{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:52:41Z","timestamp":1793145161669,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400761"],"award-info":[{"award-number":["82400761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370661"],"award-info":[{"award-number":["82370661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Team cultivation project of the First Affiliated Hospital of Nanchang University","award":["YFYKCTDPY202202"],"award-info":[{"award-number":["YFYKCTDPY202202"]}]},{"name":"Jiangxi Province\u2019s Thousand Talents Plan for introducing and cultivating high-level talents in innovation and entrepreneurship","award":["jxsp2019201028"],"award-info":[{"award-number":["jxsp2019201028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Microbiol"],"DOI":"10.1186\/s12866-025-04467-6","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:21:21Z","timestamp":1762957281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal dysbiosis of gut bacteriome and mycobiome in patients with severe acute pancreatitis and its association with mortality"],"prefix":"10.1186","volume":"25","author":[{"given":"Cong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nonghua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"issue":"1","key":"4467_CR1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","volume":"162","author":"JP Iannuzzi","year":"2022","unstructured":"Iannuzzi JP, King JA, Leong JH, Quan J, Windsor JW, Tanyingoh D, et al. Global incidence of acute pancreatitis is increasing over time: a systematic review and meta-analysis. Gastroenterology. 2022;162(1):122\u201334.","journal-title":"Gastroenterology"},{"key":"4467_CR2","doi-asserted-by":"crossref","unstructured":"van Dijk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ, et al. Acute pancreatitis: recent advances through randomised trials. Gut. 2017;66(11):2024\u201332.","DOI":"10.1136\/gutjnl-2016-313595"},{"issue":"5","key":"4467_CR3","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3748\/wjg.v26.i5.514","volume":"26","author":"L Ding","year":"2020","unstructured":"Ding L, Chen HY, Wang JY, Xiong HF, He WH, Xia L, et al. Severity of acute gastrointestinal injury grade is a good predictor of mortality in critically ill patients with acute pancreatitis. World J Gastroenterol. 2020;26(5):514\u201323.","journal-title":"World J Gastroenterol"},{"issue":"4","key":"4467_CR4","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S1072-7515(98)00334-2","volume":"188","author":"M Grewe","year":"1999","unstructured":"Grewe M, Tsiotos GG, Luque de-Leon E, Sarr MG. Fungal infection in acute necrotizing pancreatitis. J Am Coll Surg. 1999;188(4):408\u201314.","journal-title":"J Am Coll Surg"},{"issue":"7","key":"4467_CR5","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1136\/gutjnl-2022-327448","volume":"72","author":"J Glaubitz","year":"2023","unstructured":"Glaubitz J, Wilden A, Frost F, Ameling S, Homuth G, Mazloum H, et al. Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis. Gut. 2023;72(7):1355\u201369.","journal-title":"Gut"},{"issue":"4","key":"4467_CR6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s00535-018-1529-0","volume":"54","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, He C, Li X, Cai Y, Hu J, Liao Y, et al. Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. J Gastroenterol. 2019;54(4):347\u201358.","journal-title":"J Gastroenterol"},{"issue":"18","key":"4467_CR7","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.3748\/wjg.v26.i18.2187","volume":"26","author":"XY Li","year":"2020","unstructured":"Li XY, He C, Zhu Y, Lu NH. Role of gut microbiota on intestinal barrier function in acute pancreatitis. World J Gastroenterol. 2020;26(18):2187\u201393.","journal-title":"World J Gastroenterol"},{"issue":"12","key":"4467_CR8","doi-asserted-by":"publisher","first-page":"e969","DOI":"10.1016\/S2666-5247(22)00203-8","volume":"3","author":"F Zhang","year":"2022","unstructured":"Zhang F, Aschenbrenner D, Yoo JY, Zuo T. The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly. Lancet Microbe. 2022;3(12):e969\u201383.","journal-title":"Lancet Microbe"},{"issue":"1","key":"4467_CR9","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis\u20132012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102\u201311.","journal-title":"Gut"},{"issue":"17","key":"4467_CR10","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen S, Zhou Y, Chen Y, Gu J. Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018;34(17):i884-90.","journal-title":"Bioinformatics"},{"issue":"21","key":"4467_CR11","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Magoc","year":"2011","unstructured":"Magoc T, Salzberg SL. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics. 2011;27(21):2957\u201363.","journal-title":"Bioinformatics"},{"issue":"10","key":"4467_CR12","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"RC Edgar","year":"2013","unstructured":"Edgar RC. Uparse: highly accurate OTU sequences from microbial amplicon reads. Nat Methods. 2013;10(10):996\u20138.","journal-title":"Nat Methods"},{"issue":"16","key":"4467_CR13","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","volume":"73","author":"Q Wang","year":"2007","unstructured":"Wang Q, Garrity GM, Tiedje JM, Cole JR. Naive bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 2007;73(16):5261\u20137.","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"4467_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.12","volume":"1","author":"Y Ren","year":"2022","unstructured":"Ren Y, Yu G, Shi C, Liu L, Guo Q, Han C, et al. Majorbio cloud: a one-stop, comprehensive bioinformatic platform for multiomics analyses. Imeta. 2022;1(2):e12.","journal-title":"Imeta"},{"issue":"18","key":"4467_CR15","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1093\/bioinformatics\/btt383","volume":"29","author":"N De Jay","year":"2013","unstructured":"De Jay N, Papillon-Cavanagh S, Olsen C, El-Hachem N, Bontempi G, Haibe-Kains B. mRMRe: an R package for parallelized mRMR ensemble feature selection. Bioinformatics. 2013;29(18):2365\u20138.","journal-title":"Bioinformatics"},{"issue":"8","key":"4467_CR16","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat Biotechnol. 2019;37(8):852\u20137.","journal-title":"Nat Biotechnol"},{"key":"4467_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77","volume":"12","author":"X Robin","year":"2011","unstructured":"Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.","journal-title":"BMC Bioinformatics"},{"issue":"7","key":"4467_CR18","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.pan.2020.08.018","volume":"20","author":"Z Imam","year":"2020","unstructured":"Imam Z, Simons-Linares CR, Chahal P. Infectious causes of acute pancreatitis: a systematic review. Pancreatology. 2020;20(7):1312\u201322.","journal-title":"Pancreatology"},{"issue":"9613","key":"4467_CR19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0140-6736(08)60207-X","volume":"371","author":"MG Besselink","year":"2008","unstructured":"Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371(9613):651\u20139.","journal-title":"Lancet"},{"key":"4467_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104849","volume":"154","author":"S Yu","year":"2021","unstructured":"Yu S, Xiong Y, Fu Y, Chen G, Zhu H, Mo X, et al. Shotgun metagenomics reveals significant gut microbiome features in different grades of acute pancreatitis. Microb Pathog. 2021;154:104849.","journal-title":"Microb Pathog"},{"issue":"5","key":"4467_CR21","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1136\/gutjnl-2019-320430","volume":"70","author":"FF van den Berg","year":"2021","unstructured":"van den Berg FF, van Dalen D, Hyoju SK, van Santvoort HC, Besselink MG, Wiersinga WJ, et al. Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. Gut. 2021;70(5):915\u201327.","journal-title":"Gut"},{"issue":"12","key":"4467_CR22","doi-asserted-by":"publisher","first-page":"e00059","DOI":"10.1128\/AEM.00059-19","volume":"85","author":"J Zheng","year":"2019","unstructured":"Zheng J, Lou L, Fan J, Huang C, Mei Q, Wu J, et al. Commensal Escherichia coli aggravates acute necrotizing pancreatitis through targeting of intestinal epithelial cells. Appl Environ Microbiol. 2019;85(12):e00059\u201319. https:\/\/doi.org\/10.1128\/AEM.00059-19.","journal-title":"Appl Environ Microbiol"},{"key":"4467_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.988326","volume":"13","author":"M Zou","year":"2022","unstructured":"Zou M, Yang Z, Fan Y, Gong L, Han Z, Ji L, et al. Gut microbiota on admission as predictive biomarker for acute necrotizing pancreatitis. Front Immunol. 2022;13:988326.","journal-title":"Front Immunol"},{"issue":"1","key":"4467_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01065-2","volume":"9","author":"Y Lei","year":"2021","unstructured":"Lei Y, Tang L, Liu S, Hu S, Wu L, Liu Y, et al. Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration. Microbiome. 2021;9(1):115.","journal-title":"Microbiome"},{"issue":"1","key":"4467_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03980-8","volume":"26","author":"R Prevel","year":"2022","unstructured":"Prevel R, Enaud R, Orieux A, Camino A, Berger P, Boyer A, et al. Gut bacteriobiota and mycobiota are both associated with day-28 mortality among critically ill patients. Crit Care. 2022;26(1):105.","journal-title":"Crit Care"},{"issue":"1","key":"4467_CR26","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2127456","volume":"14","author":"H Li","year":"2022","unstructured":"Li H, Xie J, Guo X, Yang G, Cai B, Liu J, et al. Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses. Gut Microbes. 2022;14(1):2127456.","journal-title":"Gut Microbes"},{"key":"4467_CR27","doi-asserted-by":"crossref","unstructured":"Yan X, Li J, Wu D. The role of short-chain fatty acids in acute pancreatitis. Molecules. 2023;28(13):4985.","DOI":"10.3390\/molecules28134985"},{"key":"4467_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01927","volume":"8","author":"DL Zuza-Alves","year":"2017","unstructured":"Zuza-Alves DL, Silva-Rocha WP, Chaves GM. An update on Candida tropicalis based on basic and clinical approaches. Front Microbiol. 2017;8:1927.","journal-title":"Front Microbiol"},{"issue":"3","key":"4467_CR29","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jcmgh.2021.11.008","volume":"13","author":"L Di Martino","year":"2022","unstructured":"Di Martino L, De Salvo C, Buela KA, Hager C, Ghannoum M, Osme A, et al. Candida tropicalis infection modulates the gut microbiome and confers enhanced susceptibility to colitis in mice. Cell Mol Gastroenterol Hepatol. 2022;13(3):901\u201323.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"3","key":"4467_CR30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/jof7030177","volume":"7","author":"P Fernandez-Pacheco","year":"2021","unstructured":"Fernandez-Pacheco P, Pintado C, Briones Perez A, Arevalo-Villena M. Potential probiotic strains of Saccharomyces and non-Saccharomyces: functional and biotechnological characteristics. J Fungi. 2021;7(3):177. https:\/\/doi.org\/10.3390\/jof7030177.","journal-title":"J Fungi"},{"issue":"1","key":"4467_CR31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jss.2009.02.008","volume":"160","author":"M Karen","year":"2010","unstructured":"Karen M, Yuksel O, Akyurek N, Ofluoglu E, Caglar K, Sahin TT, et al. Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats. J Surg Res. 2010;160(1):139\u201344.","journal-title":"J Surg Res"},{"issue":"11","key":"4467_CR32","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41575-023-00816-w","volume":"20","author":"KS Ost","year":"2023","unstructured":"Ost KS, Round JL. Commensal fungi in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2023;20(11):723\u201334.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"4467_CR33","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/s41591-023-02243-5","volume":"29","author":"J Schlechte","year":"2023","unstructured":"Schlechte J, Zucoloto AZ, Yu IL, Doig CJ, Dunbar MJ, McCoy KD, et al. Dysbiosis of a microbiota-immune metasystem in critical illness is associated with nosocomial infections. Nat Med. 2023;29(4):1017\u201327.","journal-title":"Nat Med"},{"issue":"1","key":"4467_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2488-4","volume":"23","author":"R Xu","year":"2019","unstructured":"Xu R, Tan C, Zhu J, Zeng X, Gao X, Wu Q, et al. Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death. Crit Care. 2019;23(1):195.","journal-title":"Crit Care"},{"key":"4467_CR35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mib.2021.09.014","volume":"64","author":"NG Shealy","year":"2021","unstructured":"Shealy NG, Yoo W, Byndloss MX. Colonization resistance: metabolic warfare as a strategy against pathogenic Enterobacteriaceae. Curr Opin Microbiol. 