links Obesity to Inflammation in Human White Adipose Tissue. Cell Metab. 2020;31(2):375-90.e11. https:\/\/doi.org\/10.1016\/j.cmet.2019.11.019.","journal-title":"Cell Metab"},{"issue":"7","key":"4245_CR72","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nm.4358","volume":"23","author":"R Liu","year":"2017","unstructured":"Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859\u201368. https:\/\/doi.org\/10.1038\/nm.4358.","journal-title":"Nat Med"},{"issue":"5","key":"4245_CR73","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/s43587-022-00193-0","volume":"2","author":"Q Xu","year":"2022","unstructured":"Xu Q, Wu C, Zhu Q, Gao R, Lu J, Valles-Colomer M, et al. Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors. Nat Aging. 2022;2(5):438\u201352. https:\/\/doi.org\/10.1038\/s43587-022-00193-0.","journal-title":"Nat Aging"},{"issue":"4","key":"4245_CR74","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s43587-023-00389-y","volume":"3","author":"S Pang","year":"2023","unstructured":"Pang S, Chen X, Lu Z, Meng L, Huang Y, Yu X, et al. Longevity of centenarians is reflected by the gut microbiome with youth-associated signatures. Nat Aging. 2023;3(4):436\u201349. https:\/\/doi.org\/10.1038\/s43587-023-00389-y.","journal-title":"Nat Aging"},{"issue":"1","key":"4245_CR75","doi-asserted-by":"publisher","first-page":"3872","DOI":"10.1038\/s41467-024-47683-w","volume":"15","author":"C Was\u00e9n","year":"2024","unstructured":"Was\u00e9n C, Beauchamp LC, Vincentini J, Li S, LeServe DS, Gauthier C, et al. Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer\u2019s disease mouse models. Nat Commun. 2024;15(1):3872. https:\/\/doi.org\/10.1038\/s41467-024-47683-w.","journal-title":"Nat Commun"},{"issue":"1","key":"4245_CR76","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41467-023-36089-9","volume":"14","author":"L Sun","year":"2023","unstructured":"Sun L, Zhang Y, Cai J, Rimal B, Rocha ER, Coleman JP, et al. Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer. Nat Commun. 2023;14(1):755. https:\/\/doi.org\/10.1038\/s41467-023-36089-9.","journal-title":"Nat Commun"},{"issue":"3","key":"4245_CR77","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.immuni.2019.02.001","volume":"50","author":"D Yang","year":"2019","unstructured":"Yang D, Chen X, Wang J, Lou Q, Lou Y, Li L, et al. Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles. Immunity. 2019;50(3):692-706.e7. https:\/\/doi.org\/10.1016\/j.immuni.2019.02.001.","journal-title":"Immunity"},{"issue":"3","key":"4245_CR78","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.chom.2017.07.018","volume":"22","author":"L Spiga","year":"2017","unstructured":"Spiga L, Winter MG, Furtado de Carvalho T, Zhu W, Hughes ER, Gillis CC, et al. An oxidative central metabolism enables Salmonella to Utilize Microbiota-Derived Succinate. Cell Host Microbe. 2017;22(3):291-301.e6. https:\/\/doi.org\/10.1016\/j.chom.2017.07.018.","journal-title":"Cell Host Microbe"},{"issue":"6","key":"4245_CR79","doi-asserted-by":"publisher","first-page":"e13848","DOI":"10.1111\/acel.13848","volume":"22","author":"J Gong","year":"2023","unstructured":"Gong J, Liu S, Wang S, Ruan H, Mou Q, Fan P, et al. Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging. Aging Cell. 2023;22(6):e13848. https:\/\/doi.org\/10.1111\/acel.13848.","journal-title":"Aging Cell"},{"issue":"7885","key":"4245_CR80","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41586-021-03832-5","volume":"599","author":"Y Sato","year":"2021","unstructured":"Sato Y, Atarashi K, Plichta DR, Arai Y, Sasajima S, Kearney SM, et al. Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature. 2021;599(7885):458\u201364. https:\/\/doi.org\/10.1038\/s41586-021-03832-5.","journal-title":"Nature"},{"key":"4245_CR81","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8101483","author":"M Kollarcikova","year":"2020","unstructured":"Kollarcikova M, Faldynova M, Matiasovicova J, Jahodarova E, Kubasova T, Seidlerova Z, et al. Different Bacteroides species colonise human and chicken intestinal tract. Microorganisms. 2020. https:\/\/doi.org\/10.3390\/microorganisms8101483.","journal-title":"Microorganisms"},{"issue":"9","key":"4245_CR82","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s00284-023-03383-0","volume":"80","author":"H Yamada","year":"2023","unstructured":"Yamada H, Miura H, Suzuki Y, Koike S, Shimamoto S, Kobayashi Y. In vitro effects of cellulose acetate on fermentation profiles, the microbiome, and gamma-aminobutyric acid production in human stool cultures. Curr Microbiol. 2023;80(9):284. https:\/\/doi.org\/10.1007\/s00284-023-03383-0.","journal-title":"Curr Microbiol"},{"issue":"1","key":"4245_CR83","doi-asserted-by":"publisher","first-page":"eaax6208","DOI":"10.1126\/sciadv.aax6208","volume":"6","author":"SL Zeng","year":"2020","unstructured":"Zeng SL, Li SZ, Xiao PT, Cai YY, Chu C, Chen BZ, et al. Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism. Sci Adv. 2020;6(1):eaax6208. https:\/\/doi.org\/10.1126\/sciadv.aax6208.","journal-title":"Sci Adv"},{"issue":"1","key":"4245_CR84","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s40168-021-01126-6","volume":"9","author":"P Zhuang","year":"2021","unstructured":"Zhuang P, Li H, Jia W, Shou Q, Zhu Y, Mao L, et al. Eicosapentaenoic and docosahexaenoic acids attenuate hyperglycemia through the microbiome-gut-organs axis in db\/db mice. Microbiome. 2021;9(1):185. https:\/\/doi.org\/10.1186\/s40168-021-01126-6.","journal-title":"Microbiome"},{"issue":"1","key":"4245_CR85","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1507\/endocrj.EJ23-0506","volume":"71","author":"H Nagao","year":"2024","unstructured":"Nagao H, Nishizawa H, Fukuda S, Fujishima Y, Kita S, Maeda N, et al. Correlation between plasma glutamate and adiponectin in patients with type 2 diabetes. Endocr J. 2024;71(1):55\u201363. https:\/\/doi.org\/10.1507\/endocrj.EJ23-0506.","journal-title":"Endocr J"},{"issue":"5","key":"4245_CR86","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00592-019-01313-w","volume":"56","author":"ME Palomo-Buitrago","year":"2019","unstructured":"Palomo-Buitrago ME, Sabater-Masdeu M, Moreno-Navarrete JM, Caballano-Infantes E, Arnoriaga-Rodr\u00edguez M, Coll C, et al. Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition. Acta Diabetol. 2019;56(5):569\u201379. https:\/\/doi.org\/10.1007\/s00592-019-01313-w.","journal-title":"Acta Diabetol"},{"issue":"16","key":"4245_CR87","doi-asserted-by":"publisher","first-page":"14007","DOI":"10.1074\/jbc.M110.183517","volume":"286","author":"ES Di Cairano","year":"2011","unstructured":"Di Cairano ES, Davalli AM, Perego L, Sala S, Sacchi VF, La Rosa S, et al. The glial glutamate transporter 1 (GLT1) is expressed by pancreatic beta-cells and prevents glutamate-induced beta-cell death. J Biol Chem. 2011;286(16):14007\u201318. https:\/\/doi.org\/10.1074\/jbc.M110.183517.","journal-title":"J Biol Chem"},{"issue":"1","key":"4245_CR88","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/mco.0000000000000991","volume":"27","author":"L Chaouche","year":"2024","unstructured":"Chaouche L, Marcotte F, Maltais-Payette I, Tchernof A. Glutamate and obesity - what is the link? Curr Opin Clin Nutr Metab Care. 2024;27(1):70\u20136. https:\/\/doi.org\/10.1097\/mco.0000000000000991.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"1","key":"4245_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","volume":"13","author":"X Liu","year":"2021","unstructured":"Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, et al. Blautia-a new functional genus with potential probiotic properties? Gut Microbes. 2021;13(1):1\u201321. https:\/\/doi.org\/10.1080\/19490976.2021.1875796.","journal-title":"Gut Microbes"},{"issue":"8","key":"4245_CR90","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","volume":"24","author":"ER Mann","year":"2024","unstructured":"Mann ER, Lam YK, Uhlig HH. Short-chain fatty acids: linking diet, the microbiome and immunity. Nat Rev Immunol. 2024;24(8):577\u201395. https:\/\/doi.org\/10.1038\/s41577-024-01014-8.","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"4245_CR91","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1002\/imt2.61","volume":"1","author":"D Wu","year":"2022","unstructured":"Wu D, Liu L, Jiao N, Zhang Y, Yang L, Tian C, et al. Targeting keystone species helps restore the dysbiosis of butyrate-producing bacteria in nonalcoholic fatty liver disease. Imeta. 