2021;64:82\u201390.","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"4467_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04780-4","volume":"28","author":"G Park","year":"2024","unstructured":"Park G, Munley JA, Kelly LS, Kannan KB, Mankowski RT, Sharma A, et al. Gut mycobiome dysbiosis after sepsis and trauma. Crit Care. 2024;28(1):18.","journal-title":"Crit Care"},{"issue":"1","key":"4467_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03943-z","volume":"26","author":"S Mu","year":"2022","unstructured":"Mu S, Xiang H, Wang Y, Wei W, Long X, Han Y, et al. The pathogens of secondary infection in septic patients share a similar genotype to those that predominate in the gut. Crit Care. 2022;26(1):68.","journal-title":"Crit Care"},{"issue":"7484","key":"4467_CR38","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"LA David","year":"2014","unstructured":"David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559\u201363.","journal-title":"Nature"},{"issue":"2","key":"4467_CR39","doi-asserted-by":"publisher","first-page":"e00092","DOI":"10.1128\/mSphere.00092-18","volume":"3","author":"TA Auchtung","year":"2018","unstructured":"Auchtung TA, Fofanova TY, Stewart CJ, Nash AK, Wong MC, Gesell JR, et al. Investigating colonization of the healthy adult gastrointestinal tract by fungi. mSphere. 2018;3(2):e00092\u201318. https:\/\/doi.org\/10.1128\/mSphere.00092-18.","journal-title":"mSphere"},{"issue":"1","key":"4467_CR40","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2399360","volume":"16","author":"J Buttar","year":"2024","unstructured":"Buttar J, Kon E, Lee A, Kaur G, Lunken G. Effect of diet on the gut mycobiome and potential implications in inflammatory bowel disease. Gut Microbes. 2024;16(1):2399360.","journal-title":"Gut Microbes"},{"issue":"1","key":"4467_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-024-00675-z","volume":"17","author":"MQ Zhao","year":"2025","unstructured":"Zhao MQ, Fan MY, Cui MY, Chen SM, Wang JJ, Lu YY, et al. Profile of intestinal fungal microbiota in acute pancreatitis patients and healthy individuals. Gut Pathog. 2025;17(1):1.","journal-title":"Gut Pathog"},{"issue":"4","key":"4467_CR42","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1136\/gutjnl-2018-317178","volume":"68","author":"OO Coker","year":"2019","unstructured":"Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, et al. Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut. 2019;68(4):654\u201362.","journal-title":"Gut"},{"issue":"1","key":"4467_CR43","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1136\/gutjnl-2018-317791","volume":"69","author":"S Lemoinne","year":"2020","unstructured":"Lemoinne S, Kemgang A, Ben Belkacem K, Straube M, Jegou S, Corpechot C, et al. Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis. Gut. 2020;69(1):92\u2013102.","journal-title":"Gut"},{"key":"4467_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/srep26087","volume":"6","author":"SN Baldassano","year":"2016","unstructured":"Baldassano SN, Bassett DS. Topological distortion and reorganized modular structure of gut microbial co-occurrence networks in inflammatory bowel disease. Sci Rep. 2016;6:26087.","journal-title":"Sci Rep"},{"issue":"2","key":"4467_CR45","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1073\/pnas.1116053109","volume":"109","author":"S Greenblum","year":"2012","unstructured":"Greenblum S, Turnbaugh PJ, Borenstein E. Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease. Proc Natl Acad Sci U S A. 2012;109(2):594\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4467_CR46","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1136\/gutjnl-2020-322753","volume":"70","author":"F Frost","year":"2021","unstructured":"Frost F, Kacprowski T, Ruhlemann M, Pietzner M, Bang C, Franke A, et al. Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function. Gut. 2021;70(3):522\u201330.","journal-title":"Gut"}],"container-title":["BMC Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04467-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12866-025-04467-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12866-025-04467-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T16:04:21Z","timestamp":1762963461000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/10.1186\/s12866-025-04467-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4467"],"URL":"https:\/\/doi.org\/10.1186\/s12866-025-04467-6","relation":{},"ISSN":["1471-2180"],"issn-type":[{"value":"1471-2180","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Medical Ethics Committee of the First Affiliated Hospital of Nanchang University (No. 2019055). All subjects gave informed consent to participate in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"730"}}