2022;1(4):e61. https:\/\/doi.org\/10.1002\/imt2.61.","journal-title":"Imeta"},{"issue":"5","key":"4245_CR92","doi-asserted-by":"publisher","first-page":"100479","DOI":"10.1016\/j.xinn.2023.100479","volume":"4","author":"S Chen","year":"2023","unstructured":"Chen S, Zhang P, Duan H, Wang J, Qiu Y, Cui Z, et al. Gut microbiota in muscular atrophy development, progression, and treatment: new therapeutic targets and opportunities. Innovation (Camb). 2023;4(5):100479. https:\/\/doi.org\/10.1016\/j.xinn.2023.100479.","journal-title":"Innovation (Camb)"},{"key":"4245_CR93","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/ncomms2852","volume":"4","author":"I Kimura","year":"2013","unstructured":"Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013;4:1829. https:\/\/doi.org\/10.1038\/ncomms2852.","journal-title":"Nat Commun"},{"key":"4245_CR94","doi-asserted-by":"publisher","first-page":"103400","DOI":"10.1016\/j.ebiom.2021.103400","volume":"68","author":"SL Dawson","year":"2021","unstructured":"Dawson SL, O\u2019Hely M, Jacka FN, Ponsonby AL, Symeonides C, Loughman A, et al. Maternal prenatal gut microbiota composition predicts child behaviour. EBioMedicine. 2021;68:103400. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103400.","journal-title":"EBioMedicine"},{"issue":"3","key":"4245_CR95","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.tim.2024.10.001","volume":"33","author":"Y Tsui","year":"2025","unstructured":"Tsui Y, Wu X, Zhang X, Peng Y, Mok CKP, Chan FKL, et al. Short-chain fatty acids in viral infection: the underlying mechanisms, opportunities, and challenges. Trends Microbiol. 2025;33(3):302\u201320. https:\/\/doi.org\/10.1016\/j.tim.2024.10.001.","journal-title":"Trends Microbiol"},{"issue":"8","key":"4245_CR96","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","volume":"16","author":"B Dalile","year":"2019","unstructured":"Dalile B, Van Oudenhove L, Vervliet B, Verbeke K. The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol. 2019;16(8):461\u201378. https:\/\/doi.org\/10.1038\/s41575-019-0157-3.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"4245_CR97","doi-asserted-by":"publisher","first-page":"2393270","DOI":"10.1080\/19490976.2024.2393270","volume":"16","author":"KE Hays","year":"2024","unstructured":"Hays KE, Pfaffinger JM, Ryznar R. The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease. Gut Microbes. 2024;16(1):2393270. https:\/\/doi.org\/10.1080\/19490976.2024.2393270.","journal-title":"Gut Microbes"},{"issue":"7606","key":"4245_CR98","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature18309","volume":"534","author":"RJ Perry","year":"2016","unstructured":"Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, et al. Acetate mediates a microbiome-brain-\u03b2-cell axis to promote metabolic syndrome. Nature. 2016;534(7606):213\u20137. https:\/\/doi.org\/10.1038\/nature18309.","journal-title":"Nature"},{"issue":"4","key":"4245_CR99","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","volume":"51","author":"S Sanna","year":"2019","unstructured":"Sanna S, van Zuydam NR, Mahajan A, Kurilshikov A, Vich Vila A, V\u00f5sa U, et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat Genet. 2019;51(4):600\u20135. https:\/\/doi.org\/10.1038\/s41588-019-0350-x.","journal-title":"Nat Genet"},{"issue":"1","key":"4245_CR100","doi-asserted-by":"publisher","first-page":"5674","DOI":"10.1038\/s41467-021-25965-x","volume":"12","author":"S Okumura","year":"2021","unstructured":"Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, et al. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. Nat Commun. 2021;12(1):5674. https:\/\/doi.org\/10.1038\/s41467-021-25965-x.","journal-title":"Nat Commun"},{"issue":"11","key":"4245_CR101","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1136\/gutjnl-2023-330291","volume":"72","author":"X Kang","year":"2023","unstructured":"Kang X, Liu C, Ding Y, Ni Y, Ji F, Lau HCH, et al. Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8(+) T cells. Gut. 2023;72(11):2112\u201322. https:\/\/doi.org\/10.1136\/gutjnl-2023-330291.","journal-title":"Gut"},{"issue":"1","key":"4245_CR102","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40168-019-0650-5","volume":"7","author":"A Tovaglieri","year":"2019","unstructured":"Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, et al. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019;7(1):43. https:\/\/doi.org\/10.1186\/s40168-019-0650-5.","journal-title":"Microbiome"},{"issue":"4","key":"4245_CR103","doi-asserted-by":"publisher","first-page":"463","DOI":"10.2332\/allergolint.13-OA-0552","volume":"62","author":"S Yamashita","year":"2013","unstructured":"Yamashita S, Segawa R, Satou N, Hiratsuka M, Leonard WJ, Hirasawa N. Induction of thymic stromal lymphopoietin production by nonanoic acid and exacerbation of allergic inflammation in mice. Allergol Int. 2013;62(4):463\u201371. https:\/\/doi.org\/10.2332\/allergolint.13-OA-0552.","journal-title":"Allergol Int"},{"issue":"1","key":"4245_CR104","doi-asserted-by":"publisher","first-page":"2501185","DOI":"10.1080\/19490976.2025.2501185","volume":"17","author":"KM Jardon","year":"2025","unstructured":"Jardon KM, Umanets A, Gijbels A, Trouwborst I, Hul GB, Siebelink E, et al. Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity. Gut Microbes. 2025;17(1):2501185. https:\/\/doi.org\/10.1080\/19490976.2025.2501185.","journal-title":"Gut Microbes"},{"key":"4245_CR105","doi-asserted-by":"publisher","unstructured":"Dos Santos Quaresma M, Souza W, Lemos VA, Caris AV, Thomatieli-Santos RV. The Possible Importance of Glutamine Supplementation to Mood and Cognition in Hypoxia from High Altitude. Nutrients. 2020;12(12); https:\/\/doi.org\/10.3390\/nu12123627.","DOI":"10.3390\/nu12123627"},{"issue":"1","key":"4245_CR106","doi-asserted-by":"publisher","first-page":"9723","DOI":"10.1038\/s41598-017-10097-4","volume":"7","author":"D Capitanio","year":"2017","unstructured":"Capitanio D, Fania C, Torretta E, Vigan\u00f2 A, Moriggi M, Bravat\u00e0 V, et al. TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans. Sci Rep. 2017;7(1):9723. https:\/\/doi.org\/10.1038\/s41598-017-10097-4.","journal-title":"Sci Rep"},{"issue":"3","key":"4245_CR107","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.cmet.2023.02.007","volume":"35","author":"AD Midha","year":"2023","unstructured":"Midha AD, Zhou Y, Queliconi BB, Barrios AM, Haribowo AG, Chew BTL, et al. Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism. Cell Metab. 2023;35(3):504-16.e5. https:\/\/doi.org\/10.1016\/j.cmet.2023.02.007.","journal-title":"Cell Metab"},{"issue":"4","key":"4245_CR108","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41574-024-01067-8","volume":"21","author":"M Cadena Sandoval","year":"2025","unstructured":"Cadena Sandoval M, Haeusler RA. Bile acid metabolism in type 2 diabetes mellitus. Nat Rev Endocrinol. 2025;21(4):203\u201313. https:\/\/doi.org\/10.1038\/s41574-024-01067-8.","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"4245_CR109","doi-asserted-by":"publisher","first-page":"e243","DOI":"10.1002\/imt2.243","volume":"3","author":"D Zheng","year":"2024","unstructured":"Zheng D, Zhang H, Zheng X, Zhao A, Jia W. Novel microbial modifications of bile acids and their functional implications. Imeta. 2024;3(5):e243. https:\/\/doi.org\/10.1002\/imt2.243.","journal-title":"Imeta"},{"issue":"1","key":"4245_CR110","doi-asserted-by":"publisher","first-page":"1949095","DOI":"10.1080\/19490976.2021.1949095","volume":"13","author":"J Xiang","year":"2021","unstructured":"Xiang J, Zhang Z, Xie H, Zhang C, Bai Y, Cao H, et al. Effect of different bile acids on the intestine through enterohepatic circulation based on FXR. Gut Microbes. 2021;13(1):1949095. https:\/\/doi.org\/10.1080\/19490976.2021.1949095.","journal-title":"Gut Microbes"},{"issue":"1","key":"4245_CR111","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","volume":"24","author":"A Wahlstr\u00f6m","year":"2016","unstructured":"Wahlstr\u00f6m A, Sayin SI, Marschall HU, B\u00e4ckhed F. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 2016;24(1):41\u201350. https:\/\/doi.org\/10.1016\/j.cmet.2016.05.005.","journal-title":"Cell Metab"},{"issue":"36","key":"4245_CR112","doi-asserted-by":"publisher","first-page":"13580","DOI":"10.1073\/pnas.0804437105","volume":"105","author":"BV Jones","year":"2008","unstructured":"Jones BV, Begley M, Hill C, Gahan CG, Marchesi JR. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 2008;105(36):13580\u20135. https:\/\/doi.org\/10.1073\/pnas.0804437105.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"4245_CR113","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s40168-021-01101-1","volume":"9","author":"DV Guzior","year":"2021","unstructured":"Guzior DV, Quinn RA. Review: microbial transformations of human bile acids. Microbiome. 2021;9(1):140. https:\/\/doi.org\/10.1186\/s40168-021-01101-1.","journal-title":"Microbiome"},{"issue":"8","key":"4245_CR114","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.medj.2024.03.023","volume":"5","author":"JL He","year":"2024","unstructured":"He JL, Zhao YW, Yang JL, Ju JM, Ye BQ, Huang JY, et al. Enhanced interactions among gut mycobiomes with the deterioration of glycemic control. Med. 2024;5(8):909-25.e7. https:\/\/doi.org\/10.1016\/j.medj.2024.03.023.","journal-title":"Med"},{"issue":"6","key":"4245_CR115","doi-asserted-by":"publisher","first-page":"e251","DOI":"10.1002\/imt2.251","volume":"3","author":"Y Wang","year":"2024","unstructured":"Wang Y, Hou H, Luo H, Xun J, Ma C, Yang H, et al. Imeta conference 2024: building an innovative scientific research ecosystem for microbiome and one health. Imeta. 2024;3(6):e251. https:\/\/doi.org\/10.1002\/imt2.251.","journal-title":"Imeta"},{"issue":"7","key":"4245_CR116","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1136\/gutjnl-2020-320666","volume":"70","author":"Q Feng","year":"2021","unstructured":"Feng Q, Lan X, Ji X, Li M, Liu S, Xiong J, et al. Time series analysis of microbiome and metabolome at multiple body sites in steady long-term isolation confinement. Gut. 2021;70(7):1409\u201312. https:\/\/doi.org\/10.1136\/gutjnl-2020-320666.","journal-title":"Gut"},{"key":"4245_CR117","doi-asserted-by":"publisher","first-page":"745214","DOI":"10.3389\/fendo.2021.745214","volume":"12","author":"M Ren","year":"2022","unstructured":"Ren M, Lin D, Liu Z, Sun K, Wang C, Lao G, et al. Potential novel serum metabolic markers associated with progression of prediabetes to overt diabetes in a Chinese population. Front Endocrinol (Lausanne). 2022;12:745214. https:\/\/doi.org\/10.3389\/fendo.2021.745214.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"4245_CR118","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1038\/s41467-022-30857-9","volume":"13","author":"L Chen","year":"2022","unstructured":"Chen L, Zhao N, Cao J, Liu X, Xu J, Ma Y, et al. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes. Nat Commun. 2022;13(1):3175. https:\/\/doi.org\/10.1038\/s41467-022-30857-9.","journal-title":"Nat Commun"},{"issue":"1","key":"4245_CR119","doi-asserted-by":"publisher","first-page":"2350151","DOI":"10.1080\/19490976.2024.2350151","volume":"16","author":"H Zhao","year":"2024","unstructured":"Zhao H, Sun L, Liu J, Shi B, Zhang Y, Qu-Zong CR, et al. Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation. Gut Microbes. 2024;16(1):2350151. https:\/\/doi.org\/10.1080\/19490976.2024.2350151.","journal-title":"Gut Microbes"},{"issue":"1","key":"4245_CR120","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40168-024-01781-5","volume":"12","author":"Y Han","year":"2024","unstructured":"Han Y, Liu X, Jia Q, Xu J, Shi J, Li X, et al. Longitudinal multi-omics analysis uncovers the altered landscape of gut microbiota and plasma metabolome in response to high altitude. Microbiome. 2024;12(1):70. https:\/\/doi.org\/10.1186\/s40168-024-01781-5.","journal-title":"Microbiome"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04245-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:54:07Z","timestamp":1759406047000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04245-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":120,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4245"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04245-4","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"16 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The human study protocol was approval by the Human Research and Ethics Committee of the People's Hospital of Nyingchi and was registered at ChiCTR.org.cn (registration no. ChiCTR1800016854) with approval number of 2015S00011. This study was conducted in full compliance with the principles outlined in the Helsinki Declaration II. Written informed consent was obtained from all the participants. The mice experimental procedures were approved by the Research Ethics Committee of Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences (approval number: KY-N2022-010\u201302).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"591"}}